The effects of qindan-capsule-containing serum on the TGF-β1/ERK signaling pathway, matrix metalloproteinase synthesis and cell function in adventitial fibroblasts

Pharmaceutical Biology

Volumn 51, Issue 6, 2013, Pages 712-721

  Yijing, Lv ^a   Liu, Heng ^b   Yuan, Cunzhong ^c   Wang, Bo ^a   Ren, Min ^a   Yan, Lei ^a   Wang, Xuping ^a   Zhang, Jidong ^a  

^a SHANDONG UNIVERSITY   (China)

^b Otorhinolaryngology Key Laboratory of MOH   (China)

^c Gynecology Oncology Key Laboratory of Shandong Province   (China)

Author keywords

Adventitial fibroblast; Extracellular matrix; Migration; Proliferation; TGF ERK CTGF

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; BETA ACTIN; CHINESE DRUG; CONNECTIVE TISSUE GROWTH FACTOR; GELATINASE A; GELATINASE B; LOSARTAN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; QINDAN CAPSULE; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIHYPERTENSIVE ACTIVITY; AORTA; APOPTOSIS; ARTICLE; BIOLOGICAL ACTIVITY; BLOOD VESSEL WALL; CELL ASSAY; CELL CYCLE; CELL CYCLE G1 PHASE; CELL CYCLE PROGRESSION; CELL FUNCTION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; DRUG MEGADOSE; DRUG PROTEIN BINDING; EXPERIMENTAL RAT; EXPLANT; FIBROBLAST; FIBROBLAST CULTURE; FLOW CYTOMETRY; HYPERTENSION; IN VITRO STUDY; LOW DRUG DOSE; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SYNTHESIS; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALS; AORTA; APOPTOSIS; BLOTTING, WESTERN; CELL CYCLE; CELL MOVEMENT; CELL PROLIFERATION; CONNECTIVE TISSUE GROWTH FACTOR; DRUGS, CHINESE HERBAL; FIBROBLASTS; GENE EXPRESSION REGULATION; MALE; MAP KINASE SIGNALING SYSTEM; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MEDICINE, CHINESE TRADITIONAL; RATS; RATS, INBRED WKY; SERUM; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84877793936     PISSN: 13880209     EISSN: 17445116     Source Type: Journal    
DOI: 10.3109/13880209.2013.764328     Document Type: Article

References (47)

1. Ahmed MS, Oie E, Vinge LE, et al. (2004). Connective tissue growth factor-a novel mediator of angiotensin II-stimulated cardiac fibroblast activation in heart failure in rats. J Mol Cell Cardiol 36:393-404. (Pubitemid 38316944)
2. Asano K, Shikama Y, Shoji N, et al. (2010). Tiotropium bromide inhibits TGF-beta-induced MMP production from lung fibroblasts by interfering with Smad and MAPK pathways in vitro. Int J Chron Obstruct Pulmon Dis 5:277-86.
3. Bradham DM, Igarashi A, Potter RL, Grotendorst GR. (1991). Connective tissue growth factor: A cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10. J Cell Biol 114:1285-94. (Pubitemid 21909886)
4. Cai XJ, Chen L, Li L, et al. (2009). Adiponectin inhibits lipopolysaccharide-induced adventitial fibroblast migration and transition to myofibroblasts via AdipoR1-AMPK-iNOS pathway. Mol Endocrinol 24:218-28.
5. Chen MM, Lam A, Abraham JA, et al. (2000). CTGF expression is induced by TGF-beta in cardiac fibroblasts and cardiac myocytes: A potential role in heart fibrosis. J Mol Cell Cardiol 32:1805-19.
6. Esparza J, Kruse M, Lee J, et al. (2004). MMP-2 null mice exhibit an early onset and severe experimental autoimmune encephalomyelitis due to an increase in MMP-9 expression and activity. FASEB J 18:1682-91. (Pubitemid 39463707)
7. Fan WH, Karnovsky MJ. (2002). Increased MMP-2 expression in connective tissue growth factor over-expression vascular smooth muscle cells. J Biol Chem 277:9800-5. (Pubitemid 34968083)
8. Galis ZS, Khatri JJ. (2002). Matrix metalloproteinases in vascular remodeling and atherogenesis: The good, the bad, and the ugly. Circ Res 90:251-62. (Pubitemid 34633925)
9. Gao X, Li J, Huang H, Li X. (2008). Connective tissue growth factor stimulates renal cortical myofibroblast-like cell proliferation and matrix protein production. Wound Repair Regen 16:408-15. (Pubitemid 351661579)
10. Geng F, Song K, Xing JZ, et al. (2011). Thio-glucose bound gold nanoparticles enhance radio-cytotoxic targeting of ovarian cancer. Nanotechnology 22:285101 (8 pp.).
11. Grotendorst GR. (1997). Connective tissue growth factor: A mediator of TGF-beta action on fibroblasts. Cytokine Growth Factor Rev 8:171-9. (Pubitemid 28077925)
12. Grotendorst GR, Duncan MR. (2005). Individual domains of connective tissue growth factor regulate fibroblast proliferation and myofibroblast differentiation. FASEB J 19:729-38. (Pubitemid 40617377)
13. Hayashida T, Decaestecker M, Schnaper HW. (2003). Cross-talk between ERK MAP kinase and Smad signaling pathways enhances TGF-beta-dependent responses in human mesangial cells. FASEB J 17:1576-8.
14. Johnson C, Galis ZS. (2004). Matrix metalloproteinase-2 and-9 differentially regulate smooth muscle cell migration and cell-mediated collagen organization. Arterioscler Thromb Vasc Biol 24:54-60. (Pubitemid 38082411)
15. Kalluri R, Neilson EG. (2003). Epithelial-mesenchymal transition and its implications for fibrosis. J Clin Invest 112:1776-84. (Pubitemid 38063698)
16. Kuzuya M Iguchi A. (2003). Role of matrix metalloproteinases in vascular remodeling. J Atheroscler Thromb 10:275-82.
17. Kyriakis JM, Avruch J. (2001). Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol Rev 81:807-69. (Pubitemid 32267078)
18. Leask A, Abraham DJ. (2003). The role of connective tissue growth factor, a multifunctional matricellular protein, in fibroblast biology. Biochem Cell Biol 81:355-63. (Pubitemid 38186975)
19. Leivonen SK, Hakkinen L, Liu D, Kahari VM. (2005). Smad3 and extracellular signal-regulated kinase 1/2 coordinately mediate transforming growth factor-beta-induced expression of connective tissue growth factor in human fibroblasts. J Invest Dermatol 124:1162-9. (Pubitemid 40847402)
20. Lessner SM, Martinson DE, Galis ZS. (2004). Compensatory vascular remodeling during atherosclerotic lesion growth depends on matrix metalloproteinase-9 activity. Arterioscler Thromb Vasc Biol 24: 2123-9. (Pubitemid 39482440)
21. Li X, Kong X, Huo Q, et al. (2011). Metadherin enhances the invasiveness of breast cancer cells by inducing epithelial to mesenchymal transition. Cancer Sci 102:1151-7.
22. Liu P, Zhang C, Feng JB, et al. (2008). Cross talk among Smad, MAPK, and integrin signaling pathways enhances adventitial fibroblast functions activated by transforming growth factor-beta1 and inhibited by Gax. Arterioscler Thromb Vasc Biol 28:725-31. (Pubitemid 351651340)
23. Mason RP. (2011). Optimal therapeutic strategy for treating patients with hypertension and atherosclerosis: Focus on olmesartan medoxomil. Vasc Health Risk Manag 7:405-16.
24. Massague J, Wotton D. (2000). Transcriptional control by the TGF-beta/ Smad signaling system. EMBO J 19:1745-54. (Pubitemid 30204386)
25. Matsuura I, Wang G, He D, Liu F. (2005). Identification and characterization of ERK MAP kinase phosphorylation sites in Smad3. Biochemistry 44:12546-53. (Pubitemid 41324345)
26. McGrath JC, Deighan C, Briones AM, et al. (2005). New aspects of vascular remodelling: The involvement of all vascular cell types. Exp Physiol 90:469-75. (Pubitemid 40980147)
27. Nishida T, Kawaki H, Baxter RM, et al. (2007). CCN2 (Connective Tissue Growth Factor) is essential for extracellular matrix production and integrin signaling in chondrocytes. J Cell Commun Signal 1:45-58.
28. Overall CM, Wrana JL, Sodek J. (1989). Independent regulation of collagenase, 72-kDa progelatinase, and metalloendoproteinase inhibitor expression in human fibroblasts by transforming growth factor-beta. J Biol Chem 264:1860-9. (Pubitemid 19051035)
29. Perbal B. (2004). CCN proteins: Multifunctional signalling regulators. Lancet 363:62-4. (Pubitemid 38076928)
30. Ren M, Wang B, Zhang J. (2009). Study on quality standard of Qindan Capsule. Chin J Integrative Med Cardio-/Cerebrovascular Dis 7:597-8.
31. Ren M, Wang B, Zhang J, et al. (2011). Smad2 and Smad3 as mediators of the response of adventitial fibroblasts induced by transforming growth factor beta1. Mol Med Report 4:561-7.
32. Ren M, Zhang J, Wang B, et al. (2010). Qindan-capsule inhibits proliferation of adventitial fibroblasts and collagen synthesis. J Ethnopharmacol 129:53-8.
33. Ruperez M, Lorenzo O, Blanco-Colio LM, et al. (2003). Connective tissue growth factor is a mediator of angiotensin II-induced fibrosis. Circulation 108:1499-505. (Pubitemid 37176458)
34. Sartore S, Chiavegato A, Faggin E, et al. (2001). Contribution of adventitial fibroblasts to neointima formation and vascular remodeling: From innocent bystander to active participant. Circ Res 89:1111-21. (Pubitemid 34627868)
35. Schulze-Bauer CA, Regitnig P, Holzapfel GA. (2002). Mechanics of the human femoral adventitia including the high-pressure response. Am J Physiol Heart Circ Physiol 282:lH2427-40.
36. Scott J. (2002). The pathogenesis of atherosclerosis and new opportunities for treatment and prevention. J Neural Transm Suppl 63:1-17. (Pubitemid 38471306)
37. Shi-Wen X, Leask A, Abraham D. (2008). Regulation and function of connective tissue growth factor/CCN2 in tissue repair, scarring and fibrosis. Cytokine Growth Factor Rev 19:133-44. (Pubitemid 351382279)
38. Shi Y, O'Brien Jr JE, Fard A, Zalewski A. (1996). Transforming growth factor-beta 1 expression and myofibroblast formation during arterial repair. Arterioscler Thromb Vasc Biol 16:1298-305. (Pubitemid 26339719)
39. Standridge JB. (2005). Hypertension and atherosclerosis: Clinical implications from the ALLHAT trial. Curr Atheroscler Rep 7:132-9.
40. Tian Y, Yuan C, Ma D, et al. (2011). IL-21 and IL-12 inhibit differentiation of Treg and TH17 cells and enhance cytotoxicity of peripheral blood mononuclear cells in patients with cervical cancer. Int J Gynecol Cancer 21:1672-8.
41. Wang B, Zhang JD, Feng JB, et al. (2007). Effect of traditional Chinese medicine Qin-Dan-Jiang-Ya-Tang on remodeled vascular phenotype and osteopontin in spontaneous hypertensive rats. J Ethnopharmacol 110:176-82. (Pubitemid 46209579)
42. Wang B, Zhang JD, Wang SH. (2006). Effects of qindan capsule on blood pressure, endothelin, calcitonin gene-related peptide and angiotensin-II in spontaneous hypertensive rats. Chin J Integr Med 12:287-91. (Pubitemid 46087144)
43. Werb Z. (1997). ECM and cell surface proteolysis: Regulating cellular ecology. Cell 91:439-42. (Pubitemid 27508232)
44. Wetzker R, Bohmer FD. (2003). Transactivation joins multiple tracks to the ERK/MAPK cascade. Nat Rev Mol Cell Biol 4:651-7. (Pubitemid 36934967)
45. Yang M, Huang H, Li J, et al. (2004). Tyrosine phosphorylation of the LDL receptor-related protein (LRP) and activation of the ERK pathway are required for connective tissue growth factor to potentiate myofibroblast differentiation. FASEB J 18:1920-1. (Pubitemid 39602284)
46. Yang M, Huang H, Li J, et al. (2007). Connective tissue growth factor increases matrix metalloproteinase-2 and suppresses tissue inhibitor of matrix metalloproteinase-2 production by cultured renal interstitial fibroblasts. Wound Repair Regen 15:817-24. (Pubitemid 350135228)
47. Yuan C, Jiao L, Yang L, et al. (2008). The up-regulation of 14-3-3 proteins in Smad4 deficient epidermis and hair follicles at catagen. Proteomics 8:2230-43. (Pubitemid 351898029)