Platelet-activating factor-induced chloride channel activation is associated with intracellular acidosis and apoptosis of intestinal epithelial cells

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 294, Issue 5, 2008, Pages

  Claud, Erika C ^a   Lu, Jing ^b   Wang, Xue Qing ^a   Abe, Mark ^a   Petrof, Elaine O ^a,c   Sun, Jun ^a,d   Nelson, Deborah J ^a   Marks, Jeremy ^a   Jilling, Tamas ^b  

^a UNIVERSITY OF CHICAGO   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c QUEEN S UNIVERSITY   (Canada)

^d UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

Ca2+ activated Cl channel; Intestinal barrier; Intestinal injury; Ion transport

Indexed keywords

CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CALCIUM ION; CASPASE; CHLORIDE CHANNEL; DIHYDRO 4,4' DIISOTHIOCYANO 2,2' STILBENEDISULFONIC ACID; PROTON; SHORT HAIRPIN RNA; SODIUM PROTON EXCHANGE PROTEIN 1; THROMBOCYTE ACTIVATING FACTOR; 1,2-BIS(2-AMINOPHENOXY)ETHANE-N,N,N',N'-TETRAACETIC ACID; 4,4' DIISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; CALCIUM; CAMKII INHIBITOR AIP; CASPASE 3; CHELATING AGENT; CLC 3 CHANNEL; CLC-3 CHANNEL; DRUG DERIVATIVE; EGTAZIC ACID; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; FLUORESCENT DYE; FURA 2; PEPTIDE; PROTEIN KINASE INHIBITOR; SLC9A1 PROTEIN, RAT; SODIUM PROTON EXCHANGE PROTEIN;

ACIDOSIS; ANIMAL CELL; APOPTOSIS; ARTICLE; CALCIUM SIGNALING; CHANNEL GATING; CONTROLLED STUDY; DNA DEGRADATION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; INTESTINE EPITHELIUM CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RAT; ANIMAL; CELL LINE; CHEMICALLY INDUCED DISORDER; CHEMISTRY; CYTOLOGY; DNA FRAGMENTATION; DRUG EFFECT; DRUG POTENTIATION; ELECTROPHYSIOLOGY; EPITHELIUM CELL; GENE EXPRESSION; GENETICS; HUMAN; INTESTINE; METABOLISM; PH; RNA INTERFERENCE;

4,4'-DIISOTHIOCYANOSTILBENE-2,2'-DISULFONIC ACID; ACIDOSIS; ANIMALS; APOPTOSIS; CALCIUM; CASPASE 3; CELL LINE; CHELATING AGENTS; CHLORIDE CHANNELS; DNA FRAGMENTATION; EGTAZIC ACID; ELECTROPHYSIOLOGY; EPITHELIAL CELLS; FLUORESCENT DYES; FURA-2; GENE EXPRESSION; HUMANS; HYDROGEN-ION CONCENTRATION; INTESTINES; PEPTIDES; PLATELET ACTIVATING FACTOR; PROTEIN KINASE INHIBITORS; RATS; RNA INTERFERENCE; SODIUM-HYDROGEN ANTIPORTER;

EID: 45849109149     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00318.2007     Document Type: Article

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