Biopharmaceutics and therapeutic potential of engineered nanomaterials

Current Drug Metabolism

Volumn 9, Issue 8, 2008, Pages 697-709

  Liang, Xing Jie ^a   Chen, Chunying ^a,b   Zhao, Yuliang ^a,b   Jia, Lee ^c   Wang, Paul C ^d  

^a NATIONAL CENTER FOR NANOSCIENCE AND TECHNOLOGY   (China)

^b INSTITUTE OF HIGH ENERGY PHYSICS   (China)

^c NATIONAL CANCER INSTITUTE   (United States)

^d HOWARD UNIVERSITY   (United States)

Author keywords

Carbon nanotube; Engineered nanomaterials; Fullerenol; Magnetic nanoparticles; Metabolism; Nanomedicine; Silica dioxide (SiO2); Titanium dioxide (TiO2)

Indexed keywords

AMPHOTERICIN; CADMIUM SELENIDE; CARBON NANOTUBE; CISPLATIN; DAUNORUBICIN; FULLERENE DERIVATIVE; GADODIAMIDE; GADOLINIUM; GADOLINIUM ENDOHEDRAL METALLOFULLERENOL; GADOLINIUM PENTETATE; LIPOSOME; NANOMATERIAL; PACLITAXEL; PLATINUM COMPLEX; QUANTUM DOT; SINGLE WALLED NANOTUBE; TITANIUM DIOXIDE; UNCLASSIFIED DRUG; FULLERENOL; NANOPARTICLE;

ANTIOXIDANT ACTIVITY; BREAST CANCER; CENTRAL NERVOUS SYSTEM; CONTRAST ENHANCEMENT; CONTROLLED RELEASE FORMULATION; CYTOTOXICITY; DRUG ELIMINATION; DRUG FORMULATION; DRUG METABOLISM; DRUG PENETRATION; DRUG SOLUBILITY; ENDOCYTOSIS; GENOTOXICITY; HUMAN; HYDROPHOBICITY; INFLAMMATION; NANOENGINEERING; NANOMEDICINE; NANOPHARMACEUTICS; NANOTECHNOLOGY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OXIDATIVE STRESS; PARTICLE SIZE; PHAGOCYTOSIS; REVIEW; TISSUE DISTRIBUTION; UNSPECIFIED SIDE EFFECT; ANIMAL; MAGNETISM; TRANSPORT AT THE CELLULAR LEVEL;

ANIMALS; BIOLOGICAL TRANSPORT; FULLERENES; HUMANS; MAGNETIC RESONANCE IMAGING; MAGNETICS; NANOMEDICINE; NANOPARTICLES; NANOSTRUCTURES; NANOTECHNOLOGY;

EID: 58149357363     PISSN: 13892002     EISSN: None     Source Type: Journal    
DOI: 10.2174/138920008786049230     Document Type: Review

References (98)

1. Jia, L. (2005) Global governmental investment in nanotechnologies. Curr. Nanosci., 3, 263-6.
2. Whitesides, G. M. (2003) The 'right' size in nanobiotechnology. Nat. Biotechnol., 21, 1161-5.
3. Seaton, A. and Donaldson, K. (2005) Nanoscience, nanotoxicology, and the need to think small. Lancet, 365, 923-4.
4. Mazzola, L. (2003) Commercializing nanotechnology. Nat. Biotechnol., 21, 1137-43.
5. Paull, R.; Wolfe, J.; Hebert, P. and Sinkula, M. (2003) Investing in nanotechnology. Nat. Biotechnol., 21, 1144-7.
6. Roszek, B.; de Jong, W.H.; Geertsma, R.E. (2005) Nanotechnology in medical applications: state-of-the-art in materials and devices. RIVM report 265001001/2005.
7. Jia, L. (2005) Nanoparticle formulation Increases oral bioavailability of poorly soluble drugs: experimental evidences, theory, and approaches. Curr. Nanosci., 3(1), 237-43.
8. Oberdorster G, O. E.; Oberdorster J. (2005b) Nanotoxicology: An Emerging Discipline Evolving from Studies of Ultrafine Particles. Environ. Health Perspect., 113, 823-39.
9. de Jong, W. H.; Roszek, B.; Geertsma, R.E. (2005) Nanotechnology in medical applications: possible risks for human health. RIVM report 265001002/2005.
10. Zhao, Y. and Nalwa, H. S. (2007) Nanotoxicology, American Scientific Publishers, California, 2007.
11. Nel, A.; Xia, T.; Madler, L. and Li, N. (2006) Toxic potential of materials at the nanolevel. Science, 311, 622-7.
12. Hoet, P. H.; Bruske-Hohlfeld, I. and Salata, O. V. (2004) Nanoparticles - known and unknown health risks. J. Nanobiotechnol., 2, 12.
13. Liu, Y. and Wang., H. F. (2007) Nanotechnology tackles tumours. Nat. Nanotechnol., 2 (1), 20-1.
14. Jia, L. W.; Cerna, C.; Weitman, S. (2002) Effect of nanonization on absorption of 301029: Ex vivo and in vivo pharmacokinetic correlations determined by LC/MS. Pharm. Res., 14, 1091-6.
15. Bittner, B. and Mountfield, R. J. (2002) Intravenous administration of poorly soluble new drug entities in early drug discovery: the potential impact of formulation on pharmacokinetic parameters. Curr. Opin. Drug Discov. Dev., 5, 59-71.
16. Li, N.; Kommireddy, D. S.; Lvov, Y.; Liebenberg, W.; Tiedt, L. R. and De Villiers, M. M. (2006) Nanoparticle multilayers: surface modification of photosensitive drug microparticles for increased stability and in vitro bioavailability. J. Nanosci. Nanotechnol., 6, 3252-60.
17. Kam, N. W.; O'Connell, M.; Wisdom, J. A., and Dai, H. (2005) Carbon nanotubes as multifunctional biological transporters and near-infrared agents for selective cancer cell destruction. Proc. Natl. Acad. Sci. USA, 102, 11600-5.
18. Pantarotto, D.; Briand, J. P.; Prato, M. and Bianco, A. (2004) Translocation of bioactive peptides across cell membranes by carbon nanotubes. Chem. Commun. (Camb.)., 1, 16-7.
19. Kostarelos, K. L. L.; Pastorin, G.; Wu, W.; Wieckowski, S.; Luangsivilay, J.; Godefroy, S.; Pantarotto, D.; Briand, J.; Muller, S.; Prato, M.; Bianco, A. (2007) Cellular uptake of functionalized carbon nanotubes is independent of functional group and cell type. Nat. Nanotechnol., 2, 108-13.
20. Arunachalam, B.; Phan, U. T.; Geuze, H. J. and Cresswell, P. (2000) Enzymatic reduction of disulfide bonds in lysosomes: characterization of a gamma-interferon-inducible lysosomal thiol reductase (GILT) Proc. Natl. Acad. Sci. USA, 97, 745-50.
21. Feazell, R. P.; Nakayama-Ratchford, N.; Dai, H. and Lippard, S. J. (2007) Soluble single-walled carbon nanotubes as longboat delivery systems for platinum(IV) anticancer drug design. J. Am. Chem. Soc., 129, 8438-9.
22. Service, R. F. (2003) American Chemical Society meeting. Nanomaterials show signs of toxicity. Science, 300, 243.
23. Zhu, L.; Chang, D. W.; Dai, L. and Hong, Y. (2007) DNA damage induced by multiwalled carbon nanotubes in mouse embryonic stem cells. Nano. Lett., 7, 3592-7.
24. Lam, C. W.; James, J. T.; McCluskey, R. and Hunter, R. L. (2004) Pulmonary toxicity of single-wall carbon nanotubes in mice 7 and 90 days after intratracheal instillation. Toxicol. Sci., 77, 126-34.
25. Liu, A.; Sun, K.; Yang, J.; Zhao, D. (2008) Toxicological effects of multi-wall carbon nanotubes in rats. J. Nanopart. Res., DOI10.1007/ s11051-008-9369-0.
26. Maynard, A. D.; Baron, P. A.; Foley, M.; Shvedova, A. A.; Kisin, E. R. and Castranova, V. (2004) Exposure to carbon nanotube material: aerosol release during the handling of unrefined single-walled carbon nanotube material. J. Toxicol. Environ. Health A., 67, 87-107.
27. Shedova, A. A.; Castranova, V.; Kisin, E.R.; Schwegler-Berry, D.; Murray, A.R.; Gandelsman, and V.Z.; M.; A.; Baron, P. (2003) Exposure to carbon nanotube material: assessment of nanotube cytotoxicity using human keratinocyte cells. J. Toxicol. Environ. Health A., 66, 1909-26.
28. Deng, X. J.; G; Wang, H.; Sun, H.; Wang, X.; Yang, S.; Wang, T.; Liu, Y. (2007) Translocation and fate of multi-walled carbon nanotubes in vivo. Carbon, 45, 1419-24.
29. Moller, W.; Brown, D. M.; Kreyling, W. G.; and Stone, V. (2005) Ultrafine particles cause cytoskeletal dysfunctions in macrophages: role of intracellular calcium. Part. Fibre Toxicol., 2, 7.
30. Driscoll, K. E.; Deyo, L. C.; Carter, J. M.; Howard, B. W.; Hassenbein, D. G. and Bertram, T. A. (1997) Effects of particle exposure and particle-elicited inflammatory cells on mutation in rat alveolar epithelial cells. Carcinogenesis, 18, 423-30.
31. Chougule, M.; Padhi, B. and Misra, A. (2007) Nano-liposomal dry powder inhaler of tacrolimus: preparation, characterization, and pulmonary pharmacokinetics. Int. J. Nanomed., 2, 675-88.
32. Warheit, D. B.; Laurence, B. R.; Reed, K. L.; Roach, D. H.; Reynolds, G. A. and Webb, T. R. (2004) Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats. Toxicol. Sci., 77, 117-25.
33. Pope, C. A.; 3rd, Burnett, R. T.; Thurston, G. D.; Thun, M. J.; Calle, E. E.; Krewski, D. and Godleski, J. J. (2004) Cardiovascular mortality and long-term exposure to particulate air pollution: epidemiological evidence of general pathophysiological pathways of disease. Circulation, 109, 71-7.
34. Borm, P. J.; Schins, R. P. and Albrecht, C. (2004) Inhaled particles and lung cancer, part B: paradigms and risk assessment. Int. J. Cancer, 110, 3-14.
35. Pantarotto, D.; Singh, R.; McCarthy, D.; Erhardt, M.; Briand, J. P.; Prato, M.; Kostarelos, K. and Bianco, A. (2004) Functionalized carbon nanotubes for plasmid DNA gene delivery. Angew. Chem. Int. Ed. Engl., 43, 5242-6.
36. Singh, R.; Pantarotto, D.; McCarthy, D.; Chaloin, O.; Hoebeke, J.; Partidos, C. D.; Briand, J. P.; Prato, M.; Bianco, A. and Kostarelos, K. (2005) Binding and condensation of plasmid DNA onto functionalized carbon nanotubes: toward the construction of nanotube-based gene delivery vectors. J. Am. Chem. Soc., 127, 4388-96.
37. He, P. and Bayachou, M. (2005) Layer-by-layer fabrication and characterization of DNA-wrapped single-walled carbon nanotube particles. Langmuir, 21, 6086-92.
38. Tan, Y.; Whitmore, M.; Li, S.; Frederik, P. and Huang, L. (2002) LPD nanoparticles-novel nonviral vector for efficient gene delivery. Methods Mol. Med., 69, 73-81.
39. Gemeinhart, R. A.; Luo, D. and Saltzman, W. M. (2005) Cellular fate of a modular DNA delivery system mediated by silica nanoparticles. Biotechnol. Prog., 21, 532-7.
40. Bejjani, R. A.; BenEzra, D.; Cohen, H.; Rieger, J.; Andrieu, C.; Jeanny, J. C.; Gollomb, G. and Behar-Cohen, F. F. (2005) Nanoparticles for gene delivery to retinal pigment epithelial cells. Mol. Vis., 11, 124-32.
41. Zheng, M.; Jagota, A.; Semke, E. D.; Diner, B. A.; McLean, R. S.; Lustig, S. R.; Richardson, R. E. and Tassi, N. G. (2003) DNA-assisted dispersion and separation of carbon nanotubes. Nat. Mater., 2, 338-42.
42. Rajendra, J.; Baxendale, M.; Dit Rap, L. G. and Rodger, A. (2004) Flow linear dichroism to probe binding of aromatic molecules and DNA to single-walled carbon nanotubes. J. Am. Chem. Soc., 126, 11182-8.
43. Rajendra, J. and Rodger, A. (2005) The binding of single-stranded DNA and PNA to single-walled carbon nanotubes probed by flow linear dichroism. Chemistry, 11, 4841-7.
44. Audette, G. F.; van Schaik, J.; Hazes, B.; Irvin, R.T. (2004). DNA-binding protein nanotubes. Nano. Lett., 4, 1897-902.
45. Green, M. and Howman, E. (2005) Semiconductor quantum dots and free radical induced DNA nicking. Chem. Commun. (Camb)., 7(1), 121-3.
46. Florence, A. T. and Hussain, N. (2001) Transcytosis of nanoparticle and dendrimer delivery systems: evolving vistas. Adv. Drug. Deliv. Rev., 50 (Suppl 1), S69-89.
47. Li, W. C.; Ye, C.; Wei, T.; Zhao, Y.; Lao, F.; Chen, Z.; Meng, H.; Gao, Y.; Yuan, H.; Xing, G.; Zhao, F.; Chai, Z.; Zhao, Y.; Yang, F.; Han, D.; Tang, X.; Zhang, Y. (2008) The translocation of Fullerenic nanoparticles into lysosome via the pathway of clathrin-mediated endocytosis. Nanotechnology, 19, 145102-145114.
48. Heckel, K.; Kiefmann, R.; Dorger, M.; Stoeckelhuber, M. and Goetz, A. E. (2004) Colloidal gold particles as a new in vivo marker of early acute lung injury. Am. J. Physiol. Lung Cell Mol. Physiol., 287, L867-78.
49. Nemmar, A.; Hoet, P. H.; Vanquickenborne, B.; Dinsdale, D.; Thomeer, M.; Hoylaerts, M. F.; Vanbilloen, H.; Mortelmans, L. and Nemery, B. (2002) Passage of inhaled particles into the blood circulation in humans. Circulation, 105, 411-4.
50. Nemmar, A.; Vanbilloen, H.; Hoylaerts, M. F.; Hoet, P. H.; Verbruggen, A. and Nemery, B. (2001) Passage of intratracheally instilled ultrafine particles from the lung into the systemic circulation in hamster. Am. J. Respir. Crit. Care Med., 164, 1665-8.
51. Verma, D. D.; Verma, S.; Blume, G. and Fahr, A. (2003) Particle size of liposomes influences dermal delivery of substances into skin. Int. J. Pharm., 258, 141-51.
52. Langer, R. (2000) Biomaterials in drug delivery and tissue engineering: one laboratory's experience. Acc. Chem. Res., 33, 94-101.
53. Meng, H.; Chen, Z.; Xing, G.; Yuan, H.; Chen, C.; Zhao, F.; Zhang, C. and Zhao, Y. (2007) Ultrahigh reactivity provokes nanotoxicity: explanation of oral toxicity of nano-copper particles. Toxicol. Lett., 175, 102-10.
54. Wang, B.; Feng, W. Y.; Wang, T. C.; Jia, G.; Wang, M.; Shi, J. W.; Zhang, F.; Zhao, Y. L. and Chai, Z. F. (2006) Acute toxicity of nano-and micro-scale zinc powder in healthy adult mice. Toxicol. Lett., 161, 115-23.
55. Chen, Z.; Meng, H.; Xing, G.; Chen, C.; Zhao, Y.; Jia, G.; Wang, T.; Yuan, H.; Ye, C.; Zhao, F.; Chai, Z.; Zhu, C.; Fang, X.; Ma, B. and Wan, L. (2006) Acute toxicological effects of copper nanoparticles in vivo. Toxicol. Lett., 163, 109-20.
56. Wang, J.; Zhou, G.; Chen, C.; Yu, H.; Wang, T.; Ma, Y.; Jia, G.; Gao, Y.; Li, B.; Sun, J.; Li, Y.; Jiao, F.; Zhao, Y. and Chai, Z. (2007) Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administration. Toxicol. Lett., 168, 176-85.
57. Oberdorster, G.; Ferin, J. and Lehnert, B. E. (1994) Correlation between particle size, in vivo particle persistence, and lung injury. Environ. Health Perspect., 102 (Suppl. 5), 173-9.
58. Huggins, C. B. and Froehlich, J. P. (1966) High concentration of injected titanium dioxide in abdominal lymph nodes. J. Exp. Med., 124, 1099-106.
59. Kreyling, W. G.; Semmler-Behnke, M. and Moller, W. (2006) Ultrafine particle-lung interactions: does size matter? J. Aerosol. Med., 19, 74-83.
60. Borm, P.; Klaessig, F. C.; Landry, T. D.; Moudgil, B.; Pauluhn, J.; Thomas, K.; Trottier, R. and Wood, S. (2006) Research strategies for safety evaluation of nanomaterials, part V: role of dissolution in biological fate and effects of nanoscale particles. Toxicol. Sci., 90, 23-32.
61. Olivier, J. C. (2005) Drug transport to brain with targeted nanoparticles. NeuroRx., 2, 108-19.
62. Boffetta, P.; Soutar, A.; Cherrie, J. W.; Granath, F.; Andersen, A.; Anttila, A.; Blettner, M.; Gaborieau, V.; Klug, S. J.; Langard, S.; Luce, D.; Merletti, F.; Miller, B.; Mirabelli, D.; Pukkala, E.; Adami, H. O. and Weiderpass, E. (2004) Mortality among workers employed in the titanium dioxide production industry in Europe. Cancer. Causes Control., 15, 697-706.
63. Oberdorster, G.; Sharp, Z.; Atudorei, V.; Elder, A.; Gelein, R.; Kreyling, W. and Cox, C. (2004) Translocation of inhaled ultrafine particles to the brain. Inhal. Toxicol., 16, 437-45.
64. Oberdorster, E. (2004) Manufactured nanomaterials (fullerenes, C60) induce oxidative stress in the brain of juvenile largemouth bass. Environ. Health Perspect., 112, 1058-62.
65. Wang, J. C.; Yu, H.; Sun, J.; Li, B.; Li, Y.; Gao, Y.; Chai, Z.; He, W.; Huang, Y.; Zhao, Y. (2007) Distribution of TiO2 particles in the olfactory bulb of mice after nasal inhalation using microbeam SRXRF mapping techniques. J. Radioanal. Nucl. Chem., 272(3), 527-31.
66. Oberdorster, G.; Oberdorster, E. and Oberdorster, J. (2005) Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ. Health Perspect., 113, 823-39.
67. Kroto H. W.; H. J. R.; O'Brien S. C.; Curl R. F. and Smalley R. E. (1985) C60: Buckminsterfullerene. Nature, 318, 162-3.
68. Liu, S.; Lu, Y. J.; Kappes, M. M. and Ibers, J. A. (1991) The Structure of the C60 Molecule: X-Ray Crystal Structure Determination of a Twin at 110 K. Science, 254, 408-10.
69. W. Kratschmer, L. D. L.; K. Fostiropoulos and D.R. Huffman (1990) Solid C60: a new form of carbon. Nature, 347, 354-7.
70. Qiao, R.; Roberts, A. P.; Mount, A. S.; Klaine, S. J. and Ke, P. C. (2007) Translocation of C60 and its derivatives across a lipid bilayer. Nano. Lett., 7, 614-9.
71. Satoh, M. and Takayanagi, I. (2006) Pharmacological studies on fullerene (C60), a novel carbon allotrope, and its derivatives. J. Pharmacol. Sci., 100, 513-8.
72. Yamakoshi, Y.; Umezawa, N.; Ryu, A.; Arakane, K.; Miyata, N.; Goda, Y.; Masumizu, T. and Nagano, T. (2003) Active oxygen species generated from photoexcited fullerene (C60) as potential medicines: O2-* versus 1O2. J. Am. Chem. Soc., 125, 12803-9.
73. Zhao, X.; Striolo, A. and Cummings, P. T. (2005) C60 binds to and deforms nucleotides. Biophys. J., 89, 3856-62.
74. Friedman, S. H. D.; D.L.; Sijbesma, R.P.; Srdanov, G.; Wudl, F.; Kenyon, G.L (1993) Inhibitionof HIV-1 Protease by Fullerene Derivatives: Model Building Studies and Experimental Verification. J. Am. Chem. Soc., 115, 6505-9.
75. Buseck, P. R.; Tsipursky, S. J. and Hettich, R. (1992) Fullerenes from the Geological Environment. Science, 257, 215-7.
76. Tang, J.; Xing, G.; Zhao, F.; Yuan, H. and Zhao, Y. (2007) Modulation of structural and electronic properties of fullerene and metallofullerenes by surface chemical modifications. J. Nanosci. Nanotechnol., 7, 1085-101.
77. Tang, J.; Xing, G.; Zhao, Y.; Jing, L.;,Gao, X.;Cheng, Y.; Yuan, H.; Zhao, F.; Chen, Z.; Meng, H.; Zhang, H.; Qian, H.; Su, R.; Ibrahim, K. (2006) Periodical variation of electronic properties in polyhydroxylated metallofullerene materials. Adv. Mater., 18, 1458-62.
78. Chen, C.; Xing, G.; Wang, J.; Zhao, Y.; Li, B.; Tang, J.; Jia, G.; Wang, T.; Sun, J.; Xing, L.; Yuan, H.; Gao, Y.; Meng, H.; Chen, Z.; Zhao, F.; Chai, Z. and Fang, X. (2005) Antioxidative function and biodistribution of [GdΓ82(OH)22]n nanoparticles in tumor-bearing mice. Nano. Lett., 5, 2050-7.
79. Wang, J.; Chen, C.; Li, B.; Yu, H.; Zhao, Y.; Sun, J.; Li, Y.; Xing, G.; Yuan, H.; Tang, J.; Chen, Z.; Meng, H.; Gao, Y.; Ye, C.; Chai, Z.; Zhu, C.; Ma, B.; Fang, X. and Wan, L. (2006) One-dimensional metallofullerene crystal generated inside single-walled carbon nanotubes. Biochem. Pharmacol., 71, 872-81.
80. Hirahara, K.; Suenaga, K.; Bandow, S.; Kato, H.; Okazaki, T.; Shinohara, H. and Iijima, S. (2000) In vivo studies of fullerene-based materials using endohedral metallofullerene radiotracers. Phys. Rev. Lett., 85, 5384-7.
81. Cagle, D. W.; Kennel, S. J.; Mirzadeh, S.; Alford, J. M. and Wilson, L. J. (1999) The structural determination of endohedral metallofullerene GdΓ(82) by XANES. Proc. Natl. Acad. Sci. USA, 96, 5182-7.
82. Liu, L.; Gao, B.; Chu, W.; Chen, D.; Hu, T.; Wang, C.; Dunsch, L.; Marcelli, A.; Luo, Y. and Wu, Z. (2008) Magnetic Nanoparticles for Cancer Therapy. Chem. Commun. (Camb)., 28(4), 474-6.
83. Goya, G. F. G. V.; Ibarra, M. R. (2008) Magnetically modulated therapeutic systems. Curr. Nanosci., 4(1), 1-16.
84. Häfeli, U. I. J. P. (2004) Antioxidant, prooxidant and cytotoxic activity of hydroxylated resveratrol analogues: structure-activity relationship. Int. J. Pharm., 277, 19-24.
85. Murias, M.; Jager, W.; Handler, N.; Erker, T.; Horvath, Z.; Szekeres, T.; Nohl, H. and Gille, L. (2005) A biologically effective fullerene (C60) derivative with superoxide dismutase mimetic properties. Biochem. Pharmacol., 69, 903-12.
86. Zhu, X.; Zhu, L.; Li, Y.; Duan, Z.; Chen, W. and Alvarez, P. J. (2007) Developmental toxicity in zebrafish (Danio rerio) embryos after exposure to manufactured nanomaterials: buckminsterfullerene aggregates (nC60) and fullerol. Environ. Toxicol. Chem., 26, 976-9.
87. Dugan, L. L.; Gabrielsen, J. K.; Yu, S. P.; Lin, T. S.; and Choi, D. W. (1996) Buckminsterfullerenol free radical scavengers reduce excitotoxic and apoptotic death of cultured cortical neurons. Neurobiol. Dis., 3, 129-35.
88. Tsai, M. C.; Chen, Y. H. and Chiang, L. Y. (1997) Polyhydroxylated C60, fullerenol, a novel free-radical trapper, prevented hydrogen peroxide- and cumene hydroperoxide-elicited changes in rat hippocampus in vitro. J. Pharm. Pharmacol., 49, 438-45.
89. Watanabe, T.; Ichikawa, H. and Fukumori, Y. (2002) Tumor accumulation of gadolinium in lipid-nanoparticles intravenously injected for neutron-capture therapy of cancer. Eur. J. Pharm. Biopharm., 54, 119-24.
90. Mikawa, M.; Kato, H.; Okumura, M.; Narazaki, M.; Kanazawa, Y.; Miwa, N. and Shinohara, H. (2001) Paramagnetic water-soluble metallofullerenes having the highest relaxivity for MRI contrast agents. Bioconjug. Chem., 12, 510-4.
91. Sies, H. (1999) Glutathione and its role in cellular functions. Free. Radic. Biol. Med., 27, 916-21.
92. Hardman, R. (2006) A toxicologic review of quantum dots: toxicity depends on physicochemical and environmental factors. Environ. Health Perspect., 114, 165-72.
93. Coyle, P.; Philcox, J. C.; Carey, L. C. and Rofe, A. M. (2002) Metallothionein: the multipurpose protein. Cell. Mol. Life Sci., 59, 627-47.
94. Yacoby, A.; Heiblum, M.; Mahalu, D. and Shtrikman, H. (1995) Coherence and Phase Sensitive Measurements in a Quantum Dot. Phys. Rev. Lett., 74, 4047-50.
95. Chan, W. C.; Maxwell, D. J.; Gao, X.; Bailey, R. E.; Han, M. and Nie, S. (2002) Luminescent quantum dots for multiplexed biological detection and imaging. Curr. Opin. Biotechnol., 13, 40-6.
96. Wu, X.; Liu, H.; Liu, J.; Haley, K. N.; Treadway, J. A.; Larson, J. P.; Ge, N.; Peale, F. and Bruchez, M. P. (2003) Immunofluorescent labeling of cancer marker Her2 and other cellular targets with semiconductor quantum dots. Nat. Biotechnol., 21, 41-6.
97. Dahan, M.; Levi, S.; Luccardini, C.; Rostaing, P.; Riveau, B. and Triller, A. (2003) Diffusion dynamics of glycine receptors revealed by single-quantum dot tracking. Science, 302, 442-5.
98. Chen, Z.; Meng. H; Xing, G.; Chen, C.; Zhao, Y. (2007) Toxicological and biological effects of nanomaterials. Int. J. Nanotechnol., 4(1/2), 179-96.