Encephalopathy caused by ablation of very long acyl chain ceramide synthesis may be largely due to reduced galactosylceramide levels

Journal of Biological Chemistry

Volumn 286, Issue 34, 2011, Pages 30022-30033

  Ben David, Oshrit ^a   Pewzner Jung, Yael ^a   Brenner, Ori ^a   Laviad, Elad L ^a   Kogot Levin, Aviram ^b   Weissberg, Itai ^c   Biton, Inbal E ^a   Pienik, Reut ^a   Wang, Elaine ^d   Kelly, Samuel ^d   Alroy, Joseph ^e   Raas Rothschild, Annick ^b   Friedman, Alon ^c   Brügger, Britta ^f   Merrill Jr , Alfred H ^d   Futerman, Anthony H ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^c BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^d GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^e TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL CHAIN; ASTROGLIOSIS; BRAIN AREAS; BRAIN LESIONS; BRAIN REGIONS; CERAMIDE SYNTHASE; CERAMIDES; LYSOSOMAL STORAGE DISORDER; MOTOR BEHAVIOR; NEURONAL CELL; SIGNALING MOLECULES; SPHINGOLIPIDS; STRUCTURAL COMPONENT; TIME COURSE; VACUOLIZATION;

AMIDES; BRAIN; MAMMALS; SYNTHESIS (CHEMICAL);

ABLATION;

CERAMIDE SYNTHASE 2; GALACTOSYLCERAMIDE; MYELIN; SPHINGOLIPID; SYNTHETASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; ASTROCYTOSIS; BRAIN DISEASE; BRAIN REGION; BRAIN TISSUE; CELL ACTIVATION; CONTROLLED STUDY; DEGENERATION; ENZYME ACTIVITY; GLIOSIS; LIPOGENESIS; LYSOSOME; MICROGLIA; MOTOR DYSFUNCTION; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; ASTROCYTES; BRAIN; BRAIN DISEASES, METABOLIC, INBORN; GALACTOSYLCERAMIDES; MICE; MICE, MUTANT STRAINS; MICROGLIA; MYELIN SHEATH; SPHINGOSINE N-ACYLTRANSFERASE;

EID: 80051927751     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.261206     Document Type: Article

References (67)

1. Schwarz, A., and Futerman, A. H. (1997) J. Neurosci. 17, 2929-2938
2. Furuya, S., Ono, K., and Hirabayashi, Y. (1995) J. Neurochem. 65, 1551-1561
3. Schwarz, A., Rapaport, E., Hirschberg, K., and Futerman, A. H. (1995) J. Biol. Chem. 270, 10990-10998
4. Brann, A. B., Scott, R., Neuberger, Y., Abulafia, D., Boldin, S., Fainzilber, M., and Futerman, A. H. (1999) J. Neurosci. 19, 8199-8206
5. Brann, A. B., Tcherpakov, M., Williams, I. M., Futerman, A. H., and Fainzilber, M. (2002) J. Biol. Chem. 277, 9812-9818
6. Jana, A., and Pahan, K. (2010) Neuromolecular Med. 12, 351-361
7. Venkataraman, K., Riebeling, C., Bodennec, J., Riezman, H., Allegood, J. C., Sullards, M. C., Merrill, A. H., Jr., and Futerman, A. H. (2002) J. Biol. Chem. 277, 35642-35649
8. Riebeling, C., Allegood, J. C., Wang, E., Merrill, A. H., Jr., and Futerman, A. H. (2003) J. Biol. Chem. 278, 43452-43459
9. Mizutani, Y., Kihara, A., and Igarashi, Y. (2005) Biochem. J. 390, 263-271
10. Mizutani, Y., Kihara, A., and Igarashi, Y. (2006) Biochem. J. 398, 531-538
11. Pewzner-Jung, Y., Ben-Dor, S., and Futerman, A. H. (2006) J. Biol. Chem. 281, 25001-25005
12. Laviad, E. L., Albee, L., Pankova-Kholmyansky, I., Epstein, S., Park, H., Merrill, A. H., Jr., and Futerman, A. H. (2008) J. Biol. Chem. 283, 5677-5684
13. Levy, M., and Futerman, A. H. (2010) IUBMB Life 62, 347-356
14. Pewzner-Jung, Y., Park, H., Laviad, E. L., Silva, L. C., Lahiri, S., Stiban, J., Erez-Roman, R., Brügger, B., Sachsenheimer, T., Wieland, F., Prieto, M., Merrill, A. H., Jr., and Futerman, A. H. (2010) J. Biol. Chem. 285, 10902-10910
15. Pewzner-Jung, Y., Brenner, O., Braun, S., Laviad, E. L., Ben-Dor, S., Feldmesser, E., Horn-Saban, S., Amann-Zalcenstein, D., Raanan, C., Berkutzki, T., Erez-Roman, R., Ben-David, O., Levy, M., Holzman, D., Park, H., Nyska, A., Merrill, A. H., Jr., and Futerman, A. H. (2010) J. Biol. Chem. 285, 10911-10923
16. Becker, I., Wang-Eckhardt, L., Yaghootfam, A., Gieselmann, V., and Eckhardt, M. (2008) Histochem. Cell Biol. 129, 233-241
17. Baumann, N., and Pham-Dinh, D. (2001) Physiol. Rev. 81, 871-927
18. Ben-David, O., and Futerman, A. H. (2010) Neuromolecular Med. 12, 341-350
19. Imgrund, S., Hartmann, D., Farwanah, H., Eckhardt, M., Sandhoff, R., Degen, J., Gieselmann, V., Sandhoff, K., and Willecke, K. (2009) J. Biol. Chem. 284, 33549-33560
20. Hirschberg, K., Rodger, J., and Futerman, A. H. (1993) Biochem. J. 290, 751-757
21. Shaner, R. L., Allegood, J. C., Park, H., Wang, E., Kelly, S., Haynes, C. A., Sullards, M. C., and Merrill, A. H., Jr. (2009) J. Lipid Res. 50, 1692-1707
22. Brügger, B., Sandhoff, R., Wegehingel, S., Gorgas, K., Malsam, J., Helms, J. B., Lehmann, W. D., Nickel, W., and Wieland, F. T. (2000) J. Cell Biol. 151, 507-518
23. Brügger, B., Glass, B., Haberkant, P., Leibrecht, I., Wieland, F. T., and Kräusslich, H. G. (2006) Proc. Natl. Acad. Sci. U.S.A. 103, 2641-2646
24. Lahiri, S., Lee, H., Mesicek, J., Fuks, Z., Haimovitz-Friedman, A., Kolesnick, R. N., and Futerman, A. H. (2007) FEBS Lett. 581, 5289-5294
25. Futerman, A. H., Stieger, B., Hubbard, A. L., and Pagano, R. E. (1990) J. Biol. Chem. 265, 8650-8657
26. Ginzburg, L., and Futerman, A. H. (2005) J. Neurochem. 95, 1619-1628
27. Hayashi, Y., Okino, N., Kakuta, Y., Shikanai, T., Tani, M., Narimatsu, H., and Ito, M. (2007) J. Biol. Chem. 282, 30889-30900
28. Li, H. H., Yu, W. H., Rozengurt, N., Zhao, H. Z., Lyons, K. M., Anagnostaras, S., Fanselow, M. S., Suzuki, K., Vanier, M. T., and Neufeld, E. F. (1999) Proc. Natl. Acad. Sci. U.S.A. 96, 14505-14510
29. Prence, E. M., and Natowicz, M. R. (1992) Clin. Chem. 38, 501-503
30. Petushkova, N. A., Ivleva, T. S., and Vozniy, Ya. M. (1992) Prenat. Diagn. 12, 835-839
31. Schnaar, R. L. (1994) Methods Enzymol. 230, 348-370
32. Folch, J., Lees, M., and Sloane Stanley, G. H. (1957) J. Biol. Chem. 226, 497-509
33. Svennerholm, L. (1957) Biochim. Biophys. Acta 24, 604-611
34. Norton, W. T., and Poduslo, S. E. (1973) J. Neurochem. 21, 749-757
35. Farfel-Becker, T., Vitner, E. B., Pressey, S. N., Eilam, R., Cooper, J. D., and Futerman, A. H. (2011) Hum. Mol. Genet. 20, 1375-1386
36. Pitsch, J., Schoch, S., Gueler, N., Flor, P. J., Van der Putten, H., and Becker, A. J. (2007) Neurobiol. Dis. 26, 623-633
37. Welch, P. D. (1967) IEEE Trans. Audio Electroacoustics 15, 70-73
38. Novgorodov, S. A., Chudakova, D. A., Wheeler, B. W., Bielawski, J., Kindy, M. S., Obeid, L. M., and Gudz, T. I. (2011) J. Biol. Chem. 286, 4644-4658
39. Sastry, P. S. (1985) Prog. Lipid Res. 24, 69-176
40. Muse, E. D., Jurevics, H., Toews, A. D., Matsushima, G. K., and Morell, P. (2001) J. Neurochem. 76, 77-86
41. Coetzee, T., Fujita, N., Dupree, J., Shi, R., Blight, A., Suzuki, K., Suzuki, K., and Popko, B. (1996) Cell 86, 209-219
42. Van der Bijl, P., Strous, G. J., Lopes-Cardozo, M., Thomas-Oates, J., and Van Meer, G. (1996) Biochem. J. 317, 589-597
43. Hama, H. (2010) Biochim. Biophys. Acta 1801, 405-414
44. Zöller, I., Büssow, H., Gieselmann, V., and Eckhardt, M. (2005) Glia 52, 190-198
45. Dupree, J. L., Suzuki, K., and Popko, B. (1998) Microsc. Res. Tech. 41, 431-440
46. David, Y., Cacheaux, L. P., Ivens, S., Lapilover, E., Heinemann, U., Kaufer, D., and Friedman, A. (2009) J. Neurosci. 29, 10588-10599
47. Müller, G., Alldinger, S., Moritz, A., Zurbriggen, A., Kirchhof, N., Sewell, A., and Baumgärtner, W. (2001) Vet. Pathol. 38, 281-290
48. Zöller, I., Meixner, M., Hartmann, D., Büssow, H., Meyer, R., Gieselmann, V., and Eckhardt, M. (2008) J. Neurosci. 28, 9741-9754
49. Meixner, M., Jungnickel, J., Grothe, C., Gieselmann, V., and Eckhardt, M. (2011) BMC Neurosci. 12, 22
50. Stewart, R. J., and Boggs, J. M. (1993) Biochemistry 32, 10666-10674
51. Dupree, J. L., and Popko, B. (1999) J. Neurocytol. 28, 271-279
52. Ledeen, R. W., and Wu, G. (1992) Trends Glycosci. Glycotechnol. 4, 174-187
53. Fewou, S. N., Büssow, H., Schaeren-Wiemers, N., Vanier, M. T., Macklin, W. B., Gieselmann, V., and Eckhardt, M. (2005) J. Neurochem. 94, 469-481
54. Taniike, M., Marcus, J. R., Nishigaki, T., Fujita, N., Popko, B., Suzuki, K., and Suzuki, K. (1998) J. Neurosci. Res. 51, 536-540
55. Marcus, J., Honigbaum, S., Shroff, S., Honke, K., Rosenbluth, J., and Dupree, J. L. (2006) Glia 53, 372-381
56. Walker, F. O. (2007) Semin. Neurol. 27, 143-150
57. Gregory, A., Polster, B. J., and Hayflick, S. J. (2009) J. Med. Genet. 46, 73-80
58. Baudry, M., Yao, Y., Simmons, D., Liu, J., and Bi, X. (2003) Exp. Neurol. 184, 887-903
59. Summers, B. A., Cummings, J. F., and DeLahunta, A. (1995) Veterinary Neuropathology, pp. 208-351, Mosby, St. Louis, MO
60. Matkowskyj, K. A., Marrero, J. A., Carroll, R. E., Danilkovich, A. V., Green, R. M., and Benya, R. V. (1999) Am. J. Physiol. Gastrointest. Liver Physiol. 277, G455-G462
61. Van Zyl, R., Gieselmann, V., and Eckhardt, M. (2010) J. Neurochem. 112, 282-295
62. Burck, U., Moser, H. W., Goebel, H. H., Grüttner, R., and Held, K. R. (1985) Eur. J. Pediatr. 143, 203-208
63. Rauch, H. J., and Auböck, L. (1983) Am. J. Dermatopathol. 5, 263-266
64. Fujiwaki, T., Hamanaka, S., Tate, S., Inagaki, F., Suzuki, M., Suzuki, A., and Mori, C. (1995) Clin. Chim. Acta 234, 23-36
65. Beirowski, B., Nógrádi, A., Babetto, E., Garcia-Alias, G., and Coleman, M. P. (2010) J. Neuropathol. Exp. Neurol. 69, 455-472
66. Coleman, M. (2005) Nat. Rev. Neurosci. 6, 889-898
67. Svennerholm, L. (1963) J. Neurochem. 10, 455-463