MEIC evaluation of acute systemic toxicity: Part VII. Prediction of human toxicity by results from testing of the first 30 reference chemicals with 27 further in vitro assays

Alternatives to Laboratory Animals

Volumn 28, Issue SUPPL. 1, 2000, Pages 161-200

  Clemedson, Cecilia ^a   Barile, Frank A ^a   Chesné, Christophe ^a   Cottin, Martine ^a   Curren, Rodger ^a   Ekwall, Barbro ^a   Ferro, Margherita ^a   Gómez Lechón, Maria José ^a   Imai, Koichi ^a   Janus, Jeffrey ^a   Kemp, Richard B ^a   Kerszman, Gustaw ^a   Kjellstrand, Per ^a   Lavrijsen, Karel ^a   Logemann, Pam ^a   McFarlane Abdulla, Elisabeth ^a   Roguet, Roland ^a   Segner, Helmut ^a   Thuvander, Ann ^a   Walum, Erik ^a   Ekwall, Björn ^a   more..

^a Pavals   (Sweden)

Author keywords

Acute poisoning; Alternatives; Basal cytotoxicity; Clinical toxicology; Cytotoxicity; Differential cytotoxicity; Evaluation; Forensic medicine; Hepatocytes; Human toxicity; Keratinocytes; Lethal blood concentrations; Recovery assay; Toxicity; Toxicokinetics; Toxicology; Validation

Indexed keywords

2,4 DICHLOROPHENOXYACETIC ACID; ARSENIC TRIOXIDE; COPPER SULFATE; FERROUS SULFATE; PARACETAMOL; PARAQUAT; THALLIUM SULFATE;

ACUTE TOXICITY; ANIMAL CELL; ARTICLE; CYTOTOXICITY; FORENSIC MEDICINE; HUMAN; HUMAN CELL; LC 50; LIVER CELL; LIVER TOXICITY; NONHUMAN; PRIORITY JOURNAL; TOXICITY TESTING; TOXICOKINETICS;

ANIMALIA; BACTERIA (MICROORGANISMS);

EID: 18544410941     PISSN: 02611929     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Bondesson, I., Ekwall, B., Hellberg, S., Romert, L., Stenberg, K. & Walum, E. (1989). MEIC - a new international multicenter project to evaluate the relevance to human toxicity of in vitro cytotoxicity tests. Cell Biology and Toxicology 5, 331-347.
2. Ekwall, B. (1992). Features and prospects of the MEIC cytotoxicity evaluation project. AATEX 1, 231-237.
3. Walum, E., Clemedson, C. & Ekwall, B. (1994) Principles for the validation of in vitro toxicology test methods. Toxicology in Vitro 8, 807-812.
4. Clemedson, C. et al. (1996). MEIC evaluation of acute systemic toxicity. Part I. Methodology of 68 in vitro toxicity assays used to test the first 30 reference chemicals. ATLA 24, 249-272.
5. Clemedson, C. et al. (1996). MEIC evaluation of acute systemic toxicity. Part II. In vitro results from 68 toxicity assays used to test the first 30 reference chemicals and a comparative cytotoxicity analysis. ATLA 24, 273-311.
6. Clemedson, C. et al. (1998). MEIC evaluation of acute systemic toxicity. Part III. In vitro results from 16 additional methods used to test the first 30 reference chemicals and a comparative cytotoxicity analysis. ATLA 26, 93-129.
7. Clemedson, C. et al. (1998). MEIC evaluation of acute systemic toxicity. Part IV. In vitro results from 67 toxicity assays used to test reference chemicals 31-50 and a comparative cytotoxicity analysis. ATLA 26, 131-183.
8. Ekwall, B., Clemedson, C., Crafoord, B., Ekwall, B., Hallander, S., Walum, E., & Bondesson, I. (1998). MEIC evaluation of acute systemic toxicity. Part V. Rodent and human toxicity data for the 50 reference chemicals. ATLA 26, 571-616.
9. Ekwall, B. et al. (1998). MEIC evaluation of acute systemic toxicity. Part VI. Prediction of human toxicity by rodent LD50 values and results from 61 in vitro tests. ATLA 26, 617-658.
10. Gómez-Lechón, M.J., Fabra, R., Lopez, P., Donato, M.T., Montoya, A., Larrauri, A., Trullenque, R. & Castell, J.V. (1992). Isolation and culture of human hepatocytes from surgical liver biopsies. In In Vitro Alternatives to Animal Pharmaco-Toxicology (ed. J.V. Castell & M.J. Gómez-Lechón), pp. 129-147. Madrid, Spain: Farmaindustria.
11. Ekwall B. & Ekwall B., eds (1999). Time-related High Survived and Lethal Blood Concentrations of Chemicals from Acute, Human Poisoning: Monographs 1-50. Web site http://www.ctlu.se. När, Sweden: CTLU.
12. Baselt, R.C. & Cravey, R.H. (1995). Disposition of Toxic Drugs and Chemicals in Man, 4th edn, 802pp. Foster City, CA, USA: Chemical Toxicology Institute.
13. Ekwall, B. & Acosta, D. (1982). In vitro comparative toxicity of selected drugs and chemicals in HeLa cells, Chang liver cells, and rat hepatocytes. Drug and Chemical Toxicology 5, 219-231.
14. Ekwall, B. & Ekwall, K. (1988). Comments on the use of diverse cell systems in toxicity testing. ATLA 15, 193-200.
15. Ekwall, B. (1980). Toxicity to HeLa cells of 205 drugs as determined by the metabolic inhibition test supplemented by microscopy. Toxicology 17, 273-295.
16. Clemedson, C. & Ekwall, B. (1998). The MEIC In Vitro Database. Web sites: http://www.ctlu.se; http://www.cctoxconsulting.a.se. När, Sweden: CTLU.
17. Fry, J.R., Hammond, A.H., Garle, M.J. & Lal, K. (1993). Comparison of xenobiotic-mediated cytotoxicity in rat cultured hepatocytes and the V79 Chinese hamster lung fibroblast cell line: can metabolically activated hepatotoxins be identified by selective cytotoxicity to hepatocytes? ATLA 21, 8-13
18. Imai, K., Nakamura, F., Takoka, Y. & Nakamura, M. (1988). Cytotoxicity of metal ions from the viewpoint of cell recovery. Journal of Dental Technology 16, 980-983.
19. Imai, K., Nakamura, M., Matsumoto, R. & Kokita, K. (1992). Cytotoxicity test using a cell recovery test method. Medicine and Biology 125, 109-112.
20. Ellenhorn, M.J. & Barceloux, D.G. (1988). Medical Toxicology: Diagnosis and Treatment of Human Poisoning, 1512pp. New York, USA: Elsevier.
21. Bentur, Y., Shosham, O., Tabak, A., Bin-Nun, A., Ramon, Y., Ulman, Y., Berger, Y., Nachlieli, T. & Peled, Y. (1998). Prolonged elimination half-life of phenol after dermal exposure. Clinical Toxicology 36, 707-711.
22. Horch, R., Spilker, G. & Stark, G.B. (1994). Phenol burns and intoxications. Burns 20, 45-50.
23. Ekwall, B., Clemedson, C., Ekwall, B., Ring, P. & Romert, L. (1999). EDIT: a new international multicentre programme to develop and evaluate batteries of in vitro tests for acute and chronic systemic toxicity. ATLA 27, 339-349.