A response-regulator-like activator of antibiotic synthesis from Streptomyces coelicolor A3(2) with an amino-terminal domain that lacks a phosphorylation pocket

Microbiology

Volumn 144, Issue 3, 1998, Pages 727-738

  Guthrie, Ellen P ^a,c   Flaxman, Christine S ^b   White, Janet ^a   Hodgson, David A ^b   Bibb, Mervyn J ^a   Chater, Keith F ^a  

^a JOHN INNES CENTRE   (United Kingdom)

^b UNIVERSITY OF WARWICK   (United Kingdom)

^c NEW ENGLAND BIOLABS   (United States)

Author keywords

bldA; RedD; RedZ; Streptomyces coelicolor A3(2); Undecylprodigiosin

Indexed keywords

ANTIBIOTIC AGENT; ASPARTIC ACID; LEUCINE; PROTEIN KINASE; TRANSFER RNA;

ANTIBIOTIC BIOSYNTHESIS; ARTICLE; BACTERIOPHAGE; CLONING VECTOR; CODON; GENE CLUSTER; HYDROPHOBICITY; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; STREPTOMYCES COELICOLOR;

ACTINOBACTERIA (CLASS); PROKARYOTA; STREPTOMYCES COELICOLOR; UNCULTURED ACTINOMYCETE;

EID: 0031906193     PISSN: 13500872     EISSN: None     Source Type: Journal    
DOI: 10.1099/00221287-144-3-727     Document Type: Article

References (57)

1. Altenbuchner, J. & Cullum, J. (1984). DNA amplification and an unstable arginine gene in Streptomyces lividans 66. Mol Gen Genet 195, 134-138.
2. Altschul, S. F., Gish, W., Miller, W., Myers, E. W. & Lipman, D. J. (1990). Basic local alignment search tool. J Mol Biol 215, 403-410.
3. Baltz, R. H. & Hosted, T. J. (1996). Molecular genetic methods for improving secondary-metabolite production in actinomycetes. Trends Biotechnol 14, 245-250.
4. Bibb, M. J. (1996). The regulation of antibiotic production in Streptomyces coelicolor A3(2). Microbiology 142, 1335-1344.
5. Bibb, M. J., Findlay, P. R. & Johnson, M. W. (1984). The relationship between base composition and codon usage in bacterial genes and its use in the simple and reliable identification of protein coding sequences. Gene 30, 157-166.
6. Brian, P., Riggle, P., Santos, R. A. & Champness, W. C. (1996). Global negative regulation of Streptomyces coelicolor antibiotic synthesis mediated by an absA-encoded putative signal transduction system. J Bacteriol 178, 3221-3231.
7. Brown, K. L., Wood, S. & Buttner, M. J. (1992). Isolation and characterisation of the major vegetative RNA polymerase of Streptomyces coelicolor A3(2); renaturation of a sigma subunit using GroEL. Mol Microbiol 6, 1133-1139.
8. Bruton, C. J., Guthrie, E. P. & Chater, K. F. (1991). Phage vectors that allow monitoring of transcription of secondary metabolism genes in Streptomyces. Bio/Technology 9, 652-656.
9. Bystrykh, L. V., Fernández-Moreno, M. A., Herrema, J. K., Malpartida, F., Hopwood, D. A. & Dijkhuizen, L. (1996). Production of actinorhodin-related blue pigments by Streptomyces coelicolor A3(2). J Bacteriol 178, 2238-2244.
10. Chakraburtty, R. & Bibb, M. J. (1997). The ppGpp synthetase gene (relA) of Streptomyces coelicolor A3(2) plays a conditional role in antibiotic production and morphological differentiation. J Bacteriol 179, 5854-5861.
11. Chakraburtty, R., White, J., Takano, E. & Bibb, M. J. (1996). Cloning, characterization and disruption of a (p)ppGpp synthetase gene (relA) of Streptomyces coelicolor A3(2). Mol Microbiol 19, 357-368.
12. Champness, W. C. & Chater, K. F. (1994). Regulation and integration of antibiotic production and morphological differentiation in Streptomyces spp. In Regulation of Bacterial Differentiation, pp. 61-93. Edited by P. Piggot, C. P. Moran & P. Youngman. Washington, DC: American Society for Microbiology.
13. Chater, K. F. (1990). The improving prospects for yield increase by genetic engineering in antibiotic-producing streptomycetes. Bio/ Technology 8, 115-121.
14. Chater, K. F. & Bibb, M. J. (1997). Regulation of bacterial antibiotic production. In Biotechnology, Volume 7, Products of Secondary Metabolism, pp. 57-105. Edited by H. Kleinkauf & H. von Döhren. Weinheim, Germany: VCH.
15. Chater, K. F., Bruton, C. J., King, A. A. & Suarez, J. E. (1982). The expression of Streptomyces and Escherichia coli drug resistance determinants cloned into the Streptomyces phage φC31. Gene 19, 21-32.
16. Coco, E. A., Narva, K. E. & Feitelson, J. S. (1991). New classes of Streptomyces coelicolor A3(2) mutants blocked in undecylprodigiosin (Red) biosynthesis. Mol Gen Genet 227, 28-32.
17. Covarrubias, L. & Bolivar, F. (1982). Construction and characterisation of new cloning vehicles VI. Plasmid pBR329, a new derivative of pBR328 lacking the 482 base pair inverted duplication. Gene 17, 79-89.
18. Devereux, J., Haeberli, P. & Smithies, O. (1984). A comprehensive set of sequence analysis programs for the VAX. Nucleic Acids Res 12, 387-395.
19. Dyson, P. & Schrempf, H. (1987). Genetic instability and DNA amplification in Streptomyces lividans 66. J Bacteriol 169, 4796-4803.
20. Feitelson, J. S., Malpartida, F. & Hopwood, D. A. (1985). Genetic and biochemical characterization of the red gene cluster of Streptomyces coelicolor A3(2). J Gen Microbiol 131, 2431-2441.
21. Felsenstein, J. (1989). PHYLIP - phylogeny inference package (version 3.2). Cladistics 5, 164-166.
22. Fernández-Moreno, M. A., Caballero, J. L., Hopwood, D. A. & Malpartida, F. (1991). The act cluster contains regulatory and antibiotic export genes, direct targets for translational control by the bldA transfer RNA gene of Streptomyces. Cell 66, 769-780.
23. Gramajo, H. C., Takano, E. & Bibb, M. J. (1993). Stationary-phase production of the antibiotic actinorhodin in Streptomyces coelicolor A3(2) is transcriptionally regulated. Mol Microbiol 7, 837-845.
24. Guthrie, E. P. & Chater, K. F. (1990). The level of a transcript required for production of a Streptomyces coelicolor antibiotic is conditionally dependent on a transfer RNA gene. J Bacteriol 172, 6189-6193.
25. Hackenbeck, R. & Stock, J. B. (1996). Analysis of two-component signal transduction systems involved in transcriptional regulation. Methods Enzymol 273, 281-300.
26. Hopwood, D. A., Bibb, M. J., Chater, K. F., Kieser, T., Bruton, C. J., Kieser, H. M., Lydiate, D. J., Smith, C. P., Ward, J. M. & Schrempf, H. (1985). Genetic Manipulation of Streptomyces: a Laboratory Manual. Norwich: John Innes Foundation.
27. Hopwood, D. A., Chater, K. F. & Bibb, M. J. (1995). Genetics of antibiotic production in Streptomyces coelicolor A3(2), a model streptomycete. In Biochemistry and Genetics of Antibiotic Production, pp. 65-102. Edited by L. C. Vining & C. Stuttard. Newton, MA: Butterworth-Heinemann.
28. Janssen, G. R., Ward, J. M. & Bibb, M. J. (1989). Unusual transcriptional and translational features of the aminoglycoside phosphotransferase gene (aph) from Streptomyces fradiae. Genes Dev 3, 415-429.
29. Kieser, T. & Hopwood, D. A. (1991). Genetic manipulation of Streptomyces - integrating vectors and gene replacement. Methods Enzymol 204, 430-458.
30. Kieser, T. & Melton, R. E. (1988). Plasmid pIJ699, a multi-copy positive-selection vector for Streptomyces. Gene 65, 83-91.
31. Lawlor, E. J., Baylis, H. A. & Chater, K. F. (1987). Pleiotropic morphological and antibiotic deficiencies result from mutations in a gene encoding a tRNA-like product in Streptomyces coelicolor A3(2). Genes Dev 1, 1305-1310.
32. Leskiw, B. K., Bibb, M. J. & Chater, K. F. (1991a). The use of a rare codon specifically during development. Mol Microbiol 5, 2861-2867.
33. Leskiw, B. K., Lawlor, E. J., Fernández-Abalos, J. M. & Chater, K. F. (1991b). TTA codons in some genes prevent their expression in a class of developmental, antibiotic-negative, Streptomyces mutants. Proc Natl Acad Sci USA 88, 2461-2465.
34. Leskiw, B. K., Mah, R., Lawlor, E. J. & Chater, K. F. (1993). Accumulation of bldA-specified transfer RNA is temporally regulated in Streptomyces coelicolor A3(2). J Bacteriol 175, 1995-2005.
35. Madduri, K. & Hutchinson, C. R. (1995). Functional characterization and transcriptional analysis of the dnrR1 locus, which controls daunorubicin biosynthesis in Streptomyces peucetius. J Bacteriol 177, 1208-1215.
36. Malpartida, F., Niemi, J., Navarrete, R. & Hopwood, D. A. (1990). Cloning and expression in a heterologous host of the complete set of genes for biosynthesis of the Streptomyces coelicolor antibiotic undecylprodigiosin. Gene 93, 91-99.
37. Martínez-Costa, O. H., Arias, P., Romero, N. M., Parro, V., Mellado, R. P. & Malpartida, F. (1996). A relA/spoT homologous gene from Streptomyces coelicolor A3(2) controls antibiotic biosynthetic genes. J Biol Chem 271, 10627-10634.
38. Merrick, M. J. (1976). A morphological and genetic mapping study of bald colony mutants of Streptomyces coelicolor. J Gen Microbiol 96, 299-315.
39. Murray, M. G. (1986). Use of sodium trichloroacetate and mung bean nuclease to increase sensitivity and precision during transcript mapping. Anal Biochem 158, 165-170.
40. Narva, K. E. & Feitelson, J. S. (1990). Nucleotide sequence and transcriptional analysis of the redD locus of Streptomyces coelicolor A3(2). J Bacteriol 172, 326-333.
41. Otten, S. L., Ferguson, J. & Hutchinson, C. R. (1995). Regulation of daunorubicin production in Streptomyces peucetius by the dnrR2 locus. J Bacteriol 177, 1216-1224.
42. Page, R. D. M. (1996). TREEVIEW, an application to display phylogenetic trees on personal computers. CABIOS 12, 357-358.
43. Pao, G. M. & Saier, M. H. (1995). Response regulators of bacterial signal transduction systems, selective domain shuffling during evolution. J Mol Evol 40, 136-154.
44. Passantino, R., Puglia, A. M. & Chater, K. F. (1991). Additional copies of the actII regulatory gene induce actinorhodin production in pleiotropic bld mutants of Streptomyces coelicolor A3(2). J Gen Microbiol 137, 2059-2064.
45. Piret, J. M. & Chater, K. F. (1985). Phage-mediated cloning of bldA, a region involved in Streptomyces coelicolor morphological development and its analysis by genetic complementation. J Bacteriol 163, 965-972.
46. Sambrook, J., Fritsch, E. F. & Maniatis, T. (1989). Molecular Cloning: a Laboratory Manual, 2nd edn. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory.
47. Sanger, F., Nicklen, S. & Coulson, A. R. (1977). DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci USA 74, 5463-5467.
48. Sermonti, G., Petris, A., Micheli, M. R. & Lanfaloni, L. (1977). A factor involved in chloramphenicol resistance in Streptomyces coelicolor A3(2): its transfer in the absence of the fertility factor. J Gen Microbiol 100, 347-353.
49. Strohl, W. R. (1992). Compilation and analysis of DNA sequences associated with apparent streptomycete promoters. Nucleic Acids Res 20, 961-974.
50. Stutzman-Engwall, K. J., Otten, S. & Hutchinson, C. R. (1992). Regulation of secondary metabolism in Streptomyces spp. and overproduction of daunorubicin in Streptomyces peucetius. J Bacteriol 174, 144-154.
51. Takano, E., Gramajo, H. C., Strauch, E., Andres, N., White, J. & Bibb, M. J. (1992). Transcriptional regulation of the redD transcriptional activator gene accounts for growth-phase-dependent production of the antibiotic undecylprodigiosin in Streptomyces coelicolor A3(2). Mol Microbiol 6, 2797-2804.
52. Thompson, J. D., Higgins, D. G. & Gibson, T. J. (1994). CLUSTAL W, improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res 22, 4673-4680.
53. Tsao, S. W., Rudd, B. A. M., He, X., Chang, C. & Floss, H. G. (1985). Identification of a red pigment from Streptomyces coelicolor A3(2) as a mixture of prodigiosin derivatives. J Antibiot 38, 128-130.
54. Volz, K. (1995). Structural and functional constraints in response regulators. In Two-Component Signal Transduction, pp. 53-64. Edited by J. A. Hoch & T. J. Silhavy. Washington DC: American Society for Microbiology.
55. White, J. & Bibb, M. J. (1997). The bldA-dependence of undecylprodigiosin production in Streptomyces coelicolor A3(2) involves a pathway-specific regulatory cascade. J Bacteriol 179, 627-633.
56. Wright, F. & Bibb, M. J. (1992). Codon usage in the G + C-rich Streptomyces genome. Gene 113, 55-65.
57. Yanisch-Perron, C., Vieira, J. & Messing, J. (1985). Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors. Gene 33, 103-119.