Biomarkers for anti-angiogenic therapy in cancer

International Journal of Molecular Sciences

Volumn 14, Issue 5, 2013, Pages 9338-9364

  Wehland, Markus ^a   Bauer, Johann ^b   Magnusson, Nils E ^c   Infanger, Manfred ^a   Grimm, Daniela ^c  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

^b MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^c AARHUS UNIVERSITY   (Denmark)

Author keywords

Anti angiogenic therapy; Biomarkers; Cancer; VEGF

Indexed keywords

AFLIBERCEPT; BEVACIZUMAB; BIOLOGICAL MARKER; CAPECITABINE; CELL ADHESION MOLECULE; DOCETAXEL; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; EPIDERMAL GROWTH FACTOR RECEPTOR 2; FLUOROURACIL; FOLINIC ACID; GELATINASE A; GELATINASE B; INTERLEUKIN 6; IRINOTECAN; LACTATE DEHYDROGENASE; MATRILYSIN; MOTESANIB; OXALIPLATIN; PACLITAXEL; PAZOPANIB; PLACEBO; PREDNISONE; PROTEIN P53; RAMUCIRUMAB; SORAFENIB; SUNITINIB; UNINDEXED DRUG; VASCULAR CELL ADHESION MOLECULE 1; VASCULOTROPIN A; VASCULOTROPIN RECEPTOR 2; ANGIOGENESIS INHIBITOR; TUMOR MARKER;

ANTIANGIOGENIC THERAPY; BREAST CANCER; CANCER SURVIVAL; CARCINOGENESIS; COLON CANCER; COLORECTAL CANCER; CXR1 GENE; CXR2 GENE; DISEASE ACTIVITY; DOSE RESPONSE; DRUG EFFICACY; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG RESPONSE; DRUG SAFETY; DRUG TARGETING; DRUG TOLERABILITY; DRUG TREATMENT FAILURE; ENDOTHELIUM CELL; GASTROINTESTINAL STROMAL TUMOR; GLIOBLASTOMA; HUMAN; HYPERTENSION; INTERLEUKIN 6 GENE; INTRACELLULAR ADHESION MOLECULE GENE; KIDNEY CANCER; KIDNEY CARCINOMA; KINASE INSERT DOMAIN RECEPTOR GENE; LIVER CELL CARCINOMA; LOW DRUG DOSE; LUNG CANCER; MALIGNANT NEOPLASTIC DISEASE; MATRIX METALLOPROTEINASE 2 GENE; MATRIX METALLOPROTEINASE 7 GENE; MATRIX METALLOPROTEINASE 9 GENE; MELANOMA; METASTASIS; MOLECULAR PATHOLOGY; NONHUMAN; OVARY CANCER; OVARY CARCINOMA; OVERALL SURVIVAL; PANCREAS CANCER; PREDICTION; PROGRESSION FREE SURVIVAL; PROSTATE CANCER; PROTEIN BLOOD LEVEL; PROTEIN DETERMINATION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REPEATED DRUG DOSE; REVIEW; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; SOFT TISSUE CANCER; SOFT TISSUE SARCOMA; STOMACH CANCER; SURVIVAL RATE; THYROID CANCER; THYROID MEDULLARY CARCINOMA; TRANSITIONAL CELL CARCINOMA; TUMOR GENE; TUMOR SUPPRESSOR GENE; UROTHELIAL METASTASIS; UTERUS CANCER; VASCULAR ENDOTHELIAL GROWTH FACTOR 2 GENE; VASCULAR ENDOTHELIAL GROWTH FACTOR GENE; ANIMAL; BIOLOGICAL MODEL; GENETICS; METABOLISM; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; VASCULARIZATION;

ANGIOGENESIS INHIBITORS; ANIMALS; HUMANS; MODELS, BIOLOGICAL; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; TUMOR MARKERS, BIOLOGICAL;

EID: 84877354216     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms14059338     Document Type: Review

References (177)

1. Straume, O.; Chappuis, P.O.; Salvesen, H.B.; Halvorsen, O.J.; Haukaas, S.A.; Goffin, J.R.; Bégin, L.R.; Foulkes, W.D.; Akslen, L.A. Prognostic importance of glomeruloid microvascular proliferation indicates an aggressive angiogenic phenotype in human cancers. Cancer Res. 2002, 62, 6808-6811.
2. Folkman, J. Tumor angiogenesis: Therapeutic implications. N. Engl. J. Med. 1971, 285, 1182-1186.
3. Arnold, F.; West, D.C. Angiogenesis in wound healing. Pharmacol. Ther. 1991, 52, 407-422.
4. Reynolds, L.P.; Redmer, D.A. Angiogenesis in the placenta. Biol. Reprod. 2001, 64, 1033-1040.
5. Folkman, J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat. Med. 1995, 1, 27-31.
6. Hanahan, D.; Folkman, J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 1996, 86, 353-364.
7. Skobe, M.; Rockwell, P.; Goldstein, N.; Vosseler, S.; Fusenig, N.E. Halting angiogenesis suppresses carcinoma cell invasion. Nat. Med. 1997, 3, 1222-1227.
8. Sullivan, R.; Graham, C.H. Hypoxia-driven selection of the metastatic phenotype. Cancer Metastasis. Rev. 2007, 26, 319-331.
9. Ferrara, N. Role of vascular endothelial growth factor. Am. J. Physiol. Cell Physiol. 2001, 280, C1358-C1366.
10. Ferrara, N.; Gerber, H.P.; LeCouter, J. The biology of VEGF and its receptors. Nat. Med. 2003, 9, 666-669.
11. Tammela, T.; Enholm, B.; Alitalo, K.; Paavonen, K. The biology of vascular endothelial growth factors. Cardiovasc. Res. 2005, 65, 550-563.
12. Kowanetz, M.; Ferrara, N. Vascular endothelial growth factor signaling pathways, therapeutic perspective. Clin. Cancer Res. 2006, 12, 5018-5022.
13. Holderfield, M.T.; Hughes, C.C. Crosstalk between vascular endothelial growth factor, notch, and transforming growth factor-beta in vascular morphogenesis. Circ. Res. 2008, 102, 637-652.
14. Bergers, G.; Hanahan, D. Modes of resistance to anti-angiogenic therapy. Nat. Rev. Cancer 2008, 8, 592-603.
15. Carmeliet, P.; Ng, Y.S.; Nuyens, D.; Theilmeier, G.; Brusselmans, K.; Cornelissen, I.; Ehler, E.; Kakkar, V.V.; Stalmans, I.; Mattot, V.; et al. Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF(164) and VEGF(188). Nat. Med. 1999, 5, 495-502.
16. Valtola, R.; Salven, P.; Heikkilä, P.; Taipale, J.; Joensuu, H.; Rehn, M.; Pihlajaniemi, T.; Weich, H.; de Waal, R.; Alitalo K. VEGFR-3 and its ligand VEGF-C are associated with angiogenesis in breast cancer. Am. J. Pathol. 1999, 154, 1381-1390.
17. Roskoski, R. Vascular endothelial growth factor (VEGF) signaling in tumor progression. Crit. Rev. Oncol. Hematol. 2007, 62, 179-213.
18. Ruohola, J.K.; Valve, E.M.; Karkkainen, M.J.; Joukov, V.; Alitalo, K.; Härkönen, P.L. Vascular endothelial growth factors are differentially regulated by steroid hormones and antiestrogens in breast cancer cells. Mol. Cell Endocrinol. 1999, 149, 29-40.
19. Dumont, N.; Arteaga, C.L. Transforming growth factor-beta and breast cancer-Tumor promoting effects of transforming growth factor-beta. Breast Cancer Res. 2000, 2, 125-132.
20. Gerber, H.P.; McMurtrey, A.; Kowalski, J.; Yan, M.; Keyt, B.A.; Dixit, V.; Ferrara, N. Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation. Requirement for Flk-1/KDR activation. J. Biol. Chem. 1998, 273, 30336-30343.
21. Dor, Y.; Porat, R.; Keshet, E. Vascular endothelial growth factor and vascular adjustments to perturbations in oxygen homeostasis. Am. J. Physiol. Cell Physiol. 2001, 280, C1367-C1374.
22. Infanger, M.; Faramarzi, S.; Grosse, J.; Kurth, E.; Ulbrich, C.; Bauer, J.; Wehland, M.; Kreutz R.; Kossmehl, P.; Paul, M.; et al. Expression of vascular endothelial growth factor and receptor tyrosine kinases in cardiac ischemia/reperfusion injury. Cardiovasc. Pathol. 2007, 16, 291-299.
23. Semenza, G. Signal transduction to hypoxia-inducible factor 1. Biochem. Pharmacol. 2002, 64, 993-998.
24. Ferrara, N.; Davis-Smyth, T. The biology of vascular endothelial growth factor. Endocr. Rev. 1997, 18, 4-25.
25. Herbert, S.P.; Stainier, D.Y. Molecular control of endothelial cell behavior during blood vessel morphogenesis. Nat. Rev. 2011, 12, 551-564.
26. Shibuya, M.; Yamaguchi, S.; Yamane, A.; Ikeda, T.; Tojo, A.; Matsushime, H.; Sato, M. Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family. Oncogene 1990, 5, 519-524.
27. Terman, B.I.; Carrion, M.E.; Kovacs, E.; Rasmussen, B.A.; Eddy, R.L.; Shows, T.B. Identification of a new endothelial cell growth factor receptor tyrosine kinase. Oncogene 1991, 6, 1677-1683.
28. Karkkainen, M.J.; Mäkinen, T.; Alitalo, K. Lymphatic endothelium, a new frontier of metastasis research. Nat. Cell Biol. 2002, 4, E2-E5.
29. Ferrara, N. Vascular endothelial growth factor, basic science and clinical progress. Endocr. Rev. 2004, 25, 581-611.
30. Alitalo, K.; Tammela, T.; Petrova, T.V. Lymphangiogenesis in development and human disease. Nature 2005, 438, 946-953.
31. Paavonen, K.; Puolakkainen, P.; Jussila, L.; Jahkola, T.; Alitalo, K. Vascular endothelial growth factor receptor-3 in lymphangiogenesis in wound healing. Am. J. Pathol. 2000, 156, 1499-1504.
32. Tammela, T.; Zarkada, G.; Nurmi, H.; Jakobsson, L.; Heinolainen, K.; Tvorogov, D.; Zheng, W.; Franco, C.A.; Murtomäki, A.; Aranda, E.; et al. VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling. Nat. Cell Biol. 2011, 3, 1202-1213.
33. Takahashi, H.; Shibuya, M. The vascular endothelial growth factor (VEGF)/VEGF receptor system and its role under physiological and pathological conditions. Clin. Sci. 2005, 109, 227-241.
34. Olsson, A.K.; Dimberg, A.; Kreuger, J.; Claesson-Welsh, L. VEGF receptor signaling-In control of vascular function. Nat. Rev. Mol. Cell Biol. 2006, 7, 359-371.
35. Park, J.E.; Chen, H.H.; Winer, J.; Houck, K.A.; Ferrara, N. Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR. J. Biol. Chem. 1994, 269, 25646-25654.
36. Hiratsuka, S.; Minowa, O.; Kuno, J.; Noda, T.; Shibuya, M. Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice. Proc. Natl. Acad. Sci. USA 1998, 4, 9349-9354.
37. Infanger, M.; Schmidt, O.; Kossmehl, P.; Grad, S.; Ertel, W.; Grimm D. Vascular endothelial growth factor serum level is strongly enhanced after burn injury and correlated with local and general tissue edema. Burns 2004, 30, 305-311.
38. Infanger, M.; Shakibaei, M.; Kossmehl, P.; Hollenberg, S.M.; Grosse, J.; Faramarzi, S.; Schulze-Tanzil, G.; Paul, M.; Grimm, D. Intraluminal application of vascular endothelial growth factor enhances healing of microvascular anastomosis in a rat model. J. Vasc. Res. 2005, 42, 202-213.
39. Infanger, M.; Grosse, J.; Westphal, K.; Leder, A.; Ulbrich, C.; Paul, M.; Grimm, D. Vascular Endothelial Growth Factor induces extracellular matrix proteins and osteopontin in the umbilical artery. Ann. Vasc. Surg. 2008, 22, 273-284.
40. Alon, T.; Hemo, I.; Itin, A.; Pe'er, J.; Stone, J.; Keshet, E. Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity. Nat. Med. 1995, 1, 1024-1028.
41. Gerber, H.P.; Dixit, V.; Ferrara, N. Vascular Endothelial Growth Factor induces expression of the antiapoptotic proteins Bcl-2 and A1 in vascular endothelial cells. J. Biol. Chem. 1998, 273, 13313-13316.
42. Benjamin, L.E.; Golijanin, D.; Itin, A.; Pode, D.; Keshet, E. Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal. J. Clin. Invest. 1999, 103, 159-165.
43. Infanger, M.; Kossmehl, P.; Shakibaei, M.; Baatout, S.; Witzing, A.; Grosse, J.; Bauer, J.; Cogoli, A.; Faramarzi, S.; Derradji, H.; et al. Induction of three-dimensional assembly and increase in apoptosis of human endothelial cells by simulated microgravity. Impact of vascular endothelial growth factor. Apoptosis 2006, 11, 749-764.
44. Ferrara, N.; Hillan, K.; Gerber, H.P.; Novotny, W. Discovery and development of Bevacizumab, an anti VEGF antibody for treating cancer. Nat. Rev. Drug Discov. 2004, 3, 391-398.
45. Reck, M.; von Pawel, J.; Zatloukal, P.; Ramlau, R.; Gorbounova, V.; Hirsh, V.; Leighl, N.; Mezger, J.; Archer, V.; Moore, N.; et al. BO17704 Study Group. Overall survival with cisplatin-gemcitabina and Bevacizumab or placebo as first line therapy for non-squamous NSCLC: Results from a randomized phase III trial (AVAiL). Ann. Oncol. 2010, 21, 1804-1809.
46. Sandler, A.; Gray, R.; Perry, M.C.; Brahmer, J.; Schiller, J.H.; Dowlati, A.; Lilenbaum, R.; Johnson, D.H. Paclitaxel-Carboplatin alone or with Bevacizumab for non-small-cell lung cancer. N. Engl. J. Med. 2006, 355, 2542-2550.
47. Johnson, D.H.; Fehrenbacher, L.; Novotny, W.F.; Herbst, R.S.; Nemunaitis, J.J.; Jablons, D.M.; Langer, C.J.; DeVore, R.F., 3rd; Gaudreault, J.; Damico, L.A.; et al. Randomized phase II trial comparing Bevacizumab plus Carboplatin and Paclitaxel with Carboplatin and Paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer. J. Clin. Oncol. 2004, 22, 2184-2191.
48. Herbst, R.S.; O'Neill, V.J.; Fehrenbacher, L.; Belani, C.P.; Bonomi, P.D.; Hart, L.; Melnyk, O.; Ramies, D.; Lin, M.; Sandler, A. Phase II study of efficacy and safety of Bevacizumab in combination with chemotherapy or Erlotinib compared with chemotherapy alone for treatment of recurrent or refractory non-small-cell lung cancer. J. Clin. Oncol. 2007, 25, 4743-4750.
49. Miller, K.D.; Chap, L.I.; Holmes, F.A.; Cobleigh, M.A.; Marcom, P.K.; Fehrenbacher, L.; Dickler, M.; Overmoyer, B.A.; Reimann, J.D.; Sing, A.P.; et al. Randomized phase III trial of Capecitabine compared with Bevacizumab plus Capecitabine in patient with previously treated metastatic breast cancer. J. Clin. Oncol. 2005, 23,792-799.
50. Miller, K.; Wang, M.; Gralow, J.; Dickler, M.; Cobleigh, M.; Perez, E.A.; Shenkier, T.; Cella, D.; Davidson, N.E. Paclitaxel with Bevacizumab versus Paclitaxel alone in metastatic breast cancer. N. Engl. J. Med. 2007, 357, 2666-2676.
51. Robert, N.J.; Dieras, V.; Glaspy, J.; Brufsky, A.; Bondarenko, I.; Lipatov, O.; Perez, E.; Yardley, D.; Zhou, X.; Phan, S. RIBBON-1, randomized, double blind, placebo controlled phase III trial of chemotherapy with or without Bevacizumab for first line treatment of HER2 negative locally recurrent or metastatic breast cancer. ASCO Present. J. Clin. Oncol. 2009, 27, 15s.
52. Miles, D.W.; Chan, A.; Dirix, L.Y.; Cortés, J.; Pivot, X.; Tomczak, P.; Delozier, T.; Sohn, J.H.; Provencher, L.; Puglisi, F.; et al. Phase III study of Bevacizumab plus Docetaxel campared with placebo plus docetaxel for the first line treatment of human epidermal growth factor receptor-2-negative metastatic breast cancer. J. Clin. Oncol. 2010, 28, 3239-3247.
53. Brufsky, A.M.; Hurvitz, S.; Perez, E.; Swamy, R.; Valero, V.; O'Neill, V.; Rugo, H.S. RIBBON-2, a randomized, double-blind, placebo-controlled, phase III trial evaluating the efficacy and safety of Bevacizumab in combination with chemotherapy for second-line treatment of human epidermal growth factor receptor 2-negative metastatic breast cancer. J. Clin. Oncol. 2011, 29, 4286-4293.
54. Kabbinavar, F.; Hurwitz, H.I.; Fehrenbacher, L.; Meropol, N.J.; Novotny, W.F.; Lieberman, G.; Griffing, S.; Bergsland, E. Phase II randomized trial comparing Bevacizumab plus Fluorouracil(FU)/Leucovorin(LV) with FU/LV alone in patients with metastatic colorectal cancer. J. Clin. Oncol. 2003, 21, 60-65.
55. Kabbinavar, F.F.; Schulz, J.; McCleod, M.; Patel, T.; Hamm, J.T.; Hecht, J.R.; Mass, R.; Perrou, B.; Nelson, B.; Novotny, W.F. Addition of Bevacizumab to bolus Fluorouracil and Leucovorin in first line metastatic colorectal cancer, results of randomized phase II trial. J. Clin. Oncol. 2005, 23, 3697-3705.
56. Hurwitz, H.; Fehrenbacher, L.; Novotny, W.; Cartwright, T.; Hainsworth, J.; Heim, W.; Berlin, J.; Baron, A.; Griffing, S.; Holmgren, E.; et al. Bevacizumab plus Irinotecan, Flouorouracil and Leucovorin for metastatic colorectal cancer. N. Engl. J. Med. 2004, 350, 2335-2342.
57. Saltz, L.B.; Clarke, S.; Díaz-Rubio; E.; Scheithauer, W.; Figer, A.; Wong, R.; Koski, S.; Lichinitser, M.; Yang, T.S.; Rivera, F.; et al. Bevacizumab in combination with oxaliplatin based chemotherapy as first line therapy in metastatic colorectal cancer: A randomized phase III study. J. Clin. Oncol. 2008, 26, 2013-2019.
58. Tebbutt, N.C.; Wilson, K.; Gebski, V.J.; Cummins, M.M.; Zannino, D.; van Hazel, G.A.; Robinson, B.; Broad, A.; Ganju, V.; Ackland, S.P.; et al. Capecitabine, Bevacizumab and Mitomycin in first line treatment of metastatic colorectal cancer: Results of the Australian gastrointestinal trials group randomized phase III MAX study. J. Clin. Oncol. 2010, 28, 3191-3198.
59. Rini, B.I.; Halabi, S.; Rosenberg, J.E.; Stadler, W.M.; Vaena, D.A.; Archer, L.; Atkins, J.N.; Picus, J.; Czaykowski, P.; Dutcher, J.; et al. Phase III trial of Bevacizumab plus interferon alfa versus interferon alfa monotherapy in patients with metastatic renal cell carcinoma: Final results of CALGB 90206. J. Clin. Oncol. 2010, 28, 1-7.
60. Escudier, B.; Pluzanska, A.; Koralewski, P.; Ravaud, A.; Bracarda, S.; Szczylik, C.; Chevreau, C.; Filipek, M.; Melichar, B.; Bajetta, E.; et al. AVOREN Trial investigators. Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: A randomized double blind phase III trial. Lancet 2007, 370, 2103-2111.
61. Ohtsu, A.; Shah, M.A.; van Cutsem, E.; Rha, S.Y.; Sawaki, A.; Park, S.R.; Lim, H.Y.; Yamada, Y.; Wu, J.; Langer, B.; et al. Bevacizumab in combination with chemotherapy as first-line therapy in advanced gastric cancer: A randomized, double-blind, placebo-controlled phase III study. J. Clin. Oncol. 2011, 29, 3968-3976.
62. Kindler, H.L.; Niedzwiecki, D.; Hollis, D.; Sutherland, S.; Schrag, D.; Hurwitz, H.; Innocenti, F.; Mulcahy, M.F.; O'Reilly, E.; Wozniak, T.F.; et al. Gemcitabine plus Bevacizumab compared with Gemcitabine plus placebo in patients with advanced pancreatic cancer: Phase III trial of the cancer and leukemia group B (CALGB 80303). J. Clin. Oncol. 2010, 28, 3617.
63. Van Cutsem, E.; Vervenne, W.L.; Bennouna, J.; Humblet, Y.; Gill, S.; van Laethem, J.L.; Verslype, C.; Scheithauer, W.; Shang, A.; Cosaert, J.; et al. Phase III trial of Bevacizumab in combination with Gemcitabine and Erlotinib in patients with metastatic pancreatic cancer. J. Clin. Oncol. 2009, 27, 2231-2237.
64. Kelly, W.K.; Halabi, S.; Carducci, M.; George, D.; Mahoney, J.F.; Stadler, W.M.; Morris, M.; Kantoff, P.; Monk, J.P.; Kaplan, E.; et al. Randomized, double-blind, placebo-controlled phase III trial comparing docetaxel and prednisone with or without bevacizumab in men with metastatic castration-resistant prostate cancer: CALGB 90401. J. Clin. Oncol. 2012, 30, 1534-1540.
65. Kim, K.B.; Sosman, J.A.; Fruehauf, J.P.; Linette, G.P.; Markovic, S.N.; McDermott, D.F.; Weber, J.S.; Nguyen, H.; Cheverton, P.; Chen, D.; et al. BEAM: A randomized phase II study evaluating the activity of Bevacizumab in combination with Carboplatinum plus Paclitaxel in patients with previously untreated advanced melanoma. J. Clin. Oncol. 2012, 30, 34-41.
66. Tew, W.P.; Colombo, N.; Ray-Coquard, I.; Oza, A.; del Campo, J.; Scambia, G.; Spriggs, D. VEGF-Trap for patients (pts) with recurrent platinum-resistant epithelial ovarian cancer (EOC), preliminary results of a randomized, multicenter phase II study. ASCO Meet. Abstr. 2007, 25, 5508.
67. Tang, P.; Cohen, S.J.; Bjarnason, G.A.; Kollmannsberger, C.; Virik, K.; MacKenzie, M.J.; Brown, J.; Wang, L.; Chen, A.P.; Moore, M.J. Phase II trial of aflibercept (VEGF Trap) in previously treated patients with metastatic colorectal cancer (MCRC): A PMH phase II consortium trial. ASCO Meet. Abstr. 2008, 26, 4027.
68. Massarelli, E.; Miller, V.A.; Leighl, N.B.; Rosen, P.J.; Albain, K.S.; Hart, L.L.; Melnyk, O.; Sternas, L.; Ackerman, J.; Herbst, R.S. Phase II study of the efficacy and safety of intravenous (IV) AVE0005 (VEGF Trap) given every 2 weeks in patients (Pts) with platinum- and erlotinib-resistant adenocarcinoma of the lung (NSCLA). ASCO Meet. Abstr. 2007, 25, 7627.
69. Townsley, C.; Hirte, H.; Hoskins, P.; Buckanovich, R.; Mackay, H.; Welch, S.; Wang, L.; Polintan, R.; Chen, A.; Oza, A.M. A phase II study of aflibercept (VEGF trap) in recurrent or metastatic gynecologic soft-tissue sarcomas: A study of the Princess Margaret Hospital Phase II Consortium. ASCO Meet. Abstr. 2009, 27, 5591.
70. Twardowski, P.; Stadler, W.M.; Frankel, P.; Lara, P.N.; Ruel, C.; Chatta, G.; Heath, E.I.; Quinn, D.I.; Gandara, D.R. Phase II study of aflibercept (VEGFTrap) in patients with recurrent or metastatic transitional cell carcinoma (TCC) of the urothelium: A California Cancer Consortium trial. ASCO Meet. Abstr. 2009, 27, e16030.
71. Tarhini, A.A.; Christensen, S.; Frankel, P.; Margolin, K.; Ruel, C.; Shipe-Spotloe, J.; DeMark, M.; Kirkwood, J.M. Phase II study of aflibercept (VEGF trap) in recurrent inoperable stage III or stage IV melanoma of cutaneous or ocular origin. ASCO Meet. Abstr. 2009, 27, 9028.
72. De Groot, J.F.; Wen, P.Y.; Lamborn, K.; Chang, S.; Cloughesy, T.F.; Chen, A.P.; DeAngelis, L.M.; Mehta, M.P.; Gilbert, M.R.; Yung, W.K.; et al. Phase II single arm trial of aflibercept in patients with recurrent temozolomide-resistant glioblastoma: NABTC 0601. ASCO Meet. Abstr. 2008, 26, 2020.
73. Lu, D.; Jimenez, X.; Zhang, H.; Bohlen, P.; Witte, L.; Zhu, Z. Selection of high affinity human neutralizing antibodies to VEGFR2 from a large antibody phage display library for antiangiogenesis therapy. Int. J. Cancer 2002, 97, 393-399.
74. Spratlin, J. Ramucirumab (IMC-1121B), Monoclonal antibody inhibition of vascular endothelial growth factor receptor-2. Curr. Oncol. Rep. 2011, 13, 97-102.
75. Wood, L. Sunitinib malate for the treatment of renal cell carcinoma. Expert Opin. Pharmacother. 2012, 13, 1323-1336.
76. Sekkate, S.; Kairouani, M.; Abahssain, H.; Serji, B.; Boutayeb, S.; Mrabti, H.; Errihani, H. Gastrointestinal stromal tumors. Presse. Med. 2012, 41, 917-926.
77. Escudier, B.; Eisen, T.; Stadler, W.M.; Szczylik, C.; Oudard, S.; Staehler, M.; Negrier, S.; Chevreau, C.; Desai, A.A.; Rolland, F.; et al. Sorafenib for treatment of renal cell carcinoma, Final efficacy and safety results of the phase III treatment approaches in renal cancer global evaluation trial. J. Clin. Oncol. 2009, 27, 3312-3318.
78. Zhu, A.X. Development of sorafenib and other molecularly targeted agents in hepatocellular carcinoma. Cancer 2008, 112, 250-259.
79. Scagliotti, G.V.; Vynnychenko, I.; Park, K.; Ichinose, Y.; Kubota, K.; Blackhall, F.; Pirker, R. Galiulin, R.; Ciuleanu, T.E.; Sydorenko, O.; et al. International, randomized, placebo-controlled, double-blind phase III study of motesanib plus carboplatin/paclitaxel in patients with advanced nonsquamous non-small-cell lung cancer: MONET1. J. Clin. Oncol. 2012, 30, 2829-2836.
80. Coxon, A.; Bready, J.; Kaufman, S.; Estrada, J.; Osgood, T.; Canon, J.; Wang, L.; Radinsky, R.; Kendall, R.; Hughes, P.; et al. Anti-tumor activity of motesanib in a medullary thyroid cancer model. J. Endocrinol. Invest. 2012, 35, 181-190.
81. Gennigens, C.; Jerusalem, G. Pazopanib (Votrient) in the management of renal cell cancer and soft tissue sarcomas. Rev. Med. Liege 2012, 67, 437-442.
82. Grimm, D.; Wise, P.; Lebert, M.; Richter, P.; Baatout, S. How and why does the proteome respond to microgravity? Expert Rev. Proteomics 2011, 8, 13-27.
83. Pietsch, J.; Bauer, J.; Egli, M.; Infanger, M.; Wise, P.; Ulbrich, C.; Grimm, D. The effects of weightlessness on the human organism and mammalian cells. Curr. Mol. Med. 2011, 11, 350-364.
84. Grimm, D.; Infanger, M.; Westphal, K.; Ulbrich, C.; Pietsch, J.; Kossmehl, P.; Vadrucci, S.; Baatout, S.; Flick, B.; Paul, M.; et al. A delayed type of three-dimensional growth of human endothelial cells under simulated weightlessness. Tissue Eng. Part. A 2009, 15, 2267-2275.
85. Grimm, D.; Bauer, J.; Ulbrich, C.; Westphal, K.; Wehland, M.; Infanger, M.; Aleshcheva, G.; Pietsch, J.; Ghardi, M.; Beck, M.; et al. Different responsiveness of endothelial cells to vascular endothelial growth factor and basic fibroblast growth factor added to culture media under gravity and simulated microgravity. Tissue Eng. Part A 2010, 16, 1559-1573.
86. De Gruttola, V.G.; Clax, P.; DeMets, D.L.; Downing, G.J.; Ellenberg, S.S.; Friedman, L.; Gail, M.H.; Prentice, R.; Wittes, J.; Zeger, S.L. Considerations in the evaluation of surrogate endpoints in clinical trials. Summary of a National Institutes of Health workshop. Control. Clin. Trials 2001, 22, 485-502.
87. Oldenhuis, C.N.; Oosting, S.F.; Gietema, J.A.; de Vries, E.G. Prognostic versus predictive value of biomarkers in oncology. Eur. J. Cancer 2008, 44, 946-953.
88. McShane, L.M.; Altman, D.G.; Sauerbrei, W.; Taube, S.E.; Gion, M.; Clark, G.M. Statistics Subcommittee of NCI-EORTC Working Group on Cancer Diagnostics. Reporting recommendations for tumor MARKer prognostic studies (REMARK). Breast Cancer Res. Treat. 2006, 100, 229-235.
89. Ferlay, J.; Shin, H.R.; Bray, F.; Forman, D.; Mathers, C.; Parkin, D.M. GLOBOCAN 2008 v1.2, Cancer Incidence and Mortality Worldwide, IARC CancerBase No. 10 Internet. Lyon, France, International Agency for Research on Cancer, 2010. Available online: http://globocan.iarc.fr (accessed on 15 February 2013).
90. Ince, W.L.; Jubb, A.M.; Holden, S.N.; Holmgren, E.B.; Tobin, P.; Sridhar, M.; Hurwitz, H.I.; Kabbinavar, F.; Novotny, W.F.; Hillan, K.J.; et al. Association of k-ras, b-raf, and p53 status with the treatment effect of Bevacizumab. J. Natl. Cancer Inst. 2005, 97, 981-989.
91. Jubb, A.M.; Hurwitz, H.I.; Bai, W.; Holmgren, E.B.; Tobin, P.; Guerrero, A.S.; Kabbinavar, F.; Holden, S.N.; Novotny, W.F.; Frantz, G.D.; et al. Impact of vascular endothelial growth factor-A expression, thrombospondin-2 expression, and microvessel density on the treatment effect of Bevacizumab in metastatic colorectal cancer. J. Clin. Oncol. 2006, 24, 217-227.
92. Cetin, B.; Kaplan, M.A.; Berk, V.; Ozturk, S.C.; Benekli, M.; Isikdogan, A.; Ozkan, M.; Coskun, U.; Buyukberber, S. Prognostic factors for overall survival in patients with metastatic colorectal carcinoma treated with vascular endothelial growth factor-targeting agents. Asian Pac. J. Cancer Prev. 2012, 13, 1059-1063.
93. Kopetz, S.; Hoff, P.M.; Morris, J.S.; Wolff, R.A.; Eng, C.; Glover, K.Y.; Adinin, R.; Overman, M.J.; Valero, V.; Wen, S.; et al. Phase II trial of infusional fluorouracil, Irinotecan, and Bevacizumab for metastatic colorectal cancer, efficacy and circulating angiogenic biomarkers associated with therapeutic resistance. J. Clin. Oncol. 2010, 28, 453-459.
94. Goede, V.; Coutelle, O.; Neuneier, J.; Reinacher-Schick, A.; Schnell, R.; Koslowsky, T.C.; Weihrauch, M.R.; Cremer, B.; Kashkar, H.; Odenthal, M.; et al. Identification of serum angiopoietin-2 as a biomarker for clinical outcome of colorectal cancer patients treated with Bevacizumab-containing therapy. Br. J. Cancer 2010, 103, 1407-1414.
95. Matsusaka, S.; Suenaga, M.; Mishima, Y.; Takagi, K.; Terui, Y.; Mizunuma, N.; Hatake, K. Circulating endothelial cells predict for response to Bevacizumab-based chemotherapy in metastatic colorectal cancer. Cancer Chemother. Pharmacol. 2011, 68, 763-768.
96. Matsusaka, S.; Mishima, Y.; Suenaga, M.; Terui, Y.; Kuniyoshi, R.; Mizunuma, N.; Hatake, K. Circulating endothelial progenitors and CXCR4-positive circulating endothelial cells are predictive markers for Bevacizumab. Cancer 2011, 117, 4026-4032.
97. Ronzoni, M.; Manzoni, M.; Mariucci, S.; Loupakis, F.; Brugnatelli, S.; Bencardino, K.; Rovati, B.; Tinelli, C.; Falcone, A.; Villa, E.; et al. Circulating endothelial cells and endothelial progenitors as predictive markers of clinical response to Bevacizumab-based first-line treatment in advanced colorectal cancer patients. Ann. Oncol. 2010, 21, 2382-2389.
98. Manzoni, M.; Mariucci, S.; Delfanti, S.; Rovati, B.; Ronzoni, M.; Loupakis, F.; Brugnatelli, S.; Tinelli, C.; Villa, E.; Falcone, A.; et al. Circulating endothelial cells and their apoptotic fraction are mutually independent predictive biomarkers in Bevacizumab-based treatment for advanced colorectal cancer. J. Cancer Res. Clin. Oncol. 2012, 138, 1187-1196.
99. Singh, H.; Pohl, A.; El-Khoueiry, A.; Lurje, G.; Zhang, W.; Yang, D.; Ning, Y.; Shriki, J.; Iqbal, S.; Lenz, H. Use of genetic variants to predict clinical outcome in patients (pts) with metastatic colorectal cancer (mCRC) treated with first-line 5-FU or capecitabine in combination with oxaliplatin and Bevacizumab (FOLFOX/BV or XELOX/BV). J. Clin. Oncol. 2009, 27, 15s.
100. Hansen, T.F.; Christensen, R.D.; Andersen, R.F.; Garm Spindler, K.L.; Johnsson, A.; Jakobsen, A. The predictive value of single nucleotide polymorphisms in the VEGF system to the efficacy of first-line treatment with Bevacizumab plus chemotherapy in patients with metastatic colorectal cancer: Results from the Nordic ACT trial. Int. J. Colorectal Dis. 2012, 27, 715-720.
101. O'Brien, C.A.; Pollett, A.; Gallinger, S.; Dick, J.E. A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature 2007, 445, 106-110.
102. Ricci-Vitiani, L.; Lombardi, D.G.; Pilozzi, E.; Biffoni, M.; Todaro, M.; Peschle, C.; De Maria, R. Identification and expansion of human colon-cancer-initiating cells. Nature 2007, 445, 111-115.
103. Pohl, A.; Zhang, W.; Yang, D.; Lurje, G.; Ning, Y.; Khambata-Ford, S.; Langer, C.; Kahn, M.; Teo, J.L.; Lenz, H.J. Association of CD133 polymorphisms and clinical outcome in metastatic colorectal cancer (mCRC) patients (pts) treated with either first-line 5-FU Bevacizumab (BV) or second-line Irinotecan (IR)/Cetuximab (CB) or IR alone. J. Clin. Oncol. 2009, 27, 15s.
104. Hurwitz, H.I.; Douglas, P.S.; Middleton, J.P.; Sledge, G.W.; Johnson, D.H.; Reardon, D.A.; Chen, D.; Rosen, O. Analysis of early hypertension and clinical outcome with bevacizumab: results from seven phase iii studies. Oncologist 2013, 18, 273-280.
105. Jubb, A.M.; Harris, A.L. Biomarkers to predict the clinical efficacy of Bevacizumab in cancer. Lancet Oncol. 2010, 11, 1172-1183.
106. Scartozzi, M.; Galizia, E.; Chiorrini, S.; Giampieri, R.; Berardi, R.; Pierantoni, C.; Cascinu, S. Arterial hypertension correlates with clinical outcome in colorectal cancer patients treated with first-line Bevacizumab. Ann. Oncol. 2009, 20, 227-230.
107. Österlund, P.; Soveri, L.M.; Isoniemi, H.; Poussa, T.; Alanko, T.; Bono, P. Hypertension and overall survival in metastatic colorectal cancer patients treated with Bevacizumab-containing chemotherapy. Br. J. Cancer 2011, 104, 599-604.
108. De Stefano, A.; Carlomagno, C.; Pepe, S.; Bianco, R.; de Placido, S. Bevacizumab-related arterial hypertension as a predictive marker in metastatic colorectal cancer patients. Cancer Chemother. Pharmacol. 2011, 68, 1207-1213.
109. Wehland, M.; Bauer, J.; Infanger, M.; Grimm, D. Target-based anti-angiogenic therapy in breast cancer. Curr. Pharm. Des. 2012, 18, 4244-4257.
110. Burstein, H.J.; Chen, Y.H.; Parker, L.M.; Savoie, J.; Younger, J.; Kuter, I.; Ryan, P.D.; Garber, J.E.; Chen, H.; Campos, S.M.; et al. VEGF as a marker for outcome among advanced breast cancer patients receiving anti-VEGF therapy with Bevacizumab and vinorelbine chemotherapy. Clin. Cancer Res. 2008, 14, 7871-7877.
111. Baar, J.; Silverman, P.; Lyons, J.; Fu, P.; Abdul-Karim, F.; Ziats, N.; Wasman, J.; Hartman, P.; Jesberger, J.; Dumadag, L.; et al. A vasculature-targeting regimen of preoperative docetaxel with or without Bevacizumab for locally advanced breast cancer: Impact on angiogenic biomarkers. Clin. Cancer Res. 2009, 15, 3583-3590.
112. Burstein, H.J.; Elias, A.D.; Rugo, H.S.; Cobleigh, M.A.; Wolff, A.C.; Eisenberg, P.D.; Lehman, M.; Adams, B.J.; Bello, C.L.; DePrimo, S.E.; et al. Phase II study of Sunitinib malate, an oral multitargeted tyrosine kinase inhibitor, in patients with metastatic breast cancer previously treated with an Anthracycline and a Taxane. J. Clin. Oncol. 2008, 26, 1810-1816.
113. Calleri, A.; Bono, A.; Bagnardi, A.; Quarna, J.; Mancuso, P.; Rabascio, C.; Dellapasqua, S.; Campagnoli, E.; Shaked, Y.; Goldhirsch, A.; et al. Predictive potential of angiogenic growth factors and circulating endothelial cells in breast cancer patients receiving metronomic chemotherapy plus Bevacizumab. Clin. Cancer Res. 2009, 15, 7652-7657.
114. Schneider, B.P.; Wang, M.; Radovich, M.; Sledge, G.W.; Badve, S.; Thor, A.; Flockhart, D.A.; Hancock, B.; Davidson, N.; Gralow, J.; et al. ECOG 2100. Association of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 genetic polymorphisms with outcome in a trial of paclitaxel compared with paclitaxel plus Bevacizumab in advanced breast cancer: ECOG 2100. J. Clin. Oncol. 2008, 26, 4672-4678.
115. Hurwitz, H.; Douglas, P.S.; Middleton, J.P.W.; Sledge, G.; Johnson, D.H.; Reardon, D.A.; Chen, D.; Rosen, O. Analysis of early hypertension (HTN) and clinical outcome with Bevacizumab (BV). J. Clin. Oncol. 2010, 28, 15s.
116. Fountzilas, G.; Kourea, H.P.; Bobos, M.; Televantou, D.; Kotoula, V.; Papadimitriou, C.; Papazisis, K.T.; Timotheadou, E.; Efstratiou, I.; Koutras, A.; et al. Paclitaxel and Bevacizumab as first line combined treatment in patients with metastatic breast cancer, the Hellenic Cooperative Oncology Group experience with biological marker evaluation. Anticancer Res. 2011, 31, 3007-3018.
117. Busnardo, B.; de Vido, D. The epidemiology and etiology of differentiated thyroid carcinoma. Biomed. Pharmacother. 2000, 54, 322-326.
118. Okuieff, P.; Chen, Y.; Maguire, D.J.; Huser, A.K. Molecular markers of radiation-related normal tissue toxicity. Cancer Metastasis Rev. 2008, 27, 363-374.
119. Gilliland, F.D.; Hunt, W.C.; Morris, D.M.; Key, C.R. Prognostic factors for thyroid carcinoma. A population-based study of 15,698 cases from the Surveillance, Epidemiology and End Results (SEER) program 1973-1991. Cancer 1997, 79,564-573.
120. Durante, C.; Haddy, N.; Baudin, E.; Leboulleux, S.; Hartl, D.; Travagli, J.P.; Caillou, B.; Ricard, M.; Lumbroso, J.D.; de Vathaire, F.; et al. Long-term outcome of 444 patients with distant metastases from papillary and follicular thyroid carcinoma, benefits and limits of radioiodine therapy. J. Clin. Endocrinol. Metab. 2006, 91, 2892-2899.
121. Ain, K.B.; Lee, C.; Williams, K.D. Phase II trial of thalidomide for therapy of radioiodine-unresponsive and rapidly progressive thyroid carcinomas. Thyroid 2007, 17, 663-670.
122. Schönberger, J.; Bauer, J.; Spruss, T.; Weber, G.; Chahoud, I.; Eilles, C.; Grimm, D. Establishment and characterization of the follicular thyroid carcinoma cell line ML-1. J. Mol. Med. 2000, 78, 102-110.
123. Schoenberger, J.; Grimm, D.; Kossmehl, P.; Infanger, M.; Kurth, E.; Eilles, C. Effects of PTK787/ZK222584, a tyrosine kinase inhibitor, on the growth of a poorly differentiated thyroid carcinoma, an animal study. Endocrinology 2004, 145, 1031-1038.
124. Niedzwiecki, S.; Stepien, T.; Kopec, K.; Kuzdak, K.; Komorowski, J.; Krupinski, R.; Stepien, H. Angiopoietin 1 (Ang-1), angiopoietin 2 (Ang-2) and Tie-2 (a receptor tyrosine kinase) concentrations in peripheral blood of patients with thyroid cancers. Cytokine 2006, 36, 291-295.
125. Liang, H.; Zhong, Y.; Luo, Z.; Huang, Y.; Lin, H.; Zhan, S.; Xie, K.; Li, Q.Q. Diagnostic value of 16 cellular tumor markers for metastatic thyroid cancer, an immunohistochemical study. Anticancer Res. 2011, 31, 3433-3440.
126. Antonelli, A.; Fallahi, P.; Ferrari, S.M.; Ruffilli, I.; Santini, F.; Minuto, M.; Galleri, D.; Miccoli, P. New targeted therapies for thyroid cancer. Curr. Genomics 2011, 12, 626-631.
127. Schlumberger, M.J.; Elisei, R.; Bastholt, L.; Wirth, L.J.; Martins, R.G.; Locati, L.D.; Jarzab, B.; Pacini, F.; Daumerie, C.; Droz, J.P.; et al. Phase II study of safety and efficacy of motesanib in patients with progressive or symptomatic, advanced or metastatic medullary thyroid cancer. J. Clin. Oncol. 2009, 27, 3794-3801.
128. Pennell, N.A.; Daniels, G.H.; Haddad, R.I.; Ross, D.S.; Evans, T.; Wirth, L.J.; Fidias, P.H.; Temel, J.S.; Gurubhagavatula, S.; Heist, R.S.; et al. A phase II study of gefitinib in patients with advanced thyroid cancer. Thyroid 2008, 18, 317-323.
129. Sherman, S.I.; Wirth, L.J.; Droz, J.P.; Hofmann, M.; Bastholt, L.; Martins, R.G.; Licitra, L.; Eschenberg, M.J.; Sun, Y.N.; Juan, T.; et al. Motesanib Thyroid Cancer Study Group. Motesanib diphosphate in progressive differentiated thyroid cancer. N. Engl. J. Med. 2008, 359, 31-42.
130. Kloos, R.T.; Ringel, M.D.; Knopp, M.V.; Hall, N.C.; King, M.; Stevens, R.; Liang, J.; Wakely, P.E., Jr.; Vasko, V.V.; Saji, M.; et al. Phase II trial of sorafenib in metastatic thyroid cancer. J. Clin. Oncol. 2009, 27, 1675-1684.
131. Cohen, E.E.; Rosen, L.S.; Vokes, E.E.; Kies, M.S.; Forastiere, A.A.; Worden, F.P.; Kane, M.A.; Sherman, E.; Kim, S.; Bycott, P.; et al. Axitinib is an active treatment for all histologic subtypes of advanced thyroid cancer, results from a phase II study. J. Clin. Oncol. 2008, 26, 4708-4713.
132. Wells, S.A., Jr.; Gosnell, J.E.; Gagel, R.F.; Moley, J.; Pfister, D.; Sosa, J.A.; Skinner, M.; Krebs, A.; Vasselli, J.; Schlumberger, M. Vandetanib for the treatment of patients with locally advanced or metastatic hereditary medullary thyroid cancer. J. Clin. Oncol. 2010, 28, 767-772.
133. Schneider, T.C.; Abdulrahman, R.M.; Corssmit, E.P.; Morreau, H.; Smit, J.W.; Kapiteijn, E. Long-term analysis of the efficacy and tolerability of sorafenib in advanced radio-iodine refractory differentiated thyroid carcinoma, final results of a phase II trial. Eur. J. Endocrinol. 2012, 167, 643-650.
134. Broutin, S.; Ameur, N.; Lacroix, L.; Robert, T.; Petit, B.; Oumata, N.; Talbot, M.; Caillou, B.; Schlumberger, M.; Dupuy, C.; et al. Identification of soluble candidate biomarkers of therapeutic response to sunitinib in medullary thyroid carcinoma in preclinical models. Clin. Cancer Res. 2011, 17, 2044-2054.
135. Grosse, J.; Wehland, M.; Pietsch, J.; Schulz, H.; Saar, K.; Hübner, N.; Eilles, C.; Bauer, J.; Abou-El-Ardat, K.; Baatout, S.; et al. Gravity-sensitive signaling drives 3-dimensional formation of multicellular thyroid cancer spheroids. FASEB J. 2012, 26, 5124-5140.
136. Bass, M.B.; Sherman, S.I.; Schlumberger, M.J.; Davis, M.T.; Kivman, L.; Khoo, H.M.; Notari, K.H.; Peach, M.; Hei, Y.J.; Patterson, S.D. Biomarkers as predictors of response to treatment with motesanib in patients with progressive advanced thyroid cancer. J. Clin. Endocrinol. Metab. 2010, 95, 5018-5027.
137. Marotta, V.; Ramundo, V.; Camera, L.; del Prete, M.; Fonti, R.; Esposito, R.; Palmieri, G.; Salvatore, M.; Vitale, M.; Colao, A.; et al. Sorafenib in advanced iodine-refractory differentiated thyroid cancer, efficacy, safety and exploratory analysis of role of serum thyroglobulin and FDG-PET. Clin. Endocrinol. 2012, 78, 760-767.
138. Cabanillas, M.E.; Waguespack, S.G.; Bronstein, Y.; Williams, M.D.; Feng, L.; Hernandez, M.; Lopez, A.; Sherman, S.I.; Busaidy, N.L. Treatment with tyrosine kinase inhibitors for patients with differentiated thyroid cancer, the M. D. Anderson experience. J. Clin. Endocrinol. Metab. 2010, 95, 2588-2595.
139. Lee, E.K.; Chung, K.W.; Min, H.S.; Kim, T.S.; Kim, T.H.; Ryu, J.S.; Jung, Y.S.; Kim, S.K.; Lee, Y.J. Preoperative serum thyroglobulin as a useful predictive marker to differentiate follicular thyroid cancer from benign nodules in indeterminate nodules. J. Korean Med. Sci. 2012, 27, 1014-1018.
140. Yim, J.H.; Kim, E.Y.; Bae Kim, W.; Kim, W.G.; Kim, T.Y.; Ryu, J.S.; Gong, G.; Hong, S.J.; Yoon, J.H.; Shong, Y.K. Long-term consequence of elevated thyroglobulin in differentiated thyroid cancer. Thyroid 2013, 23, 58-63.
141. Webb, R.C.; Howard, R.S.; Stojadinovic, A.; Gaitonde, D.Y.; Wallace, M.K.; Ahmed, J.; Burch, H.B. The utility of serum thyroglobulin measurement at the time of remnant ablation for predicting disease-free status in patients with differentiated thyroid cancer: A meta-analysis involving 3947 patients. J. Clin. Endocrinol. Metab. 2012, 97, 2754-2763.
142. Shaik, S.; Nucera, C.; Inuzuka, H.; Gao, D.; Garnaas, M.; Frechette, G.; Harris, L.; Wan, L.; Fukushima, H.; Husain, A.; et al. SCF(β-TRCP) suppresses angiogenesis and thyroid cancer cell migration by promoting ubiquitination and destruction of VEGF receptor 2. J. Exp. Med. 2012, 209, 1289-1307.
143. Zerilli, M.; Zito, G.; Martorana, A.; Pitrone, M.; Cabibi, D.; Cappello, F.; Giordano, C.; Rodolico, V. BRAF(V600E) mutation influences hypoxia-inducible factor-1alpha expression levels in papillary thyroid cancer. Mod. Pathol. 2010, 23, 1052-1060.
144. Bottos, A.; Martini, M.; di Nicolantonio, F.; Comunanza, V.; Maione, F.; Minassi, A.; Appendino, G.; Bussolino, F.; Bardelli, A. Targeting oncogenic serine/threonine-protein kinase BRAF in cancer cells inhibits angiogenesis and abrogates hypoxia. Proc. Natl. Acad. Sci. USA 2012, 109, E353-E359.
145. Grimm, D.; Bauer, J.; Pietsch, J.; Infanger, M.; Eucker, J.; Eilles, C.; Schoenberger, J. Diagnostic and therapeutic use of membrane proteins in cancer cells. Curr. Med. Chem. 2011, 18, 176-190.
146. Pietsch, J.; Kussian, R.; Sickmann, A.; Bauer, J.; Weber, G.; Nissum, M.; Westphal, K.; Egli, M.; Grosse, J.; Schönberger, J.; et al. Application of free-flow IEF to identify protein candidates changing under microgravity conditions. Proteomics 2010, 10, 904-913.
147. Pietsch, J.; Sickmann, A.; Weber, G.; Bauer, J.; Egli, M.; Wildgruber, R.; Infanger, M.; Grimm, D. A proteomic approach to analysing spheroid formation of two human thyroid cell lines cultured on a random positioning machine. Proteomics 2011, 11, 2095-2104.
148. Pietsch, J.; Sickmann, A.; Weber, G.; Bauer, J.; Egli, M.; Wildgruber, R.; Infanger, M.; Grimm, D. Metabolic enzyme diversity in different human thyroid cell lines and their sensitivity to gravitational forces. Proteomics 2012, 12, 2539-2546.
149. Pietsch, J.; Riwaldt, S.; Bauer, J.; Sickmann, A.; Weber, G.; Grosse, J.; Infanger, M.; Eilles, C.; Grimm, D. Interaction of proteins identified in human thyroid cells. Int. J. Mol. Sci. 2013, 14, 1164-1178.
150. Ferlay, J.; Shin, H.R.; Bray, F.; Forman, D.; Mathers, C.; Parkin, D.M. Estimates of worldwide burden of cancer in 2008, GLOBOCAN 2008. Int. J. Cancer 2010, 15, 2893-2917
151. Bukowski, R.M.; Eisen, T.; Szczylik, C.; Stadler, W.M.; Simantov, R.; Shan, M.; Elting, J.; Pena, C.; Escudier, B. Final results of the randomized phase III trial of sorafenib in advanced renal cell carcinoma, Survival and biomarker analysis. J. Clin. Oncol. 2007, 25, 15s.
152. Deprimo, S.E.; Bello, C.L.; Smeraglia, J.; Baum, C.M.; Spinella, D.; Rini, B.I.; Michaelson, M.D.; Motzer, R.J. Circulating protein biomarkers of pharmacodynamic activity of Sunitinib in patients with metastatic renal cell carcinoma, Modulation of VEGF and VEGF-related proteins. J. Transl. Med. 2007, 5, 32.
153. Genega, E.M.; Ghebremichael, M.; Najarian, R.; Fu, Y.; Wang, Y.; Argani, P.; Grisanzio, C.; Signoretti, S. Carbonic anhydrase IX expression in renal neoplasms, Correlation with tumor type and grade. Am. J. Clin. Pathol. 2010, 134, 873-879.
154. Porta, C.; Paglino, C.; de Amici, M.; Quaglini, S.; Sacchi, L.; Imarisio, I.; Canipari, C. Predictive value of baseline serum vascular endothelial growth factor and neutrophil gelatinase-associated lipocalin in advanced kidney cancer patients receiving Sunitinib. Kidney Int. 2010, 77, 809-815.
155. Kjeldsen, L.; Johnsen, A.H.; Sengeløv, H.; Borregaard, N. Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase. J. Biol. Chem. 1993, 268, 10425-10432.
156. Pantuck, A.J.; Fang, Z.; Liu, X.; Seligson, D.B.; Horvath, S.; Leppert, J.T.; Belldegrun, A.S.; Figlin, R.A. Gene expression and tissue microarray analysis of interleukin-2 complete responders in patients with metastatic renal cell carcinoma. J. Clin. Oncol. 2005, 23, 15s.
157. Atkins, M.; Regan, M.; McDermott, D.; Mier, J.; Stanbridge, E.; Youmans, A.; Febbo, P.; Upton, M.; Lechpammer, M.; Signoretti, S. Carbonic anhydrase IX expression predicts outcome of interleukin 2 therapy for renal cancer. Clin. Cancer Res. 2005, 11, 3714-3721.
158. Klatte, T.; Seligson, D.B.; Riggs, S.B.; Leppert, J.T.; Berkman, M.K.; Kleid, M.D.; Yu, H.; Kabbinavar, F.F.; Pantuck, A.J.; Belldegrun, A.S. Hypoxia-inducible factor 1 alpha in clear cell renal cell carcinoma. Clin. Cancer Res. 2007, 13, 7388-7393.
159. Patel, P.H.; Chadalavada, R.S.; Ishill, N.M.; Patil, S.; Reuter, V.E.; Motzer, R.J.; Chaganti, R.S. Hypoxia-inducible factor (HIF) 1a and 2a levels in cell lines and human tumor predicts response to Sunitinib in renal cell carcinoma (RCC). J. Clin. Oncol. 2008, 26, 15s.
160. Hoffmann, N.E.; Sheinin, Y.; Lohse, C.M.; Parker, A.S.; Leibovich, B.C.; Jiang, Z.; Kwon, E.D. External validation of IMP3 expression as an independent prognostic marker for metastatic progression and death for patients with clear cell renal cell carcinoma. Cancer 2008, 112, 1471-1479.
161. Thompson, R.H.; Kuntz, S.M.; Leibovich, B.C.; Dong, H.; Lohse, C.M.; Webster, W.S.; Sengupta, S.; Frank, I.; Parker, A.S.; Zincke, H.; et al. Tumor B7-H1 is associated with poor prognosis in renal cell carcinoma patients with long-term follow-up. Cancer Res. 2006, 66, 3381-3385.
162. Zurita, A.J.; Jonasch, E.; Wang, X.; Khajavi, M.; Yan, S.; Du, D.Z.; Xu, L.; Herynk, M.H.; McKee, K.S.; Tran, H.T.; et al. A cytokine and angiogenic factor (CAF) analysis in plasma for selection of sorafenib therapy in patients with metastatic renal cell carcinoma. Ann. Oncol. 2012, 23, 46-52.
163. Tran, H.T.; Liu, Y.; Zurita, A.J.; Lin, Y.; Baker-Neblett, K.L.; Martin, A.M.; Figlin, R.A.; Hutson, T.E.; Sternberg, C.N.; Amado, R.G.; et al. Prognostic or predictive plasma cytokines and angiogenic factors for patients treated with pazopanib for metastatic renal-cell cancer: A retrospective analysis of phase 2 and phase 3 trials. Lancet Oncol. 2012, 13, 827-837.
164. Purdue, M.P.; Johansson, M.; Zelenika, D.; Toro, J.R.; Scelo, G.; Moore, L.E.; Prokhortchouk, E.; Wu, X.; Kiemeney, L.A.; Gaborieau, V.; et al. Genome-wide association study of renal cell carcinoma identifies two susceptibility loci on 2p21 and 11q13.3. Nat. Genet. 2011, 43, 60-65.
165. Wu, X.; Scelo, G.; Purdue, M.P.; Rothman, N.; Johansson, M.; Ye, Y.; Wang, Z.; Zelenika, D.; Moore, L.E.; Wood, C.G.; et al. A genome-wide association study identifies a novel susceptibility locus for renal cell carcinoma on 12p11.23. Hum. Mol. Genet. 2012, 21, 456-462.
166. Xu, C.F.; Bing, N.X.; Ball, H.A.; Rajagopalan, D.; Sternberg, C.N.; Hutson, T.E.; de Souza, P.; Xue, Z.G.; McCann, L.; King, K.S.; et al. Pazopanib efficacy in renal cell carcinoma, evidence for predictive genetic markers in angiogenesis related and exposure-related genes. J. Clin. Oncol. 2011, 29, 2557-2564.
167. Huang, D.; Ding, Y.; Zhou, M.; Rini, B.I.; Petillo, D.; Qian, C.N.; Kahnoski, R.; Futreal, P.A.; Furge, K.A.; Teh, B.T. Interleukin-8 mediates resistance to anti-angiogenic agent Sunitinib in renal cell carcinoma. Cancer Res. 2010, 70, 1063-1071.
168. Climent, M.A.; Arranz, J.A.; Gallardo, E.; Puente, J.; Bellmunt, J.; Mellado, B.; Martínez, E.; Moreno, F.; Font, A.; Robledo, M.; et al. Single nucleotide polymorphism associations with response and toxic effects in patients with advanced renal-cell carcinoma treated with first-line Sunitinib, a multicentre, observational, prospective study. Lancet Oncol. 2011, 12, 1143-1150.
169. Van der Veldt, A.A.; Eechoute, K.; Gelderblom, H.; Gietema, J.; Guchelaar, H.J.; van Erp, N.P.; van den Eertwegh, A.J.; Haanen, J.B.; Mathijssen, R.H.; Wessels, J.A. Genetic polymorphisms associated with a prolonged progression-free survival in patients with metastatic renal cell cancer treated with Sunitinib. Clin. Cancer Res. 2011, 17, 620-629.
170. Brannon, A.R.; Reddy, A.; Seiler, M.; Arreola, A.; Moore, D.T.; Pruthi, R.S.; Wallen, E.M.; Nielsen, M.E.; Liu, H.; Nathanson, K.L.; et al. Molecular stratification of clear cell renal cell carcinoma by consensus clustering reveals distinct subtypes and survival patterns. Genes Cancer 2010, 1, 152-163.
171. Jemal, A.; Siegel, R.; Ward, E.; Hao, Y.; Xu, J.; Thun, M.J. Cancer statistics, 2009. CA Cancer J. Clin. 2009, 59, 225-249.
172. Ferlay, J.; Autier, P.; Boniol, M.; Heanue, M.; Colombet, M.; Boyle, P. Estimates of the cancer incidence and mortality in Europe in 2006. Ann. Oncol. 2007, 18, 581-592.
173. Bradford, T.J.; Tomlins, S.A.; Wang, X.; Chinnaiyan, A.M. Molecular markers of prostate cancer. Urol. Oncol. 2006, 24, 538-551.
174. Lambrechts, D.; Lenz, H.J.; de Haas, S.; Carmeliet, P.; Scherer, S.J. Markers of response for the antiangiogenic agent bevacizumab. J. Clin. Oncol. 2013, 31, 1219-1230.
175. François, P.; Bertos, N.; Laferrière, J.; Sadekova, S.; Souleimanova, M.; Zhao, H.; Finak, G.; Meterissian, S.; Hallett, M.T.; Park, M. Gene-expression profiling of microdissected breast cancer microvasculature identifies distinct tumor vascular subtypes. Breast Cancer Res. 2012, 14, R120.
176. Carpi, A.; Mechanick, J.I.; Saussez, S.; Nicolini, A. Thyroid tumor marker genomics and proteomics, diagnostic and clinical implications. J. Cell Physiol. 2010, 224, 612-619.
177. Pavlou, M.P.; Diamandis, E.P. The cancer cell secretome, a good source for discovering biomarkers? J. Proteomics 2010, 73, 1896-1906.