α2A-adrenergic receptors and type 2 diabetes

New England Journal of Medicine

Volumn 362, Issue 4, 2010, Pages 361-362

  Gribble, Fiona M ^a  

^a ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 2A ADRENERGIC RECEPTOR; CLONIDINE; INSULIN; YOHIMBINE; ALPHA 2 ADRENERGIC RECEPTOR; RECEPTOR, ADRENERGIC, ALPHA 2A; RECEPTOR, ADRENERGIC, ALPHA-2A;

ARTICLE; CELL FUNCTION; DIABETES MELLITUS; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENOTYPE; GLUCOSE INTOLERANCE; HUMAN; HYPERTENSION; INSULIN RELEASE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN FUNCTION; ANIMAL; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; GENETICS; METABOLISM; RAT; RAT STRAIN; SECRETION;

ANIMALS; DIABETES MELLITUS, TYPE 2; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INSULIN; INSULIN-SECRETING CELLS; RATS; RATS, INBRED STRAINS; RECEPTORS, ADRENERGIC, ALPHA-2;

EID: 75449109352     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMcibr0911499     Document Type: Article

References (4)

1. McCarthy MI, Zeggini E. Genome-wide association studies in type 2 diabetes. Curr Diab Rep 2009;9:164-71.
2. Rosengren AH, Jokubka R, Tojjar D, et al. Overexpression of the alpha2A-adrenergic receptors contributes to type 2 diabetes. Science 2009 November 19 (Epub ahead of print).
3. de Vries A, Rachmilewitz M, Schumert M. Pheochromocytoma with diabetes and hypertension: report of two cases cured by operation. Am J Med 1949;6:51-5.
4. Small KM, Brown KM, Seman CA, Theiss CT, Liggett SB. Complex haplotypes derived from noncoding polymorphisms of the intronless alpha2A-adrenergic gene diversify receptor expression. Proc Natl Acad Sci U S A 2006;103:5472-7.