Differential targeting of brain stress circuits with a selective glucocorticoid receptor modulator

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 19, 2013, Pages 7910-7915

  Zalachoras, Ioannis ^a,b   Houtman, René ^c   Atucha, Erika ^d,e   Devos, Rene ^f   Tijssen, Ans M I ^b   Hu, Pu ^g   Lockey, Peter M ^f   Datson, Nicole A ^a,b   Belanoff, Joseph K ^h   Lucassen, Paul J ^g   Joëls, Marian ⁱ   De Kloet, E Ronald ^b   Roozendaal, Benno ^d,e   Hunt, Hazel ^h   Meijer, Onno C ^a,b  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b LEIDEN UNIVERSITY   (Netherlands)

^c PamGene International   (Netherlands)

^d RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^e RADBOUD UNIVERSITY   (Netherlands)

^f Argenta Discovery Ltd   (United Kingdom)

^g UNIVERSITY OF AMSTERDAM   (Netherlands)

^h Corcept Therapeutics ^*  (United States)

ⁱ UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

HPA axis; NCoA1; Neuroendocrinology; Steroid pharmacology; Transcription regulation

Indexed keywords

C 108297; CORTICOSTERONE; CORTICOTROPIN RELEASING FACTOR; DEXAMETHASONE; GLUCOCORTICOID RECEPTOR; GLUCOCORTICOID RECEPTOR ANTAGONIST; MIFEPRISTONE; NUCLEAR RECEPTOR COREPRESSOR; PARTIAL AGONIST; UNCLASSIFIED DRUG;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AVOIDANCE BEHAVIOR; BRAIN DEVELOPMENT; BRAIN FUNCTION; CONTROLLED STUDY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG TARGETING; GENE EXPRESSION; HIPPOCAMPUS; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; IN VITRO STUDY; LONG TERM EXPOSURE; MALE; MEMORY CONSOLIDATION; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR OCCUPANCY; SIGNAL TRANSDUCTION; SPLICING DEFECT; TASK PERFORMANCE;

HPA AXIS; NCOA1; NEUROENDOCRINOLOGY; STEROID PHARMACOLOGY; TRANSCRIPTION REGULATION;

ANIMALS; BRAIN; CORTICOTROPIN-RELEASING HORMONE; DEXAMETHASONE; GENE EXPRESSION REGULATION; HIPPOCAMPUS; LIGANDS; MALE; MIFEPRISTONE; NUCLEAR RECEPTOR COACTIVATOR 1; PEPTIDES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GLUCOCORTICOID; STEROIDS; TIME FACTORS; TRANSCRIPTION, GENETIC; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 84877357726     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1219411110     Document Type: Article

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