Novel allelic variants in the human serotonin transporter gene linked polymorphism (5-HTTLPR) among depressed patients with suicide attempt

Neuroscience Letters

Volumn 451, Issue 1, 2009, Pages 79-82

  Segal, Jair ^a,b   Schenkel, Laila Cigana ^c   Oliveira, Marcela Herbstrith de ^c   Salum, Giovanni Abrahão ^c   Bau, Claiton Henrique Dotto ^a   Manfro, Gisele Gus ^a,c   Leistner Segal, Sandra ^c  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b Hospital de Pronto Socorro   (Brazil)

^c HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

Author keywords

Depression; Genetics; Serotonin transporter linked promoter region; Suicidal behavior; Suicidality; Triallelic functional polymorphism

Indexed keywords

MESSENGER RNA; SEROTONIN TRANSPORTER;

ADULT; ALLELE; ARTICLE; CONTROLLED STUDY; DEPRESSION; FEMALE; GENE FREQUENCY; GENETIC VARIABILITY; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; SUICIDE ATTEMPT;

ADULT; BRAIN; BRAIN CHEMISTRY; CASE-CONTROL STUDIES; DEPRESSIVE DISORDER; DNA MUTATIONAL ANALYSIS; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENETIC SCREENING; GENETIC VARIATION; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; RNA, MESSENGER; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SUICIDE, ATTEMPTED;

EID: 58249139652     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2008.12.015     Document Type: Article

References (19)

1. Angst J., Angst F., and Stassen H.H. Suicide risk in patients with Major Depressive Disorder. Journal of Clinical Psychiatry 60 Suppl. 2 (1999) 57-62
2. Anguelova M., Benkelfat C., and Turecki G. A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: II. Suicidal behavior. Molecular Psychiatry 8 (2003) 646-653
3. Asberg M., Traskman L., and Thoren P. 5-HIAA in the cerebrospinal fluid. A biochemical suicide predictor?. Archives of General Psychiatry 33 (1976) 1193-1197
4. Beck A.T., Shuyler D., and Herman I. Development of suicidal intent scales. In: Beck A.T. (Ed). The Prediction of Suicide (1974), Charles Press, Philadelphia, PA 45-56
5. Bertolote J.M., and Fleischmann A. Suicide Behavior Prevention: WHO Perspectives on Research. American Journal of Medical Genetics 133C (2005) 8-12
6. De Luca V., Tharmalingan S., King N., Straus J., Bulgin N., and Kennedy J.L. Association study of the serotonin transporter gene in bipolar disorder and suicidal behavior. Psychopharmacology (2005) 1-4
7. Heils A., Teufel A., Petri S., Stober G., Riederer P., Bengel D., and Lesch P. Allelic Variation of Human Serotonin Transporter Gene Expression. Journal of Neurochemistry 66 6 (1996) 2621-2624
8. Lesch K.P., Balling U., Gross J., Strauss K., Wollosin B.L., Murphy D.L., and Riederer P. Organization of the human serotonin transporter gene. Journal of Neural Transmission 95 (1994) 157-162
9. Li D., and He L. Meta-analysis supports association between serotonin transporter (5-HTT) and suicidal behavior. Molecular Psychiatry (2006) 1-8
10. Lin P.-Y., and Tsai G. Association between serotonin transporter gene promoter polymorphism and suicide: result of a meta-analysis. Biological Psychiatry 55 (2004) 1023-1030
11. Mann J.J. The neurobiology of suicide. Nature Medicine 4 (1998) 25-30
12. Miller S.A., Dykes D.D., and Polesky H.S. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acid Research 16 7 (1988) 1215
13. Ministério da Saúde, Organização Pan-Americana de Saúde, Unicamp, Prevenção do Suicídio - Manual dirigido a profissionais de saúde mental, Brasil, 2006.
14. Sheehan D.V., Lecrubier Y., Sheehan K.H., Amorim P., Janavs J., Weiller E., Hergueta T., Baker R., and Dunbar G.C. Mini International Neuropsychiatric Interview (MINI): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. Journal of Clinical Psychiatry 59 Suppl. 20 (1998) 22-23
15. Smoller J.W., Gardner-Schuster E., and Covino J. The genetic basis of panic and phobic anxiety disorders. American Journal of Medical Genetics C Seminar Medical Genetics 148 2 (2008) 118-126
16. World Health Organization www.who.int/entity/mental_health/prevention/suicide/en/suicideprev_gp_port.pdf Prevenção do Suicídio: Um manual para Médicos Clínicos Gerais, Departamento de Saúde Mental, Transtornos Mentais e Comportamentais, Genebra, 2000.
17. Zalsman G., Huang Y., Oquendo M.A., Burke A.K., Hu X., Brent D.A., Ellis S.P., Goldman D., and Mann J.J. Association of a triallelic serotonin transporter gene promoter region (5-HTTLPR) polymorphism with stressful life events and severity of depression. American Journal of Psychiatry 163 (2006) 1588-1593
18. Zembrzuski V.M., Callegari-Jacques S.M., and Hutz M.H. Application of an African Ancestry Index as a genomic control approach in a Brazilian population. Annals of Human Genetics 70 (2006) 822-828
19. Nakamura M., Ueno S., Sano A., and Tanabe H. The human serotonin transporter gene linked polymorphism (5-HTTLPR) shows ten novel allelic variants. Molecular Psychiatry 5 (2000) 32-38