Multiplexed five-color molecular imaging of cancer cells and tumor tissues with carbon nanotube Raman tags in the near-infrared

Nano Research

Volumn 3, Issue 3, 2010, Pages 222-233

  Liu, Zhuang ^a   Tabakman, Scott ^b   Sherlock, Sarah ^b   Li, Xiaolin ^b   Chen, Zhuo ^b   Jiang, Kaili ^c   Fan, Shoushan ^c   Dai, Hongjie ^b  

^a SOOCHOW UNIVERSITY   (China)

^b STANFORD UNIVERSITY   (United States)

^c TSINGHUA UNIVERSITY   (China)

Author keywords

Biomedicine; Carbon nanotubes; Multiplexed imaging; Raman scattering

Indexed keywords

EID: 77953651710     PISSN: 19980124     EISSN: 19980000     Source Type: Journal    
DOI: 10.1007/s12274-010-1025-1     Document Type: Article

References (41)

1. Massoud, T. F.; Gambhir, S. S. Molecular imaging in living subjects: Seeing fundamental biological processes in a new light. Gene. Dev. 2003, 17, 545-580.
2. Wagnieres, G. A.; Star, W. M.; Wilson, B. C. In vivo fluorescence spectroscopy and imaging for oncological applications. Photochem. Photobiol. 1998, 68, 603-632.
3. Song, L. L.; Hennink, E. J.; Young, I. T.; Tanke, H. J. Photobleaching kinetics of fluorescein in quantitative fluorescence microscopy. Biophys. J. 1995, 68, 2588-2600.
4. Aubin, J. E. Autofluorescence of viable cultured mammalian-cells. J. Histochem. Cytochem. 1979, 27, 36-43.
5. Frangioni, J. V. In vivo near-infrared fluorescence imaging. Curr. Opin. Chem. Biol. 2003, 7, 626-634.
6. Alivisatos, A. P.; Gu, W. W.; Larabell, C. Quantum dots as cellular probes. Ann. Rev. Biomed. Eng. 2005, 7, 55-76.
7. Xing, Y.; Chaudry, Q.; Shen, C.; Kong, K. Y.; Zhau, H. E.; Chung, L. W.; Petros, J. A.; O'Regan, R. M.; Yezhelyev, M. V.; Simons, J. W. et al. Bioconjugated quantum dots for multiplexed and quantitative immunohistochemistry. Nat. Protoc. 2007, 2, 1152-1165.
8. Fountaine, T. J.; Wincovitch, S. M.; Geho, D. H.; Garfield, S. H.; Pittaluga, S. Multispectral imaging of clinically relevant cellular targets in tonsil and lymphoid tissue using semiconductor quantum dots. Modern Pathol. 2006, 19, 1181-1191.
9. Nie, S. M.; Emery, S. R. Probing single molecules and single nanoparticles by surface-enhanced Raman scattering. Science1997, 275, 1102-1106.
10. Cao, Y. W. C.; Jin, R. C.; Mirkin, C. A. Nanoparticles with Raman spectroscopic fingerprints for DNA and RNA detection. Science2002, 297, 1536-1540.
11. Keren, S.; Zavaleta, C.; Cheng, Z.; de la Zerda, A.; Gheysens, O.; Gambhir, S. S. Noninvasive molecular imaging of small living subjects using Raman spectroscopy. Proc. Nat. Acad. Sci. U. S. A. 2008, 105, 5844-5849.
12. Liu, Z.; Tabakman, S.; Welsher, K.; Dai, H. Carbon nanotubes in biology and medicine: In vitro and in vivo detection, imaging and drug delivery. Nano Res. 2009, 2, 85-120.
13. Liu, Z.; Cai, W.; He, L.; Nakayama, N.; Chen, K.; Sun, X.; Chen, X.; Dai, H. In vivo biodistribution and highly efficient tumour targeting of carbon nanotubes in mice. Nat Nanotechnol. 2007, 2, 47-52.
14. Liu, Z.; Sun, X.; Nakayama, N.; Dai, H. Supramolecular chemistry on water-soluble carbon nanotubes for drug loading and delivery. ACS Nano2007, 1, 50-56.
15. Feazell, R. P.; Nakayama-Ratchford, N.; Dai, H.; Lippard, S. J. Soluble single-walled carbon nanotubes as longboat delivery systems for platinum(IV) anticancer drug design. J. Am. Chem. Soc. 2007, 129, 8438-8439.
16. Moon, H. K.; Chang, C. I.; Lee, D. -K.; Choi, H. C. Effect of nucleases on the cellular internalization of fluorescent labeled DNA-functionalized single-walled carbon nanotubes. Nano Res. 2008, 1, 351-360.
17. Chen, R. J.; Bangsaruntip, S.; Drouvalakis, K. A.; Kam, N. W. S.; Shim, M.; Li, Y. M.; Kim, W.; Utz, P. J.; Dai, H. J. Noncovalent functionalization of carbon nanotubes for highly specific electronic biosensors. Proc. Nat. Acad. Sci. U. S. A. 2003, 100, 4984-4989.
18. Chen, Z.; Tabakman, S. M.; Goodwin, A. P.; Kattah, M. G.; Daranciang, D.; Wang, X.; Zhang, G.; Li, X.; Liu, Z.; Utz, P. J. et al. Protein microarrays with carbon nanotubes as multicolor Raman labels. Nat. Biotechnol. 2008, 26, 1285-1292.
19. Welsher, K.; Liu, Z.; D, D.; Dai, H. Selective probing and imaging of cells with single walled carbon nanotubes as near-infrared fluorescent molecules. Nano Lett. 2008, 8, 586-590.
20. Cherukuri, P.; Gannon, C. J.; Leeuw, T. K.; Schmidt, H. K.; Smalley, R. E.; Curley, S. A.; Weisman, R. B. Mammalian pharmacokinetics of carbon nanotubes using intrinsic near-infrared fluorescence. Proc. Natl. Acad. Sci. U. S. A. 2006, 103, 18882-18886.
21. Hanlon, E. B.; Manoharan, R.; Koo, T. W.; Shafer, K. E.; Motz, J. T.; Fitzmaurice, M.; Kramer, J. R.; Itzkan, I.; Dasari, R. R.; Feld, M. S. Prospects for in vivo Raman spectroscopy. Phys. Med. Biol. 2000, 45, R1-R59.
22. O'Connell, M. J.; Bachilo, S. M.; Huffman, C. B.; Moore, V. C.; Strano, M. S.; Haroz, E. H.; Rialon, K. L.; Boul, P. J.; Noon, W. H.; Kittrell, C. et al. Band gap fluorescence from individual single-walled carbon nanotubes. Science2002, 297, 593-596.
23. Rao, A. M.; Richter, E.; Bandow, S.; Chase, B.; Eklund, P. C.; Williams, K. A.; Fang, S.; Subbaswamy, K. R.; Menon, M.; Thess, A. et al. Diameter-selective Raman scattering from vibrational modes in carbon nanotubes. Science1997, 275, 187-191.
24. Liu, Z.; Li, X.; Tabakman, S. M.; Jiang, K.; Fan, S.; Dai, H. Multiplexed multi-color Raman imaging of live cells with isotopically modified single walled carbon nanotubes. J. Am. Chem. Soc. 2008, 130, 13540-13541.
25. Li, X. L.; Tu, X. M.; Zaric, S.; Welsher, K.; Seo, W. S.; Zhao, W.; Dai, H. J. Selective synthesis combined with chemical separation of single-walled carbon nanotubes for chirality selection. J. Am. Chem. Soc. 2007, 129, 15770-15771.
26. Liu, Z.; Davis, C.; Cai, W.; He, L.; Chen, X.; Dai, H. Circulation and long-term fate of functionalized, biocompatible single-walled carbon nanotubes in mice probed by Raman spectroscopy. Proc. Natl. Acad. Sci. U. S. A. 2008, 105, 1410-1415.
27. Liu, Z.; Cai, W. B.; He, L. N.; Nakayama, N.; Chen, K.; Sun, X. M.; Chen, X. Y.; Dai, H. J. In vivo biodistribution and highly efficient tumour targeting of carbon nanotubes in mice. Nat. Nanotechnol. 2007, 2, 47-52.
28. Liu, Z.; Tabakman, S. M.; Chen, Z.; Dai, H. Preparation of carbon nanotube bioconjugates for biomedical applications. Nat. Protoc. 2009, 4, 1372-1382.
29. HER2 monoclonal antibodies. Cancer Immunol. Immun. 1993, 37, 255-263.
30. Haubner, R.; Wester, H. -J.; Weber, W. A.; Mang, C.; Ziegler, S. I.; Goodman, S. L.; Senekowitsch-Schmidtke, R.; Kessler, H.; Schwaiger, M. Noninvasive imaging of αvβ3 integrin expression using 18F-labeled RGD-containing glycopeptide and positron emission tomography. Cancer Res. 2001, 61, 1781-1785.
31. Cai, W.; Shin, D. -W.; Chen, K.; Gheysens, O.; Cao, Q.; Wang, S. X.; Gambhir, S. S.; Chen, X. Peptide-labeled near-infrared quantum dots for imaging tumor vasculature in living subjects. Nano Lett. 2006, 6, 669-676.
32. Eliceiri, B. P.; Cheresh, D. A. The role of αv integrins during angiogenesis: insights into potential mechanisms of action and clinical development. J. Clin. Invest. 1999, 103, 1227-1230.
33. Mulder, W. J. M.; Strijkers, G. J.; Habets, J. W.; Bleeker, E. J. W.; van der Schaft, D. W. J.; Storm, G.; Koning, G. A.; Griffioen, A. W.; Nicolay, K. MR molecular imaging and fluorescence microscopy for identification of activated tumor endothelium using a bimodal lipidic nanoparticle. FASEB J. 2005, 19, 2008-2010.
34. Bonner, J. A.; Buchsbaum, D. J.; Russo, S. M.; Fiveash, J. B.; Trummell, H. Q.; Curiel, D. T.; Raisch, K. P. Anti-EGFR-mediated radiosensitization as a result of augmented EGFR expression. Int. J. Radiat. Oncol. 2004, 59, 2-10.
35. Milenic, D. E.; Wong, K. J.; Baidoo, K. E.; Ray, G. L.; Garmestani, K.; Williams, M.; Brechbiel, M. W. Cetuximab: Preclinical evaluation of a monoclonal antibody targeting EGFR for radioimmunodiagnostic and radioimmunotherapeutic applications. Cancer Biother. Radio. 2008, 23, 619-631.
36. Milenic, D. E.; Garmestani, K.; Brady, E. D.; Albert, P. S.; Ma, D.; Abdulla, A.; Brechbiel, M. W. Targeting of HER2 antigen for the treatment of disseminated peritoneal disease. Clin. Cancer Res. 2004, 10, 7834-7841.
37. Oliveira, S.; Henegouwen, P. M. V. E.; Storm, G.; Schiffelers, R. M. Molecular biology of epidermal growth factor receptor inhibition for cancer therapy. Expert Opin. Biol. Th. 2006, 6, 605-617.
38. Heller, D. A.; Baik, S.; Eurell, T. E.; Strano, M. S. Single-walled carbon nanotube spectroscopy in live cells: Towards long-term labels and optical sensors. Adv. Mater. 2005, 17, 2793-2799.
39. Freudiger, C. W.; Min, W.; Saar, B. G.; Lu, S.; Holtom, G. R.; He, C.; Tsai, J. C.; Kang, J. X.; Xie, X. S. Label-free biomedical imaging with high sensitivity by stimulated Raman scattering microscopy. Science2008, 322, 1857-1861.
40. Tu, X.; Zheng, M. A DNA-based approach to the carbon nanotube sorting problem. Nano Res. 2008, 1, 185-194.
41. Kam, N. W. S.; O'Connell, M.; Wisdom, J. A.; Dai, H. Carbon nanotubes as multifunctional biological transporters and near-infrared agents for selective cancer cell destruction. Proc. Natl. Acad. Sci. USA2005, 102, 11600-11605.