Gene-gene interaction between MAOA and COMT in suicidal behavior: Analysis in schizophrenia

Brain Research

Volumn 1097, Issue 1, 2006, Pages 26-30

  De Luca, Vincenzo ^a,b   Tharmalingam, Subi ^a   Müller, Daniel J ^a,c   Wong, Greg ^a   de Bartolomeis, Andrea ^b   Kennedy, James L ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

COMT; Genetics; MAOA; Norepinephrine; Parasuicide; Schizophrenia

Indexed keywords

AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; CATECHOL METHYLTRANSFERASE; METHIONINE; VALINE;

3' UNTRANSLATED REGION; ADULT; ARTICLE; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; GENE EXPRESSION; GENE INTERACTION; GENETIC EPISTASIS; GENOTYPE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROMOTER REGION; RISK ASSESSMENT; RISK FACTOR; SCHIZOPHRENIA; STATISTICAL SIGNIFICANCE; SUICIDAL BEHAVIOR; SUICIDE ATTEMPT;

ADULT; CATECHOL O-METHYLTRANSFERASE; FEMALE; HAPLOTYPES; HUMANS; MALE; MIDDLE AGED; MONOAMINE OXIDASE; POLYMORPHISM, GENETIC; SCHIZOPHRENIA; SUICIDE, ATTEMPTED;

EID: 33745997393     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2006.04.053     Document Type: Article

References (29)

1. Arango V., Ernsberger P., Sved A.F., and Mann J.J. Quantitative autoradiography of alpha 1- and alpha 2-adrenergic receptors in the cerebral cortex of controls and suicide victims. Brain Res. 630 (1993) 271-282
2. Cases O., Seif I., Grimsby J., Gaspar P., Chen K., Pournin S., Muller U., Aguet M., Babinet C., and Shih J.C. Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA. Science 268 (1995) 1763-1766
3. Caspi A., McClay J., Moffitt T.E., Mill J., Martin J., Craig I.W., Taylor A., and Poulton R. Role of genotype in the cycle of violence in maltreated children. Science 297 (2002) 851-854
4. Caldwell C.B., and Gottesman I.I. Schizophrenia-a high-risk factor for suicide: clues to risk reduction. Suicide Life-Threat. Behav. 22 (1992) 479-493
5. Chen J., Lipska B.K., Halim N., Ma Q.D., Matsumoto M., Melhem S., Kolachana B.S., Hyde T.M., Herman M.M., Apud J., Egan M.F., Kleinman J.E., and Weinberger D.R. Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain. Am. J. Hum. Genet. 75 (2004) 807-821
6. Deckert J., Catalano M., Syagailo Y.V., Bosi M., Okladnova O., DiBella D., Nothen M.M., Maffei P., Franke P., Fritze J., Maier W., Propping P., Beckmann H., Bellodi L., and Lesch K.P. Excess of high activity monoamine oxidase A gene promoter alleles in female patients with panic disorder. Hum. Mol. Genet. 8 (1999) 621-624
7. De Luca V., Tharmalingam S., Sicard T., and Kennedy J.L. Gene-gene interaction between MAOA and COMT in suicidal behavior. Neurosci. Lett. 383 (2005) 151-154
8. De Mille M.M., Kidd J.R., Ruggeri V., Palmatier M.A., Goldman D., Odunsi A., Okonofua F., Grigorenko E., Schulz L.O., Bonne-Tamir B., Lu R.B., Parnas J., Pakstis A.J., and Kidd K.K. Population variation in link age disequilibrium across the COMT gene considering promoter region and coding region variation. Hum. Genet. 111 (2002) 521-537
9. Du L., Faludi G., Palkovits M., Sotonyi P., Bakish D., and Hrdina P.D. High activity-related allele of MAO-A gene associated with depressed suicide in males. NeuroReport 13 (2002) 1195-1198
10. Dudbridge F. Pedigree disequilibrium tests for multilocus haplotypes. Genet. Epidemiol. 25 (2003) 115-121
11. Eisenhofer G., and Finberg J.P. Different metabolism of norepinephrine and epinephrine by catechol-O-methyltransferase and monoamine oxidase in rats. J. Pharmacol. Exp. Ther. 268 (1994) 1242-1251
12. Ekblom S., Aquilonius S.M., and Jossan S.S. Differential increases in catecholamine metabolizing enzymes in amyotrophic. Lateral Sclerosis Exp. Neurol. 123 (1993) 289-294
13. First M.B., Spitzer R.I., Gibbon M., and Williams J.B.W. Structured Clinical Interview for DSM-IV Axis I Disorders-Clinical Version (SCID-CV) (1997), American Press, Washington, DC 18
14. Hedges L.V., Olkin I., and Ingram O. Statistical methods for meta-analysis (1985), Academic Press, London 39
15. Huang Y.Y., Cate S.P., Battistuzzi C., Oquendo M.A., Brent D., and Mann J.J. An association between a functional polymorphism in the monoamine oxidase a gene promoter, impulsive traits and early abuse experiences. Neuropsychopharmacology 29 (2004) 1498-1505
16. Jones J.S., Stanley B., Mann J.J., Frances A.J., Guido J.R., Traskman-Bendz L., Winchel R., Brown R.P., and Stanley M. CSF 5-HIAA and HVA concentrations in elderly depressed patients who attempted suicide. Am. J. Psychiatry 147 (1990) 1225-1227
17. Kunugi H., Vallada H.P., Sham P.C., Hoda F., Arranz M.J., Li T., Nanko S., Murray R.M., McGuffin P., Owen M., Gill M., and Collier D.A. Catechol-O-methyltransferase polymorphisms and schizophrenia: a transmission disequilibrium study in multiply affected families. Psychiatr. Genet. 7 (1997) 97-101
18. Lachman H.M., Papolos D.F., Saito T., Yu Y.M., Szumlanski C.L., and Weinshilboum R.M. Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders. Pharmacogenetics 6 (1996) 243-250
19. Lahiri D.K., and Nurnberger Jr. J.I. A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studies. Nucleic Acids Res. 19 (1991) 5444
20. Lester D. The concentration of neurotransmitter metabolites in the cerebrospinal fluid of suicidal individuals: a meta-analysis. Pharmacopsychiatry 28 (1995) 45-50
21. Nolan K.A., Volavka J., Czobor P., Cseh A., Lachman H., Saito T., Tiihonen J., Putkonen A., Hallikainen T., Kotilainen I., Rasanen P., Isohanni M., Jarvelin M.R., and Karvonen M.K. Suicidal behavior in patients with schizophrenia is related to COMT polymorphism. Psychiatr. Genet. 10 (2000) 117-124
22. Persson M.L., Wasserman D., Geijer T., Jonsson E.G., and Terenius L. Tyrosine hydroxylase allelic distribution in suicide attempters. Psychiatry Res. 72 (1997) 73-80
23. Powell J., Geddes J., Deeks J., Goldacre M., and Hawton K. Suicide in psychiatric hospital in-patients. Risk factor and their predictive power. Br. J. Psychiatry 176 (2000) 266-272
24. Rydin E., Asberg M., Edman G., and Schalling D. Violent and nonviolent suicide attempts-a controlled Rorschach study. Acta Psychiatr. Scand. 82 (1990) 30-39
25. Roy A. Genetic and biologic risk factors for suicide in depressive disorders. Psychiatr. Q. 64 (1993) 345-358
26. Roy A., Agren H., Pickar D., Linnoila M., Doran A.R., Cutler N.R., and Paul S.M. Reduced CSF concentrations of homovanillic acid and homovanillic acid to 5-hydroxyindoleacetic acid ratios in depressed patients: relationship to suicidal behavior and dexamethasone nonsuppression. Am. J. Psychiatry 143 (1986) 1539-1545
27. Roy A., Nielsen D., Rylander G., Sarchiapone M., and Segal N. Genetics of suicide in depression. J. Clin. Psychiatry 60 Suppl. 2 (1999)
28. Sabol S.Z., Hu S., and Hamer D. A functional polymorphism in the monoamine oxidase A gene promoter. Hum. Genet. 103 (1998) 273-279
29. Sherif F., Marcusson J., and Oreland L. Brain gamma-aminobutyrate transaminase and monoamine oxidase activities in suicide victims. Eur. Arch. Psychiatry Clin. Neurosci. 241 (1991) 139-144