Effects of Qindan Capsule on blood pressure, endothelin, calcitonin gene-related peptide and angiotensin-II in spontaneous hypertensive rats

Chinese Journal of Integrative Medicine

Volumn 12, Issue 4, 2006, Pages 287-291

  Wang, Bo ^a   Zhang, Ji Dong ^a   Wang, Shi Hua ^a  

^a SHANDONG UNIVERSITY   (China)

Author keywords

Angiotensin II; Calcitonin gene related peptide; Endothelin; Qindan Capsule; Spontaneous hypertensive rat

Indexed keywords

ANGIOTENSIN II; CALCITONIN GENE RELATED PEPTIDE; CAPTOPRIL; CHINESE DRUG; ENDOTHELIN; NIUHUANG JIANGYA; QINDAN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; BLOOD PRESSURE REGULATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG CAPSULE; DRUG EFFECT; DRUG MECHANISM; HYPERTENSION; MALE; MESENTERIC ARTERY; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; STOMACH LAVAGE; SYSTOLIC BLOOD PRESSURE; VASCULAR TISSUE; WISTAR KYOTO RAT;

ANGIOTENSIN II; ANIMALS; BLOOD PRESSURE; CALCITONIN GENE-RELATED PEPTIDE; CAPSULES; ENDOTHELINS; HYPERTENSION; MALE; MEDICINE, CHINESE TRADITIONAL; MESENTERIC ARTERIES; RATS; RATS, INBRED SHR; RATS, INBRED WKY;

EID: 33846140461     PISSN: 16720415     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11655-001-0287-6     Document Type: Article

References (13)

1. Zollmann FS, Paul M. Transgenic models for the study of endothelin function in the cardiovascular system. J Cardiovasc Pharmacol 2000; 35(4 Suppl 2): S13-S16.
2. Rossi GP, Cavallin M, Belloni AS, et al. Aortic smooth muscle cell phenotypic modulation and fibrillar collagen deposition in angiotensin II-dependent hypertension. Cardiovasc Res 2002; 55(1): 178-189
3. Bell D, McDermott BJ. Calcitonin gene-related peptide in the cardiovascular system: characterization of receptor populations and their (patho) physiological significance. Pharmacol Rev 1996; 48(2): 253-288.
4. Ohhashi Y, Shindo T, Kurihara Y, et al. Elevated sympathetic nervous activity in mice deficient in alpha CGRP. Circ Res 2001; 89(11): 983-990.
5. Supowit SC, Ramana CV, Westlund KN, et al. Calcitonin gene-related peptide gene expression in the spontaneously hypertensive rat. Hypertension 1993; 21 (6 Pt 2): 1010-1014.
6. Hong HJ, Chan P, Liu JC, et al. Angiotensin II induces endothelin-1 gene expression via extracellular signal-regulated kinase pathway in rat aortic smooth muscle cells. Cardiovasc Res 2004; 61(1): 159-168.
7. Kawasaki H, Takenaga M, Araki H, et al. Angiotensin inhibits neurotransmission of calcitonin gene-related peptide-containing vasodilator nerves in mesenteric artery of spontaneously hypertensive rats. J Pharmacol Exp Ther 1998; 284(2): 508-515.
8. Siragy HM, Carey RM. Angiotensin type 2 receptors: potential importance in the regulation of blood pressure. Curr Opin Nephrol Hypertens 2001; 10(1): 99-103.
9. Han NL, Sim MK. Hypothalamic angiotensin receptor subtypes in normotensive and hypertensive rats. Am J Physiol 1998; 275(2 Pt 2): H703-H709.
10. Chen ZY, Su YL, Lau CW, et al. Endothelium-dependent contraction and direct relaxation induced by baicalin in rat mensenteric artery. Eur J Phamarcol 1999; 374(1): 41-47.
11. Takahashi K, Ouyang X, Komatsu K, et al. Sodium tanshinone II A sulfonate derived from Danshen (Salvia miltiorrhiza) attenuates hypertrophy induced by angiotensin II in cultured neonatal rat cardiac cells. Biochem Pharmacol 2002; 64(4): 745-749.
12. Ma JC, Yuan HT, Sheng SL, et al. Endothelin-1 induced actions on rat aortic smooth muscles and antagonistic effect of tetramethylpyrazine. Chin J Pharmac Toxicol 1993; 7(3): 170-172.
13. Shao FM, Wang XY, Zhang XL, et al. The study of effect of earthworm extract on the renal hypertension. Chin J Integr Tradit West Nephrol 2001; 2(2): 80-82.