Association of the ADRA2A polymorphisms with the risk of type 2 diabetes: A meta-analysis

Clinical Biochemistry

Volumn 46, Issue 9, 2013, Pages 722-726

  Chen, Xi ^a   Liu, Lei ^a   He, Wentao ^a   Lu, Yu ^a   Ma, Delin ^a   Du, Tingting ^a   Liu, Qian ^a   Chen, Cai ^a   Yu, Xuefeng ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

ADRA2A; Genetics; Meta analysis; Type 2 diabetes

Indexed keywords

ALPHA 2A ADRENERGIC RECEPTOR;

ARTICLE; ETHNICITY; EUROPE; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; META ANALYSIS (TOPIC); NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; RECESSIVE GENE; SINGLE NUCLEOTIDE POLYMORPHISM;

CASE-CONTROL STUDIES; DIABETES MELLITUS, TYPE 2; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; HUMANS; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, ADRENERGIC, ALPHA-2; RISK FACTORS;

EID: 84877798138     PISSN: 00099120     EISSN: 18732933     Source Type: Journal    
DOI: 10.1016/j.clinbiochem.2013.02.004     Document Type: Article

References (32)

1. Zimmet P., Alberti K.G., Shaw J. Global and societal implications of the diabetes epidemic. Nature 2001, 414:782-787.
2. Yang W., Lu J., Weng J., Jia W., Ji L., Xiao J., et al. Prevalence of diabetes among men and women in China. N Engl J Med 2010, 362:1090-1101.
3. Staiger H., Machicao F., Fritsche A., Haring H.U. Pathomechanisms of type 2 diabetes genes. Endocr Rev 2009, 30:557-585.
4. DeFronzo R.A., Bonadonna R.C., Ferrannini E. Pathogenesis of niddm. A balanced overview. Diabetes Care 1992, 15:318-368.
5. McCarthy M.I., Zeggini E. Genome-wide association studies in type 2 diabetes. Curr Diab Rep 2009, 9:164-171.
6. + channel in mouse pancreatic b cells. Nature 1991, 349:77-79.
7. Fagerholm V., Haaparanta M., Scheinin M. Alpha2-adrenoceptor regulation of blood glucose homeostasis. Basic Clin Pharmacol Toxicol 2011, 108:365-370.
8. Rosengren A.H., Jokubka R., Tojjar D., Granhall C., Hansson O., Li D.Q., et al. Overexpression of alpha2a-adrenergic receptors contributes to type 2 diabetes. Science 2010, 327:217-220.
9. Dupuis J., Langenberg C., Prokopenko I., Saxena R., Soranzo N., Jackson A.U., et al. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet 2010, 42:105-116.
10. Devedjian J.C., Pujol A., Cayla C., George M., Casellas A., Paris H., et al. Transgenic mice overexpressing alpha2a-adrenoceptors in pancreatic beta-cells show altered regulation of glucose homeostasis. Diabetologia 2000, 43:899-906.
11. Fagerholm V., Gronroos T., Marjamaki P., Viljanen T., Scheinin M., Haaparanta M. Altered glucose homeostasis in alpha2a-adrenoceptor knockout mice. Eur J Pharmacol 2004, 505:243-252.
12. Liggett S.B. Alpha2a-adrenergic receptors in the genetics, pathogenesis, and treatment of type 2 diabetes. Sci Transl Med 2009, 1. [12ps5].
13. Gribble F.M. Alpha2a-adrenergic receptors and type 2 diabetes. N Engl J Med 2010, 362:361-362.
14. Talmud P.J., Cooper J.A., Gaunt T., Holmes M.V., Shah S., Palmen J., et al. Variants of adra2a are associated with fasting glucose, blood pressure, body mass index and type 2 diabetes risk: meta-analysis of four prospective studies. Diabetologia 2011, 54:1710-1719.
15. Liu C., Li H., Qi L., Loos R.J., Qi Q., Lu L., et al. Variants in glis3 and cry2 are associated with type 2 diabetes and impaired fasting glucose in Chinese Hans. PLoS One 2011, 6:e21464.
16. Rees S.D., Hydrie M.Z., O'Hare J.P., Kumar S., Shera A.S., Basit A., et al. Effects of 16 genetic variants on fasting glucose and type 2 diabetes in south Asians: Adcy5 and glis3 variants may predispose to type 2 diabetes. PLoS One 2011, 6:e24710.
17. Hu C., Zhang R., Wang C., Wang J., Ma X., Hou X., et al. Variants from gipr, tcf7l2, dgkb, madd, cry2, glis3, prox1, slc30a8 and igf1 are associated with glucose metabolism in the Chinese. PLoS One 2010, 5:e15542.
18. Bao X.Y., Peng B., Yang M.S. Replication study of novel risk variants in six genes with type 2 diabetes and related quantitative traits in the Han Chinese lean individuals. Mol Biol Rep 2012, 39:2447-2454.
19. Fujita H., Hara K., Shojima N., Horikoshi M., Iwata M., Hitota Y., et al. Variations with modest effects have an important role in the genetic background of type 2 diabetes and diabetes-related traits. J Hum Genet 2012, 57:776-779.
20. Travers M.E., McCarthy M.I. Type 2 diabetes and obesity: genomics and the clinic. Hum Genet 2011, 130:41-58.
21. Prokopenko I., McCarthy M.I., Lindgren C.M. Type 2 diabetes: new genes, new understanding. Trends Genet 2008, 24:613-621.
22. Doria A., Patti M.E., Kahn C.R. The emerging genetic architecture of type 2 diabetes. Cell Metab 2008, 8:186-200.
23. Ahlqvist E., Ahluwalia T.S., Groop L. Genetics of type 2 diabetes. Clin Chem 2011, 57:241-254.
24. Boesgaard T.W., Grarup N., Jorgensen T., Borch-Johnsen K., Hansen T., Pedersen O. Variants at dgkb/tmem195, adra2a, glis3 and c2cd4b loci are associated with reduced glucose-stimulated beta cell function in middle-aged Danish people. Diabetologia 2010, 53:1647-1655.
25. Saxena R., Voight B.F., Lyssenko V., Burtt N.P., de Bakker P.I., Chen H., et al. Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 2007, 316:1331-1336.
26. Rampersaud E., Damcott C.M., Fu M., Shen H., McArdle P., Shi X., et al. Identification of novel candidate genes for type 2 diabetes from a genome-wide association scan in the old order Amish: evidence for replication from diabetes-related quantitative traits and from independent populations. Diabetes 2007, 56:3053-3062.
27. Sladek R., Rocheleau G., Rung J., Dina C., Shen L., Serre D., et al. A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature 2007, 445:881-885.
28. Scott L.J., Mohlke K.L., Bonnycastle L.L., Willer C.J., Li Y., Duren W.L., et al. A genome-wide association study of type 2 diabetes in fins detects multiple susceptibility variants. Science 2007, 316:1341-1345.
29. Unoki H., Takahashi A., Kawaguchi T., Hara K., Horikoshi M., Andersen G., et al. Snps in kcnq1 are associated with susceptibility to type 2 diabetes in East Asian and European populations. Nat Genet 2008, 40:1098-1102.
30. Parra E.J., Below J.E., Krithika S., Valladares A., Barta J.L., Cox N.J., et al. Genome-wide association study of type 2 diabetes in a sample from Mexico City and a meta-analysis of a Mexican-American sample from Starr County, Texas. Diabetologia 2011, 54:2038-2046.
31. Takeuchi F., Serizawa M., Yamamoto K., Fujisawa T., Nakashima E., Ohnaka K., et al. Confirmation of multiple risk loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population. Diabetes 2009, 58:1690-1699.
32. McCarthy M.I. Genomics, type 2 diabetes, and obesity. N Engl J Med 2010, 363:2339-2350.