Analysis of heterogeneity and instability of stable mAb-expressing CHO cells

Biotechnology and Bioprocess Engineering

Volumn 18, Issue 2, 2013, Pages 419-429

  Du, Zhimei ^a   Mujacic, Mirna ^a   Le, Kim ^a   Caspary, Guy ^a   Nunn, Heather ^a   Heath, Carole ^a   Reddy, Pranhitha ^a  

^a AMGEN INC   (United States)

Author keywords

cell line development; FACS; production, CHO; recombinant antibody

Indexed keywords

CELL LINES; FACS; FLUORESCENCE ACTIVATED CELL SORTING; RECOMBINANT ANTIBODY; RECOMBINANT EXPRESSION; RECOMBINANT PROTEIN EXPRESSION; SUBSTANTIAL VARIATIONS; TIME-CONSUMING PROCEDURE;

CELLS; CLONING; LAKES; MOLECULAR BIOLOGY; RECOMBINANT PROTEINS; STABILITY;

CELL CULTURE;

GENOMIC DNA; MONOCLONAL ANTIBODY; RECOMBINANT ANTIBODY; RIBOSOME DNA;

ARTICLE; CELL ISOLATION; CELL SCREENING; CELL SURFACE; CHO CELL; CONTROLLED STUDY; FLUORESCENCE ACTIVATED CELL SORTING; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE REARRANGEMENT; GENETIC ANALYSIS; GENETIC HETEROGENEITY; GENOMIC INSTABILITY; IMMUNOFLUORESCENCE MICROSCOPY; MOLECULAR CLONING; STABLE EXPRESSION;

EID: 84877790638     PISSN: 12268372     EISSN: 19763816     Source Type: Journal    
DOI: 10.1007/s12257-012-0577-1     Document Type: Article

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