Ablation of ceramide synthase 2 causes chronic oxidative stress due to disruption of the mitochondrial respiratory chain

Journal of Biological Chemistry

Volumn 288, Issue 7, 2013, Pages 4947-4956

  Zigdon, Hila ^a   Kogot Levin, Aviram ^b   Park, Joo Won ^a,d   Goldschmidt, Ruth ^a   Kelly, Samuel ^c   Merrill, Alfred H ^c   Scherz, Avigdor ^a   Pewzner Jung, Yael ^a   Saada, Ann ^b   Futerman, Anthony H ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^c GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^d Ewha Womans University School of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CHAINS; MAMMALS;

ACYL CHAIN; CERAMIDE SYNTHASE; CHRONIC OXIDATIVE STRESS; LONG CHAINS; MITOCHONDRIAL FUNCTION; MITOCHONDRIAL RESPIRATORY CHAIN; REACTION OXYGEN SPECIES; RESPIRATORY CHAINS; SPHINGANINE; SPHINGOLIPIDS;

CERAMIDES;

C16 CERAMIDE; CERAMIDE; CERAMIDE SYNTHETASE 2; COPPER ZINC SUPEROXIDE DISMUTASE; CYTOCHROME C OXIDASE; DIACYLGLYCEROL; GLUTATHIONE PEROXIDASE 3; GLUTATHIONE TRANSFERASE M1; GLUTATHIONE TRANSFERASE P1; MESSENGER RNA; PHOSPHOLIPID HYDROPEROXIDE GLUTATHIONE PEROXIDASE; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SPHINGANINE; SPHINGOMYELIN; SPHINGOSINE; SUCCINATE DEHYDROGENASE (UBIQUINONE); SYNTHETASE; UBIQUINOL CYTOCHROME C REDUCTASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELLULAR DISTRIBUTION; CHRONIC STRESS; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION; INTRACELLULAR SIGNALING; LIPID ANALYSIS; LIPID PEROXIDATION; LIVER CELL; LIVER DISEASE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; MOLECULAR DYNAMICS; MOUSE; NITROSYLATION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL;

EID: 84874086182     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.402719     Document Type: Article

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