FHA domains as phospho-threonine binding modules in cell signaling

IUBMB Life

Volumn 55, Issue 1, 2003, Pages 23-27

  Hammet, Andrew ^a,c   Pike, Brietta L ^a,b   McNees, Carolyn J ^a,b   Conlan, Lindus A ^a   Tenis, Nora ^a   Heierhorst, Jörg ^a,b  

^a ST VINCENT'S INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Cell cycle; Checkpoint; Chk2; FHA domain; Phospho threonine binding domain; Protein phosphorylation; Rad53

Indexed keywords

BINDING PROTEIN; FORKHEAD ASSOCIATED PROTEIN; PHOSPHOTHREONINE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; BACTERIUM; CELL CYCLE; DISEASE ASSOCIATION; FAMILIAL CANCER; MAMMAL; NONHUMAN; POINT MUTATION; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANIMALS; CELL CYCLE; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PHOSPHOTHREONINE; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION;

BACTERIA (MICROORGANISMS); MAMMALIA;

EID: 0037256803     PISSN: 15216543     EISSN: None     Source Type: Journal    
DOI: 10.1080/1521654031000070636     Document Type: Review

References (31)

1. Hofmann, K., and Bucher, P. (1995) The FHA domain: a putative nuclear signalling domain found in protein kinases and transcription factors. Trends Biochem. Sci. 20, 347-349.
2. Li, J., Lee, G., Van Doren, S.R., and Walker, J.C. (2000) The FHA domain mediates phosphoprotein interactions. J. Cell Sci. 113, 4143-4149.
3. Tsai, M.-D. (2002) FHA: A signal transduction domain with diverse specificity and function. Structure 10, 887-888.
4. Hammet, A., Pike, B.L., Mitchelhill, K.I., Teh, T., Kobe, B., House, C.M., Kemp, B.E., and Heierhorst, J. (2000) FHA domain boundaries of the Dun1p and Rad53p cell cycle checkpoint kinases. FEBS Lett. 471. 141-146.
5. Durocher, D., Taylor, I.A., Sarbassova, D., Haire, L.F., Westcott, S.-L., Jackson, S.P., Smerdon, S.J., and Yaffe, M.B. (2000) The molecular basis of FHA Domain:Phosphopeptide binding specificity and implications for phospho-dependent signaling mechanisms. Mol. Cell 6, 1169-1182.
6. Liao, H., Byeon, I.J., and Tsai, M.D. (1999) Structure and function of a new phosphopeptide-binding domain containing the FHA2 of Rad53. J. Mol. Biol. 294, 1041-1049.
7. Yuan, C., Yongkiettrakul, S., Byeon, I.J., Zhou, S., and Tsai, M.D. (2001) Solution structures of two FHA1-phosphothreonine peptide complexes provide insight into the structural basis of the ligand specificity of FHA1 from yeast Rad53. J. Mol. Biol. 314, 563-575.
8. Byeon, I.J., Yongkiettrakul, S., and Tsai, M.D. (2001) Solution structure of the yeast Rad53 FHA2 complexed with a phosphothreonine peptide pTXXL: comparison with the structures of FHA2-pYXL and FHA1-pTXXD complexes. J. Mol. Biol. 314, 577-588.
9. Li, J., Williams, B.I., Haire, L.F., Goldberg, M., Wilker, E., Durocher, D., Yaffe, M.B., Jackson, S.P., and Smerdon, S.J. (2002) Structural and functional versatility of the FHA domain in DNA-damage signaling by the tumor suppressor kinase Chk2. Mol. Cell 9, 1045-1054.
10. Stavridi, E.S., Huyen, Y., Loreto, I.R., Scolnick, D.M., Halazonetis, T.D., Pavletich, N.P., and Jeffrey, P.D. (2002) Crystal structure of the FHA domain of the Chfr mitotic checkpoint protein and its complex with tungstate. Structure 10, 891-899.
11. Stone, J.M., Collinge, M.A., Smith, R.D., Horn, M.A., and Walker, J.C. (1994) Interaction of a protein phosphatase with an Arabidopsis serine-threonine receptor kinase. Science 266, 793-795.
12. Li, J., Smith, G.P., and Walker, J.C. (1999) Kinase interaction domain of kinase-associated protein phosphatase, a phosphoprotein-binding domain. Proc. Natl. Acad. Sci. USA 96, 7821-7826.
13. Sun, Z., Hsiao, J., Fay, D.S., and Stern, D.F. (1998) Rad53 FHA domain associated with phosphorylated Rad9 in the DNA damage checkpoint. Science 281, 272-274.
14. Durocher, D., Henckel, J., Ferscht, A.R., and Jackson, S.P. (1999) The FHA domain is a modular phosphopeptide recognition motif. Mol. Cell 4, 387-394.
15. Schwartz, M.F., Duong, J.K., Sun, Z., Morrow, J.S., Pradhan, D., and Stern, D.F. (2002) Rad9 phosphorylation sites couple Rad53 to the Saccharomyces cerevisiae DNA damage checkpoint. Mol. Cell 9, 1055-1065.
16. Qin, B.Y., Chacko, B.M., Lam, S.S., de Caestecker, M.P., Correia, J.J., and Lin, K. (2001) Structural basis of Smadl activation by receptor kinase phosphorylation. Mol. Cell 8, 1303-1312.
17. Bell, D.W., Varley, J.M., Szydlo, T.E., Kang, D.H., Wahrer, D.C., Shannon, K.E., Lubratovich, M., Verselis, S.J., Isselbacher, K.J., Fraumeni, J.F., Birch, J.M., Li, F.P., Garber, J.E., and Haber, D.A. (1999) Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome. Science 286, 2528-2531.
18. Ahn, J.-Y., Li, X., Davis, HL., and Canman, C.E. (2002) Phosphorylation of threonine 68 promotes oligomerization and autophosphorylation of the Chk2 protein kinase via the forkhead-associated, FHA) domain. J. Biol. Chem. 277, 19389-19395.
19. Falck, J., Mailand, N., Syljuasen, R.G., Bartek, J., and Lukas, J. (2001) The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis. Nature 410, 842-847.
20. Chen, X.B., Melchionna, R., Denis, C.M., Gaillard, P.H., Blasina, A., Van de Weyer, I., Boddy, M.N., Russell, P., Vialard, J., and McGowan, C.H. (2001) Human Mus81-associated endonuclease cleaves Holliday junctions in vitro. Mol. Cell 8, 1117-1127.
21. Hammet, A., Pike, BL., and Heierhorst, J. (2002) Posttranscriptional regulation of the RAD5 DNA repair gene by the Dun1 kinase and the Pan2-Pan3 poly(A)-nuclease complex contributes to survival of replication blocks. J. Biol. Chem. 277, 22469-22474.
22. Pike, B.L., Hammet, A., and Heierhorst, J. (2001) Role of the N-terminal forkhead-associated domain in the cell cycle checkpoint function of the Rad53 kinase. J. Biol. Chem. 276, 14019-14026.
23. Tauchi, H., Kobayashi, J., Morishima, K., Matsuura, S., Nakamura, A., Shiraishi, T., Ito, E., Masnada, D., Delia, D., and Komatsu, K. (2001) The forkhead-associated domain of NBS1 is essential for nuclear foci formation after irradiation but not essential for hRAD50/hMRE11/NBS1 complex DNA repair activity. J. Biol. Chem. 276, 12-15.
24. Scolnick, D.M., and Halazonetis, T.D. (2000) Chfr defines a mitotic stress checkpoint that delays entry into metaphase. Nature 406, 430-435.
25. Kang, D., Chen, J., Wong, J., and Fang, G. (2002) The checkpoint protein Chfr is a ligase that ubiquitinates Plk1 and inhibits Cdc2 at the G2 to M transition. J. Cell Biol. 156, 249-259.
26. Kumar, R., Reynolds, D.M., Shevchenko, A., Goldstone, S.D., and Dalton, S. (2000) Forkhead transcription factors, Fkh1p and Fkh2p, collaborate with Mcm1p to control transcription required for M-phase. Curr. Biol. 10, 896-906.
27. Yang, Q., Kong, Y., Rothermel, B., Garry, D.J., Bassel-Duby, R., and Williams, R.S. (2000) The winged-helix/forkhead protein myocyte nuclear factor beta, MNF-beta) forms a co-repressor complex with mammalian sin3B. Biochem. J. 345, 335-343.
28. Westerholm-Parvinen, A., Vernos, I., and Serrano, L. (2000) Kinesin subfamily UNC104 contains a FHA domain: boundaries and physicochemical characterization. FEBS Lett. 486, 285-290.
29. Hubner, S., Jans, D.A., Xiao, C.Y., John, A.P., and Drenckhahn, D. (2002) Signal- and importin-dependent nuclear targeting of the kidney anion exchanger 1-binding protein kanadaptin. Biochem. J. 361, 287-296.
30. Boudrez, A., Beullens, M., Groenen, P., Van Eynde, A., Vulsteke, V., Jagiello, I., Murray, M., Krainer, A.R., Stalmans, W., and Bollen, M. (2000) NIPP1-mediated interaction of protein phosphatase-1 with CDC5L, a regulator of pre-mRNA splicing and mitotic entry. J. Biol. Chem. 275, 25411-25417.
31. Takagi, M., Sueishi, M., Saiwaki, T., Kametaka, A., and Yoneda, Y. (2001) A novel nucleolar protein, NIFK, interacts with the forkhead associated domain of Ki-67 antigen in mitosis. J. Biol. Chem. 276, 25386-25391.