A genome-wide association study of attempted suicide

Molecular Psychiatry

Volumn 17, Issue 4, 2012, Pages 433-444

  Willour, V L ^a   Seifuddin, F ^a   Mahon, P B ^a   Jancic, D ^a   Pirooznia, M ^a   Steele, J ^b   Schweizer, B ^a   Goes, F S ^a   Mondimore, F M ^a   MacKinnon, D F ^a   Perlis, R H ^c   Lee, P H ^c   Huang, J ^c   Kelsoe, J R ^d   Shilling, P D ^d   Rietschel, M ^e,f   Nothen M ^f   Cichon, S ^f,g   Gurling, H ^h   Purcell, S ^c   Smoller, J W ^c   Craddock, N ⁱ   DePaulo Jr , J R ^a   Schulze, T G ^b,j   McMahon, F J ^b   Zandi, P P ^a   Potash, J B ^a   more..

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e CENTRAL INSTITUTE OF MENTAL HEALTH   (Germany)

^f UNIVERSITY OF BONN   (Germany)

^g FORSCHUNGSZENTRUM JÜLICH   (Germany)

^h UNIVERSITY COLLEGE LONDON   (United Kingdom)

ⁱ CARDIFF UNIVERSITY   (United Kingdom)

^j UNIVERSITY OF GÖTTINGEN   (Germany)

more..

Author keywords

2p25; ACP1; lithium; LRRTM4; Wnt

Indexed keywords

ACID PHOSPHATASE; LITHIUM; PROTEIN TYROSINE PHOSPHATASE;

ARTICLE; BIPOLAR DISORDER; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENETIC RISK; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; MENTAL PATIENT; PHENOTYPE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; SUICIDE ATTEMPT; WNT SIGNALING PATHWAY;

BIPOLAR DISORDER; BRAIN; CASE-CONTROL STUDIES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN TYROSINE PHOSPHATASES; PROTO-ONCOGENE PROTEINS; SUICIDE, ATTEMPTED;

EID: 84859001540     PISSN: 13594184     EISSN: 14765578     Source Type: Journal    
DOI: 10.1038/mp.2011.4     Document Type: Article

References (46)

1. Brent DA, Mann JJ. Family genetic studies, suicide, and suicidal behavior. Am J Med Genet C Semin Med Genet 2005; 133C: 13-24. (Pubitemid 40194125)
2. Statham DJ, Heath AC, Madden PA, Bucholz KK, Bierut L, Dinwiddie SH et al. Suicidal behaviour: an epidemiological and genetic study. Psychol Med 1998; 28: 839-855. (Pubitemid 28393563)
3. Brent DA, Oquendo M, Birmaher B, Greenhill L, Kolko D, Stanley B et al. Familial pathways to early-onset suicide attempt: risk for suicidal behavior in offspring of mood-disordered suicide attempters. Arch Gen Psychiatry 2002; 59: 801-807. (Pubitemid 35001145)
4. Glowinski AL, Bucholz KK, Nelson EC, Fu Q, Madden PA, Reich W et al. Suicide attempts in an adolescent female twin sample. J Am Acad Child Adolesc Psychiatry 2001; 40: 1300-1307. (Pubitemid 32995798)
5. Brent DA, Oquendo M, Birmaher B, Greenhill L, Kolko D, Stanley B et al. Peripubertal suicide attempts in offspring of suicide attempters with siblings concordant for suicidal behavior. Am J Psychiatry 2003; 160: 1486-1493. (Pubitemid 41070925)
6. Pfeffer CR, Normandin L, Kakuma T. Suicidal children grow up: suicidal behavior and psychiatric disorders among relatives. J Am Acad Child Adolesc Psychiatry 1994; 33: 1087-1097. (Pubitemid 24296826)
7. Melhem NM, Brent DA, Ziegler M, Iyengar S, Kolko D, Oquendo M et al. Familial pathways to early-onset suicidal behavior: familial and individual antecedents of suicidal behavior. Am J Psychiatry 2007; 164: 1364-1370. (Pubitemid 47461136)
8. Asberg M, Traskman L, Thoren P. 5-HIAA in the cerebrospinal fluid. A biochemical suicide predictor? Arch Gen Psychiatry 1976; 33: 1193-1197.
9. Brezo J, Klempan T, Turecki G. The genetics of suicide: a critical review of molecular studies. Psychiatr Clin North Am 2008; 31: 179-203. (Pubitemid 351551424)
10. Hesselbrock V, Dick D, Hesselbrock M, Foroud T, Schuckit M, Edenberg H et al. The search for genetic risk factors associated with suicidal behavior. Alcohol Clin Exp Res 2004; 28: 70S-76S. (Pubitemid 38658125)
11. Zubenko GS, Maher BS, Hughes HB, Zubenko WN, Scott Stiffler J, Marazita ML. Genome-wide linkage survey for genetic loci that affect the risk of suicide attempts in families with recurrent, early-onset, major depression. Am J Med Genet B Neuropsychiatr Genet 2004; 129B: 47-54. (Pubitemid 38989068)
12. Willour VL, Zandi PP, Badner JA, Steele J, Miao K, Lopez V et al. Attempted suicide in bipolar disorder pedigrees: evidence for linkage to 2p12. Biol Psychiatry 2007; 61: 725-727. (Pubitemid 46343540)
13. Cheng R, Juo SH, Loth JE, Nee J, Iossifov I, Blumenthal R et al. Genome-wide linkage scan in a large bipolar disorder sample from the national institute of mental health genetics initiative suggests putative loci for bipolar disorder, psychosis, suicide, and panic disorder. Mol Psychiatry 2006; 11: 252-260.
14. Sequeira A, Gwadry FG, Ffrench-Mullen JM, Canetti L, Gingras Y, Casero RA et al. Implication of SSAT by gene expression and genetic variation in suicide and major depression. Arch Gen Psychiatry 2006; 63: 35-48. (Pubitemid 43037467)
15. Sequeira A, Klempan T, Canetti L, ffrench-Mullen J, Benkelfat C, Rouleau GA et al. Patterns of gene expression in the limbic system of suicides with and without major depression. Mol Psychiatry 2007; 12: 640-655. (Pubitemid 46998251)
16. Sequeira A, Mamdani F, Ernst C, Vawter MP, Bunney WE, Lebel V et al. Global brain gene expression analysis links glutamatergic and GABAergic alterations to suicide and major depression. PLoS One 2009; 4: e6585.
17. Tochigi M, Iwamoto K, Bundo M, Sasaki T, Kato N, Kato T. Gene expression profiling of major depression and suicide in the prefrontal cortex of postmortem brains. Neurosci Res 2008; 60: 184-191.
18. Kim S, Choi KH, Baykiz AF, Gershenfeld HK. Suicide candidate genes associated with bipolar disorder and schizophrenia: an exploratory gene expression profiling analysis of post-mortem prefrontal cortex. BMC Genomics 2007; 8: 413.
19. Shi J, Levinson DF, Duan J, Sanders AR, Zheng Y, Pe I et al. Common variants on chromosome 6p22.1 are associated with schizophrenia. Nature 2009; 460: 753-757.
20. Ferreira MA, O'Donovan MC, Meng YA, Jones IR, Ruderfer DM, Jones L et al. Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. Nat Genet 2008; 40: 1056-1058.
21. Novick DM, Swartz HA, Frank E. Suicide attempts in bipolar I and bipolar II disorder: a review and meta-analysis of the evidence. Bipolar Disord 2010; 12: 1-9.
22. Nurnberger Jr JI, DePaulo JR, Gershon ES, Reich T, Blehar MC, Edenberg HJ et al. Genomic survey of bipolar illness in the NIMH genetics initiative pedigrees: a preliminary report. Am J Med Genet 1997; 74: 227-237. (Pubitemid 27251220)
23. Smith EN, Bloss CS, Badner JA, Barrett T, Belmonte PL, Berrettini W et al. Genome-wide association study of bipolar disorder in European American and African American individuals. Mol Psychiatry 2009; 14: 755-763.
24. Nurnberger JI, Blehar MC, Kaufmann CA, York-Cooler C, Simpson SG, Harkavy-Friedman J et al. Diagnostic interview for genetic studies. Rationale, unique features, and training. NIMH genetics initiative. Arch Gen Psychiatry 1994; 51: 849-859; discussion 863-4.
25. McMahon FJ, Akula N, Schulze TG, Muglia P, Tozzi F, Detera-Wadleigh SD et al. Meta-analysis of genome-wide association data identifies a risk locus for major mood disorders on 3p21.1. Nat Genet 2010; 42: 128-131.
26. Price AL, Patterson NJ, Plenge RM, Weinblatt ME, Shadick NA, Reich D. Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet 2006; 38: 904-909. (Pubitemid 44141658)
27. Browning BL, Browning SR. A unified approach to genotype imputation and haplotype-phase inference for large data sets of trios and unrelated individuals. Am J Hum Genet 2009; 84: 210-223.
28. Li Y, Willer C, Sanna S, Abecasis G. Genotype imputation. Annu Rev Genomics Hum Genet 2009; 10: 387-406.
29. Dudbridge F, Gusnanto A. Estimation of significance thresholds for genomewide association scans. Genet Epidemiol 2008; 32: 227-234. (Pubitemid 351550369)
30. Ioannidis JP, Thomas G, Daly MJ. Validating, augmenting and refining genome-wide association signals. Nat Rev Genet 2009; 10: 318-329.
31. Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 2007; 81: 559-575. (Pubitemid 47330214)
32. Filmus J, Capurro M, Rast J. Glypicans. Genome Biol 2008; 9: 224.
33. Aoki N, Ito K, Ito M. A novel mouse gene, Sh3yl1, is expressed in the anagen hair follicle. J Invest Dermatol 2000; 114: 1050-1056. (Pubitemid 30252731)
34. Hauge H, Fjelland KE, Sioud M, Aasheim HC. Evidence for the involvement of FAM110C protein in cell spreading and migration. Cell Signal 2009; 21: 1866-1873.
35. Souza AC, Azoubel S, Queiroz KC, Peppelenbosch MP, Ferreira CV. From immune response to cancer: a spot on the low molecular weight protein tyrosine phosphatase. Cell Mol Life Sci 2009; 66: 1140-1153.
36. O'Brien WT, Klein PS. Validating GSK3 as an in vivo target of lithium action. Biochem Soc Trans 2009; 37: 1133-1138.
37. Gould TD, Chen G, Manji HK. In vivo evidence in the brain for lithium inhibition of glycogen synthase kinase-3. Neuropsychopharmacology 2004; 29: 32-38. (Pubitemid 38068011)
38. Wexler EM, Geschwind DH, Palmer TD. Lithium regulates adult hippocampal progenitor development through canonical wnt pathway activation. Mol Psychiatry 2008; 13: 285-292. (Pubitemid 351272655)
39. Taddei ML, Chiarugi P, Cirri P, Buricchi F, Fiaschi T, Giannoni E et al. Beta-catenin interacts with low-molecular-weight protein tyrosine phosphatase leading to cadherin-mediated cell-cell adhesion increase. Cancer Res 2002; 62: 6489-6499. (Pubitemid 35364113)
40. Baca-Garcia E, Perez-Rodriguez MM, Keyes KM, Oquendo MA, Hasin DS, Grant BF et al. Suicidal ideation and suicide attempts in the United States: 1991-1992 and 2001-2002. Mol Psychiatry 2010; 15: 250-259.
41. Hawton K, van Heeringen K. Suicide. Lancet 2009; 373: 1372-1381.
42. Linhoff MW, Laurén J, Cassidy RM, Dobie FA, Takahashi H, Nygaard HB et al. An unbiased expression screen for synaptogenic proteins identifies the LRRTM protein family as synaptic organizers. Neuron 2009; 61: 734-49.
43. Perlis RH, Huang J, Purcell S, Fava M, Rush AJ, Sullivan PF et al., Wellcome Trust Case Control Consortium Bipolar Disorder Group, Craddock N, Sklar P, Smoller JW. Genome-wide association study of suicide attempts in mood disorder patients. Am J Psychiatry 2010; 167: 1499-507.
44. Dick DM, Meyers J, Aliev F, Nurnberger J Jr, Kramer J, Kuperman S et al. Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts. Am J Med Genet B Neuropsychiatr Genet 2010; 153B: 1179-1188.
45. Currier D, Mann JJ. Stress, genes and the biology of suicidal behavior. Psychiatr Clin North Am 2008; 31: 247-269. (Pubitemid 351551422)
46. Angst J, Angst F, Gerber-Werder R, Gamma A. Suicide in 406 mood-disorder patients with and without long-term medication: a 40 to 44 years' follow-up. Arch Suicide Res 2005; 9: 279-300. (Pubitemid 40977549)