Specific acetylation of p53 by HDAC inhibition prevents DNA damage-induced apoptosis in neurons

Journal of Neuroscience

Volumn 33, Issue 20, 2013, Pages 8621-8632

  Brochier, Camille ^a,b   Dennis, Gretel ^a   Rivieccio, Mark A ^a,b   McLaughlin, Kathryn ^a   Coppola, Giovanni ^c   Ratan, Rajiv R ^a,b   Langley, Brett ^a,b  

^a BURKE MEDICAL RESEARCH INSTITUTE   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE DEACETYLASE INHIBITOR; PROTEIN P53; PUMA PROTEIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CANCER INHIBITION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DNA DAMAGE; ELECTROPORATION; FEMALE; GENETIC TRANSCRIPTION; HISTONE ACETYLATION; IMMUNOCYTOCHEMISTRY; MALE; MICROARRAY ANALYSIS; MOUSE; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PURIFICATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SITE DIRECTED MUTAGENESIS; WESTERN BLOTTING;

ACETYLATION; ANALYSIS OF VARIANCE; ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BRAIN; CELLS, CULTURED; CHROMATIN IMMUNOPRECIPITATION; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DNA DAMAGE; ELECTROPORATION; EMBRYO, MAMMALIAN; ENZYME INHIBITORS; FEMALE; HISTONE DEACETYLASES; HUMANS; LYSINE; MALE; MICE; MICE, INBRED C57BL; MICROARRAY ANALYSIS; MUTAGENESIS, SITE-DIRECTED; MUTATION; NEURONS; RNA, SMALL INTERFERING; TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS;

EID: 84877773314     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.5214-12.2013     Document Type: Article

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