Molecular control of polyene macrolide biosynthesis: Direct binding of the regulator pimm to eight promoters of pimaricin genes and identification of binding boxes

Journal of Biological Chemistry

Volumn 286, Issue 11, 2011, Pages 9150-9161

  Santos Aberturas, Javier ^a   Vicente, Cláudia M ^a   Guerra, Susana M ^a   Payero, Tamara D ^a   Martín, Juan F ^a   Aparicio, Jesús F ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOTERICIN; ANTI-FUNGAL; BINDING AFFINITIES; BIOSYNTHETIC GENE CLUSTER; CDNA ENDS; DNA-BINDING DOMAIN; ELECTROPHORETIC MOBILITY SHIFT ASSAY; EXPERIMENTAL VALIDATIONS; HELIX-TURN-HELIX MOTIFS; HEXAMERS; INFORMATION CONTENT ANALYSIS; MOLECULAR CONTROLS; N-TERMINALS; POLYENE MACROLIDE; POLYKETIDE SYNTHASE GENES; POLYKETIDES; PROMOTER REGION; RNA POLYMERASE; START POINT; SYNTHETIC DNA; TARGET GENES; TRANSCRIPTIONAL ACTIVATORS;

BINDING ENERGY; BIOCHEMISTRY; BIOSYNTHESIS; CHEMICAL ACTIVATION; ELECTROPHORETIC MOBILITY; ESCHERICHIA COLI; GENES; METABOLITES; NUCLEIC ACIDS; ORGANIC COMPOUNDS; PROTEINS; RNA;

TRANSCRIPTION;

MACROLIDE; RNA POLYMERASE;

ANTIBIOTIC BIOSYNTHESIS; ARTICLE; BACTERIAL GENE; BINDING AFFINITY; BINDING SITE; CONSENSUS SEQUENCE; CONTROLLED STUDY; ESCHERICHIA COLI; GENE CLUSTER; HETEROLOGOUS EXPRESSION; NONHUMAN; PIMARICIN GENE; PIMM GENE; POLYKETIDE SYNTHASE GENE; PRIORITY JOURNAL; PROMOTER REGION; SEQUENCE ANALYSIS; STREPTOMYCES; STREPTOMYCES NATALENSIS; TRANSCRIPTION INITIATION; TRANSCRIPTION INITIATION SITE;

ESCHERICHIA COLI; GENES, BACTERIAL; HELIX-TURN-HELIX MOTIFS; MULTIGENE FAMILY; NATAMYCIN; POLYENES; POLYKETIDE SYNTHASES; PROTEIN STRUCTURE, TERTIARY; RESPONSE ELEMENTS; STREPTOMYCES; TRANS-ACTIVATORS;

ESCHERICHIA COLI; STREPTOMYCES NATALENSIS; STREPTOMYCES NODOSUS;

EID: 79953201151     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.182428     Document Type: Article

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