PEG-b-PPA/DNA micelles improve transgene expression in rat liver through intrabiliary infusion

Journal of Controlled Release

Volumn 122, Issue 3, 2007, Pages 297-304

  Jiang, Xuan ^a   Dai, Hui ^b   Ke, Chyan Ying ^b   Mo, Xiao ^a   Torbenson, Michael S ^b   Li, Zhiping ^b   Mao, Hai Quan ^a  

^a Johns Hopkins University   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Block copolymer; Gene delivery; Intrabiliary infusion; Liver targeted; Polymeric micelles; Polyphosphoramidate

Indexed keywords

BILE DUCT INFUSION; GENE DELIVERY; INTRABILIARY INFUSION; POLYMERIC MICELLES; POLYPHOSPHORAMIDATE;

BIOCOMPATIBILITY; CONDENSATION; COPOLYMERS; DNA; GENE EXPRESSION; RATS;

MICELLES;

CATION; COPOLYMER; FIREFLY LUCIFERASE; PHOSPHORAMIDIC ACID DERIVATIVE; PLASMID DNA; POLYETHYLENEGLYCOL BLOCK POLYPHOSPHORAMIDATE; POLYETHYLENEIMINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AQUEOUS SOLUTION; ARTICLE; BILE DUCT; BIOCOMPATIBILITY; CELL STRAIN HEPG2; CONTROLLED STUDY; DRUG ADMINISTRATION ROUTE; GENE EXPRESSION; GENETIC TRANSFECTION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; INTRABILIARY DRUG ADMINISTRATION; LIVER CELL; LIVER FUNCTION TEST; MALE; MICELLE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PARTICLE SIZE; POLYMERIZATION; PRIORITY JOURNAL; RAT; SURFACE CHARGE; TRANSGENE; WISTAR RAT;

ANIMALS; BILE DUCTS; BIOCOMPATIBLE MATERIALS; CELL LINE, TUMOR; DNA; DRUG CARRIERS; GENE TARGETING; HEPATOCYTES; HUMANS; INFUSION PUMPS; LIVER; MICELLES; MICROSCOPY, ELECTRON, TRANSMISSION; PARTICLE SIZE; PHOSPHORIC ACID ESTERS; POLYETHYLENE GLYCOLS; RATS; TRANSFECTION; TRANSGENES;

EID: 34548656849     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2007.06.014     Document Type: Article

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