Alternative methods for ocular toxicology testing: Validation, applications and troubleshooting

Expert Opinion on Drug Metabolism and Toxicology

Volumn 9, Issue 6, 2013, Pages 699-712

  Dholakiya, Sanjay L ^a   Barile, Frank A ^a  

^a ST JOHN'S UNIVERSITY   (United States)

Author keywords

Alternative toxicology testing; ECVAM; ICCVAM; in vitro models; Ocular irritation; Tiered approach; Validation

Indexed keywords

ACCURACY; ALGORITHM; BOVINE CORNEAL OPACITY AND PERMEABILITY ASSAY; CORNEA OPACITY; CORNEA THICKNESS; CYTOSENSOR MICROPHYSIOMETER TEST; EYE DISCHARGE; EYE EDEMA; EYE IRRITATION; EYE REDNESS; EYE TOXICITY; FALSE POSITIVE RESULT; FLUORESCEIN LEAKAGE TEST; HEN EGG TEST CHORIOALLANTOIC MEMBRANE; HUMAN; HUMAN CORNEAL EPITHELIUM METHOD; IRITIS; IRRITATION TEST METHOD; ISOLATED CHICKEN EYE TEST; ISOLATED RABBIT EYE TEST; LOW VOLUME EYE TEST; MODIFIED DRAIZE RABBIT EYE TEST; NONHUMAN; PREDICTION; REVIEW; SENSITIVITY AND SPECIFICITY; SENSOR; SHORT TIME EXPOSURE TEST; TIERED TESTING APPROACH; TOXICITY TESTING; TRADITIONAL DRAIZE RABBIT EYE TEST; VALIDATION PROCESS;

ANIMAL TESTING ALTERNATIVES; ANIMALS; CATTLE; CHICKENS; ENDPOINT DETERMINATION; EYE; EYE DISEASES; HUMANS; RABBITS; REPRODUCIBILITY OF RESULTS; TOXICITY TESTS; TOXICOLOGY; VALIDATION STUDIES AS TOPIC;

EID: 84877851006     PISSN: 17425255     EISSN: 17447607     Source Type: Journal    
DOI: 10.1517/17425255.2013.783013     Document Type: Review

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