Genes against aging

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 67 A, Issue 5, 2012, Pages 495-502

  Miller, Richard A ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Comparative biology; Genetics; Longevity; Mice

Indexed keywords

CANIS FAMILIARIS; MUS; RODENTIA;

AGING; ALLELE; ANIMAL; BIOLOGICAL MODEL; CYTOLOGY; DISEASE MODEL; DOG; EVOLUTION; GENETIC MARKER; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENETICS; GERIATRICS; HUMAN; METHODOLOGY; MOUSE; MUTATION; REVIEW;

AGING; ALLELES; ANIMALS; BIOLOGICAL EVOLUTION; CELL BIOLOGY; DISEASE MODELS, ANIMAL; DOGS; GENETIC MARKERS; GENETIC VARIATION; GERIATRICS; HUMANS; MICE; MODELS, GENETIC; MUTATION; POLYMORPHISM, GENETIC;

EID: 84860188844     PISSN: 10795006     EISSN: 1758535X     Source Type: Journal    
DOI: 10.1093/gerona/gls082     Document Type: Review

References (51)

1. Williams GC. Pleiotropy, natural selection, and the evolution of senescence. Evolution. 1957;11:398-411.
2. Charlesworth B. Evolution in Age-Structured Populations. Cambridge, UK: Cambridge University Press; 1980.
3. Medawar PT. An Unsolved Problem of Biology. London, UK: H. K. Lewis; 1952.
4. Austad SN. Retarded senescence in an insular population of Virginia opossums (Didelphis virginiana). J Zool. 1993;229:695-708.
5. Partridge L, Barton NH. Optimality, mutation and the evolution of ageing. Nature. 1993;362:305-311. (Pubitemid 23101301)
6. Partridge L, Harvey PH. Methuselah among nematodes. Nature. 1993;366:404-405. (Pubitemid 24013869)
7. Brown-Borg HM, Borg KE, Meliska CJ, Bartke A. Dwarf mice and the ageing process. Nature. 1996;384:33.
8. Coschigano KT, Clemmons D, Bellush LL, Kopchick JJ. Assessment of growth parameters and life span of GHR/BP gene-disrupted mice. Endocrinology. 2000;141:2608-2613. (Pubitemid 32269083)
9. Flurkey K, Papaconstantinou J, Miller RA, Harrison DE. Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production. Proc Natl Acad Sci USA. 2001;98:6736-6741. (Pubitemid 32538286)
10. Conover CA, Bale LK. Loss of pregnancy-associated plasma protein A extends lifespan in mice. Aging Cell. 2007;6:727-729. (Pubitemid 47400055)
11. Bluher M, Kahn BB, Kahn CR. Extended longevity in mice lacking the insulin receptor in adipose tissue. Science. 2003;299:572-574. (Pubitemid 36135156)
12. Longo VD, Finch CE. Evolutionary medicine: from dwarf model systems to healthy centenarians? Science. 2003;299:1342-1346. (Pubitemid 36254638)
13. Tatar M, Bartke A, Antebi A. The endocrine regulation of aging by insulin-like signals. Science. 2003;299:1346-1351. (Pubitemid 36254639)
14. Kenyon CJ. The genetics of ageing. Nature. 2010;464:504-512.
15. Schachter F, Faure-Delanef L, Guenot F, et al. Genetic associations with human longevity at the APOE and ACE loci. Nat Genet. 1994;6:29-32. (Pubitemid 24191909)
16. Bloss CS, Pawlikowska L, Schork NJ. Contemporary human genetic strategies in aging research. Ageing Res Rev. 2011;10:191-200.
17. Miller RA, Austad SN. Growth and aging: why do big dogs die young? In: Masoro EJ, Austad SN, eds. Handbook of the Biology of Aging. 6th ed. New York: Academic Press; 2006:512-533.
18. Miller RA. Kleemeier award lecture: are there genes for aging? J Gerontol A Biol Sci Med Sci. 1999;54:B297-B307. (Pubitemid 29418917)
19. Li Y, Deeb B, Pendergrass W, Wolf N. Cellular proliferative capacity and life span in small and large dogs. J Gerontol A Biol Sci Med Sci. 1996;51:B403-B408. (Pubitemid 26394066)
20. Michell AR. Longevity of British breeds of dog and its relationships with sex, size, cardiovascular variables and disease. Vet Rec. 1999;145:625-629.
21. Patronek GJ, Waters DJ, Glickman LT. Comparative longevity of pet dogs and humans: implications for gerontology research. J Gerontol A Biol Sci Med Sci. 1997;52:B171-B178. (Pubitemid 27235340)
22. Eigenmann JE, Patterson DF, Froesch ER. Body size parallels insulin-like growth factor I levels but not growth hormone secretory capacity. Acta Endocrinol. 1984;106:448-453. (Pubitemid 14053015)
23. Bonnett BN, Egenvall A, Hedhammar A, Olson P. Mortality in over 350,000 insured Swedish dogs from 1995-2000: I. Breed-, gender-, age-and cause-specific rates. Acta Vet Scand. 2005;46:105-120. (Pubitemid 43978697)
24. Williams DL, Heath MF, Wallis C. Prevalence of canine cataract: preliminary results of a cross-sectional study. Vet Ophthalmol. 2004;7:29-35. (Pubitemid 38251167)
25. Brosnahan MM, Paradis MR. Demographic and clinical characteristics of geriatric horses: 467 cases (1989-1999). J Am Vet Med Assoc. 2003;223:93-98. (Pubitemid 36750317)
26. Davey SG, Hart C, Upton M, et al. Height and risk of death among men and women: aetiological implications of associations with cardiorespiratory disease and cancer mortality. J Epidemiol Community Health. 2000;54:97-103. (Pubitemid 30066242)
27. Albanes D, Jones DY, Schatzkin A, Micozzi MS, Taylor PR. Adult stature and risk of cancer. Cancer Res. 1988;48:1658-1662. (Pubitemid 18091223)
28. Hebert PR, Rich-Edwards JW, Manson JE, et al. Height and incidence of cardiovascular disease in male physicians. Circulation. 1993;88:1437-1443. (Pubitemid 23296889)
29. Tretli S. Height and weight in relation to breast cancer morbidity and mortality. A prospective study of 570,000 women in Norway. Int J Cancer. 1989;44:23-30. (Pubitemid 19184671)
30. Petrelli JM, Calle EE, Rodriguez C, Thun MJ. Body mass index, height, and postmenopausal breast cancer mortality in a prospective cohort of US women. Cancer Causes Control. 2002;13:325-332. (Pubitemid 34553513)
31. Tretli S, Robsahm TE. Height, weight and cancer of the oesophagus and stomach: a follow-up study in Norway. Eur J Cancer Prev. 1999;8:115-122. (Pubitemid 29210216)
32. Barker DJP, Osmond C, Golding J. Height and mortality in the counties of England and Wales. Ann Hum Biol. 1990;17:1-6. (Pubitemid 20121989)
33. Schaumberg DA, Glynn RJ, Christen WG, Hankinson SE, Hennekens CH. Relations of body fat distribution and height with cataract in men. Am J Clin Nutr. 2000;72:1495-1502.
34. Guevara-Aguirre J, Balasubramanian P, Guevara-Aguirre M, et al. Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans. Sci Transl Med. 2011;3:70ra13.
35. Kinney BA, Coschigano KT, Kopchick JJ, Steger RW, Bartke A. Evidence that age-induced decline in memory retention is delayed in growth hormone resistant GH-R-KO (Laron) mice. Physiol Behav. 2001;72:653-660. (Pubitemid 32406213)
36. Silberberg R. Articular aging and osteoarthritis in dwarf mice. Pathol Microbiol. 1972;38:417-430.
37. Vergara M, Smith-Wheelock M, Harper JM, Sigler R, Miller RA. Hormone-treated Snell dwarf mice regain fertility but remain long-lived and disease resistant. J Gerontol A Biol Sci Med Sci. 2004;59:1244-1250. (Pubitemid 40209410)
38. Miller RA. 'Accelerated aging': a primrose path to insight? Aging Cell. 2004;3:47-51. (Pubitemid 40246663)
39. Miller RA. Evaluating evidence for aging. Science. 2005;310:441-443.
40. Kuro-o M, Matsumura Y, Aizawa H, et al. Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature. 1997;390:45-51. (Pubitemid 27494749)
41. Lanske B, Razzaque MS. Premature aging in klotho mutant mice: cause or consequence? Ageing Res Rev. 2007;6:73-79. (Pubitemid 46661813)
42. Razzaque MS, Lanske B. Hypervitaminosis D and premature aging: lessons learned from Fgf23 and Klotho mutant mice. Trends Mol Med. 2006;12:298-305. (Pubitemid 44110001)
43. Fabris N, Pierpaoli W, Sorkin E. Lymphocytes, hormones and ageing. Nature. 1972;240:557-559.
44. Kikis EA, Gidalevitz T, Morimoto RI. Protein homeostasis in models of aging and age-related conformational disease. Adv Exp Med Biol. 2010;694:138-159.
45. Aledo JC, Li Y, de Magalhaes JP, Ruiz-Camacho M, Perez-Claros JA. Mitochondrially encoded methionine is inversely related to longevity in mammals. Aging Cell. 2011;10:198-207.
46. Kitazoe Y, Kishino H, Hasegawa M, Nakajima N, Thorne JL, Tanaka M. Adaptive threonine increase in transmembrane regions of mitochondrial proteins in higher primates. PLoS One. 2008;3:e3343.
47. Harper JM, Salmon AB, Leiser SF, Galecki AT, Miller RA. Skin-derived fibroblasts from long-lived species are resistant to some, but not all, lethal stresses and to the mitochondrial inhibitor rotenone. Aging Cell. 2007;6:1-13. (Pubitemid 46140135)
48. Harper JM, Wang M, Galecki AT, Ro J, Williams JB, Miller RA. Fibroblasts from long-lived bird species are resistant to multiple forms of stress. J Exp Biol. 2011;214:1902-1910.
49. Kapahi P, Boulton ME, Kirkwood TB. Positive correlation between mammalian life span and cellular resistance to stress. Free Radic Biol Med. 1999;26:495-500. (Pubitemid 29146251)
50. Olshansky SJ, Carnes BA, Cassel C. In search of Methuselah: estimating the upper limits to human longevity. Science. 1990;250:634-640. (Pubitemid 120034278)
51. Miller RA. Extending life: scientific prospects and political obstacles. Milbank Q. 2002;80:155-174.