Kalopanaxsaponin A ameliorates experimental colitis in mice by inhibiting IRAK-1 activation in the NF-κB and MAPK pathways

British Journal of Pharmacology

Volumn 162, Issue 8, 2011, Pages 1731-1742

  Joh, Eun Ha ^a   Kim, Dong Hyun ^a  

^a Kyung Hee University   (South Korea)

Author keywords

colitis; inflammation; IRAK 1; kalopanaxsaponin A; TNBS

Indexed keywords

I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 1; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; KALOPANAXSAPONIN A; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; SALAZOSULFAPYRIDINE; SAPONIN DERIVATIVE; STRESS ACTIVATED PROTEIN KINASE; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; COLITIS; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; COLITIS; CYTOKINES; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; INFLAMMATION MEDIATORS; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES; MACROPHAGES, PERITONEAL; MALE; MICE; MICE, INBRED ICR; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; OLEANOLIC ACID; SAPONINS; SULFASALAZINE;

EID: 79953054617     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2010.01195.x     Document Type: Article

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