Reactive oxygen species and imbalance of calcium homeostasis contributes to curcumin induced programmed cell death in Leishmania donovani

Apoptosis

Volumn 13, Issue 7, 2008, Pages 867-882

  Das, Rakhee ^a   Roy, Amit ^a   Dutta, Neeta ^a   Majumder, Hemanta K ^a  

^a INDIAN INSTITUTE OF CHEMICAL BIOLOGY   (India)

Author keywords

Calcium homeostasis; Curcumin; Leishmania donovani; NAC; ROS

Indexed keywords

CALCIUM; CURCUMIN; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CALCIUM HOMEOSTASIS; CELL CYCLE ARREST; CONTROLLED STUDY; FLOW CYTOMETRY; LEISHMANIA DONOVANI; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROMASTIGOTE;

ANIMALS; ANTIPROTOZOAL AGENTS; APOPTOSIS; CALCIUM; CASPASES; CELL CYCLE; CELL LINE; CURCUMIN; CYTOCHROMES C; CYTOSOL; DNA FRAGMENTATION; ENZYME ACTIVATION; HOMEOSTASIS; LEISHMANIA DONOVANI; LIPID PEROXIDATION; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; OXIDATIVE STRESS; PHOSPHATIDYLSERINES; REACTIVE OXYGEN SPECIES;

LEISHMANIA DONOVANI;

EID: 46549086785     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-008-0224-7     Document Type: Article

References (57)

1. Iwu MM, Jackson JE, Schuster BG (1994) Medicinal plants in the fight against leishmaniasis. Parasitol Today 10:65-68. doi: 10.1016/0169-4758(94) 90398-0
2. Kayser O, Kiderlen AF, Croft SL (2003) Natural products as antiparasitic drugs. Parasitol Res 90:S55-S62. doi: 10.1007/s00436-002-0768-3
3. Sharma RA, Gescher AJ, Steward WP (2005) Curcumin: the story so far. Eur J Cancer 41:1955-1968. doi: 10.1016/j.ejca.2005.05.009
4. Mukherjee Nee Chakraborty S, Ghosh U, Bhattacharyya NP, Bhattacharya RK, Dey S, Roy M (2007) Curcumin-induced apoptosis in human leukemia cell HL-60 is associated with inhibition of telomerase activity. Mol Cell Biochem 297:31-39. doi: 10.1007/s11010-006-9319-z
5. Fang J, Lu J, Holmgren A (2005) Thioredoxin reductase is irreversibly modified by curcumin: a novel molecular mechanism for its anticancer activity. J Biol Chem 280:25284-25290. doi: 10.1074/jbc.M414645200
6. Su CC, Chen GW, Lin JG, Wu LT, Chung JG (2006) Curcumin inhibits cell migration of human colon cancer colo 205 cells through the inhibition of nuclear factor kappa B/p65 and down-regulates cyclooxygenase-2 and matrix metalloproteinase-2 expressions. Anticancer Res 26:1281-1288
7. Reddy AC, Lokesh BR (1994) Effect of dietary turmeric (Curcuma longa) on iron-induced lipid peroxidation in the rat liver. Food Chem Toxicol 32:279-283. doi: 10.1016/0278-6915(94)90201-1
8. Nagabhushan M, Amonkar AJ, Bhide SV (1987) In vitro antimutagenicity of curcumin against environmental mutagens. Food Chem Toxicol 25:545-547. doi: 10.1016/0278-6915(87)90207-9
9. Mazumder A, Raghavan K, Weinstein J, Kohn KW, Pommier Y (1995) Inhibition of human immunodeficiency virus type-1 integrase by curcumin. Biochem Pharmacol 49:1165-1170. doi: 10.1016/0006-2952(95)98514-A
10. Joe B, Vijaykumar M, Lokesh BR (2004) Biological properties of curcumin-cellular and molecular mechanisms of action. Crit Rev Food Sci Nutr 44:97-111. doi: 10.1080/10408690490424702
11. Cui SX, Qu XJ, Xie YY, Zhou L, Nakata M, Makuuchi M et al (2006) Curcumin inhibits telomerase activity in human cancer cell lines. Int J Mol Med 18:227-231
12. Liao YF, Hung HC, Hour TC, Hsu PC, Kao MC, Tsay GJ et al (2008) Curcumin induces apoptosis through an ornithine decarboxylase-dependent pathway in human promyelocytic leukemia HL-60 cells. Life Sci 82:367-375
13. Nose M, Koide T, Ogihara Y, Yabu Y, Ohta N (1998) Trypanocidal effects of curcumin in vitro. Biol Pharm Bull 21:643-645
14. Pérez-Arriaga L, Mendoza-Magaña ML, Cortés- Zárate R, Corona-Rivera A, Bobadilla-Morales L, Troyo-Sanromán R et al (2006) Cytotoxic effect of curcumin on Giardia lamblia trophozoites. Acta Trop 98:152-161. doi: 10.1016/j.actatropica.2006.03.005
15. Rasmussen HB, Christensen SB, Kvist LP, Karazmi A (2000) A simple and efficient separation of the curcumins, the antiprotozoal constituents of Curcuma longa. Planta Med 66:396-398. doi: 10.1055/s-2000-8533
16. Reddy RC, Vatsala PG, Keshamouni VG, Padmanaban G, Rangarajan PN (2005) Curcumin for malaria therapy. Biochem Biophys Res Commun 326:472-474. doi: 10.1016/j.bbrc.2004.11.051
17. Nandakumar DN, Nagaraj VA, Vathsala PG, Rangarajan P, Padmanaban G (2006) Curcumin-artemisinin combination therapy for malaria. Antimicrob Agents Chemother 50:1859-1860. doi: 10.1128/AAC.50.5.1859-1860.2006
18. Cui L, Miao J, Cui L (2007) Cytotoxic effect of curcumin on malaria parasite Plasmodium falciparum: inhibition of histone acetylation and generation of reactive oxygen species. Antimicrob Agents Chemother 51:488-494. doi: 10.1128/AAC.01238-06
19. Lee N, Bertholet S, Debrabant A, Muller J, Duncan R, Nakhasi HL (2002) Programmed cell death in the unicellular protozoan parasite Leishmania. Cell Death Differ 9:53-64. doi: 10.1038/sj.cdd.4400952
20. Sen N, Das BB, Ganguly A, Mukherjee T, Tripathi G, Bandyopadhyay S et al (2004) Camptothecin induced mitochondrial dysfunction leading to programmed cell death in unicellular hemoflagellate Leishmania donovani. Cell Death Differ 11:924-936. doi: 10.1038/sj.cdd.4401435
21. Das M, Mukherjee SB, Shaha C (2001) Hydrogen peroxide induces apoptosis-like death in Leishmania donovani promastigotes. J Cell Sci 114:2461-2469
22. Zangger H, Mottram JC, Fasel N (2002) Cell death in Leishmania induced by stress and differentiation: programmed cell death or necrosis? Cell Death Differ 9:1126-1139. doi: 10.1038/sj.cdd.4401071
23. Debrabant A, Lee N, Bertholet S, Duncan R, Nakhasi HL (2003) Programmed cell death in trypanosomatids and other unicellular organisms. Int J Parasitol 33:257-267. doi: 10.1016/S0020-7519(03)00008-0
24. Saleheen D, Ali SA, Ashfaq K, Siddiqui AA, Agha A, Yasinzai MM (2002) Latent activity of curcumin against leishmaniasis in vitro. Biol Pharm Bull 25:386-389. doi: 10.1248/bpb.25.386
25. Le Bras M, Clément MV, Pervaiz S, Brenner C (2005) Reactive oxygen species and the mitochondrial signaling pathway of cell death. Histol Histopathol 20:205-219
26. Soto M, Iborra S, Quijada L, Folgueira C, Alonso C, Requena JM (2004) Cell-cycle-dependent translation of histone mRNAs is the key control point for regulation of histone biosynthesis in Leishmania infantum. Biochem J 379:617-625. doi: 10.1042/BJ20031522
27. 2+ levels through the activation of non-selective cation channels induced by oxidative stress causes mitochondrial depolarization leading to apoptosis-like death in Leishmania donovani promastigotes. J Biol Chem 277:24717-24727. doi: 10.1074/jbc.M201961200
28. Kunwar A, Barik A, Mishra B, Rathinasamy K, Pandey R, Priyadarsini KI (2008) Quantitative cellular uptake, localization and cytotoxicity of curcumin in normal and tumor cells. Biochim Biophys Acta 1780:673-679
29. Mehta A, Shaha C (2004) Apoptotic death in Leishmania donovani promastigotes in response to respiratory chain inhibition: complex II inhibition results in increased pentamidine cytotoxicity. J Biol Chem 279:11798-11813. doi: 10.1074/jbc.M309341200
30. Compton MM (1992) A biochemical hallmark of apoptosis: internucleosomal degradation of the genome. Cancer Metastasis Rev 11:105-119. doi: 10.1007/BF00048058
31. Wan CP, Myung E, Lau BH (1993) An automated micro-fluorometric assay for monitoring oxidative burst activity of phagocytes. J Immunol Methods 159:131-138. doi: 10.1016/0022-1759(93)90150-6
32. Bhaumik S, Anjum R, Rangaraj N, Pardhasaradhi BV, Khar A (1999) Curcumin mediated apoptosis in AK-5 tumor cells involves the production of reactive oxygen intermediates. FEBS Lett 456:311-314. doi: 10.1016/S0014-5793(99)00969-2
33. Jana NR, Dikshit P, Goswami A, Nukina N (2004) Inhibition of proteasomal function by curcumin induces apoptosis through mitochondrial pathway. J Biol Chem 279:11680-11685. doi: 10.1074/jbc.M310369200
34. Duchen MR (2000) Mitochondria and calcium: from cell signalling to cell death. J Physiol 529:57-68. doi: 10.1111/j.1469-7793.2000.00057.x
35. Sen N, Das BB, Ganguly A, Mukherjee T, Bandyopadhyay S, Majumder HK (2004) Camptothecin-induced imbalance in intracellular cation homeostasis regulates programmed cell death in unicellular hemoflagellate Leishmania donovani. J Biol Chem 279:52366-52375. doi: 10.1074/jbc.M406705200
36. Koya RC, Fujita H, Shimizu S, Ohtsu M, Takimoto M, Tsujimoto Y et al (2000) Gelsolin inhibits apoptosis by blocking mitochondrial membrane potential loss and cytochrome c release. J Biol Chem 275:15343-15349. doi: 10.1074/jbc.275.20.15343
37. Scheffler IE (1999) Mitochondria. Wiley-Liss, New York
38. Rittig MG, Bogdan C (2000) Leishmania-host-cell interaction: complexities and alternative views. Parasitol Today 16:292-297. doi: 10.1016/S0169-4758(00) 01692-6
39. Park C, Kim GY, Kim GD, Choi BT, Park YM, Choi YH (2006) Induction of G2/M arrest and inhibition of cyclooxygenase-2 activity by curcumin in human bladder cancer T24 cells. Oncol Rep 15:1225-1231
40. Chipuk JE, Green DR (2005) Do inducers of apoptosis trigger caspase-independent cell death? Nat Rev Mol Cell Biol 6:268-275. doi: 10.1038/nrm1573
41. Ahsan H, Parveen N, Khan NU, Hadi SM (1999) Pro-oxidant, anti-oxidant and cleavage activities on DNA of curcumin and its derivatives demethoxycurcumin and bisdemethoxycurcumin. Chem Biol Interact 121:161-175. doi: 10.1016/S0009-2797(99)00096-4
42. Litwinienko G, Ingold KU (2004) Abnormal solvent effects on hydrogen atom abstraction. 2. Resolution of the curcumin antioxidant controversy. The role of sequential proton loss electron transfer. J Org Chem 69:5888-5896. doi: 10.1021/jo049254j
43. Chan MM, Adapala NS, Fong D (2005) Curcumin overcomes the inhibitory effect of nitric oxide on Leishmania. Parasitol Res 96:49-56. doi: 10.1007/s00436-005-1323-9
44. Galati G, Sabzevari O, Wilson JX, O'Brien PJ (2002) Prooxidant activity and cellular effects of the phenoxyl radicals of dietary flavonoids and other polyphenolics. Toxicology 177:91-104. doi: 10.1016/S0300-483X(02)00198-1
45. Cao J, Liu Y, Jia L, Zhou HM, Kong Y, Yang G et al (2007) Curcumin induces apoptosis through mitochondrial hyperpolarization and mtDNA damage in human hepatoma G2 cells. Free Radic Biol Med 43:968-975. doi: 10.1016/j.freeradbiomed.2007.06.006
46. Mishra B, Priyadarsini KI, Bhide MK, Kadam RM, Mohan H (2004) Reactions of superoxide radicals with curcumin: probable mechanisms by optical spectroscopy and EPR. Free Radic Res 38:355-362. doi: 10.1080/ 10715760310001660259
47. De Grey AD (2002) HO2*: the forgotten radical. DNA Cell Biol 21:251-257. doi: 10.1089/104454902753759672
48. Ingolfsson HI, Koeppe RE II, Andersen OS (2007) Curcumin is a modulator of bilayer material properties. Biochemistry 46:10384-10391. doi: 10.1021/bi701013n
49. 2+ pumps by curcumin. Curcumin putatively stabilizes the interaction between the nucleotide-binding and phosphorylation domains in the absence of ATP. Eur J Biochem 268:6318-6327. doi: 10.1046/j.0014-2956.2001. 02589.x
50. Green DR, Kroemer G (2004) The pathophysiology of mitochondrial cell death. Science 305:626-629. doi: 10.1126/science.1099320
51. Palit P, Ali N (2008) Oral therapy with amlodipine and lacidipine, 1,4-dihydropyridine derivatives showing activity against experimental visceral Leishmaniasis. Antimicrob Agents Chemother 52:374-377. doi: 10.1128/AAC.00522-07
52. Verma NK, Dey CS (2004) Possible mechanism of miltefosine-mediated death of Leishmania donovani. Antimicrob Agents Chemother 48:3010-3015. doi: 10.1128/AAC.48.8.3010-3015.2004
53. Dutta A, Bandyopadhyay S, Mandal C, Chatterjee M (2007) Aloe vera leaf exudate induces a caspase-independent cell death in Leishmania donovani promastigotes. J Med Microbiol 56:629-636. doi: 10.1099/jmm.0.47039-0
54. Sen R, Bandyopadhyay S, Dutta A, Mandal G, Ganguly S, Saha P et al (2007) Artemisinin triggers induction of cell-cycle arrest and apoptosis in Leishmania donovani promastigotes. J Med Microbiol 56:1213-1218. doi: 10.1099/jmm.0.47364- 0
55. Dutta A, Ghoshal A, Mandal D, Mondal NB, Banerjee S, Sahu NP et al (2007) Racemoside A, an anti-leishmanial, water-soluble, natural steroidal saponin, induces programmed cell death in Leishmania Donovani. J Med Microbiol 56:1196-1204. doi: 10.1099/jmm.0.47114-0
56. Anand P, Kunnumakkara AB, Newman RA, Aggarwal BB (2007) Bioavailability of curcumin: problems and promises. Mol Pharm 4:807-818. doi: 10.1021/mp700113r
57. Shoba G, Joy D, Joseph T, Majeed M, Rajendran R, Srinivas PS (1998) Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med 64:353-356. doi: 10.1055/s-2006-957450