Liver tumor promoting effect of orphenadrine in rats and its possible mechanism of action including CAR activation and oxidative stress

Journal of Toxicological Sciences

Volumn 38, Issue 3, 2013, Pages 403-413

  Morita, Reiko ^a,b   Yafune, Atsunori ^a,b   Shiraki, Ayako ^a,b   Itahashi, Megu ^a   Ishii, Yuji ^c   Akane, Hirotoshi ^a   Nakane, Fumiyuki ^a   Suzuki, Kazuhiko ^a   Shibutani, Makoto ^a   Mitsumori, Kunitoshi ^a  

^a TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Japan)

^b GIFU UNIVERSITY   (Japan)

^c NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

Constitutive active androstane receptor; Cytochrome P450 2B inducer; Liver tumor; Orphenadrine; Rat; Reactive oxygen species

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; CONSTITUTIVE ANDROSTANE RECEPTOR; CYCLIN D1; CYTOCHROME P450 2B1; CYTOCHROME P450 2B2; DIETHYLNITROSAMINE; GLUTATHIONE PEROXIDASE 2; GLUTATHIONE TRANSFERASE M3; MULTIDRUG RESISTANCE PROTEIN 2; ORPHENADRINE; REACTIVE OXYGEN METABOLITE; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPSY; BODY WEIGHT; CELL PROLIFERATION; CONTROLLED STUDY; DEATH; DNA DAMAGE; FLUID INTAKE; FOOD INTAKE; GENE EXPRESSION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; LIPID PEROXIDATION; LIVER CARCINOGENESIS; LIVER RESECTION; LIVER TUMOR; LIVER WEIGHT; MALE; MICROARRAY ANALYSIS; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 84877789338     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.38.403     Document Type: Article

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