An association study of suicide and candidate genes in the serotonergic system

Journal of Affective Disorders

Volumn 148, Issue 2-3, 2013, Pages 291-298

  Buttenschøn, Henriette N ^a,b   Flint, Tracey J ^a   Foldager, Leslie ^a,b,c   Qin, Ping ^c   Christoffersen, Søren ^d   Hansen, Nikolaj F ^e   Kristensen, Ingrid B ^c   Mortensen, Preben B ^b,c   Børglum, Anders D ^a,b,c   Mors, Ole ^a,b  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b Aarhus   (Denmark)

^c AARHUS UNIVERSITY   (Denmark)

^d UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^e UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Association; Genetics; Monoamine; Serotonin; Suicide; Tryptophan

Indexed keywords

AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; SEROTONIN TRANSPORTER; TRYPTOPHAN HYDROXYLASE; TRYPTOPHAN HYDROXYLASE 1; TRYPTOPHAN HYDROXYLASE 2; UNCLASSIFIED DRUG;

ADULT; AGE; ALLELE; ARTICLE; AUTOPSY; CASE CONTROL STUDY; CONTROLLED STUDY; DENMARK; FEMALE; GENETIC ASSOCIATION; GENETIC MARKER; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SEX DIFFERENCE; SUICIDE;

ADULT; AGE FACTORS; AGED; ALLELES; CASE-CONTROL STUDIES; DENMARK; FEMALE; GENETIC MARKERS; HUMANS; MALE; MIDDLE AGED; MONOAMINE OXIDASE; RISK FACTORS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SUICIDE; TRYPTOPHAN HYDROXYLASE;

EID: 84877716914     PISSN: 01650327     EISSN: 15732517     Source Type: Journal    
DOI: 10.1016/j.jad.2012.12.011     Document Type: Article

References (64)

1. J.C. Alvarez, D. Cremniter, N. Gluck, P. Quintin, M. Leboyer, I. Berlin, P. Therond, and O. Spreux-Varoquaux Low serum cholesterol in violent but not in non-violent suicide attempters Psychiatric Research 95 2 2000 103 108
2. G. Arsenault-Lapierre, C. Kim, and G. Turecki Psychiatric diagnoses in 3275 suicides: a meta-analysis BMC. Psychiatry 4 2004 37
3. S. Augui, E.P. Nora, and E. Heard Regulation of X-chromosome inactivation by the X-inactivation centre Nature Reviews Genetic 12 6 2011 429 442
4. P.J. Bennett, W.M. McMahon, J. Watabe, J. Achilles, M. Bacon, H. Coon, T. Grey, T. Keller, D. Tate, I. Tcaciuc, J. Workman, and D. Gray Tryptophan hydroxylase polymorphisms in suicide victims Psychiatric Genetics 10 1 2000 13 17
5. D.A. Brent, J. Bridge, B.A. Johnson, and J. Connolly Suicidal behavior runs in families. A controlled family study of adolescent suicide victims Archives of General Psychiatry 53 12 1996 1145 1152
6. L. Carrel, and H.F. Willard X-inactivation profile reveals extensive variability in X-linked gene expression in females Nature 434 7031 2005 400 404
7. K.H. Chung, H.C. Lee, S. Kao, and H.C. Lin Urbanicity and methods of suicide: a nationwide population-based study Journal of Urban Health 85 1 2008 136 145
8. D. Clayton Testing for association on the X chromosome Biostatistics 9 4 2008 593 600
9. D.G. Clayton Sex chromosomes and genetic association studies Genome Medicine 1 11 2009 110
10. P. Courtet, P. Baud, M. Abbar, J.P. Boulenger, D. Castelnau, D. Mouthon, A. Malafosse, and C. Buresi Association between violent suicidal behavior and the low activity allele of the serotonin transporter gene Molecular Psychiatry 6 3 2001 338 341
11. P. Courtet, F. Jollant, C. Buresi, D. Castelnau, D. Mouthon, and A. Malafosse The monoamine oxidase A gene may influence the means used in suicide attempts Psychiatric Genetics 15 3 2005 189 193
12. W.L. Coventry, M.R. James, L.J. Eaves, S.D. Gordon, N.A. Gillespie, L. Ryan, A.C. Heath, G.W. Montgomery, N.G. Martin, and N.R. Wray Do 5HTTLPR and stress interact in risk for depression and suicidality? Item response analyses of a large sample American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 153B 3 2010 757 765
13. V. De Luca, S. Tharmalingam, D.J. Muller, G. Wong, B.A. de, and J.L. Kennedy Gene-gene interaction between MAOA and COMT in suicidal behavior: analysis in schizophrenia Brain Research 1097 1 2006 26 30
14. V. De Luca, S. Tharmalingam, T. Sicard, and J.L. Kennedy Gene-gene interaction between MAOA and COMT in suicidal behavior Neuroscience Letters 383 1-2 2005 151 154
15. V. De Luca, G. Zai, S. Tharmalingam, B.A. de, G. Wong, and J.L. Kennedy Association study between the novel functional polymorphism of the serotonin transporter gene and suicidal behaviour in schizophrenia European Neuropsychopharmacology 16 4 2006 268 271
16. J. Deckert, M. Catalano, Y.V. Syagailo, M. Bosi, O. Okladnova, B.D. Di, M.M. Nothen, P. Maffei, P. Franke, J. Fritze, W. Maier, P. Propping, H. Beckmann, L. Bellodi, and K.P. Lesch Excess of high activity monoamine oxidase A gene promoter alleles in female patients with panic disorder Human Molecular Genetics 8 4 1999 621 624
17. R.A. Furlong, L. Ho, J.S. Rubinsztein, C. Walsh, E.S. Paykel, and D.C. Rubinsztein Analysis of the monoamine oxidase A (MAOA) gene in bipolar affective disorder by association studies, meta-analyses, and sequencing of the promoter American Journal of Medical Genetics 88 4 1999 398 406
18. T. Geijer, A. Frisch, M.L. Persson, D. Wasserman, R. Rockah, E. Michaelovsky, A. Apter, E.G. Jonsson, M.M. Nothen, and A. Weizman Search for association between suicide attempt and serotonergic polymorphisms Psychiatric Genetics 10 1 2000 19 26
19. X. Gonda, K.N. Fountoulakis, J. Harro, M. Pompili, H.S. Akiskal, G. Bagdy, and Z. Rihmer The possible contributory role of the S allele of 5-HTTLPR in the emergence of suicidality Journal of Psychopharmacology 25 7 2011 857 866
20. Health Law no. 546 (2005) The Danish Government section XIII (§179 and § 184).
21. A. Heils, A. Teufel, S. Petri, G. Stober, P. Riederer, D. Bengel, and K.P. Lesch Allelic variation of human serotonin transporter gene expression Journal of Neurochemistry 66 6 1996 2621 2624
22. P. Heuveline, and G.B. Slap Adolescent and young adult mortality by cause: age, gender, and country, 1955 to 1994 Journal of Adolescent Health 30 1 2002 29 34
23. L.W. Ho, R.A. Furlong, J.S. Rubinsztein, C. Walsh, E.S. Paykel, and D.C. Rubinsztein Genetic associations with clinical characteristics in bipolar affective disorder and recurrent unipolar depressive disorder American Journal of Medical Genetics 96 1 2000 36 42
24. X.Z. Hu, R.H. Lipsky, G. Zhu, L.A. Akhtar, J. Taubman, B.D. Greenberg, K. Xu, P.D. Arnold, M.A. Richter, J.L. Kennedy, D.L. Murphy, and D. Goldman Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder American Journal of Human Genetics 78 5 2006 815 826
25. Y.Y. Huang, S.P. Cate, C. Battistuzzi, M.A. Oquendo, D. Brent, and J.J. Mann An association between a functional polymorphism in the monoamine oxidase a gene promoter, impulsive traits and early abuse experiences Neuropsychopharmacology 29 8 2004 1498 1505
26. C.F. Hung, F.W. Lung, C.H. Chen, E. O'Nions, T.H. Hung, M.Y. Chong, C.K. Wu, J.K. Wen, and P.Y. Lin Association between suicide attempt and a tri-allelic functional polymorphism in serotonin transporter gene promoter in Chinese patients with schizophrenia Neuroscience Letters 504 3 2011 242 246
27. C.F. Hung, F.W. Lung, T.H. Hung, M.Y. Chong, C.K. Wu, J.K. Wen, and P.Y. Lin Monoamine oxidase A gene polymorphism and suicide: an association study and meta-analysis Journal of Affective Disorders 2011
28. J. Joo, M. Kwak, K. Ahn, and G. Zheng A robust genome-wide scan statistic of the Wellcome Trust Case-Control Consortium Biometrics 65 4 2009 1115 1122
29. J.T. Judy, F. Seifuddin, P.B. Mahon, Y. Huo, F.S. Goes, D. Jancic, B. Schweizer, F.M. Mondimore, D.F. Mackinnon, J.R. Depaulo Jr,; E.S. Gershon, F.J. McMahon, D.J. Cutler, P.P. Zandi, J.B. Potash, and V.L. Willour Association study of serotonin pathway genes in attempted suicide American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 159 1 2012 112 119
30. J.B. Kraft, S.L. Slager, P.J. McGrath, and S.P. Hamilton Sequence analysis of the serotonin transporter and associations with antidepressant response Biological Psychiatry 58 5 2005 374 381
31. D. Li, and L. He Meta-analysis supports association between serotonin transporter (5-HTT) and suicidal behavior Molecular Psychiatry 12 1 2007 47 54
32. D. Li, and L. He Further clarification of the contribution of the tryptophan hydroxylase (TPH) gene to suicidal behavior using systematic allelic and genotypic meta-analyses Human Genetics 119 3 2006 233 240
33. F.W. Lung, D.S. Tzeng, M.F. Huang, and M.B. Lee Association of the MAOA promoter uVNTR polymorphism with suicide attempts in patients with major depressive disorder BMC Medical Genetics 12 2011 74
34. D. Marcinko, M. Martinac, D. Karlovic, I. Filipcic, C. Loncar, N. Pivac, and M. Jakovljevic Are there differences in serum cholesterol and cortisol concentrations between violent and non-violent schizophrenic male suicide attempters? Collegium Antropologicum 29 1 2005 153 157
35. O. Mors, G.P. Perto, and P.B. Mortensen The Danish Psychiatric Central Research Register Scandinavian Journal of Public Health 39 7 Suppl 2011 54 57
36. F.S. Neves, L.F. Malloy-Diniz, M.A. Romano-Silva, G.C. Aguiar, L.O. de Matos, and H. Correa Is the serotonin transporter polymorphism (5-HTTLPR) a potential marker for suicidal behavior in bipolar disorder patients? Journal of Affective Disorders 125 1-3 2010 98 102
37. M. Ohtani, S. Shindo, and N. Yoshioka Polymorphisms of the tryptophan hydroxylase gene and serotonin 1A receptor gene in suicide victims among Japanese Tohoku Journal of Experimental Medicine 202 2 2004 123 133
38. H. Ono, O. Shirakawa, N. Nishiguchi, A. Nishimura, H. Nushida, Y. Ueno, and K. Maeda No evidence of an association between a functional monoamine oxidase a gene polymorphism and completed suicides American Journal of Medical Genetics 114 3 2002 340 342
39. H. Ono, O. Shirakawa, N. Nishiguchi, A. Nishimura, H. Nushida, Y. Ueno, and K. Maeda Tryptophan hydroxylase gene polymorphisms are not associated with suicide American Journal of Medical Genetics 96 6 2000 861 863
40. R.V. Parsey, R.S. Hastings, M.A. Oquendo, X. Hu, D. Goldman, Y.Y. Huang, N. Simpson, J. Arcement, Y. Huang, R.T. Ogden, R.L. Van Heertum, V. Arango, and J.J. Mann Effect of a triallelic functional polymorphism of the serotonin-transporter-linked promoter region on expression of serotonin transporter in the human brain American Journal of Psychiatry 163 1 2006 48 51
41. C.B. Pedersen, H. Gotzsche, J.O. Moller, and P.B. Mortensen The Danish Civil Registration System. A cohort of eight million persons Danish Medical Bulletin 2006 53 2006 441 449
42. R.H. Perlis, J. Huang, S. Purcell, M. Fava, A.J. Rush, P.F. Sullivan, S.P. Hamilton, F.J. McMahon, T.G. Schulze, J.B. Potash, P.P. Zandi, V.L. Willour, B.W. Penninx, D.I. Boomsma, N. Vogelzangs, C.M. Middeldorp, M. Rietschel, M. Nothen, S. Cichon, H. Gurling, N. Bass, A. McQuillin, M. Hamshere, N. Craddock, P. Sklar, and J.W. Smoller Genome-wide association study of suicide attempts in mood disorder patients American Journal of Psychiatry 167 12 2010 1499 1507
43. N. Perroud, A. Salzmann, P.A. Saiz, E. Baca-Garcia, M. Sarchiapone, M.P. Garcia-Portilla, V. Carli, C. Vaquero-Lorenzo, I. Jaussent, D. Mouthon, M. Vessaz, P. Huguelet, P. Courtet, and A. Malafosse Rare genotype combination of the serotonin transporter gene associated with treatment response in severe personality disorder American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 153B 8 2010 1494 1497
44. J.K. Pinsonneault, A.C. Papp, and W. Sadee Allelic mRNA expression of X-linked monoamine oxidase a (MAOA) in human brain: dissection of epigenetic and genetic factors Human Molecular Genetics 15 17 2006 2636 2649
45. P. Qin The impact of psychiatric illness on suicide: differences by diagnosis of disorders and by sex and age of subjects Journal of Psychiatric Research 45 11 2011 1445 1452
46. A. Roy, N.L. Segal, B.S. Centerwall, and C.D. Robinette Suicide in twins Archives of General Psychiatry 48 1 1991 29 32
47. A. Roy, N.L. Segal, and M. Sarchiapone Attempted suicide among living co-twins of twin suicide victims American Journal of Psychiatry 152 7 1995 1075 1076
48. D. Rujescu, I. Giegling, T. Sato, and H.J. Moeller A polymorphism in the promoter of the serotonin transporter gene is not associated with suicidal behavior Psychiatric Genetics 11 3 2001 169 172
49. S.Z. Sabol, S. Hu, and D. Hamer A functional polymorphism in the monoamine oxidase A gene promoter Human Genetics 103 3 1998 273 279
50. P. Saetre, P. Lundmark, T. Hansen, H.B. Rasmussen, S. Djurovic, I. Melle, O.A. Andreassen, T. Werge, I. Agartz, H. Hall, L. Terenius, and E.G. Jonsson The tryptophan hydroxylase 1 (TPH1) gene, schizophrenia susceptibility, and suicidal behavior: a multi-centre case-control study and meta-analysis American Journal of Medical Genetics B Neuropsychiatric Genetics 153B 2 2010 387 396
51. A. Schosser, A.W. Butler, M. Ising, N. Perroud, R. Uher, M.Y. Ng, S. Cohen-Woods, N. Craddock, M.J. Owen, A. Korszun, L. Jones, I. Jones, M. Gill, J.P. Rice, W. Maier, O. Mors, M. Rietschel, S. Lucae, E.B. Binder, M. Preisig, J. Perry, F. Tozzi, P. Muglia, K.J. Aitchison, G. Breen, I.W. Craig, A.E. Farmer, B. Muller-Myhsok, P. McGuffin, and C.M. Lewis Genomewide association scan of suicidal thoughts and behaviour in major depression PLoS One 6 7 2011 e20690
52. J. Segal, C. Pujol, A. Birck, M.G. Gus, and S. Leistner-Segal Association between suicide attempts in south Brazilian depressed patients with the serotonin transporter polymorphism Psychiatry Research 143 2-3 2006 289 291
53. J. Segal, L.C. Schenkel, M.H. Oliveira, G.A. Salum, C.H. Bau, G.G. Manfro, and S. Leistner-Segal Novel allelic variants in the human serotonin transporter gene linked polymorphism (5-HTTLPR) among depressed patients with suicide attempt Neuroscience Letters 451 1 2009 79 82
54. Y. Shen, H. Li, N. Gu, Z. Tan, J. Tang, J. Fan, X. Li, W. Sun, and L. He Relationship between suicidal behavior of psychotic inpatients and serotonin transporter gene in Han Chinese Neuroscience Letters 372 1-2 2004 94 98
55. J. Stefulj, M. Kubat, M. Balija, J. Skavic, and B. Jernej Variability of the tryptophan hydroxylase gene: study in victims of violent suicide Psychiatry Research 134 1 2005 67 73
56. S.J. Tsai, C.J. Hong, and Y.J. Liou Recent molecular genetic studies and methodological issues in suicide research Progress in Neuro-psychopharmacology and Biological Psychiatry 35 4 2011 809 817
57. G. Turecki Suicidal behavior: is there a genetic predisposition? Bipolar Disorders 3 6 2001 335 349
58. G. Turecki, Z. Zhu, J. Tzenova, A. Lesage, M. Seguin, M. Tousignant, N. Chawky, C. Vanier, O. Lipp, M. Alda, R. Joober, C. Benkelfat, and G.A. Rouleau TPH and suicidal behavior: a study in suicide completers Molecular Psychiatry 6 1 2001 98 102
59. M.M. Viana, L.A. De Marco, W.L. Boson, M.A. Romano-Silva, and H. Correa Investigation of A218C tryptophan hydroxylase polymorphism: association with familial suicide behavior and proband's suicide attempt characteristics Genes, Brain and Behavior 5 4 2006 340 345
60. M. Voracek, and L.M. Loibl Genetics of suicide: a systematic review of twin studies Wiener klinische Wochenschrift 119 15-16 2007 463 475
61. Wellcome Trust Case Control Consortium (WTCCC) Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls Nature 447 7145 2007 661 678
62. V.L. Willour, F. Seifuddin, P.B. Mahon, D. Jancic, M. Pirooznia, J. Steele, B. Schweizer, F.S. Goes, F.M. Mondimore, D.F. Mackinnon, R.H. Perlis, P.H. Lee, J. Huang, J.R. Kelsoe, P.D. Shilling, M. Rietschel, M. Nothen, S. Cichon, H. Gurling, S. Purcell, J.W. Smoller, N. Craddock, J.R. Depaulo Jr,; T.G. Schulze, F.J. McMahon, P.P. Zandi, and J.B. Potash A genome-wide association study of attempted suicide Molecular Psychiatry 17 4 2012 433 444
63. G. Zheng, J. Joo, and Y. Yang Pearson's test, trend test, and MAX are all trend tests with different types of scores Annals of Human Genetics 73 2 2009 133 140
64. P. Zill, A. Buttner, W. Eisenmenger, H.J. Moller, B. Bondy, and M. Ackenheil Single nucleotide polymorphism and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene in suicide victims Biological Psychiatry 56 8 2004 581 586