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Volumn 8, Issue 5, 2013, Pages

Ceramide Synthases Expression and Role of Ceramide Synthase-2 in the Lung: Insight from Human Lung Cells and Mouse Models

Author keywords

[No Author keywords available]

Indexed keywords

CERAMIDE; CERAMIDE SYNTHASE 2; CERAMIDE SYNTHASE 5; SPHINGOMYELIN PHOSPHODIESTERASE; SYNTHETASE; UNCLASSIFIED DRUG;

EID: 84877753914     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0062968     Document Type: Article
Times cited : (67)

References (19)
  • 1
    • 33748747214 scopus 로고    scopus 로고
    • LASS3 (longevity assurance homologue 3) is a mainly testis-specific (dihydro)ceramide synthase with relatively broad substrate specificity
    • Mizutani Y, Kihara A, Igarashi Y, (2006) LASS3 (longevity assurance homologue 3) is a mainly testis-specific (dihydro)ceramide synthase with relatively broad substrate specificity. Biochem J 398: 531-538.
    • (2006) Biochem J , vol.398 , pp. 531-538
    • Mizutani, Y.1    Kihara, A.2    Igarashi, Y.3
  • 2
    • 23944483995 scopus 로고    scopus 로고
    • Mammalian Lass6 and its related family members regulate synthesis of specific ceramides
    • Mizutani Y, Kihara A, Igarashi Y, (2005) Mammalian Lass6 and its related family members regulate synthesis of specific ceramides. Biochem J 390: 263-271.
    • (2005) Biochem J , vol.390 , pp. 263-271
    • Mizutani, Y.1    Kihara, A.2    Igarashi, Y.3
  • 3
    • 41949140023 scopus 로고    scopus 로고
    • Characterization of ceramide synthase 2: tissue distribution, substrate specificity, and inhibition by sphingosine 1-phosphate
    • Laviad EL, Albee L, Pankova-Kholmyansky I, Epstein S, Park H, et al. (2008) Characterization of ceramide synthase 2: tissue distribution, substrate specificity, and inhibition by sphingosine 1-phosphate. J Biol Chem 283: 5677-5684.
    • (2008) J Biol Chem , vol.283 , pp. 5677-5684
    • Laviad, E.L.1    Albee, L.2    Pankova-Kholmyansky, I.3    Epstein, S.4    Park, H.5
  • 5
    • 66349086742 scopus 로고    scopus 로고
    • Bioactive sphingolipids: metabolism and function
    • Bartke N, Hannun YA, (2009) Bioactive sphingolipids: metabolism and function. J Lipid Res 50 Suppl: S91-96.
    • (2009) J Lipid Res , vol.50 , Issue.SUPPL.
    • Bartke, N.1    Hannun, Y.A.2
  • 6
    • 0038352072 scopus 로고    scopus 로고
    • BcR-induced apoptosis involves differential regulation of C16 and C24-ceramide formation and sphingolipid-dependent activation of the proteasome
    • Kroesen BJ, Jacobs S, Pettus BJ, Sietsma H, Kok JW, et al. (2003) BcR-induced apoptosis involves differential regulation of C16 and C24-ceramide formation and sphingolipid-dependent activation of the proteasome. J Biol Chem 278: 14723-14731.
    • (2003) J Biol Chem , vol.278 , pp. 14723-14731
    • Kroesen, B.J.1    Jacobs, S.2    Pettus, B.J.3    Sietsma, H.4    Kok, J.W.5
  • 7
    • 70349973066 scopus 로고    scopus 로고
    • The proapoptotic C16-ceramide-dependent pathway requires the death-promoting factor Btf in colon adenocarcinoma cells
    • Renert AF, Leprince P, Dieu M, Renaut J, Raes M, et al. (2009) The proapoptotic C16-ceramide-dependent pathway requires the death-promoting factor Btf in colon adenocarcinoma cells. J Proteome Res 8: 4810-4822.
    • (2009) J Proteome Res , vol.8 , pp. 4810-4822
    • Renert, A.F.1    Leprince, P.2    Dieu, M.3    Renaut, J.4    Raes, M.5
  • 8
    • 23044486229 scopus 로고    scopus 로고
    • Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha
    • Osawa Y, Uchinami H, Bielawski J, Schwabe RF, Hannun YA, et al. (2005) Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha. J Biol Chem 280: 27879-27887.
    • (2005) J Biol Chem , vol.280 , pp. 27879-27887
    • Osawa, Y.1    Uchinami, H.2    Bielawski, J.3    Schwabe, R.F.4    Hannun, Y.A.5
  • 9
    • 80051927751 scopus 로고    scopus 로고
    • Encephalopathy caused by ablation of very long acyl chain ceramide synthesis may be largely due to reduced galactosylceramide levels
    • Ben-David O, Pewzner-Jung Y, Brenner O, Laviad EL, Kogot-Levin A, et al. (2011) Encephalopathy caused by ablation of very long acyl chain ceramide synthesis may be largely due to reduced galactosylceramide levels. J Biol Chem 286: 30022-30033.
    • (2011) J Biol Chem , vol.286 , pp. 30022-30033
    • Ben-David, O.1    Pewzner-Jung, Y.2    Brenner, O.3    Laviad, E.L.4    Kogot-Levin, A.5
  • 10
    • 77951234061 scopus 로고    scopus 로고
    • A critical role for ceramide synthase 2 in liver homeostasis: I. alterations in lipid metabolic pathways
    • Pewzner-Jung Y, Park H, Laviad EL, Silva LC, Lahiri S, et al. (2010) A critical role for ceramide synthase 2 in liver homeostasis: I. alterations in lipid metabolic pathways. J Biol Chem 285: 10902-10910.
    • (2010) J Biol Chem , vol.285 , pp. 10902-10910
    • Pewzner-Jung, Y.1    Park, H.2    Laviad, E.L.3    Silva, L.C.4    Lahiri, S.5
  • 11
    • 18844434417 scopus 로고    scopus 로고
    • Ceramide upregulation causes pulmonary cell apoptosis and emphysema-like disease in mice
    • Petrache I, Natarajan V, Zhen L, Medler TR, Richter AT, et al. (2005) Ceramide upregulation causes pulmonary cell apoptosis and emphysema-like disease in mice. Nat Med 11: 491-498.
    • (2005) Nat Med , vol.11 , pp. 491-498
    • Petrache, I.1    Natarajan, V.2    Zhen, L.3    Medler, T.R.4    Richter, A.T.5
  • 14
    • 79957880378 scopus 로고    scopus 로고
    • Lung endothelial monocyte-activating protein 2 is a mediator of cigarette smoke-induced emphysema in mice
    • Clauss M, Voswinckel R, Rajashekhar G, Sigua NL, Fehrenbach H, et al. (2011) Lung endothelial monocyte-activating protein 2 is a mediator of cigarette smoke-induced emphysema in mice. J Clin Invest 121: 2470-2479.
    • (2011) J Clin Invest , vol.121 , pp. 2470-2479
    • Clauss, M.1    Voswinckel, R.2    Rajashekhar, G.3    Sigua, N.L.4    Fehrenbach, H.5
  • 15
    • 0024300166 scopus 로고
    • Transgenes as probes for active chromosomal domains in mouse development
    • Allen ND, Cran DG, Barton SC, Hettle S, Reik W, et al. (1988) Transgenes as probes for active chromosomal domains in mouse development. Nature 333: 852-855.
    • (1988) Nature , vol.333 , pp. 852-855
    • Allen, N.D.1    Cran, D.G.2    Barton, S.C.3    Hettle, S.4    Reik, W.5
  • 16
    • 84874086182 scopus 로고    scopus 로고
    • Ablation of ceramide synthase 2 causes chronic oxidative stress due to disruption of the mitochondrial respiratory chain
    • Zigdon H, Kogot-Levin A, Park JW, Goldschmidt R, Kelly S, et al. (2013) Ablation of ceramide synthase 2 causes chronic oxidative stress due to disruption of the mitochondrial respiratory chain. J Biol Chem 288: 4947-4956.
    • (2013) J Biol Chem , vol.288 , pp. 4947-4956
    • Zigdon, H.1    Kogot-Levin, A.2    Park, J.W.3    Goldschmidt, R.4    Kelly, S.5
  • 17
    • 70450240715 scopus 로고    scopus 로고
    • Adult ceramide synthase 2 (CERS2)-deficient mice exhibit myelin sheath defects, cerebellar degeneration, and hepatocarcinomas
    • Imgrund S, Hartmann D, Farwanah H, Eckhardt M, Sandhoff R, et al. (2009) Adult ceramide synthase 2 (CERS2)-deficient mice exhibit myelin sheath defects, cerebellar degeneration, and hepatocarcinomas. J Biol Chem 284: 33549-33560.
    • (2009) J Biol Chem , vol.284 , pp. 33549-33560
    • Imgrund, S.1    Hartmann, D.2    Farwanah, H.3    Eckhardt, M.4    Sandhoff, R.5
  • 19
    • 77957113600 scopus 로고    scopus 로고
    • A large-scale, consortium-based genomewide association study of asthma
    • Moffatt MF, Gut IG, Demenais F, Strachan DP, Bouzigon E, et al. (2010) A large-scale, consortium-based genomewide association study of asthma. N Engl J Med 363: 1211-1221.
    • (2010) N Engl J Med , vol.363 , pp. 1211-1221
    • Moffatt, M.F.1    Gut, I.G.2    Demenais, F.3    Strachan, D.P.4    Bouzigon, E.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.