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Volumn 73, Issue 9, 2013, Pages 2916-2925

Activation of HIF2α in kidney proximal tubule cells causes abnormal glycogen deposition but not tumorigenesis

Author keywords

[No Author keywords available]

Indexed keywords

CD70 ANTIGEN; GAMMA HISTONE H2AX; GLYCOGEN; HISTONE H2AX; HYPOXIA INDUCIBLE FACTOR 2ALPHA; KI 67 ANTIGEN; UNCLASSIFIED DRUG;

EID: 84877732312     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-12-3983     Document Type: Article
Times cited : (40)

References (46)
  • 2
    • 21044433148 scopus 로고    scopus 로고
    • Prognostic value of histologic subtypes in renal cell carcinoma: A multicenter experience
    • Patard JJ, Leray E, Rioux-Leclercq N, Cindolo L, Ficarra V, Zisman A, et al. Prognostic value of histologic subtypes in renal cell carcinoma: a multicenter experience. J Clin Oncol 2005;23:2763-71.
    • (2005) J Clin Oncol , vol.23 , pp. 2763-71
    • Patard, J.J.1    Leray, E.2    Rioux-Leclercq, N.3    Cindolo, L.4    Ficarra, V.5    Zisman, A.6
  • 3
    • 33846876103 scopus 로고    scopus 로고
    • Identification of the genes for kidney cancer: Opportunity for disease-specific targeted therapeutics
    • Linehan WM, Pinto PA, Srinivasan R, Merino M, Choyke P, Choyke L, et al. Identification of the genes for kidney cancer: opportunity for disease-specific targeted therapeutics. Clin Cancer Res 2007;13: 671s-9s.
    • (2007) Clin Cancer Res , vol.13
    • Linehan, W.M.1    Pinto, P.A.2    Srinivasan, R.3    Merino, M.4    Choyke, P.5    Choyke, L.6
  • 4
    • 33846879810 scopus 로고    scopus 로고
    • The von hippel-lindau tumor suppressor protein and clear cell renal carcinoma
    • Kaelin WG Jr. The von Hippel-Lindau tumor suppressor protein and clear cell renal carcinoma. Clin Cancer Res 2007;13:680s-4s.
    • (2007) Clin Cancer Res , vol.13
    • Kaelin Jr., W.G.1
  • 5
    • 76349095132 scopus 로고    scopus 로고
    • Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics
    • Semenza GL. Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. Oncogene 2010;29:625-34.
    • (2010) Oncogene , vol.29 , pp. 625-34
    • Semenza, G.L.1
  • 6
    • 33846199233 scopus 로고    scopus 로고
    • Hypoxia-inducible factors: Central regulators of the tumor phenotype
    • Gordan JD, Simon MC. Hypoxia-inducible factors: central regulators of the tumor phenotype. Curr Opin Genet Dev 2007;17:71-7.
    • (2007) Curr Opin Genet Dev , vol.17 , pp. 71-7
    • Gordan, J.D.1    Simon, M.C.2
  • 7
    • 0031020884 scopus 로고    scopus 로고
    • Endothelial pas domain protein 1 (epas1), a transcription factor selectively expressed in endothelial cells
    • Tian H, McKnight SL, Russell DW. Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells. Gen Dev 1997;11:72-82.
    • (1997) Gen Dev , vol.11 , pp. 72-82
    • Tian, H.1    McKnight, S.L.2    Russell, D.W.3
  • 8
    • 33947528891 scopus 로고    scopus 로고
    • Von Hippel-Lindau disease
    • Kaelin WG. Von Hippel-Lindau disease. Annu Rev Pathol 2007;2: 145-73.
    • (2007) Annu Rev Pathol , vol.2 , pp. 145-73
    • Kaelin, W.G.1
  • 9
    • 2342597973 scopus 로고    scopus 로고
    • Inhibition of hif2alpha is sufficient to suppress pvhl-defective tumor growth
    • Kondo K, Kim WY, Lechpammer M, Kaelin WG Jr. Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth. PLoS Biol 2003;1:E83.
    • (2003) PLoS Biol , vol.1
    • Kondo, K.1    Kim, W.Y.2    Lechpammer, M.3    Kaelin Jr., W.G.4
  • 10
    • 1342280515 scopus 로고    scopus 로고
    • Inhibition of hypoxiainducible factor is sufficient for growth suppression of vhl-/- tumors
    • Zimmer M, Doucette D, Siddiqui N, Iliopoulos O. Inhibition of hypoxiainducible factor is sufficient for growth suppression of VHL-/- tumors. Mol Cancer Res 2004;2:89-95.
    • (2004) Mol Cancer Res , vol.2 , pp. 89-95
    • Zimmer, M.1    Doucette, D.2    Siddiqui, N.3    Iliopoulos, O.4
  • 11
    • 0036528246 scopus 로고    scopus 로고
    • Inhibition of hif is necessary for tumor suppression by the von hippel-lindau protein
    • Kondo K, Klco J, Nakamura E, Lechpammer M, KaelinWGJr. Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein. Cancer Cell 2002;1:237-46.
    • (2002) Cancer Cell , vol.1 , pp. 237-46
    • Kondo, K.1    Klco, J.2    Nakamura, E.3    Lechpammer, M.4    Kaelin Jr., W.G.5
  • 12
    • 20744445650 scopus 로고    scopus 로고
    • Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma
    • Raval RR, Lau KW, Tran MG, Sowter HM, Mandriota SJ, Li JL, et al. Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma. Mol Cell Biol 2005;25:5675-86.
    • (2005) Mol Cell Biol , vol.25 , pp. 5675-86
    • Raval, R.R.1    Lau, K.W.2    Tran, M.G.3    Sowter, H.M.4    Mandriota, S.J.5    Li, J.L.6
  • 13
    • 80155184068 scopus 로고    scopus 로고
    • Generation of a mouse model of Von Hippel-Lindau kidney disease leading to renal cancers by expression of a constitutively active mutant of HIF1a
    • Fu L, Wang G, Shevchuk MM, Nanus DM, Gudas LJ. Generation of a mouse model of Von Hippel-Lindau kidney disease leading to renal cancers by expression of a constitutively active mutant of HIF1a. Cancer Res 2011;71:6848-56.
    • (2011) Cancer Res , vol.71 , pp. 6848-56
    • Fu, L.1    Wang, G.2    Shevchuk, M.M.3    Nanus, D.M.4    Gudas, L.J.5
  • 14
    • 0035394516 scopus 로고    scopus 로고
    • Constitutive activation of hypoxia-inducible genes related to overexpression of hypoxia-inducible factor-1alpha in clear cell renal carcinomas
    • Wiesener MS, Munchenhagen PM, Berger I, Morgan NV, Roigas J, Schwiertz A, et al. Constitutive activation of hypoxia-inducible genes related to overexpression of hypoxia-inducible factor-1alpha in clear cell renal carcinomas. Cancer Res 2001;61:5215-22.
    • (2001) Cancer Res , vol.61 , pp. 5215-22
    • Wiesener, M.S.1    Munchenhagen, P.M.2    Berger, I.3    Morgan, N.V.4    Roigas, J.5    Schwiertz, A.6
  • 15
    • 63849150122 scopus 로고    scopus 로고
    • Hypoxia inducible factor-1alpha correlates with vascular endothelial growth factor a and c indicating worse prognosis in clear cell renal cell carcinoma
    • Dorevic G, Matusan-Ilijas K, Babarovic E, Hadzisejdic I, Grahovac M, Grahovac B, et al. Hypoxia inducible factor-1alpha correlates with vascular endothelial growth factor A and C indicating worse prognosis in clear cell renal cell carcinoma. J Exp Clin Cancer Res 2009;28:40.
    • (2009) J Exp Clin Cancer Res , vol.28 , pp. 40
    • Dorevic, G.1    Matusan-Ilijas, K.2    Babarovic, E.3    Hadzisejdic, I.4    Grahovac, M.5    Grahovac, B.6
  • 16
    • 84856486011 scopus 로고    scopus 로고
    • Renal tubular hif-2alpha expression requires vhl inactivation and causes fibrosis and cysts
    • Schietke RE, Hackenbeck T, Tran M, Gunther R, Klanke B, Warnecke CL, et al. Renal tubular HIF-2alpha expression requires VHL inactivation and causes fibrosis and cysts. PLoS ONE 2012;7:e31034.
    • (2012) PLoS ONE , vol.7
    • Schietke, R.E.1    Hackenbeck, T.2    Tran, M.3    Gunther, R.4    Klanke, B.5    Warnecke, C.L.6
  • 18
    • 84865541692 scopus 로고    scopus 로고
    • Cd31 angiogenesis and combined expression of hif-1alpha and hif-2alpha are prognostic in primary clear-cell renal cell carcinoma (cc-rcc), but hifalpha transcriptional products are not: Implications for antiangiogenic trials and hifalpha biomarker studies in primary cc-rcc
    • Biswas S, Charlesworth PJ, Turner GD, Leek R, Thamboo PT, Campo L, et al. CD31 angiogenesis and combined expression of HIF-1alpha and HIF-2alpha are prognostic in primary clear-cell renal cell carcinoma (CC-RCC), but HIFalpha transcriptional products are not: implications for antiangiogenic trials and HIFalpha biomarker studies in primary CC-RCC. Carcinogenesis 2012;33:1717-25.
    • (2012) Carcinogenesis , vol.33 , pp. 1717-25
    • Biswas, S.1    Charlesworth, P.J.2    Turner, G.D.3    Leek, R.4    Thamboo, P.T.5    Campo, L.6
  • 20
    • 0025367733 scopus 로고
    • Pattern of expression of gamma-glutamyl transpeptidase in rat liver and kidney during development: Study by immunochemistry and in situ hybridization
    • Jacquemin E, Bulle F, Bernaudin JF, Wellman M, Hugon RN, Guellaen G, et al. Pattern of expression of gamma-glutamyl transpeptidase in rat liver and kidney during development: study by immunochemistry and in situ hybridization. J Pediatr Gastroenterol Nutr 1990;11:89-95.
    • (1990) J Pediatr Gastroenterol Nutr , vol.11 , pp. 89-95
    • Jacquemin, E.1    Bulle, F.2    Bernaudin, J.F.3    Wellman, M.4    Hugon, R.N.5    Guellaen, G.6
  • 21
    • 0033942485 scopus 로고    scopus 로고
    • Targeted expression of a dominant-negative egf-r in the kidney reduces tubulo-interstitial lesions after renal injury
    • Terzi F, Burtin M, Hekmati M, Federici P, Grimber G, Briand P, et al. Targeted expression of a dominant-negative EGF-R in the kidney reduces tubulo-interstitial lesions after renal injury. J Clin Invest 2000;106:225-34.
    • (2000) J Clin Invest , vol.106 , pp. 225-34
    • Terzi, F.1    Burtin, M.2    Hekmati, M.3    Federici, P.4    Grimber, G.5    Briand, P.6
  • 22
    • 67649884743 scopus 로고    scopus 로고
    • Fast and accurate short read alignment with burrows- wheeler transform
    • Li H, Durbin R. Fast and accurate short read alignment with Burrows- Wheeler transform. Bioinformatics 2009;25:1754-60.
    • (2009) Bioinformatics , vol.25 , pp. 1754-60
    • Li, H.1    Durbin, R.2
  • 24
    • 33746890815 scopus 로고    scopus 로고
    • Cd70 (tnfsf7) is expressed at high prevalence in renal cell carcinomas and is rapidly internalised on antibody binding
    • Adam PJ, Terrett JA, Steers G, Stockwin L, Loader JA, Fletcher GC, et al. CD70 (TNFSF7) is expressed at high prevalence in renal cell carcinomas and is rapidly internalised on antibody binding. Br J Cancer 2006;95:298-306.
    • (2006) Br J Cancer , vol.95 , pp. 298-306
    • Adam, P.J.1    Terrett, J.A.2    Steers, G.3    Stockwin, L.4    Loader, J.A.5    Fletcher, G.C.6
  • 27
    • 84870352830 scopus 로고    scopus 로고
    • Distinctive features of the differentiated phenotype and infiltration of tumor-reactive lymphocytes in clear cell renal cell carcinoma
    • Wang QJ, Hanada KI, Robbins PF, Li YF, Yang JC. Distinctive features of the differentiated phenotype and infiltration of tumor-reactive lymphocytes in clear cell renal cell carcinoma. Cancer Res 2012;72: 6119-29.
    • (2012) Cancer Res , vol.72 , pp. 6119-29
    • Wang, Q.J.1    Hanada, K.I.2    Robbins, P.F.3    Li, Y.F.4    Yang, J.C.5
  • 29
    • 0141919448 scopus 로고    scopus 로고
    • Genomic instability and cancer
    • Charames GS, Bapat B. Genomic instability and cancer. Curr Mol Med 2003;3:589-96.
    • (2003) Curr Mol Med , vol.3 , pp. 589-96
    • Charames, G.S.1    Bapat, B.2
  • 30
    • 0033021437 scopus 로고    scopus 로고
    • Genetic instability and the mutator phenotype. Studies in ulcerative colitis
    • Loeb KR, Loeb LA. Genetic instability and the mutator phenotype. Studies in ulcerative colitis. Am J Pathol 1999;154:1621-6.
    • (1999) Am J Pathol , vol.154 , pp. 1621-6
    • Loeb, K.R.1    Loeb, L.A.2
  • 31
    • 0033984235 scopus 로고    scopus 로고
    • The ki-67 protein: From the known and the unknown
    • Scholzen T, Gerdes J. The Ki-67 protein: from the known and the unknown. J Cell Physiol 2000;182:311-22.
    • (2000) J Cell Physiol , vol.182 , pp. 311-22
    • Scholzen, T.1    Gerdes, J.2
  • 32
    • 0034671768 scopus 로고    scopus 로고
    • Phosphorylation-dependent regulation of cyclin d1 nuclear export and cyclin d1-dependent cellular transformation
    • Alt JR, Cleveland JL, Hannink M, Diehl JA. Phosphorylation-dependent regulation of cyclin D1 nuclear export and cyclin D1-dependent cellular transformation. Gen Dev 2000;14:3102-14.
    • (2000) Gen Dev , vol.14 , pp. 3102-14
    • Alt, J.R.1    Cleveland, J.L.2    Hannink, M.3    Diehl, J.A.4
  • 34
    • 66349100709 scopus 로고    scopus 로고
    • Patterns of gene expression and copy-number alterations in von- Hippel Lindau disease-associated and sporadic clear cell carcinoma of the kidney
    • Beroukhim R, Brunet JP, Di Napoli A, Mertz KD, Seeley A, Pires MM, et al. Patterns of gene expression and copy-number alterations in von- Hippel Lindau disease-associated and sporadic clear cell carcinoma of the kidney. Cancer Res 2009;69:4674-81.
    • (2009) Cancer Res , vol.69 , pp. 4674-81
    • Beroukhim, R.1    Brunet, J.P.2    Di Napoli, A.3    Mertz, K.D.4    Seeley, A.5    Pires, M.M.6
  • 35
    • 34548071005 scopus 로고    scopus 로고
    • Secreted frizzled-related protein 1 loss contributes to tumor phenotype of clear cell renal cell carcinoma
    • Gumz ML, Zou H, Kreinest PA, Childs AC, Belmonte LS, LeGrand SN, et al. Secreted frizzled-related protein 1 loss contributes to tumor phenotype of clear cell renal cell carcinoma. Clin Cancer Res 2007;13:4740-9.
    • (2007) Clin Cancer Res , vol.13 , pp. 4740-9
    • Gumz, M.L.1    Zou, H.2    Kreinest, P.A.3    Childs, A.C.4    Belmonte, L.S.5    LeGrand, S.N.6
  • 36
    • 3042752912 scopus 로고    scopus 로고
    • Previously unidentified changes in renal cell carcinoma gene expression identified by parametric analysis of microarray data
    • Lenburg ME, Liou LS, Gerry NP, Frampton GM, Cohen HT, Christman MF. Previously unidentified changes in renal cell carcinoma gene expression identified by parametric analysis of microarray data. BMC Cancer 2003;3:31.
    • (2003) BMC Cancer , vol.3 , pp. 31
    • Lenburg, M.E.1    Liou, L.S.2    Gerry, N.P.3    Frampton, G.M.4    Cohen, H.T.5    Christman, M.F.6
  • 37
    • 66749104378 scopus 로고    scopus 로고
    • High-resolution dna copy number and gene expression analyses distinguish chromophobe renal cell carcinomas and renal oncocytomas
    • Yusenko MV, Kuiper RP, Boethe T, Ljungberg B, van Kessel AG, Kovacs G. High-resolution DNA copy number and gene expression analyses distinguish chromophobe renal cell carcinomas and renal oncocytomas. BMC Cancer 2009;9:152.
    • (2009) BMC Cancer , vol.9 , pp. 152
    • Yusenko, M.V.1    Kuiper, R.P.2    Boethe, T.3    Ljungberg, B.4    Van Kessel, A.G.5    Kovacs, G.6
  • 38
    • 0033456260 scopus 로고    scopus 로고
    • The mainz classification of renal cell tumors
    • Diaz JI, Mora LB, Hakam A. The Mainz classification of renal cell tumors. Cancer Control 1999;6:571-9.
    • (1999) Cancer Control , vol.6 , pp. 571-9
    • Diaz, J.I.1    Mora, L.B.2    Hakam, A.3
  • 39
    • 0344063368 scopus 로고    scopus 로고
    • Oct-3/4 is a dose-dependent oncogenic fate determinant
    • Gidekel S, Pizov G, Bergman Y, Pikarsky E. Oct-3/4 is a dose-dependent oncogenic fate determinant. Cancer Cell 2003;4:361-70.
    • (2003) Cancer Cell , vol.4 , pp. 361-70
    • Gidekel, S.1    Pizov, G.2    Bergman, Y.3    Pikarsky, E.4
  • 40
    • 56849096837 scopus 로고    scopus 로고
    • Hif-alpha effects on c-myc distinguish two subtypes of sporadic vhl-deficient clear cell renal carcinoma
    • Gordan JD, Lal P, Dondeti VR, Letrero R, Parekh KN, Oquendo CE, et al. HIF-alpha effects on c-Myc distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinoma. Cancer Cell 2008;14:435-46.
    • (2008) Cancer Cell , vol.14 , pp. 435-46
    • Gordan, J.D.1    Lal, P.2    Dondeti, V.R.3    Letrero, R.4    Parekh, K.N.5    Oquendo, C.E.6
  • 41
    • 40949088476 scopus 로고    scopus 로고
    • Biology of hypoxia-inducible factor-2alpha in development and disease
    • Patel SA, Simon MC. Biology of hypoxia-inducible factor-2alpha in development and disease. Cell Death Differ 2008;15:628-34.
    • (2008) Cell Death Differ , vol.15 , pp. 628-34
    • Patel, S.A.1    Simon, M.C.2
  • 42
    • 33644747418 scopus 로고    scopus 로고
    • Hif- 2alpha regulates oct-4: Effects of hypoxia on stem cell function, embryonic development, and tumor growth
    • Covello KL, Kehler J, Yu H, Gordan JD, Arsham AM, Hu CJ, et al. HIF- 2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth.Gen Dev 2006;20:557-70.
    • (2006) Gen Dev , vol.20 , pp. 557-70
    • Covello, K.L.1    Kehler, J.2    Yu, H.3    Gordan, J.D.4    Arsham, A.M.5    Hu, C.J.6
  • 43
    • 33749451610 scopus 로고    scopus 로고
    • Molecular pathways in renal cell carcinoma- rationale for targeted treatment
    • Kim WY, Kaelin WG Jr. Molecular pathways in renal cell carcinoma- rationale for targeted treatment. Semin Oncol 2006;33:588-95.
    • (2006) Semin Oncol , vol.33 , pp. 588-95
    • Kim, W.Y.1    Kaelin Jr., W.G.2
  • 44
    • 0015322583 scopus 로고
    • Renal tubular antigens in kidney tumors
    • Wallace AC, Nairn RC. Renal tubular antigens in kidney tumors. Cancer 1972;29:977-81.
    • (1972) Cancer , vol.29 , pp. 977-81
    • Wallace, A.C.1    Nairn, R.C.2
  • 45
    • 0022531221 scopus 로고
    • Proximal renal tubular surface membrane antigens identified in primary and metastatic renal cell carcinomas
    • Yoshida SO, Imam A, Olson CA, Taylor CR. Proximal renal tubular surface membrane antigens identified in primary and metastatic renal cell carcinomas. Arch Pathol Lab Med 1986;110:825-32.
    • (1986) Arch Pathol Lab Med , vol.110 , pp. 825-32
    • Yoshida, S.O.1    Imam, A.2    Olson, C.A.3    Taylor, C.R.4
  • 46
    • 17044452288 scopus 로고    scopus 로고
    • Hif activation identifies early lesions in vhl kidneys: Evidence for site-specific tumor suppressor function in the nephron
    • Mandriota SJ, Turner KJ, Davies DR, Murray PG, Morgan NV, Sowter HM, et al. HIF activation identifies early lesions in VHL kidneys: evidence for site-specific tumor suppressor function in the nephron. Cancer Cell 2002;1:459-68.
    • (2002) Cancer Cell , vol.1 , pp. 459-68
    • Mandriota, S.J.1    Turner, K.J.2    Davies, D.R.3    Murray, P.G.4    Morgan, N.V.5    Sowter, H.M.6


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