The X-ray structure of RU486 bound to the progesterone receptor in a destabilized agonistic conformation

Journal of Biological Chemistry

Volumn 284, Issue 29, 2009, Pages 19572-19579

  Raaijmakers, Hans C A ^a   Versteegh, Judith E ^a   Ultdehaag, Joost C M ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FACTOR ANALYSIS; GLUCOCORTICOID RECEPTOR; LIGAND BINDING DOMAIN; LIGAND EXCHANGES; MIFEPRISTONE; NORETHINDRONE; PROGESTERONE RECEPTOR; X-RAY STRUCTURE;

BIOCHEMISTRY; LIGANDS;

CRYSTAL STRUCTURE;

ANDROGEN RECEPTOR; ASOPRISNIL; GLUCOCORTICOID RECEPTOR; MIFEPRISTONE; NORETHISTERONE; ONAPRISTONE; PROGESTERONE RECEPTOR;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CHO CELL; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG CONFORMATION; DRUG STRUCTURE; FACTORIAL ANALYSIS; LIGAND BINDING; MALE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; RECEPTOR OCCUPANCY;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; HORMONE ANTAGONISTS; HUMANS; MIFEPRISTONE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, GLUCOCORTICOID; RECEPTORS, PROGESTERONE;

EID: 67749148919     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.007872     Document Type: Article

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