Mifepristone decreases depression-like behavior and modulates neuroendocrine and central hypothalamic-pituitary-adrenocortical axis responsiveness to stress

Psychoneuroendocrinology

Volumn 35, Issue 7, 2010, Pages 1100-1112

  Wulsin, Aynara C ^a   Herman, James P ^a   Solomon, Matia B ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

C Fos; Depression; Forced swim test; Glucocorticoids; HPA axis; Immunohistochemistry; Medial prefrontal cortex; Neuronal activation; RU486

Indexed keywords

CORTICOTROPIN; IMIPRAMINE; MIFEPRISTONE; PROTEIN C FOS;

ACUTE STRESS; AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CLIMBING; CONTROLLED STUDY; DENTATE GYRUS; DEPRESSION; DRUG EFFICACY; DRUG TARGETING; FORCED SWIMMING TEST; HIPPOCAMPUS; HORMONE RESPONSE; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; IMMOBILIZATION STRESS; MALE; NEUROENDOCRINE SYSTEM; NONHUMAN; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SUBICULUM;

ADRENOCORTICOTROPIC HORMONE; AMYGDALA; ANIMALS; CORTICOSTERONE; DEPRESSION; HIPPOCAMPUS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; HYPOTHALAMUS; LIMBIC SYSTEM; MALE; MIFEPRISTONE; PITUITARY-ADRENAL SYSTEM; PREFRONTAL CORTEX; PROTO-ONCOGENE PROTEINS C-FOS; RATS; RECEPTORS, GLUCOCORTICOID; STRESS, PSYCHOLOGICAL; SWIMMING;

EID: 77954958226     PISSN: 03064530     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.psyneuen.2010.01.011     Document Type: Article

References (47)

1. Aisa B., Tordera R., Lasheras B., Del Rio J., Ramirez M.J. Cognitive impairment associated to HPA axis hyperactivity after maternal separation in rats. Psychoneuroendocrinology 2007, 32:256-266.
2. Aisa B., Tordera R., Lasheras B., Del Rio J., Ramirez M.J. Effects of maternal separation on hypothalamic-pituitary-adrenal responses, cognition and vulnerability to stress in adult female rats. Neuroscience 2008, 154:1218-1226.
3. Arce E., Simmons A.N., Lovero K.L., Stein M.B., Paulus M.P. Escitalopram effects on insula and amygdala BOLD activation during emotional processing. Psychopharmacology (Berl.) 2008, 196:661-672.
4. Bachmann C.G., Linthorst A.C., Holsboer F., Reul J.M. Effect of chronic administration of selective glucocorticoid receptor antagonists on the rat hypothalamic-pituitary-adrenocortical axis. Neuropsychopharmacology 2003, 28:1056-1067.
5. Bachmann C.G., Bilang-Bleuel A., De Carli S., Linthorst A.C., Reul J.M. The selective glucocorticoid receptor antagonist ORG 34116 decreases immobility time in the forced swim test and affects cAMP-responsive element-binding protein phosphorylation in rat brain. Neuroendocrinology 2005, 81:129-136.
6. Barros H.M., Ferigolo M. Ethopharmacology of imipramine in the forced-swimming test: gender differences. Neurosci. Biobehav. Rev. 1998, 23:279-286.
7. Beaulieu S., Di Paolo T., Barden N. Control of ACTH secretion by the central nucleus of the amygdala: implication of the serotoninergic system and its relevance to the glucocorticoid delayed negative feedback mechanism. Neuroendocrinology 1986, 44:247-254.
8. Belanoff J.K., Flores B.H., Kalezhan M., Sund B., Schatzberg A.F. Rapid reversal of psychotic depression using mifepristone. J. Clin. Psychopharmacol. 2001, 21:516-521.
9. Campeau S., Davis M. Involvement of the central nucleus and basolateral complex of the amygdala in fear conditioning measured with fear-potentiated startle in rats trained concurrently with auditory and visual conditioned stimuli. J. Neurosci. 1995, 15:2301-2311.
10. Cryan J.F., Page M.E., Lucki I. Differential behavioral effects of the antidepressants reboxetine, fluoxetine, and moclobemide in a modified forced swim test following chronic treatment. Psychopharmacology (Berl.) 2005, 182:335-344.
11. Cryan J.F., Valentino R.J., Lucki I. Assessing substrates underlying the behavioral effects of antidepressants using the modified rat forced swimming test. Neurosci. Biobehav. Rev. 2005, 29:547-569.
12. DeBattista C., Belanoff J. The use of mifepristone in the treatment of neuropsychiatric disorders. Trends Endocrinol. Metab. 2006, 17:117-121.
13. de Kloet E.R., de Kock S., Schild V., Veldhuis H.D. Antiglucocorticoid RU 38486 attenuates retention of a behaviour and disinhibits the hypothalamic-pituitary-adrenal axis at different brain sites. Neuroendocrinology 1988, 47:109-115.
14. Delbende C., Contesse V., Mocaer E., Kamoun A., Vaudry H. The novel antidepressant, tianeptine, reduces stress-evoked stimulation of the hypothalamo-pituitary-adrenal axis. Eur. J. Pharmacol. 1991, 202:391-396.
15. Diorio D., Viau V., Meaney M.J. The role of the medial prefrontal cortex (cingulate gyrus) in the regulation of hypothalamic-pituitary-adrenal responses to stress. J. Neurosci. 1993, 13:3839-3847.
16. Drevets W.C., Price J.L., Simpson J.R., Todd R.D., Reich T., Vannier M., Raichle M.E. Subgenual prefrontal cortex abnormalities in mood disorders. Nature 1997, 386:824-827.
17. Feldman S., Conforti N., Itzik A., Weidenfeld J. Differential effect of amygdaloid lesions on CRF-41, ACTH and corticosterone responses following neural stimuli. Brain Res. 1994, 658:21-26.
18. Figueiredo H.F., Bruestle A., Bodie B., Dolgas C.M., Herman J.P. The medial prefrontal cortex differentially regulates stress-induced c-fos expression in the forebrain depending on type of stressor. Eur. J. Neurosci. 2003, 18:2357-2364.
19. Flores B.H., Kenna H., Keller J., Solvason H.B., Schatzberg A.F. Clinical and biological effects of mifepristone treatment for psychotic depression. Neuropsychopharmacology 2006, 31:628-636.
20. Glavas M.M., Yu W.K., Weinberg J. Effects of mineralocorticoid and glucocorticoid receptor blockade on hypothalamic-pituitary-adrenal function in female rats prenatally exposed to ethanol. Alcohol Clin. Exp. Res. 2006, 30:1916-1924.
21. Gold P.W., Chrousos G.P. The endocrinology of melancholic and atypical depression: relation to neurocircuitry and somatic consequences. Proc. Assoc. Am. Physicians 1999, 111:22-34.
22. Herman J.P., Mueller N.K. Role of the ventral subiculum in stress integration. Behav. Brain Res. 2006, 174:215-224.
23. Herman J.P., Dolgas C.M., Carlson S.L. Ventral subiculum regulates hypothalamo-pituitary-adrenocortical and behavioural responses to cognitive stressors. Neuroscience 1998, 86:449-459.
24. Herman J.P., Cullinan W.E., Morano M.I., Akil H., Watson S.J. Contribution of the ventral subiculum to inhibitory regulation of the hypothalamo-pituitary-adrenocortical axis. J. Neuroendocrinol. 1995, 7:475-482.
25. Herman J.P., Figueiredo H., Mueller N.K., Ulrich-Lai Y., Ostrander M.M., Choi D.C., Cullinan W.E. Central mechanisms of stress integration: hierarchical circuitry controlling hypothalamo-pituitary-adrenocortical responsiveness. Front. Neuroendocrinol. 2003, 24:151-180.
26. Ishizaki J., Yamamoto H., Takahashi T., Takeda M., Yano M., Mimura M. Changes in regional cerebral blood flow following antidepressant treatment in late-life depression. Int. J. Geriatr. Psychiatry 2008, 23:805-811.
27. Jasper M.S., Engeland W.C. Synchronous ultradian rhythms in adrenocortical secretion detected by microdialysis in awake rats. Am. J. Physiol. 1991, 261:R1257-1268.
28. Kim M., Davis M. Electrolytic lesions of the amygdala block acquisition and expression of fear-potentiated startle even with extensive training but do not prevent reacquisition. Behav. Neurosci. 1993, 107:580-595.
29. Kukolja J., Schlapfer T.E., Keysers C., Klingmuller D., Maier W., Fink G.R., Hurlemann R. Modeling a negative response bias in the human amygdala by noradrenergic-glucocorticoid interactions. J. Neurosci. 2008, 28:12868-12876.
30. Mailliet F., Qi H., Rocher C., Spedding M., Svenningsson P., Jay T.M. Protection of stress-induced impairment of hippocampal/prefrontal LTP through blockade of glucocorticoid receptors: implication of MEK signaling. Exp. Neurol. 2008, 211:593-596.
31. Mayer J.L., Klumpers L., Maslam S., de Kloet E.R., Joels M., Lucassen P.J. Brief treatment with the glucocorticoid receptor antagonist mifepristone normalises the corticosterone-induced reduction of adult hippocampal neurogenesis. J. Neuroendocrinol. 2006, 18:629-631.
32. Morley-Fletcher S., Darnaudery M., Mocaer E., Froger N., Lanfumey L., Laviola G., Casolini P., Zuena A.R., Marzano L., Hamon M., Maccari S. Chronic treatment with imipramine reverses immobility behaviour, hippocampal corticosteroid receptors and cortical 5-HT(1A) receptor mRNA in prenatally stressed rats. Neuropharmacology 2004, 47:841-847.
33. Mueller N.K., Dolgas C.M., Herman J.P. Stressor-selective role of the ventral subiculum in regulation of neuroendocrine stress responses. Endocrinology 2004, 145:3763-3768.
34. Oomen C.A., Mayer J.L., de Kloet E.R., Joels M., Lucassen P.J. Brief treatment with the glucocorticoid receptor antagonist mifepristone normalizes the reduction in neurogenesis after chronic stress. Eur. J. Neurosci. 2007, 26:3395-3401.
35. Pace T.W., Spencer R.L. Disruption of mineralocorticoid receptor function increases corticosterone responding to a mild, but not moderate, psychological stressor. Am. J. Physiol. Endocrinol. Metab. 2005, 288:E1082-E1088.
36. Pariante C.M. Depression, stress and the adrenal axis. J. Neuroendocrinol. 2003, 15:811-812.
37. Paxinos G., Watson C. The Rat Brain in Stereotaxic Coordinates 1998, Academic Press, Inc., California, p. 474. 4th ed.
38. Porsolt R.D., Le Pichon M., Jalfre M. Depression: a new animal model sensitive to antidepressant treatments. Nature 1977, 266:730-732.
39. Ratka A., Sutanto W., Bloemers M., de Kloet E.R. On the role of brain mineralocorticoid (type I) and glucocorticoid (type II) receptors in neuroendocrine regulation. Neuroendocrinology 1989, 50:117-123.
40. Reul J.M., Labeur M.S., Grigoriadis D.E., De Souza E.B., Holsboer F. Hypothalamic-pituitary-adrenocortical axis changes in the rat after long-term treatment with the reversible monoamine oxidase-A inhibitor moclobemide. Neuroendocrinology 1994, 60:509-519.
41. Schmidt H.D., Duman R.S. The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior. Behav. Pharmacol. 2007, 18:391-418.
42. Siegle G.J., Thompson W., Carter C.S., Steinhauer S.R., Thase M.E. Increased amygdala and decreased dorsolateral prefrontal BOLD responses in unipolar depression: related and independent features. Biol. Psychiatry 2007, 61:198-209.
43. Spencer R.L., Kim P.J., Kalman B.A., Cole M.A. Evidence for mineralocorticoid receptor facilitation of glucocorticoid receptor-dependent regulation of hypothalamic-pituitary-adrenal axis activity. Endocrinology 1998, 139:2718-2726.
44. Sullivan R.M., Gratton A. Lateralized effects of medial prefrontal cortex lesions on neuroendocrine and autonomic stress responses in rats. J. Neurosci. 1999, 19:2834-2840.
45. Thomson F., Craighead M. Innovative approaches for the treatment of depression: targeting the HPA axis. Neurochem. Res. 2008, 33:691-707.
46. van Haarst A.D., Oitzl M.S., Workel J.O., de Kloet E.R. Chronic brain glucocorticoid receptor blockade enhances the rise in circadian and stress-induced pituitary-adrenal activity. Endocrinology 1996, 137:4935-4943.
47. Xu Y., Day T.A., Buller K.M. The central amygdala modulates hypothalamic-pituitary-adrenal axis responses to systemic interleukin-1beta administration. Neuroscience 1999, 94:175-183.