메뉴 건너뛰기




Volumn 12, Issue 5, 2013, Pages 519-523

Targeting the hedgehog pathway to treat basal cell carcinoma

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BMS 833923; ITRACONAZOLE; LEQ 506; PF 04449913; SARIDEGIB; SMOOTHENED PROTEIN; SONIC HEDGEHOG PROTEIN; SONIDEGIB; TAK 441; UNCLASSIFIED DRUG; VISMODEGIB;

EID: 84877621042     PISSN: 15459616     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (10)

References (37)
  • 1
    • 84860322847 scopus 로고    scopus 로고
    • A systematic review of worldwide incidence of nonmelanoma skin cancer
    • Lomas A, Leonardi-Bee J, Bath-Hextall F. A systematic review of worldwide incidence of nonmelanoma skin cancer. Br J Dermatol. 2012;166(5):1069-1080.
    • (2012) Br J Dermatol , vol.166 , Issue.5 , pp. 1069-1080
    • Lomas, A.1    Leonardi-Bee, J.2    Bath-Hextall, F.3
  • 2
    • 77949392974 scopus 로고    scopus 로고
    • Prevalence of a history of skin cancer in 2007: Results of an incidence-based model
    • Stern RS. Prevalence of a history of skin cancer in 2007: results of an incidence-based model. Arch Dermatol. 2010;146(3):279-282.
    • (2010) Arch Dermatol , vol.146 , Issue.3 , pp. 279-282
    • Stern, R.S.1
  • 3
    • 0037343249 scopus 로고    scopus 로고
    • Skin cancer is among the most costly of all cancers to treat for the Medicare population
    • Housman TS, Feldman SR, Williford PM, et al. Skin cancer is among the most costly of all cancers to treat for the Medicare population. J Am Acad Dermatol. 2003;48(3):425-429.
    • (2003) J Am Acad Dermatol , vol.48 , Issue.3 , pp. 425-429
    • Housman, T.S.1    Feldman, S.R.2    Williford, P.M.3
  • 5
    • 70349238733 scopus 로고    scopus 로고
    • Inhibition of the hedgehog pathway in advanced basal-cell carcinoma
    • Von Hoff DD, LoRusso PM, Rudin CM, et al. Inhibition of the hedgehog pathway in advanced basal-cell carcinoma. N Engl J Med. 2009;361(12):1164-1172.
    • (2009) N Engl J Med , vol.361 , Issue.12 , pp. 1164-1172
    • Von Hoff, D.D.1    Lorusso, P.M.2    Rudin, C.M.3
  • 6
    • 0019133661 scopus 로고
    • Mutations affecting segment number and polarity in Drosophila
    • Nusslein-Volhard C, Wieschaus E. Mutations affecting segment number and polarity in Drosophila. Nature. 1980;287(5785):795-801.
    • (1980) Nature , vol.287 , Issue.5785 , pp. 795-801
    • Nusslein-Volhard, C.1    Wieschaus, E.2
  • 7
    • 0029842199 scopus 로고    scopus 로고
    • Hedgehog's patterning call is patched through, smoothly
    • Roush W. Hedgehog's patterning call is patched through, smoothly. Science. 1996;274(5291):1304-1305.
    • (1996) Science , vol.274 , Issue.5291 , pp. 1304-1305
    • Roush, W.1
  • 8
    • 79956308325 scopus 로고    scopus 로고
    • Mechanisms and functions of Hedgehog signalling across the metazoa
    • Ingham PW, Nakano Y, Seger C. Mechanisms and functions of Hedgehog signalling across the metazoa. Nat Rev Genet. 2011;12(6):393-406.
    • (2011) Nat Rev Genet , vol.12 , Issue.6 , pp. 393-406
    • Ingham, P.W.1    Nakano, Y.2    Seger, C.3
  • 9
    • 77953316514 scopus 로고    scopus 로고
    • Mechanism and evolution of cytosolic Hedgehog signal transduction
    • Wilson CW, Chuang PT. Mechanism and evolution of cytosolic Hedgehog signal transduction. Development. 2010;137(13):2079-2094.
    • (2010) Development , vol.137 , Issue.13 , pp. 2079-2094
    • Wilson, C.W.1    Chuang, P.T.2
  • 10
    • 13144259688 scopus 로고    scopus 로고
    • Sonic hedgehog signaling is essential for hair development
    • St-Jacques B, Dassule HR, Karavanova I, et al. Sonic hedgehog signaling is essential for hair development. Curr Biol. 1998;8(19):1058-1068.
    • (1998) Curr Biol , vol.8 , Issue.19 , pp. 1058-1068
    • St-Jacques, B.1    Dassule, H.R.2    Karavanova, I.3
  • 11
    • 0032953901 scopus 로고    scopus 로고
    • Essential role for Sonic hedgehog during hair follicle morphogenesis
    • 1
    • Chiang C, Swan RZ, Grachtchouk M, et al. Essential role for Sonic hedgehog during hair follicle morphogenesis. Dev Biol. 1999;1;205(1):1-9.
    • (1999) Dev Biol , vol.1 , Issue.205 , pp. 1-9
    • Chiang, C.1    Swan, R.Z.2    Grachtchouk, M.3
  • 12
    • 15844390388 scopus 로고    scopus 로고
    • The roles of hedgehog, wingless and lines in patterning the dorsal epidermis in Drosophila
    • Bokor P, DiNardo S. The roles of hedgehog, wingless and lines in patterning the dorsal epidermis in Drosophila. Development. 1996;122(4):1083- 1092.
    • (1996) Development , vol.122 , Issue.4 , pp. 1083-1092
    • Bokor, P.1    Dinardo, S.2
  • 13
    • 0030802458 scopus 로고    scopus 로고
    • Induction of basal cell carcinoma features in transgenic human skin expressing sonic hedgehog
    • Fan H, Oro AE, Scott MP, Khavari PA. Induction of basal cell carcinoma features in transgenic human skin expressing Sonic Hedgehog. Nat Med. 1997;3(7):788-792.
    • (1997) Nat Med , vol.3 , Issue.7 , pp. 788-792
    • Fan, H.1    Oro, A.E.2    Scott, M.P.3    Khavari, P.A.4
  • 14
    • 15844386165 scopus 로고    scopus 로고
    • Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome
    • Hahn H, Wicking C, Zaphiropoulous PG, et al. Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome. Cell. 1996;85(6):841-851.
    • (1996) Cell , vol.85 , Issue.6 , pp. 841-851
    • Hahn, H.1    Wicking, C.2    Zaphiropoulous, P.G.3
  • 15
    • 15844381336 scopus 로고    scopus 로고
    • Human homolog of patched, a candidate gene for the basal cell nevus syndrome
    • Johnson RL, Rothman AL, Xie J, et al. Human homolog of patched, a candidate gene for the basal cell nevus syndrome. Science. 1996;272(5268):1668- 1671.
    • (1996) Science , vol.272 , Issue.5268 , pp. 1668-1671
    • Johnson, R.L.1    Rothman, A.L.2    Xie, J.3
  • 16
    • 0031913524 scopus 로고    scopus 로고
    • Activating Smoothened mutations in sporadic basal-cell carcinoma
    • Xie J, Murone M, Luoh SM, et al. Activating Smoothened mutations in sporadic basal-cell carcinoma. Nature. 1998;391(6662):90-92.
    • (1998) Nature , vol.391 , Issue.6662 , pp. 90-92
    • Xie, J.1    Murone, M.2    Luoh, S.M.3
  • 17
    • 0031837549 scopus 로고    scopus 로고
    • Identification of mutations in the human PATCHED gene in sporadic basal cell carcinomas and in patients with the basal cell nevus syndrome
    • Aszterbaum M, Rothman A, Johnson RL, et al. Identification of mutations in the human PATCHED gene in sporadic basal cell carcinomas and in patients with the basal cell nevus syndrome. J Invest Dermatol. 1998;110(6):885-888.
    • (1998) J Invest Dermatol , vol.110 , Issue.6 , pp. 885-888
    • Aszterbaum, M.1    Rothman, A.2    Johnson, R.L.3
  • 18
    • 0023222358 scopus 로고
    • Nevoid basal-cell carcinoma syndrome
    • Gorlin RJ. Nevoid basal-cell carcinoma syndrome. Medicine (Baltimore). 1987;66(2):98-113.
    • (1987) Medicine (Baltimore , vol.66 , Issue.2 , pp. 98-113
    • Gorlin, R.J.1
  • 19
    • 67649869544 scopus 로고    scopus 로고
    • Identification of a SUFU germline mutation in a family with Gorlin syndrome
    • Pastorino L, Ghiorzo P, Nasti S, et al. Identification of a SUFU germline mutation in a family with Gorlin syndrome. Am J Med Genet A. 2009;149A(7):1539-1543.
    • (2009) Am J Med Genet A , vol.149 A , Issue.7 , pp. 1539-1543
    • Pastorino, L.1    Ghiorzo, P.2    Nasti, S.3
  • 20
    • 19944433687 scopus 로고    scopus 로고
    • Somatic mutations in the PTCH, SMOH, SUFUH and TP53 genes in sporadic basal cell carcinomas
    • Reifenberger J, Wolter M, Knobbe CB, et al. Somatic mutations in the PTCH, SMOH, SUFUH and TP53 genes in sporadic basal cell carcinomas. Br J Dermatol. 2005;152(1):43-51.
    • (2005) Br J Dermatol , vol.152 , Issue.1 , pp. 43-51
    • Reifenberger, J.1    Wolter, M.2    Knobbe, C.B.3
  • 21
    • 0000040356 scopus 로고
    • A congenital cyclopian-type malformation in lambs induced by maternal ingestion of a range plant, Veratrum Californicum
    • Binns W, James LF, Shupe JL, Everett G. A congenital cyclopian-type malformation in lambs induced by maternal ingestion of a range plant, Veratrum Californicum. Am J Vet Res. 1963;24:1164-1175.
    • (1963) Am J Vet Res , vol.24 , pp. 1164-1175
    • Binns, W.1    James, L.F.2    Shupe, J.L.3    Everett, G.4
  • 22
    • 0032486433 scopus 로고    scopus 로고
    • Teratogen-mediated inhibition of target tissue response to Shh signaling
    • Cooper MK, Porter JA, Young KE, Beachy PA. Teratogen-mediated inhibition of target tissue response to Shh signaling. Science. 1998;280(5369):1603-1607.
    • (1998) Science , vol.280 , Issue.5369 , pp. 1603-1607
    • Cooper, M.K.1    Porter, J.A.2    Young, K.E.3    Beachy, P.A.4
  • 23
    • 45549094236 scopus 로고    scopus 로고
    • Dose-and route-dependent teratogenicity, toxicity, and pharmacokinetic profiles of the hedgehog signaling antagonist cyclopamine in the mouse
    • Lipinski RJ, Hutson PR, Hannam PW, et al. Dose-and route-dependent teratogenicity, toxicity, and pharmacokinetic profiles of the hedgehog signaling antagonist cyclopamine in the mouse. Toxicol Sci. 2008;104(1):189-197.
    • (2008) Toxicol Sci , vol.104 , Issue.1 , pp. 189-197
    • Lipinski, R.J.1    Hutson, P.R.2    Hannam, P.W.3
  • 25
    • 18644368453 scopus 로고    scopus 로고
    • Small-molecule modulators of Hedgehog signaling: Identification and characterization of Smoothened agonists and antagonists
    • Frank-Kamenetsky M, Zhang XM, Bottega S, et al. Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists. J Biol. 2002;1(2):10.
    • (2002) J Biol , vol.1 , Issue.2 , pp. 10
    • Frank-Kamenetsky, M.1    Zhang, X.M.2    Bottega, S.3
  • 26
    • 69949084378 scopus 로고    scopus 로고
    • Gdc-26 robarge kd brunton sa castanedo gm et al0449
    • Robarge KD, Brunton SA, Castanedo GM, et al. GDC-0449-a potent inhibitor of the hedgehog pathway. Bioorg Med Chem Lett. 2009;19(19):5576-5581.
    • (2009) Bioorg Med Chem Lett , vol.19 , Issue.19 , pp. 5576-5581
    • Robarge, K.D.1    Brunton, S.A.2    Castanedo, G.M.3
  • 27
    • 67650723106 scopus 로고    scopus 로고
    • Discovery of a potent and orally active hedgehog pathway antagonist (IPI-926)
    • Tremblay MR, Lescarbeau A, Grogan MJ, et al. Discovery of a potent and orally active hedgehog pathway antagonist (IPI-926). J Med Chem. 2009;52(14):4400-4418.
    • (2009) J Med Chem , vol.52 , Issue.14 , pp. 4400-4418
    • Tremblay, M.R.1    Lescarbeau, A.2    Grogan, M.J.3
  • 28
    • 79960351998 scopus 로고    scopus 로고
    • Identification of MK-5710 ((8aS)-8a-methyl-1,3-dioxo-2-[(1S,2R)-2- phenylcyclopropyl] N-(1-phenyl-1Hpyrazol-5-yl)hexahydroimid azo [1,5-A]pyrazine-7(1H)-carboxamide), a potent smoothened antagonist for use in Hedgehog pathway dependent malignancies, part 1
    • Malancona S, Altamura S, Filocamo G, et al. Identification of MK-5710 ((8aS)-8a-methyl-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-N-(1-phenyl- 1Hpyrazol-5-yl)hexahydroimid azo[1,5-a]pyrazine-7(1H)-carboxamide), a potent smoothened antagonist for use in Hedgehog pathway dependent malignancies, part 1. Bioorg Med Chem Lett. 2011;21(15):4422-4428.
    • (2011) Bioorg Med Chem Lett , vol.21 , Issue.15 , pp. 4422-4428
    • Malancona, S.1    Altamura, S.2    Filocamo, G.3
  • 29
    • 79954611501 scopus 로고    scopus 로고
    • Phase i trial of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with refractory, locally advanced or metastatic solid tumors
    • LoRusso PM, Rudin CM, Reddy JC, et al. Phase I trial of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with refractory, locally advanced or metastatic solid tumors. Clin Cancer Res. 2011;17(8):2502-2511.
    • (2011) Clin Cancer Res , vol.17 , Issue.8 , pp. 2502-2511
    • Lorusso, P.M.1    Rudin, C.M.2    Reddy, J.C.3
  • 30
    • 84861856844 scopus 로고    scopus 로고
    • Efficacy and safety of vismodegib in advanced basal-cell carcinoma
    • Sekulic A, Migden MR, Oro AE, et al. Efficacy and safety of vismodegib in advanced basal-cell carcinoma. N Engl J Med. 2012;366(23):2171-2179.
    • (2012) N Engl J Med , vol.366 , Issue.23 , pp. 2171-2179
    • Sekulic, A.1    Migden, M.R.2    Oro, A.E.3
  • 31
    • 0035800507 scopus 로고    scopus 로고
    • Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification
    • Gorre ME, Mohammed M, Ellwood K, et al. Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification. Science. 2001;293(5531):876-880.
    • (2001) Science , vol.293 , Issue.5531 , pp. 876-880
    • Gorre, M.E.1    Mohammed, M.2    Ellwood, K.3
  • 32
    • 84869131318 scopus 로고    scopus 로고
    • Initial assessment of tumor regrowth after vismodegib in advanced Basal cell carcinoma
    • Chang AL, Oro AE. Initial assessment of tumor regrowth after vismodegib in advanced Basal cell carcinoma. Arch Dermatol. 2012;148(11):1324-1325.
    • (2012) Arch Dermatol , vol.148 , Issue.11 , pp. 1324-1325
    • Chang, A.L.1    Oro, A.E.2
  • 33
    • 84861876867 scopus 로고    scopus 로고
    • Inhibiting the hedgehog pathway in patients with the basal-cell nevus syndrome
    • Tang JY, Mackay-Wiggan JM, Aszterbaum M, et al. Inhibiting the hedgehog pathway in patients with the basal-cell nevus syndrome. N Engl J Med. 2012;366(23):2180-2188.
    • (2012) N Engl J Med , vol.366 , Issue.23 , pp. 2180-2188
    • Tang, J.Y.1    MacKay-Wiggan, J.M.2    Aszterbaum, M.3
  • 34
    • 79960340656 scopus 로고    scopus 로고
    • Topical treatment of Basal cell carcinomas in nevoid Basal cell carcinoma syndrome with a smoothened inhibitor
    • Skvara H, Kalthoff F, Meingassner JG, et al. Topical treatment of Basal cell carcinomas in nevoid Basal cell carcinoma syndrome with a smoothened inhibitor. J Invest Dermatol. 2011;131(8):1735-1744.
    • (2011) J Invest Dermatol , vol.131 , Issue.8 , pp. 1735-1744
    • Skvara, H.1    Kalthoff, F.2    Meingassner, J.G.3
  • 35
    • 77950492233 scopus 로고    scopus 로고
    • Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth
    • Kim J, Tang JY, Gong R, et al. Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth. Cancer Cell. 2010;17(4):388-399.
    • (2010) Cancer Cell , vol.17 , Issue.4 , pp. 388-399
    • Kim, J.1    Tang, J.Y.2    Gong, R.3
  • 36
    • 77955804589 scopus 로고    scopus 로고
    • Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector
    • Kim J, Lee JJ, Kim J, Gardner D, Beachy PA. Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector. Proc Natl Acad Sci U S A. 2010;107(30):13432-13437.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , Issue.30 , pp. 13432-13437
    • Kim, J.1    Lee, J.J.2    Kim, J.3    Gardner, D.4    Beachy, P.A.5
  • 37
    • 78650958235 scopus 로고    scopus 로고
    • Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathway
    • Beauchamp EM, Ringer L, Bulut G, et al. Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathway. J Clin Invest. 2011;121(1):148-160.
    • (2011) J Clin Invest , vol.121 , Issue.1 , pp. 148-160
    • Beauchamp, E.M.1    Ringer, L.2    Bulut, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.