Recent advances in carbon nanotubes as delivery systems for anticancer drugs

Current Medicinal Chemistry

Volumn 20, Issue 11, 2013, Pages 1333-1354

  Iannazzo, Daniela ^a   Piperno, Anna ^a   Pistone, Alessandro ^a   Grassi, Giovanni ^a   Galvagno, Signorino ^a  

^a UNIVERSITY OF MESSINA   (Italy)

Author keywords

Anticancer Drugs; Carbon Nanotubes; Drug Delivery Systems

Indexed keywords

10 HYDROXYCAMPTOTHECIN; ANTINEOPLASTIC AGENT; CANCER VACCINE; CARBON NANOTUBE; CARBOPLATIN; CISPLATIN; DACTINOMYCIN; DAUNORUBICIN; DOCETAXEL; DOXORUBICIN; ETOPOSIDE; FLUDARABINE PHOSPHATE; FLUOROURACIL; IRINOTECAN; METHOTREXATE; MITOMYCIN; MULTI WALLED NANOTUBE; NANOMATERIAL; NAVELBINE; OXALIPLATIN; PACLITAXEL; PLASMID DNA; SINGLE WALLED NANOTUBE; SMALL INTERFERING RNA; TENIPOSIDE; TIOGUANINE; TOPOTECAN; UNINDEXED DRUG; VINBLASTINE; VINCRISTINE;

ANGIOGENESIS; ARTICLE; BREAST ADENOCARCINOMA; CANCER CELL; CANCER DIAGNOSIS; CELL INTERACTION; CELL PROLIFERATION; CHEMICAL MODIFICATION; COLON CANCER; DNA DAMAGE; DRUG DELIVERY SYSTEM; DRUG RELEASE; DRUG TARGETING; GENE DELIVERY SYSTEM; HAZARD RATIO; HETEROZYGOTE; HUMAN; ISOTOPE LABELING; LIVER CANCER; LYMPHOMA; NANOANALYSIS; NANOTECHNOLOGY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OPTICAL COHERENCE TOMOGRAPHY; PARTICLE SIZE; PATIENT COMPLIANCE; PHOTOACOUSTIC SPECTROSCOPY; PHYSICAL CHEMISTRY; POSITRON EMISSION TOMOGRAPHY; RAMAN SPECTROMETRY; TUMOR MICROENVIRONMENT; UTERINE CERVIX CANCER;

ANIMALS; ANTINEOPLASTIC AGENTS; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; GENE TRANSFER TECHNIQUES; HUMANS; NANOTUBES, CARBON; NEOPLASMS;

EID: 84877938999     PISSN: 09298673     EISSN: 1875533X     Source Type: Journal    
DOI: 10.2174/0929867311320110001     Document Type: Article

References (179)

1. Bae, K.H.; Chung, H.J.; Park, T.G. Nanomaterials for Cancer Therapy and Imaging. Mol. Cells, 2011, 31, 295-302.
2. Mousa, S.A.; Bharali, D.J. Nanotechnology-based detection and targeted therapy in cancer: nano-bio paradigms and applications. Cancers, 2011, 3, 2888-2903.
3. Bianco, A.; Kostarelos, K.; Prato, M. Opportunities and challenges of carbon-based nanomaterials for cancer therapy. Expert Opin. Drug Deliv., 2008, 5(3), 331-342.
4. Shiva Kumar, S.; Shukla, T.P.; Vara Prasad, S.; Priyanka, C. H.; Ramanjaneyulu, K. A review on nanomedicine for cancer treatment. Int. J. Pharm. Sci. Rev. Res., 2012, 12(2), 15-21.
5. Feng, B.; Matsui, H.; Tomizawa, K. Nanoparticle-based drug delivery systems for solid brain tumors. Curr. Nanosci., 2011, 7(1), 47-54.
6. Wang, X.; Wang, Y.; Chen, Z.; Shin, D.M. Advances of Cancer Therapy by Nanotechnology. Cancer Res. Treat., 2009, 41, 1-11.
7. Ajima, K.; Murakami, T.; Mizoguchi, Y.; Tsuchida, K.; Ichihashi, T.; Iijima, S.; Yudasaka, M. Enhancement of In vivo Anticancer effects of Cisplatin by incorporation inside Single-Wall Carbon Nanohorns. ACS Nano, 2008, 2, 2057-2064.
8. Bhirde, A.A.; Patel, V.; Gavard, J.; Zhang, G.; Sousa, A.A.; Masedunskas, A.; Leapman, R.D.; Weigert, R.; Gutkind, J.S.; Rusling, J.F. Targetted Killing of Cancer Cells in vitro with EGF-Directed carbon Nanotube-Based Drug Delivery. ACS Nano, 2009, 3, 307-316.
9. Majoros, I.J.; Thomas, T.P.; Mehta, C.B.; Baker, J.R. Poly(amidoamine) Dendrimer-Based Multifunctional Engineered Nanodevice for Cancer Therapy. J. Med. Chem., 2005, 48, 5892-5899.
10. Villa, C.H.; McDevitt, M.R.; Escorcia, F.E.; Rey, D.A.; Bergkvist, M.; Batt, C.A.; Scheinberg, D.A. Synthesis and Biodistribution of Oligonucleotide-Functionalized, Tumor Targetable Carbon Nanotubes. Nano Lett., 2008, 8, 4221-4228.
11. Murakami, T.; Sawada, H.; Tamura, G.; Yudasaka, M.; Iijima, S.; Tsuchida, K. Water-dispersed single-wall carbon nanohorns as drug carriers for local cancer chemotherapy. Nanomedicine, 2008, 3(4), 453-463.
12. Yakobson, B.I.; Avouris, P. Mechanical properties of carbon nanotubes. In Carbon Nanotubes: synthesis, structure, properties and applications; Dresselhaus M.S.; Dresselhaus, G.; Avouris, P., Eds.; Springer-Verlag: Berlin Heidelberg, 2001, pp. 287-327.
13. Odom, T.W.; Huang, J.L.; Kim, P.; Lieber, C.M. Structure and electronic properties of carbon Nanotubes. J. Phys. Chem. B., 2000, 104, 2794-2809.
14. Hone, J.; Llaguno, M.C.; Biercuk, M.J.; Johnson, A.T., Batlogg, B.; Benes, Z.; Fischer, J.E. Thermal properties of Carbon Nanotubes and Nanotube-based materials. Appl. Phys. A: Mater. Sci. Process, 2002, 74, 339-343.
15. Klingeler, R.; Hampel, S.; Büchner, B. Carbon Nanotube based biomedical agents for heating, temperature sensoring and drug delivery. Int. J. Hyperther., 2008, 24, 496-505.
16. Fadel, T.R.; Look, M.; Staffier, P.A.; Haller, G.L.; Pfellerle, L.D.; Fahmy, T.M. Clustering of Stimuli on Single-Walled Carbon Nanotube Bundles enhances cellular activation. Langmuir, 2010, 26, 5645-5654.
17. Kam, N.W.S.; Liu, Z.; Dai, H. Carbon Nanotubes as intracellular transporters for proteins and DNA: an investigation of the uptake mechanism and pathway. Angew. Chem. Int. Ed., 2006, 45, 577-581.
18. Singh, R.; Pantarotto, D.; McCarthy, D.; Chaloin, O.; Hoebeke, J.; Partidos, C.D.; Briand, J.P.; Prato, M.; Bianco, A.; Kostarelos, K. Binding and Condensation of Plasmid DNA onto functionalized Carbon Nanotubes: toward the construction of Nanotube-Based gene Delivery Vectors. J. Am. Chem. Soc., 2005, 127, 4388-4396.
19. Dhar, S.; Liu, Z.; Thomale, J.; Dai, H.; Lippard, S.J. Targeted Single-Wall Carbon Nanotube-mediated Pt(IV) prodrug delivery using folate as a homing device. J. Am. Chem. Soc., 2008, 130, 11467-11476.
20. Poater, A.; Saliner, A.G.; Cavallo, L.; Poch, M.; Sola, M.; Worth, A.P. Tuning the Electronic Properties by Width and Length Modifications of Narrow-Diameter Carbon Nanotubes for Nanomedicine. Curr. Med. Chem., 2012, 19, 5219-5225.
21. Zhang, Z.; Yang, X.; Zhang, Z.; Zeng, B.; Wang, s.; Zhu, T.; Roden, R.B.; Chen, Y.; Yang, R. Delivery of Telomerase Reverse Transcriptase Small Interfering RNA in Complex with Positively Charged Single-Walled Carbon Nanotubes Suppresses Tumor Growth. Clin. Cancer. Res., 2006, 12, 4933-4939.
22. Gannon, C.J.; Cherukuri, P.; Yakobson, B.I.; Cognet, L.; Kanzius, J.S.; Kittrell, C.; Weisman, R.B.; Pasquali, M.; Schmidt, H.K.; Smalley, R.E.; Curley, S.A. Carbon nanotube-enhanced thermal destruction of cancer cells in a noninvasive radiofrequency field. Cancer, 2007, 110, 2654-2665.
23. Torti, S.V.; Byrne, F., Whelan, O.; Levi, N.; Ucer, B.; Schmid, M.; Torti, F.M.; Akman, S.; Liu, J.; Ajayan, P.M.; Nalamasu, O.; Carroll, D.L. Thermal ablation therapeutics based on CN(x) multiwalled nanotubes. Int. J. Nanomedicine, 2007, 2, 707-714.
24. Yu, X.; Zhang, Y.; Chen, C.; Yao, Q.; Li, M. Targeted drug delivery in pancreatic cancer. Biochim. Biophys. Acta, 2010, 1805, 97104.
25. Huang, H.; Yuan, Q.; Shah, J.S.; Misra, R.D.K. A new family of folate-decorated and carbon nanotube-mediated drug delivery system: Synthesis and drug delivery response. Adv. Drug. Deliver. Rev., 2011, 63, 1332-1339.
26. Heister, E.; Neves, V.; Tîlmaciu, C.; Lipert, K.; Beltràn, V.S.; Coley, H.M.; Silva, S.R.P.; McFadden, J. Triple functionalisation of Single-Walled Carbon Nanotubes with Doxorubicin, a monoclonal antibody and a fluorescent marker for targeted cancer therapy. Carbon, 2009, 47, 2152-2160.
27. Kaiser, J.-P.; Roesslein, M.; Buerki-Thurnherr, T.; Wick, P. Carbon Nanotubes-Curse or Blessing. Curr. Med. Chem., 2011, 18, 2115-2128.
28. Bianco, A.; Kostarelos, K.; Prato, M. Applications of carbon nanotubes in drug delivery. Curr. Opin. Chem. Biol., 2005, 9, 674-679.
29. Colvin, V.L. The potential environmental impact of engineered nanomaterials. Nat. Biotechnol., 2003, 21, 1166-1170.
30. Banerjee, S.; Hemraj-benny, T.; Wong, S.S. Covalent Surface Chemistry of Single-Walled Carbon Nanotubes. Adv. Mater., 2005, 17, 17-29.
31. Iijima, S. Helical microtubules of graphitic carbon. Nature, 1991, 354, 56-58.
32. Li, F.; Cheng, H. M.; Bai, S.; Su, G.; Dresselhaus M. S. Tensile strength of single-walled carbon nanotubes directly measured from their macroscopic ropes. Appl. Phys. Lett., 2000, 77, 3161-3163.
33. Berber, S.; Kwon, Y.-K.; Tománek, D. Unusually High Thermal Conductivity of Carbon Nanotubes. Phys. Rev. Lett., 2000, 84, 4613-4616.
34. Carlson, L. J.; Maccagnano, S. E.; Zheng, M.; Silcox, J.; Krauss, T. D. Fluorescence Efficiency of Individual Carbon Nanotubes. Nano Lett., 2007, 7 (12), 3698-3703.
35. Bandaru, P. R. Electrical Properties and Applications of Carbon Nanotube Structures. J. Nanosci. Nanotechnol., 2007, 7, 1-29.
36. Karthikeyan, S.; Mahalingam, P.; Karthik, M. Large scale Synthesis of Carbon Nanotubes, E-J. Chem., 2009, 6, 1-12.
37. Ebbesen, T.W.; Ajayan, P.M. Large-scale synthesis of carbon nanotubes. Nature, 1992, 358, 220-222.
38. Kong, J.; Cassell, A.M.; Dai, H.J. Chemical vapor deposition of methane for single-walled carbon nanotubes. Chem. Phys Lett., 1998, 292, 567-574
39. Liu, C.; Cong, H.T.; Li, F.; Tan, P.H.; Cheng, H.M.; Lu, K.; Zhou, B.L. Semicontinuous synthesis of single-walled carbon nanotubes by a hydrogen arc discharge method, Carbon, 1999, 37, 1865-1868.
40. Thess, A.; Lee, R.; Nikolaev, P.; Dai, H.; Petit, P.; Robert, J.; Xu, C.; Lee, Y.H.; Kim, S.G.; Rinzler, A.G.; Colbert, D.T.; Scuseria, G.E., Tomalnek, D.; Fischer, J.E.; Smalley, R.E. Crystalline Ropes of Metallic Carbon Nanotubes. Science, 1996, 273, 483-484.
41. Öncel, Ç.; Yürüm, Y. Carbon Nanotube Synthesis via the Catalytic CVD Method: A Review on the Effect of Reaction Parameters. Fuller. Nanotub. Carbon Nanostruct., 2006, 14, 17-37.
42. Donato, M.G.; Galvagno, S.; Messina, G.; Milone, C.; Pistone, A.; Santangelo, S. Optimisation of gas mixture composition for the preparation of high quality MWCNT by catalytically assisted CVD. Diamond. Relat. Mater., 2007, 16(4-7), 1095-1100.
43. Ortega-Cervantez, G.; Rueda-Morales, G.; Ortiz-Lopez, J. Catalytic CVD production of carbon nanotubes using ethanol. Microelectron. J., 2005, 36, 495-498.
44. Makris, T.D.; Giorgi, L.; Giorgi, R.; Lisi, N.; Salernitano, E. CNT growth on alumina supported nickel catalyst by thermal CVD. Diamond Relat. Mater., 2005, 14, 815-819.
45. Tasis, D.; Tagmatarchis, N.; Bianco, A.; Prato, M. Chemistry of carbon nanotubes. Chem. Rev., 2006, 106, 1105-1136.
46. Haley, B.; Frenkel, E. Nanoparticles for drug delivery in cancer treatment. Urol. Oncol., 2008, 26, 57-64.
47. Di Costanzo, F.; Gasperoni, S.; Rotella, V.; Di Costanzo, F., Targeted delivery of albumin bound paclitaxel in the treatment of advanced breast cancer. OncoTargets Ther., 2009, 2, 179-188.
48. Riganti, C.; Voena, C.; Kopecka, J.; Corsetto, P. A.; Montorfano, G.; Enrico, E.; Costamagna, C.; Rizzo, A. M.; Ghigo, D.; Bosia, A., Liposome-Encapsulated Doxorubicin Reverses Drug Resistance by Inhibiting P-Glycoprotein in Human Cancer Cells. Mol. Pharm., 2011, 8(3), 683-700.
49. Mylonakis, N.; Athanasiou, A.; Ziras, N.; Angel, J.; Rapti, A.; Lampaki, S.; Politis, N.; Karanikas, C.; Kosmas. C., Phase II study of liposomal cisplatin (lipoplatin) plus gemcitabine versus cisplatin plus gemcitabine as first line treatment in inoperable (stage IIIB/IV) non-small cell lung cancer. Lung Cancer, 2010, 68, 240-247.
50. Chaudhuri, P.; Harfouche, R.; Soni, S.; Hentschel, D. M.; Sengupta, S. Shape Effect of Carbon Nanovectors on Angiogenesis. ACS Nano, 2010, 4(1), 574-582.
51. Liu, Z.; Chen, K.; Davis, C.; Sherlock, S.; Cao, Q.; Chen, X.; Dai, H. Drug delivery with carbon nanotubes for in vivo cancer treatment. Cancer Res., 2008, 68, 6652-6660.
52. Prato, M.; Kostarelos, K.; Bianco, A. Functionalized carbon nanotubes in drug design and discovery Acc. Chem. Res., 2008, 41, 60-68.
53. Wang, X.J.; Zhuang, L. Carbon nanotubes in biology and medicine: An overview. Chin. Sci. Bull., 2012, 57 (2-3), 167-180.
54. Digge, M.S.; Moon, R.S.; Gattani, S.G. Application of Carbon Nanotubes in Drug Delivery: A Review. Int. J. PharmTech Res., 2012, 4(2), 839-847.
55. Cunha, C.; Panseri, S.; Iannazzo, D.; Piperno, A.; Pistone, A.; Fazio, M.; Russo, A.; Marcacci, M.; Galvagno, S. Hybrid composites made of multiwalled carbon nanotubes functionalized with Fe3O4 nanoparticles for tissue engineering applications. Nanotechnology, 2012, 23, 465102 (10pp).
56. Wu, W.; Li, R.; Bian, X.; Zhu, Z.; Ding, D.; Li, X.; Jia, Z.; Jiang, X.; Hu, Y., Covalently combining carbon nanotubes with anticancer agent: preparation and antitumor activity. ACS Nano, 2009, 3, 2740-2750.
57. Hampel, S.; Kunze, D.; Haase, D.; Krämer, K.; Rauschenbach, M.; Ritschel, M.; Leonhardt, A.; Thomas, J.; Oswald, S.; Hoffmann, V.; Büchner, B., Carbon nanotubes filled with a chemotherapeutic agent: a nanocarrier mediates inhibition of tumor cell growth. Nanomedicine, 2008, 3, 175-82.
58. Iannazzo, D.; Piperno, A.; Ferlazzo, A.; Pistone, A.; Milone, C.; Lanza, M.; Cimino, F.; Speciale, A.; Trombetta, D.; Saija, A.; Galvagno, S. Functionalization of multi-walled carbon nanotubes with coumarin derivatives and their biological evaluation. Org. Biomol. Chem., 2012, 10, 1025-1031.
59. Mickelson, E.T.; Huffman, C.B.;. Rinzler, A.G.; Smalley, R.E.; Hauge, R.H.; Margrave J.L. Fluorination of single-wall carbon nanotubes. Chem. Phys Lett., 1998, 296, 188-194.
60. Grassi, G.; Scala, A.; Piperno, A.; Iannazzo, D.; Lanza, M.; Milone, C.; Pistone, A.; Galvagno, S. A facile and ecofriendly functionalization of multiwalled carbon nanotubes by an old mesoionic compound. Chem. Commun., 2012, 48, 6836-6838.
61. Bahr, J. L.; Yang, J.; Kosynkin, D.V.; Bronikowski, M.J.; Smalley, R.E.; Tour, J. M. Functionalization of Carbon Nanotubes by Electrochemical Reduction of Aryl Diazonium Salts: A Bucky Paper Electrode. J. Am. Chem. Soc., 2001, 123, 6536-6542.
62. Colvin, M.; Alkylating agents and platinum antitumor compounds. Kufe, Donald W. Ed., Cancer Medicine, 2006, 7, 675-687.
63. Zaniboni, A.; Meriggi, F. The emerging role of oxaliplatin in the treatment of gastric cancer. J. Chemother., 2005, 17(6), 656-662.
64. Boulikas, T.; Vougiouka, M. Cisplatin and platinum drugs at the molecular level (review). Oncol. Rep., 2003, 10(6), 1663-1682.
65. Jiang, M.; Yi, X.; Hsu, S.; Wang, C.Y.; Dong, Z., Role of p53 in cisplatin-induced tubular cell apoptosis: dependence on p53 transcriptional activity. Am. J. Physiol. Renal Physiol., 2004, 287, 1140-1147.
66. Petersen, L. N.; Mamenta, E. L.; Stevnsner, T.; Chaney, S. G.; Bohr, V.A., Increased gene specific repair of cisplatin induced interstrand crosslinks in cisplatin resistant cell lines, and studies on carrier ligand specificity. Carcinogenesis, 1996, 17(12), 2597-2602.
67. Tripisciano, C.; Kraemer, K.; Taylor, A.; Borowiak-Palen, E. Single-wall carbon nanotubes based anticancer drug delivery system. Chem. Phys. Lett., 2009, 478, 200-205.
68. Arlt, M.; Haase, D.; Hampel, S.; Oswald, S.; Bachmatiuk, A.; Klingeler, R.; Schulze, R.; Ritschel, M.; Leonhardt, A.; Fuessel, S.; Büchner, B.; Kraemer K.; Wirth, M. P. Delivery of carboplatin by carbon-based nanocontainers mediates increased cancer cell death. Nanotechnology, 2010, 21, 335101 (9pp).
69. Feazell, R. P.; Nakayama-Ratchford, N.; Dai, H.; Lippard, S. J. Soluble Single-Walled Carbon Nanotubes as Longboat Delivery Systems for Platinum(IV) Anticancer Drug Design. J. Am. Chem. Soc., 2007, 129, 8438-8439.
70. Hilder, T. A.; Hill, J. M. Modelling the encapsulation of the anticancer drug cisplatin into carbon nanotubes. Nanotechnology, 2007, 18, 275704 (8pp).
71. Li, J.; Yap, S. Q.; Yoong, S. L.; Nayak, T. R.; Chandra, G. W.; Ang, W. H.; Panczyk, T.; Ramaprabhu, S.; Vashist, S. K.; Sheu,F.-S.; Tan, A.; Pastorin, G. Carbon nanotube bottles for incorporation, release and enhanced cytotoxic effect of cisplatin. Carbon, 2012, 50, 1625-1634.
72. Pizzorno, G.; Diasio, R. B.; Cheng, Y.C. Pyrimidine and purine antimetabolites. In Cancer Medicine, 7th Ed; Kufe, D.W.; Bast, R.C.; Hait, W.N. Eds.; Decker: Hamilton, Ontario, 2006, 7, 661-674.
73. Nicolaou, K. C.; Guy, R. K.; Potier, P. Taxoids: New Weapons against Cancer. Sci. Am., 1996, 274(6), 94-98.
74. Saltz, L. B. Clinical Use of Irinotecan: Current Status and Future Considerations. Oncologist, 1997, 2, 402-409.
75. Kaminskas, L. M.; Kelly, B. D.; McLeod, V. M.; Boyd, B. J.; Krippner, G. Y.; Williams. E. D.; Porter, C. J. H. Pharmacokinetics and Tumor Disposition of PEGylated, Methotrexate Conjugated Poly-l-lysine Dendrimers. Mol. Pharm., 2009, 6 (4), 1190-1204.
76. Chen, Y. H.; Tsai, C. Y.; Huang, P. Y.; Chang, M. Y.; Cheng, P. C.; Chou, C. H.; Chen, D. H.; Wang, C. R.; Shiau, A. L.; Wu, C. L. Methotrexate Conjugated to Gold Nanoparticles Inhibits Tumor Growth in a Syngeneic Lung Tumor Model. Mol. Pharm., 2007, 4 (5), 713-722.
77. Samorì, C.; Ali-Boucetta, H.; Sainz, R.; Guo, C.; Toma, F. M.; Fabbro, C; da Ros, T.; Prato, M.; Kostarelos, K.; Bianco, A., Enhanced anticancer activity of multi-walled carbon nanotubemethotrexate conjugates using cleavable linkers. Chem. Commun., 2010, 46, 1494-1496.
78. Chen, J.; Chen, S.; Zhao, X.; Kuznetsova, L.V.; Wong, S.S.; Ojima, I. Functionalized Single-Walled Carbon Nanotubes as Rationally Designed Vehicles for Tumor-Targeted Drug Delivery. J. Am. Chem. Soc., 2008, 130, 16778-16785.
79. Lay, C.L.; Liu, H.Q.; Tan, H.R.; Liu, Y. Delivery of paclitaxel by physically loading onto poly(ethylene glycol) (PEG)-graftcarbon nanotubes for potent cancer therapeutics. Nanotechnology, 2010, 21, 65101 (10pp).
80. Tripisciano, C.; Rümmeli, M.H.; Chen, X.; Borowiak-Palen, E. Multi-wall carbon nanotubes avehicle for targeted Irinotecan drug delivery. Phys. Status Solidi B, 2010, 247, Nos. 11-12, 2673-2677.
81. Ren, Y. P.; Pastorin, G., Incorporation of hexamethylmelamine inside capped carbon nanotubes. Adv. Mater., 2008, 20, 2031-2036.
82. Gelderblom, H.; Verweij, J.; Nooter, K.; Sparreboom, A. Cremophor EL: the drawbacks and advantages of vehicle selection for drug formulation. Eur. J. Cancer, 2001, 37, 1590-1598.
83. Crosasso, P.; Ceruti, M.; Brusa, P.; Arpicco, S.; Dosio, F.; Cattel, L. Preparation, characterization and properties of sterically stabilized paclitaxel-containing liposomes. J. Control. Release, 2000, 63, 19-30.
84. Shuai, X. T.; Merdan, T.; Schaper, A. K.; Xi, F.; Kissel, T. Corecross-linked polymeric micelles as paclitaxel carriers. Bioconjug. Chem., 2004, 15, 441-448.
85. Dong, Y.; Feng, S. S. In vitro and in vivo evaluation of methoxy polyethylene glycol-polylactide (MPEG-PLA) nanoparticles for small-molecule drug chemotherapy. Biomater., 2007, 28, 4154-4160.
86. Skwarczynski, M.; Hayashi, Y.; Kiso, Y. Paclitaxel prodrugs: toward smarter delivery of anticancer agents. J. Med. Chem., 2006, 49, 7253-7269.
87. Davis, M.E.; Chen, Z.; Shin, D.M. Nanoparticle therapeutics: an emerging treatment modality for cancer. Nat. Rev. Drug Discov., 2008, 7, 771-782.
88. Tardi, P.G.; Gallagher, R.C.; Johnstone, S.; Harasym, N.; Webb, M.; Bally, M.B.; Mayer, L.D. Coencapsulation of irinotecan and floxuridine into low cholesterol-containing liposomes that coordinate drug release. In vivo, 2007, 1768(3), 678-687.
89. Minnoti, G.; Menna, P.; Salvatorelli, E.; Cairo, G.; Gianni, L. Anthracyclines: molecular advances and pharmacologic development in antitumor activity and cardiotoxicity. Pharmacol. Rev., 2004, 56, 185-229.
90. Shiraga, E.; Barichello, J. M.; Ishida, T.; Kiwada, H. A metronomic schedule of cyclophosphamide combined with PEGylated liposomal doxorubicin has a highly antitumor effect in an experimental pulmonary metastatic mouse model. Int. J. Pharm., 2008, 353, 65-73.
91. Devi, L.; De Groot, F. M.H.; Blacher, S.; Hajitou, A.; Beusker, P.H.; Scheeren, H.W.; Foidart, J.M.; Noel, A. Plasmin-activated doxorubicin prodrugs containing a spacer reduce tumor growth and angiogenesis without systemic toxicity. FASEB J., 2004, 18, 564-569.
92. Ali-Boucetta, H.; Al-Jamal, K. T.; McCarthy, D.; Prato, M.; Bianco, A.; Kostarelos, K. Multiwalled carbon nanotube-doxorubicin supramolecular complexes for cancer therapeutics. Chem. Commun., 2008, 459-461.
93. Liu, Z.; Sun, X.; Nakayama-Ratchford, N.; Hai, D. Supramolecular chemistry on water-soluble carbon nanotubes for drug loading and delivery. ACS Nano, 2007, 1, 50-56.
94. Maeda, H.; Bharate, G. Y.; Daruwala, J. Polymeric Drugs for Efficient Tumor-Targeted Drug Delivery Based on EPR Effect. Eur. J. Pharm. Biopharm., 2009, 71, 409-419.
95. Liu, Z.; Fan, A. C.; Rakhra, K.; Sherlock, S.; Goodwin, A.; Chen, X.; Yang, Q.; Felsher, D.W.; Dai, H. Supramolecular Stacking of Doxorubicin on Carbon Nanotubes for in vivo Cancer Therapy. Angew. Chem. Int. Ed., 2009, 48, 7668-7672.
96. Zhang, Z.; Meng, L.; Lu, Q.; Fei, Z.; Dyson, P. J. Targeted delivery and controlled release of doxorubicin to cancer cells using modified single wall carbon nanotubes. Biomaterials, 2009, 30, 6041-6047.
97. Li, R.; Wu, R.; Zhao, L.; Hu, Z.; Guo, S.; Pan, X.; Zou, H. Folate and iron difunctionalized multiwall carbon nanotubes as dualtargeted drug nanocarrier to cancer cells. Carbon, 2011, 49, 1797-1805.
98. Mashat, A.; Deng, L.; Altawashi, A.; Sougrat, R.; Wang, G.; Khashab, N.M. Zippered release from polymer-gated carbon nanotubes. J. Mater. Chem., 2012, 22, 11503-11508.
99. Heister, E.; Neves, V.; Lamprecht, C.; Ravi, S.; Silva, P.; Coley, H. M.; McFadden, J. Drug loading, dispersion stability, and therapeutic efficacy in targeted drug delivery with carbon nanotubes. Carbon, 2012, 50, 622-632.
100. Ji, Z.; Lin, G.; Lu, Q.; Meng, L.; Shen, X.; Dong, L.; Fu, C.; Zhang, X. Targeted therapy of SMMC-7721 liver cancer in vitro and in vivo with carbon nanotubes based drug delivery system. J. Colloid Interface Sci., 2012, 365, 143-149.
101. Li, R.; Wu, R.; Zhao, L.; Wu, M.; Yang, L.; Zou, H. PGlycoprotein antibody functionalized carbon nanotube overcomes the multidrug resistance of human leukemia cells. ACS Nano, 2010, 4(3), 1399-1408.
102. Kim, E. Carbon nanotubes for gene delivery. Da Vinci's Notebook, 2011, 3.
103. Liang, X.; Chen, C.; Zhao, Y.: Jia, L.; Wang, P. Biopharmaceutics and therapeutic potential of engineered nanomaterials. Curr. Drug Metab., 2008, 9, 697-709.
104. Cai, D.; Mataraza, J.M.; Qin, Z.H.; Huang, Z.; Huang, J.; Chiles, T. C. Highly efficient molecular delivry into mammalian cells using carbon nanotubes spearing. Nat. Methods, 2005, 2, 449-454.
105. Jung, D. H.; Kim, B.H.; Lim, Y. T.; Kim, J.; Lee, S. Y.; Jung, H. T. Fabrication of single-walled carbon nanotubes dotted with Au nanocrystals: Potential DNA delivery nanocarriers. Carbon, 2010, 48, 1070-1078.
106. Liu, M.; Chen, B.; Xue, Y.; Huang, J.; Zhang, L.; Huang, S.; Li, Q.; Zhang, Z. Polyamidoamine-Grafted Multiwalled Carbon Nanotubes for Gene Delivery: Synthesis, Transfection and Intracellular Trafficking. Bioconjugate Chem., 2011, 22, 2237;2243.
107. Yang, R.; Yang, X.; Zhang, Z.; Zhang, Y.; Wang, S.; Cai, Z.; Jia, Y.; Ma, Y.; Zheng, C.; Lu, Y.; Roden, R.; Chen, Y. Single-walled carbon nanotubes-mediated in vivo and in vitro delivery of siRNA into antigen-presenting cells. Gene Ther., 2006, 13, 1714-1723.
108. Karmakar, A.; Bratton, S. M.; Dervishi, E.; Ghosh, A.; Mahmood, M.; Xu, Y.; Saeed, L. M Mustafa, T.; Casciano, D.; Radominska-Pandya, A.; Biris, A. S. Ethylenediamine functionalized-singlewalled nanotube (f-SWNT)-assisted in vitro delivery of the oncogene suppressor p53 gene to breast cancer MCF-7 cells. Int. J. Nanomedicine, 2011, 6, 1045-1055.
109. Zhu, Y.; Chen, W.; Qiao, R.; Wang, L.; Xu, C. Multifunctional vectors system for cancer therapy using single-walled carbon nanotubes and antisense oligonucleotide-modified gold nanoparticles composite materials. Int. J. Nanotechnol., 2011, 8, 664-678.
110. Zhao, C.; Peng, Y.; Song, Y.; Ren, J.; Qu, X. Self-Assembly of Single-Stranded RNA on Carbon Nanotube: Polyadenylic Acid to Form a Duplex Structure. Small, 2008, 4(5), 656-661.
111. Ke, P. C.; Qiao, R. Carbon nanomaterials in biological systems. J. Phys.: Condens. Matter, 2007, 19, 373101.
112. Dobson J. Gene therapy progress and prospects: magnetic nanoparticle-based gene delivery. Gene Ther., 2006, 13(4), 283-287.
113. Nguyen, C.V.; Delzeit, L.; Cassell, A.M.; Li, J.; Han, J.; Meyyappan, M. Preparation of nucleic acid functionalized carbon nanotube arrays. Nano Lett., 2002, 2, 1079-1081.
114. Yu, X.; Munge, B.; Patel, V.; Jensen, G.; Bhirde, A.; Gong, J.D.; Kim, S.N.; Gillespie, J.; Gutkind, J. S.; Papadimitrakopoulos, F.; Rusling, J. F. Carbon nanotube amplification strategies for highly sensitive immunodetection of cancer biomarkers. J. Am. Chem. Soc., 2006, 128, 11199-11205.
115. Yang W.R.; Hibbert, D.B.; Zhang, R.; Willett, G.D.; Gooding. J. J. Stepwise synthesis of gly-gly-his on gold surfaces modified with mixed self-assembled monolayers. Langmuir, 2005, 21, 260-265.
116. Ventura, A.; Kirsch, D.G.; McLaughlin, M.E.; Tuveson, D.A.; Grimm, J.; Lintault, L.; Newman, J.; Reczek, E.E.; Weissleder, R.; Jacks, T. Restoration of p53 function leads to tumour regression in vivo. Nature, 2006, 445, 661-665.
117. Villa, C.H.; Dao, T.; Ahearn, I.; Fehrenbacher, N.; Casey, E.; Rey, D.A.; Korontsvit, T.; Zakhaleva, V.; Batt, C.A.; Philips, M.R.; Scheinberg, D.A. Single-Walled Carbon Nanotubes Deliver Peptide Antigen into Dendritic Cells and Enhance IgG Responses to Tumor-Associated Antigens. ACS Nano, 2011, 5 (7), 5300-5311.
118. Weng, X.; Wang, M.; Ge, J.; Yu, S.; Liu, B.; Zhong, J.; Kong, J. Carbon nanotubes as a protein toxin transporter for selective HER2-positive breast cancer cell destruction. Mol. BioSyst., 2009, 5, 1224-1231.
119. Ou, Z.; Wu, B.; Xing, D. A novel cancer-targeting transporter with integrin v3monoclonal antibody functionalized single-walled carbon nanotubes. Proc. SPIE, 2009, 7519, 751904.
120. Yu, B.Z.; Yang, J.-S.; Li, W.-X. In vitro capability of multi-walled carbon nanotubes modified with gonadotrophin releasing hormone on killing cancer cells. Carbon, 2007, 45 1921-1927.
121. Wong, N.; Kam, S.; Jessop,T. C.; Wender, P.A.; Dai, H. Nanotube Molecular Transporters: Internalization of Carbon Nanotube-Protein Conjugates into Mammalian Cells. J. Am. Chem. Soc., 2004, 126, 6850-6851.
122. Houghton, A.N.; Guevara-Patino, J.A. Immune Recognition of Self in Immunity Against Cancer. J. Clin. Invest., 2004, 114, 468-471.
123. Heath, A. W. Cytokines as Immunological Adjuvants. Pharm. Biotechnol., 1995, 6, 645-658.
124. O'Hagan, D.T.; MacKichan, M.L.; Singh, M. Recent Developments in Adjuvants for Vaccines against Infectious Diseases. Biomol. Eng., 2001, 18, 69-85.
125. Srivastava, P.K.; Menoret, A.; Basu, S.; Binder, R.J.; McQuade, K.L. Heat Shock Proteins Come of Age: Primitive Functions Acquire New Roles in an Adaptive World. Immunity, 1998, 8, 657-665.
126. Kojima, C. Design of Stimuli-Responsive Dendrimers. Expert Opin. Drug Delivery, 2010, 7, 307-319.
127. Livingston, P.O.; Ragupathi, G. Cancer Vaccines Targeting Carbohydrate Antigens. Hum. Vaccines, 2006, 2, 137-143.
128. Pantarotto, D.; Partidos, C.D.; Hoebeke, J.; Brown, F.; Kramer, E.; Briand, J.-P.; Muller, S.; Prato, M.; Bianco, A. Immunization with Peptide-Functionalized Carbon Nanotubes Enhances Virus-Specific Neutralizing Antibody Responses. Chem. Biol., 2003, 10, 961-966.
129. Kostarelos, K.; Bianco, A.; Prato, M. Complement Monitoring of Carbon Nanotubes. Nat. Nanotechnol., 2010, 5, 382-383.
130. Massoud, T.F.; Gambhir, S.S. Molecular imaging in living subjects: seeing fundamental biological processes in a new light. Gene. Dev., 2003, 17, 545-580.
131. Shah, K.: Jacobs, A.; Breakefield, X.O.; Weissleder, R. Molecular imaging of gene therapy for cancer. Gene Ther. 2004, 11, 1175-1187.
132. Mitchell, D.G . MRI Principles; W.B . Saunders Company: Philadelphia, 1999.
133. Yang, W.; Thordarson, P.; Gooding, J.J.; Ringer, S.P.; Braet, F. Carbon nanotubes for biological and biomedical applications. Nanotechnology, 2007, 18, 412001 (12pp).
134. Liu, Z.; Yang, K.; Lee, S.-T. Single-walled carbon nanotubes in biomedical imaging. J. Mat. Chem., 2011, 21, 586-598.
135. Tao, H.; Yang, K.; Ma, Z.; Wan, J.; Zhang, Y.; Kang, Z.; Liu, Z. In vivo NIR Fluorescence Imaging, Biodistribution, and Toxicology of Photoluminescent Carbon Dots Produced from Carbon Nanotubes and Graphite. Small, 2012, 8(2), 281-290.
136. Ding, X.; Singh, R.; Burke, A.; Hatcher, H.; Olson, J.; Kraft, R. A.; Schmid, M.; Carroll, D.; Bourland, J. D.; Akman, S.; Torti, F.M.; Torti, S. V. Development of iron-containing multiwalled carbon nanotubes for MR-guided laser-induced thermotherapy. Nanomedicine, 2011, 6 (8), 1341-1352.
137. Baughman, R. H.; Zakhidov, A. A.; de Heer, W. A. Carbon nanotubes-The route toward applications. Science, 2002, 297(5582), 787-792.
138. Cherukuri, P.; Bachilo, S.M.; Litovsky, S.H.; Weisman, R.B. Nearinfrared fluorescence microscopy of single-walled carbon nanotubes in phagocytic cells. J. Am. Chem. Soc., 2004, 126(48), 15638-15639.
139. Jin, H.; Heller, D.A.; Strano, M.S. Single-Particle Tracking of Endocytosis and Exocytosis of Single-Walled Carbon Nanotubes in NIH-3T3 Cells. Nano Lett., 2008, 8, 1577-1585.
140. Welsher, K.; Liu. Z.; Daranciang, D.; Dai, H. Selective probing and imaging of cells with single walled carbon nanotubes as nearinfrared fluorescent molecules. Nano Lett., 2008, 8(2), 586-590.
141. Welsher, K.; Liu, Z.; Sherlock, S.P.; Robinson, J.T.; Chen, Z.; Daranciang, D.; Dai, H. A route to brightly fluorescent carbon nanotubes for near-infrared imaging in mice. Nat. Nanotechnol., 2009, 4, 773-780.
142. Chen, W.; Zhou, F.; Ou, Z.; Wu, B.; Song, S. Monitoring of Tumor Treatment using the Combination of Near-Infrared Laser Light and Carbon Nanotubes. Proc. SPIE, 2009, 7519, 75190X-1.
143. Cherukuri, P.; Gannon, C.J.; Leeuw, T.K.; Schmidt, H.K.; Smalley, R.E.; Curley, S.A.; Weisman, R.B. Mammalian pharmacokinetics of carbon nanotubes using intrinsic near-infrared fluorescence. PNAS, 2006, 103(50), 18882-18886.
144. Leeuw, T.K.; Reith, R.M.; Simonette, R.A.; Harden, M.E.; Cherukuri, P.; Tsyboulski, D.A.; Beckingham, K.M.; Weisman, R.B. Single-Walled Carbon Nanotubes in the Intact Organism: Near-IR Imaging and Biocompatibility Studies in Drosophila. Nano Lett., 2007, 7(9), 2650-2654.
145. Burke, A.; Ding, X.; Singh, R.; Kraft, R.A.; Levi-Polyachenko, N.; Rylander, M.N.; Szot, C., Buchanan, C.; Whitney, J.; Fisher, J.; Hatcher, H.C.; D'Agostino, R. Jr.; Kock, N.D.; Ajayan, P.M.; Carroll, D.L.; Akman, S.; Torti, F.M.; Torti, S.V. Long-term survival following a single treatment of kidney tumors with multiwalled carbon nanotubes and near-infrared radiation. Proc. Natl Acad. Sci. USA, 2009, 106(31), 12897-12902.
146. Yang, S.-T-; Wang X.; Wang, H.; Lu, F.; Luo, P.G.; Cao, L.; Meziani, M.J.; Liu, J.-H.; Liu, Y.; Chen, M.; Huang, Y.; Sun, Y.-P. Carbon Dots as Nontoxic and High-Performance Fluorescence Imaging Agents. J. Phys. Chem. C, 2009, 113, 18110-18114.
147. Liu, Z.; Li, X.; Tabakman, S.M.; Jiang, K.; Fan, S.; Dai, H. Multiplexed Multicolor Raman Imaging of Live Cells with Isotopically Modified Single Walled Carbon Nanotubes. J. Am. Chem. Soc., 2008, 130, 13540-13541.
148. Heller, D.A.; Baik, S.; Eurell, T.E.; Strano, M.S. Single-Walled Carbon Nanotube Spectroscopy in Live Cells: Towards Long-Term Labels and Optical Sensors. Adv. Mater., 2005, 17, 2793-2799.
149. Liu, Z.; Davis, C.; Cai, W.; He, L.; Chen, X.; Dai, H. Circulation and long-term fate of functionalized, biocompatible single-walled carbon nanotubes in mice probed by Raman spectroscopy Proc. Natl. Acad. Sci. U. S. A., 2008, 105, 1410-1415.
150. Zavaleta, C.; de la Zerda, A.; Liu, Z.; Keren, S.; Cheng, Z.; Schipper, M.;Chen, X.; Dai, H.; Gambhir, S.S. Noninvasive Raman Spectroscopy in Living Mice for Evaluation of Tumor Targeting with Carbon Nanotubes. Nano Lett., 2008, 8(9), 2800-2805.
151. Liu, Z.; Tabakman, S.; Sherlock, S.; Li, X.; Chen, Z.; Jiang, K.; Fan, S.; Dai, H. Multiplexed Five-Color Molecular Imaging of Cancer Cells and Tumor Tissues with Carbon Nanotube Raman Tags in the Near-Infrared. Nano Res., 2010, 3, 222-233.
152. Chivukula, V. S.; Shur, M. S.; Ciplys, D. Recent advances in application of acoustic, acousto-optic and photoacoustic methods in biology and medicine. Phys. Status Solidi A, 2007, 204, 3209-3236.
153. Wang, L.V. Prospects of photoacoustic tomography. Prospects of photoacoustic tomography. Med. Phys., 2008, 35, 5758-5767.
154. Zhang, Y.; Hong, H.; Cai, W. Photoacoustic Imaging. Cold Spring Harb. Protoc., 2011, 1015-1025.
155. Kang, B.; Yu, D.; Dai, Y.; Chang, S.; Chen, D.; Ding, Y. Cancer-Cell Targeting and Photoacoustic Therapy Using Carbon Nanotubes as ''Bomb'' Agents. Small, 2009, 5(11), 1292-1301.
156. De La Zerda, A.; Zavaleta, C.; Keren, S.; Vaithilingam, S.; Bodapati, S.; Liu, Z.; Levi J.; Smith, B. R.; Ma, T.; Oralkan, O.; Cheng, Z.; Chen, X.; Dai, H.; Khuri-Yakub, B.T.; Gambhir, S.S. Carbon nanotubes as photoacoustic molecular imaging agents in living mice. Nat. Nanotechnol., 2008, 3(9): 557-562.
157. De La Zerda, A.; Liu, Z.; Bodapati, S.; Teed, R.; Vaithilingam, S.; Khuri-Yakub, B.T.; Chen, X.; Dai, H.; Gambhir, S.S. Ultrahigh Sensitivity Carbon Nanotube Agents for Photoacoustic Molecular Imaging in Living Mice. Nano Lett., 2010, 10, 2168-2172.
158. Kim, J.-W.; Galanzha, E.I.; Shashkov, E.V.; Moon, H.-M.; Zharov, V.P. Golden carbon nanotubes as multimodal photoacoustic and photothermal high-contrast molecular agents. Nat. Nanotechnol., 2009, 4, 688-694.
159. Galanzha, E.I.; Shashkov, E V.; Kelly, T.; Kim, J.-W.; Yang, L.; Zharov, V.P. In vivo magnetic enrichment and multiplex photoacoustic detection of circulating tumour cells. Nat. Nanotechnol., 2009, 4, 855-860.
160. Wang, H. F.; Wang, J.; Deng, X.Y.; Sun, H.F.; Shi, Z.J.; Gu, Z.N.;. Liu Y.F.; Zhao, Y.L. Biodistribution of Carbon Single-Wall Carbon Nanotubes in Mice. J. Nanosci. Nanotechnol., 2004, 4, 1019-1024.
161. Deng, X.Y.; Yang, S.T.; Nie, H.Y.; Wang H.F.; Liu, Y.F. A generally adoptable radiotracing method for tracking carbon nanotubes in animals. Nanotechnology, 2008, 19, 075101.
162. Singh, R.; Pantarotto, D.; Lacerda, L.; Pastorin, G.; Klumpp, C.; Prato, M.; Bianco A.; Kostarelos, K. Tissue biodistribution and blood clearance rates of intravenously administered carbon nanotube radiotracers. Proc. Natl. Acad. Sci. U. S. A., 2006, 103, 3357-3362.
163. Lacerda, L.; Soundararajan, A.; Singh, R.; Pastorin, G.; Al-Jamal, K. T.; Turton, J.; Frederik, P.; Herrero, M. A.; Bao, S. L. A.; Emfietzoglou, D.; Mather, S.; Phillips, W. T.; Prato, M.; Bianco, A.; Goins B.; Kostarelos, K. Dynamic Imaging of Functionalized Multi-Walled Carbon Nanotube Systemic Circulation and Urinary Excretion. Adv. Mater., 2008, 20, 225-230.
164. McDevitt, M.R.; Chattopadhyay, D.; Jaggi, J.S.; Finn, R.D.; Zanzonico, P.B.; Villa, C.; Rey, D.; Mendenhall, J.; Batt, C.A.; Njardarson J.T.;. Scheinberg, D.A. Cicle Source: PET Imaging of Soluble Yttrium-86-Labeled Carbon Nanotubes in Mice. PLOS One, 2007, 2, e907.
165. Mc Devitt, M.R.; Chattopadhyay D.; Kappel, B.J.; Jaggi, J.S.; Schiffman, S.R.; Antczak, C.; Njardarson, J.T.; Brentjens, R.; Scheinberg, D.A. Tumor targeting with antibody-functionalized, radiolabeled carbon nanotubes. J. Nucl. Med., 2007, 48(7), 1180-1189.
166. Liu, Z.; Cai, W.; He, L.; Nakayama, N.; Chen, K.; Sun, X.; Chen, X.; Dai, H. In vivo biodistribution and highly efficient tumour targeting of carbon nanotubes in mice. Nat. Nanotechnol., 2007, 2, 47-52.
167. Hong, S. Y.; Tobias, G.; Al-Jamal, K. T.; Ballesteros, B.; Ali-Boucetta, H.; Lozano-Perez, S.; Nellist, P. D.; Sim, R. B.; Finucane, C.; Mather, S. J.; Green, M. L. H.; Kostarelos, K.; Davis, B. G. Filled and glycosylated carbon nanotubes for in vivo radioemitter localization and imaging. Nature Mater., 2010, 9, 485-490.
168. Mansfield, P. Snapshot magnetic resonance imaging. Angew Chem. Int. Ed Engl, 2004, 43, 5456-5464.
169. Mornet, S.; Vasseur, S.; Grasset F.; Duguet, E. Magnetic nanoparticle design for medical diagnosis and therapy. J. Mater. Chem., 2004, 14, 2161-2175.
170. Yigit, M.V.; Moore, A.; Medarova, Z. Magnetic nanoparticles for cancer diagnosis and therapy. Pharm Res., 2012, 29(5), 1180-1188.
171. Choi, J.H.; Nguyen, F.T.; Barone, P.W.; Heller, D.A.; Moll, A.E.; Patel, D.; Boppart, S.A.; Strano, M.S. Multimodal Biomedical Imaging with Asymmetric Single-Walled Carbon Nanotube/Iron Oxide Nanoparticle Complexes. Nano Lett., 2007, 7(4), 861-867.
172. Al Faraj, A.A.; Cieslar, K.; Lacroix, G.; Gaillard, S.; Canet-Soulas, E.; Cremillieux,Y. In vivo Imaging of Carbon Nanotube Biodistribution Using Magnetic Resonance Imaging. Nano Lett., 2009, 9, 1023-1027.
173. Vittorio, O.; Duce, S.L.; Pietrabissa, A.; Cuschieri, A. Multiwall carbon nanotubes as MRI contrast agents for tracking stem cells. Nanotechnology, 2011, 22, 095706.
174. Toth, E.; Bolskar, R.D.; Borel, A.; Gonzalez, G.; Helm, L.; Merbach, A.E.; Sitharaman, B.; Wilson, L.J. Water-soluble Gadofullerenes: Toward High Relaxivity, pH-responsive MRI Contrast Agents. J. Am. Chem. Soc., 2005, 127, 799-805.
175. Sintharaman, B.; Kissell, K.R.; Hartman, K.B.; Tran, L.A.; Baikalov, A.; Rusakova, I.; Sun, Y.; Khant, H. A.; Ludtke, S.J.; Chiu, W.; Laus, S.; Tóth, É.; Helm, L.; Merbach, A.E.; Wilson, L.J. Superparamagnetic gadonanotubes are high-performance MRI contrast Agents. Chem. Commun., 2005, 3915-3917.
176. Richard, C.; Doan, B.-T.; Beloeil, J.-C.; Bessodes, M.; Tòth, E.; Scherman, D. Noncovalent Functionalization of Carbon Nanotubes with Amphiphilic Gd3+ Chelates: Toward Powerful T1 and T2 MRI Contrast Agents. Nano Lett., 2008, 8(1), 231-236.
177. Saini, S.; Stark, D.D.; Hahn, P.F.; Wittenberg, J.; Brady, T.J.; Ferrucci, J.T.Jr., Ferrite particles: a superparamagnetic MR contrast agent for the reticuloendothelial system. Radiology, 1987, 162, 211-216.
178. Miyawaki,J.; Yudasaka, M.; Imai, H.; Yorimitsu, H.; Isobe, H.; Nakamura, E.; Iijima S. In vivo Magnetic Resonance Imaging of Single-Walled Carbon Nanohorns by Labeling with Magnetite Nanoparticles. Adv. Mater., 2006, 18, 1010-1014.
179. Tucker-Schwartz, J.M.; Hong, T.; Colvin, D.C.; Xu, Y.; Skala, M.C.; Dual Modality Photothermal Optical Coherence Tomography and Magnetic Resonance Imaging of Carbon Nanotubes. Opt. Lett., 2012, 37(5), 872-874.