2a, a novel curcumin analog, sensitizes cisplatin-resistant A549 cells to cisplatin by inhibiting thioredoxin reductase concomitant oxidative stress damage

European Journal of Pharmacology

Volumn 707, Issue 1-3, 2013, Pages 130-139

  Zhou, Binhua ^a   Huang, Jianing ^b   Zuo, Yinglin ^a   Li, Baojian ^c   Guo, Qiang ^a   Cui, Baicheng ^a   Shao, Weiyan ^a   Du, Jun ^a   Bu, Xianzhang ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b GUANGZHOU MEDICAL UNIVERSITY   (China)

^c UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Cisplatin resistant A549 cells; Curcumin analog; Oxidative stress; Thioredoxin reductase

Indexed keywords

5 HYDROXY 1 (4 HYDROXY 3 METHOXYPHENYL) 7 (5 METHYLFURAN 2 YL)HEPTA 1,4,6 TRIEN 3 ONE; ANTINEOPLASTIC AGENT; CISPLATIN; GLUTATHIONE; GLUTATHIONE DISULFIDE; REACTIVE OXYGEN METABOLITE; THIOREDOXIN REDUCTASE; UNCLASSIFIED DRUG;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; CANCER INHIBITION; CANCER RESISTANCE; CELL STRAIN A549; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENTIATION; DRUG SCREENING; DRUG SENSITIZATION; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LUNG CARCINOMA; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEPLETION; UPREGULATION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; CISPLATIN; CURCUMIN; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, NEOPLASM; FURANS; GLUTATHIONE; GLUTATHIONE DISULFIDE; HUMANS; LUNG NEOPLASMS; OXIDATION-REDUCTION; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; THIOREDOXIN-DISULFIDE REDUCTASE;

EID: 84877580142     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2013.03.014     Document Type: Article

References (40)

1. E.S. Arner, and A. Holmgren Physiological functions of thioredoxin and thioredoxin reductase Eur. J. Biochem. 267 2000 6102 6109
2. A. Bindoli, M.P. Rigobello, G. Scutari, C. Gabbiani, A. Casini, and L. Messori Thioredoxin reductase: a target for gold compounds acting as potential antiretain - >cancer drugs Coord. Chem. Rev. 253 2009 1692 1707
3. L. Bjorkhem-Bergman, K. Jonsson, L.C. Eriksson, J.M. Olsson, S. Lehmann, C. Paul, and M. Bjornstedt Drug-resistant human lung cancer cells are more sensitive to selenium cytotoxicity. Effects on thioredoxin reductase and glutathione reductase Biochem. Pharmacol. 63 2002 1875 1884
4. W. Cai, B. Zhang, D. Duan, J. Wu, and J. Fang Curcumin targeting the thioredoxin system elevates oxidative stress in HeLa cells Toxicol. Appl. Pharmacol. 262 2012 341 348
5. W. Cai, L. Zhang, Y. Song, B. Wang, B. Zhang, X. Cui, G. Hu, Y. Liu, J. Wu, and J. Fang Small molecule inhibitors of mammalian thioredoxin reductase Free Radic. Biol. Med. 52 2012 257 265
6. A. Cataldi Cell responses to oxidative stressors Curr. Pharm. Des. 16 2010 1387 1395
7. P.Y. Cheung, J.E. Churchich, and K.S. Lee Refolding of thioredoxin reductase assisted by groEL and PDI Biochem. Biophys. Res. Commun. 255 1999 17 22
8. M.L. Circu, and T.Y. Aw Reactive oxygen species, cellular redox systems, and apoptosis Free Radic. Biol. Med. 48 2010 749 762
9. K.C. Das, and C.K. Das Thioredoxin, a singlet oxygen quencher and hydroxyl radical scavenger: redox independent functions Biochem. Biophys. Res. Commun. 277 2000 443 447
10. R. Das, A. Roy, N. Dutta, and H.K. Majumder Reactive oxygen species and imbalance of calcium homeostasis contributes to curcumin induced programmed cell death in Leishmania donovani Apoptosis 13 2008 867 882
11. J. Fang, J. Lu, and A. Holmgren Thioredoxin reductase is irreversibly modified by curcumin: a novel molecular mechanism for its anticancer activity J. Biol. Chem. 280 2005 25284 25290
12. A.P. Fernandes, A. Capitanio, M. Selenius, O. Brodin, A.K. Rundlof, and M. Bjornstedt Expression profiles of thioredoxin family proteins in human lung cancer tissue: correlation with proliferation and differentiation Histopathology 55 2009 313 320
13. Y.M. Han, D.S. Shin, Y.J. Lee, I.A. Ismail, S.H. Hong, D.C. Han, and B.M. Kwon 2-Hydroxycurcuminoid induces apoptosis of human tumor cells through the reactive oxygen species-mitochondria pathway Bioorg. Med. Chem. Lett. 21 2011 747 751
14. H. Hatcher, R. Planalp, J. Cho, F.M. Torti, and S.V. Torti Curcumin: from ancient medicine to current clinical trials Cell. Mol. Life Sci. 65 2008 1631 1652
15. A. Holmgren, and M. Bjornstedt Thioredoxin and thioredoxin reductase Methods Enzymol. 252 1995 199 208
16. A. Holmgren, and J. Lu Thioredoxin and thioredoxin reductase: current research with special reference to human disease Biochem. Biophys. Res. Commun. 396 2010 120 124
17. N. Kondo, H. Nakamura, H. Masutani, and J. Yodoi Redox regulation of human thioredoxin network Antioxid. Redox Signal. 8 2006 1881 1890
18. C.L. Kuo, S.Y. Wu, S.W. Ip, P.P. Wu, C.S. Yu, J.S. Yang, P.Y. Chen, S.H. Wu, and J.G. Chung Apoptotic death in curcumin-treated NPC-TW 076 human nasopharyngeal carcinoma cells is mediated through the ROS, mitochondrial depolarization and caspase-3-dependent signaling responses Int. J. Oncol. 39 2011 319 328
19. S.S. Lin, H.P. Huang, J.S. Yang, J.Y. Wu, T.C. Hsia, C.C. Lin, C.W. Lin, C.L. Kuo, W. Gibson Wood, and J.G. Chung DNA damage and endoplasmic reticulum stress mediated curcumin-induced cell cycle arrest and apoptosis in human lung carcinoma A-549 cells through the activation caspases cascade- and mitochondrial-dependent pathway Cancer Lett. 272 2008 77 90
20. Y.H. Ling, L. Liebes, Y. Zou, and R. Perez-Soler Reactive oxygen species generation and mitochondrial dysfunction in the apoptotic response to Bortezomib, a novel proteasome inhibitor, in human H460 non-small cell lung cancer cells J. Biol. Chem. 278 2003 33714 33723
21. M. Lopez-Lazaro Anticancer and carcinogenic properties of curcumin: considerations for its clinical development as a cancer chemopreventive and chemotherapeutic agent Mol. Nutr. Food Res. 52 1 2008 S103 S127
22. J.M. Mates, and F.M. Sanchez-Jimenez Role of reactive oxygen species retain - >in apoptosis: implications for cancer therapy Int. J. Biochem. Cell Biol. 32 2000 157 170
23. D. Mustacich, and G. Powis Thioredoxin reductase Biochem. J. 346 Pt 1 2000 1 8
24. P. Nguyen, R.T. Awwad, D.D. Smart, D.R. Spitz, and D. Gius Thioredoxin reductase as a novel molecular target for cancer therapy Cancer Lett. 236 2006 164 174
25. J. Nordberg, and E.S. Arner Reactive oxygen species, antioxidants, and the mammalian thioredoxin system Free Radic. Biol. Med. 31 2001 1287 1312
26. R.L. Poerschke, and P.J. Moos Thioredoxin reductase 1 knockdown enhances selenazolidine cytotoxicity in human lung cancer cells via mitochondrial dysfunction Biochem. Pharmacol. 81 2011 211 221
27. X. Qiu, Z. Liu, W.Y. Shao, X. Liu, D.P. Jing, Y.J. Yu, L.K. An, S.L. Huang, X.Z. Bu, Z.S. Huang, and L.Q. Gu Synthesis and evaluation of curcumin analogues as potential thioredoxin reductase inhibitors Bioorg. Med. Chem. 16 2008 8035 8041
28. T. Sasada, H. Nakamura, S. Ueda, N. Sato, Y. Kitaoka, Y. Gon, A. Takabayashi, G. Spyrou, A. Holmgren, and J. Yodoi Possible involvement of thioretain - >redoxin reductase as well as thioredoxin in cellular sensitivity to cis-diamminedichloroplatinum (II) Free Radic. Biol. Med. 27 1999 504 514
29. W.-Y. Shao, Y.-N. Cao, Z.-W. Yu, W.-J. Pan, X. Qiu, X.-Z. Bu, L.-K. An, Z.-S. Huang, L.-Q. Gu, and A.S.C. Chan Facile preparation of new unsymmetrical curcumin derivatives by solid-phase synthesis strategy Tetrahedron Lett. 47 2006 4085 4089
30. H.U. Simon, A. Haj-Yehia, and F. Levi-Schaffer Role of reactive oxygen species (ROS) in apoptosis induction Apoptosis 5 2000 415 418
31. Y. Soini, K. Kahlos, U. Napankangas, R. Kaarteenaho-Wiik, M. Saily, P. Koistinen, P. Paaakko, A. Holmgren, and V.L. Kinnula Widespread expression of thioredoxin and thioredoxin reductase in non-small cell lung carcinoma Clin. Cancer Res. 7 2001 1750 1757
32. Q.A. Sun, Y. Wu, F. Zappacosta, K.T. Jeang, B.J. Lee, D.L. Hatfield, and V.N. Gladyshev Redox regulation of cell signaling by selenocysteine in mammalian thioredoxin reductases J. Biol. Chem. 274 1999 24522 24530
33. K.F. Tonissen, and G. Di Trapani Thioredoxin system inhibitors as mediators of apoptosis for cancer therapy Mol. Nutr. Food Res. 53 2009 87 103
34. S. Urig, and K. Becker On the potential of thioredoxin reductase inhibitors for cancer therapy Semin. Cancer Biol. 16 2006 452 465
35. A. Yokomizo, M. Ono, H. Nanri, Y. Makino, T. Ohga, M. Wada, T. Okamoto, J. Yodoi, M. Kuwano, and K. Kohno Cellular levels of thioredoxin associated with drug sensitivity to cisplatin, mitomycin C, doxorubicin, and etoposide Cancer Res. 55 1995 4293 4296
36. M.H. Yoo, X.M. Xu, B.A. Carlson, V.N. Gladyshev, and D.L. Hatfield Thioredoxin reductase 1 deficiency reverses tumor phenotype and tumorigenicity of lung carcinoma cells J. Biol. Chem. 281 2006 13005 13008
37. M.H. Yoo, X.M. Xu, B.A. Carlson, A.D. Patterson, V.N. Gladyshev, and D.L. Hatfield Targeting thioredoxin reductase 1 reduction in cancer cells inhibits self-sufficient growth and DNA replication PLoS One 2 2007 e1112
38. Y.F. Zhao, C. Zhang, and Y.R. Suo MMPT as a reactive oxygen species generator induces apoptosis via the depletion of intracellular GSH contents in A549 cells Eur. J. Pharmacol. 688 2012 6 13
39. Y. Zuo, J. Huang, B. Zhou, S. Wang, W. Shao, C. Zhu, L. Lin, G. Wen, H. Wang, J. Du, and X. Bu Synthesis, cytotoxicity of new 4-arylidene curcumin analogues and their multi-functions in inhibition of both NF-kappaB and Akt signalling Eur. J. Med. Chem. 55 2012 346 357
40. Y. Zuo, Y. Yu, S. Wang, W. Shao, B. Zhou, L. Lin, Z. Luo, R. Huang, J. Du, and X. Bu Synthesis and cytotoxicity evaluation of biaryl-based chalcones and their potential in TNFalpha-induced nuclear factor-kappaB activation inhibition Eur. J. Med. Chem. 50 2012 393 404