SsaA, a member of a novel class of transcriptional regulators, controls sansanmycin production in streptomyces sp. strain SS through a feedback mechanism

Journal of Bacteriology

Volumn 195, Issue 10, 2013, Pages 2232-2243

  Li, Qinglian ^a   Wang, Lifei ^a   Xie, Yunying ^a   Wang, Songmei ^a   Chen, Ruxian ^a   Hong, Bin ^a  

^a INSTITUTE OF MEDICINAL BIOTECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; BACTERIAL PROTEIN; PACIDAMYCIN 4; PACIDAMYCIN A; PACIDAMYCIN D; POLYPEPTIDE ANTIBIOTIC AGENT; SANSAMYCIN; SANSAMYCIN A; SANSAMYCIN B; SANSAMYCIN C; SANSAMYCIN D; SANSAMYCIN E; SANSAMYCIN F; SANSAMYCIN G; SANSAMYCIN H; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANTIBACTERIAL ACTIVITY; ARTICLE; AUTOREGULATION; BACTERIAL GENE; BACTERIAL STRAIN; BIOSYNTHESIS; CONCENTRATION (PARAMETERS); CONSENSUS; DNA BINDING; GENE CLUSTER; GENE EXPRESSION; NONHUMAN; OPEN READING FRAME; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN MOTIF; STREPTOMYCES; TRANSCRIPTION REGULATION;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; GENE EXPRESSION REGULATION, BACTERIAL; OLIGOPEPTIDES; STREPTOMYCES; URIDINE;

EID: 84877939989     PISSN: 00219193     EISSN: 10985530     Source Type: Journal    
DOI: 10.1128/JB.00054-13     Document Type: Article

References (46)

1. Xie Y, Chen R, Si S, Sun C, Xu H. 2007. A new nucleosidyl-peptide antibiotic, sansanmycin. J. Antibiot. (Tokyo) 60:158-161.
2. Xie Y, Xu H, Si S, Sun C, Chen R. 2008. Sansanmycins B and C, new components of sansanmycins. J. Antibiot. (Tokyo) 61:237-240.
3. Chen RH, Buko AM, Whittern DN, McAlpine JB. 1989. Pacidamycins, a novel series of antibiotics with anti-Pseudomonas aeruginosa activity. II. Isolation and structural elucidation. J. Antibiot. (Tokyo) 42:512-520.
4. Chatterjee S, Nadkarni SR, Vijayakumar EK, Patel MV, Ganguli BN, Fehlhaber HW, Vertesy L. 1994. Napsamycins, new Pseudomonas active antibiotics of the mureidomycin family from Streptomyces sp. HIL Y-82,11372. J. Antibiot. (Tokyo) 47:595-598.
5. Isono F, Inukai M, Takahashi S, Haneishi T, Kinoshita T, Kuwano H. 1989. Mureidomycins A-D, novel peptidylnucleoside antibiotics with spheroplast forming activity. II. Structural elucidation. J. Antibiot. (Tokyo) 42:667-673.
6. Winn M, Goss RJ, Kimura K, Bugg TD. 2010. Antimicrobial nucleoside antibiotics targeting cell wall assembly: recent advances in structurefunction studies and nucleoside biosynthesis. Nat. Prod. Rep. 27:279-304.
7. Zhang W, Ostash B, Walsh CT. 2010. Identification of the biosynthetic gene cluster for the pacidamycin group of peptidyl nucleoside antibiotics. Proc. Natl. Acad. Sci. U. S. A. 107:16828-16833.
8. Rackham EJ, Gruschow S, Ragab AE, Dickens S, Goss RJ. 2010. Pacidamycin biosynthesis: identification and heterologous expression of the first uridyl peptide antibiotic gene cluster. Chembiochem 11:1700-1709.
9. Kaysser L, Tang X, Wemakor E, Sedding K, Hennig S, Siebenberg S, Gust B. 2011. Identification of a napsamycin biosynthesis gene cluster by genome mining. Chembiochem 12:477-487.
10. Zhang W, Ntai I, Bolla ML, Malcolmson SJ, Kahne D, Kelleher NL, Walsh CT. 2011. Nine enzymes are required for assembly of the pacidamycin group of peptidyl nucleoside antibiotics. J. Am. Chem. Soc. 133: 5240-5243.
11. Martin JF, Liras P. 2010. Engineering of regulatory cascades and networks controlling antibiotic biosynthesis in Streptomyces. Curr. Opin. Microbiol. 13:263-273.
12. van Wezel GP, McDowall KJ. 2011. The regulation of the secondary metabolism of Streptomyces: new links and experimental advances. Nat. Prod. Rep. 28:1311-1333.
13. Wietzorrek A, Bibb M. 1997. A novel family of proteins that regulates antibiotic production in streptomycetes appears to contain an OmpR-like DNA-binding fold. Mol. Microbiol. 25:1181-1184.
14. Wilson DJ, Xue Y, Reynolds KA, Sherman DH. 2001. Characterization and analysis of the PikD regulatory factor in the pikromycin biosynthetic pathway of Streptomyces venezuelae. J. Bacteriol. 183:3468-3475.
15. Sekurova ON, Brautaset T, Sletta H, Borgos SE, Jakobsen MO, Ellingsen TE, Strom AR, Valla S, Zotchev SB. 2004. In vivo analysis of the regulatory genes in the nystatin biosynthetic gene cluster of Streptomyces noursei ATCC 11455 reveals their differential control over antibiotic biosynthesis. J. Bacteriol. 186:1345-1354.
16. Santos-Aberturas J, Payero TD, Vicente CM, Guerra SM, Canibano C, Martin JF, Aparicio JF. 2011. Functional conservation of PAS-LuxR transcriptional regulators in polyene macrolide biosynthesis. Metab. Eng. 13:756-767.
17. Santos-Aberturas J, Vicente CM, Guerra SM, Payero TD, Martin JF, Aparicio JF. 2011. Molecular control of polyene macrolide biosynthesis: direct binding of the regulator PimM to eight promoters of pimaricin genes and identification of binding boxes. J. Biol. Chem. 286:9150-9161.
18. Guthrie EP, Flaxman CS, White J, Hodgson DA, Bibb MJ, Chater KF. 1998. A response-regulator-like activator of antibiotic synthesis from Streptomyces coelicolor A3(2) with an amino-terminal domain that lacks a phosphorylation pocket. Microbiology 144(Pt 3):727-738.
19. Wang L, Tian X, Wang J, Yang H, Fan K, Xu G, Yang K, Tan H. 2009. Autoregulation of antibiotic biosynthesis by binding of the end product to an atypical response regulator. Proc. Natl. Acad. Sci. U. S. A. 106:8617-8622.
20. Kutas P, Feckova L, Rehakova A, Novakova R, Homerova D, Mingyar E, Rezuchova B, Sevcikova B, Kormanec J. 2012. Strict control of auricin production in Streptomyces aureofaciens CCM 3239 involves a feedback mechanism. Appl. Microbiol. Biotechnol. 97:2413-2421.
21. Wang L, Hu Y, Zhang Y, Wang S, Cui Z, Bao Y, Jiang W, Hong B. 2009. Role of sgcR3 in positive regulation of enediyne antibiotic C-1027 production of Streptomyces globisporus C-1027. BMC Microbiol. 9:14. doi:10.1186/1471-2180-9-14.
22. Kieser T, Bibb MJ, Buttner MJ, Chater KF, Hopwood DA. 2000. Practical Streptomyces genetics. The John Innes Foundation, Norwich, CT.
23. Korn F, Weingartner B, Kutzner HJ. 1978. A study of twenty actinophages: morphology, serological relationship and host range, p 251-270. In Freerksen E, Tarnok I, Thumin H (ed), Genetics of the Actinomycetales. G. Fisher, New York, NY.
24. Sambrook J, Russell DW. 2001. Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
25. Paget MS, Chamberlin L, Atrih A, Foster SJ, Buttner MJ. 1999. Evidence that the extracytoplasmic function sigma factor sigmaE is required for normal cell wall structure in Streptomyces coelicolor A3(2). J. Bacteriol. 181:204-211.
26. Gust B, Challis GL, Fowler K, Kieser T, Chater KF. 2003. PCR-targeted Streptomyces gene replacement identifies a protein domain needed for biosynthesis of the sesquiterpene soil odor geosmin. Proc. Natl. Acad. Sci. U. S. A. 100:1541-1546.
27. Studier FW. 2005. Protein production by auto-induction in high density shaking cultures. Protein Expr. Purif. 41:207-234.
28. Hong B, Phornphisutthimas S, Tilley E, Baumberg S, McDowall KJ. 2007. Streptomycin production by Streptomyces griseus can be modulated by a mechanism not associated with change in the adpA component of the A-factor cascade. Biotechnol. Lett. 29:57-64.
29. Pfaffl MW. 2001. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 29:e45.
30. Delcher AL, Bratke KA, Powers EC, Salzberg SL. 2007. Identifying bacterial genes and endosymbiont DNA with Glimmer. Bioinformatics 23:673-679.
31. van Helden J. 2003. Regulatory sequence analysis tools. Nucleic Acids Res. 31:3593-3596.
32. Wang L, Xie Y, Li Q, He N, Yao E, Xu H, Yu Y, Chen R, Hong B. 2012. Draft genome sequence of Streptomyces sp. SS, which produces a series of uridyl peptide antibiotic sansanmycins. J. Bacteriol. 194:6988-6989.
33. Soding J, Biegert A, Lupas AN. 2005. The HHpred interactive server for protein homology detection and structure prediction. Nucleic Acids Res. 33:W244-W248.
34. Liang X, van Doren SR. 2008. Mechanistic insights into phosphoproteinbinding FHA domains. Acc. Chem. Res. 41:991-999.
35. Hammet A, Pike BL, McNees CJ, Conlan LA, Tenis N, Heierhorst J. 2003. FHA domains as phospho-threonine binding modules in cell signaling. IUBMB Life 55:23-27.
36. Crooks GE, Hon G, Chandonia JM, Brenner SE. 2004. WebLogo: a sequence logo generator. Genome Res. 14:1188-1190.
37. Retzlaff L, Distler J. 1995. The regulator of streptomycin gene expression, StrR, of Streptomyces griseus is a DNA binding activator protein with multiple recognition sites. Mol. Microbiol. 18:151-162.
38. Pompeani AJ, Irgon JJ, Berger MF, Bulyk ML, Wingreen NS, Bassler BL. 2008. The Vibrio harveyi master quorum-sensing regulator, LuxR, a TetR-type protein is both an activator and a repressor: DNA recognition and binding specificity at target promoters. Mol. Microbiol. 70:76-88.
39. Zhu J, Winans SC. 1999. Autoinducer binding by the quorum-sensing regulator TraR increases affinity for target promoters in vitro and decreases TraR turnover rates in whole cells. Proc. Natl. Acad. Sci. U. S. A. 96:4832-4837.
40. Tong Y, Tempel W, Wang H, Yamada K, Shen L, Senisterra GA, MacKenzie F, Chishti AH, Park HW. 2010. Phosphorylationindependent dual-site binding of the FHA domain of KIF13 mediates phosphoinositide transport via centaurin alpha1. Proc. Natl. Acad. Sci. U. S. A. 107:20346-20351.
41. Fish SA, Cundliffe E. 1997. Stimulation of polyketide metabolism in Streptomyces fradiae by tylosin and its glycosylated precursors. Microbiology 143(Pt 12):3871-3876.
42. Jiang H, Hutchinson CR. 2006. Feedback regulation of doxorubicin biosynthesis in Streptomyces peucetius. Res. Microbiol. 157:666-674.
43. Tahlan K, Ahn SK, Sing A, Bodnaruk TD, Willems AR, Davidson AR, Nodwell JR. 2007. Initiation of actinorhodin export in Streptomyces coelicolor. Mol. Microbiol. 63:951-961.
44. Le TB, Fiedler HP, den Hengst CD, Ahn SK, Maxwell A, Buttner MJ. 2009. Coupling of the biosynthesis and export of theDNAgyrase inhibitor simocyclinone in Streptomyces antibioticus. Mol. Microbiol. 72:1462-1474.
45. Horbal L, Rebets Y, Rabyk M, Makitrynskyy R, Luzhetskyy A, Fedorenko V, Bechthold A. 2012. SimReg1 is a master switch for biosynthesis and export of simocyclinone D8 and its precursors. AMB Express 2:1.
46. Bierman M, Logan R, O'Brien K, Seno ET, Rao RN, Schoner BE. 1992. Plasmid cloning vectors for the conjugal transfer of DNA from Escherichia coli to Streptomyces spp. Gene 116:43-49.