DNA-reactive protein monoepoxides induce cell death and mutagenesis in mammalian cells

Biochemistry

Volumn 52, Issue 18, 2013, Pages 3171-3181

  Tretyakova, Natalia Y ^a   Michaelson Richie, Erin D ^a   Gherezghiher, Teshome B ^a   Kurtz, Jamie ^c   Ming, Xun ^a   Wickramaratne, Susith ^a   Campion, Melissa ^c   Kanugula, Sreenivas ^b   Pegg, Anthony E ^b   Campbell, Colin ^c  

^a UNIVERSITY OF MINNESOTA   (United States)

^b PENN STATE COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 ,2 ,3 ,4-DIEPOXYBUTANE; ALKYLATING AGENTS; ALKYLTRANSFERASE; CHROMOSOMAL DNAS; CYSTEINE RESIDUES; MAMMALIAN CELLS; MUTAGENIC EFFECT; PHOSPHORIBOSYLTRANSFERASE;

AMINO ACIDS; CELL DEATH; CHEMICAL REACTIONS; DNA; MASS SPECTROMETRY; MUTAGENESIS; RECOMBINANT PROTEINS; TOXICITY; TRANSCRIPTION;

BIOMOLECULES;

2 HYDROXY 3,4 EPOXYBUTYL; 6 O ALKYLGUANINE DNA ALKYLTRANSFERASE; BUTADIENE DIEPOXIDE; CELL NUCLEUS DNA; CYSTEINE; DEOXYRIBONUCLEOPROTEIN; DOUBLE STRANDED DNA; EPOXIDE; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; NUCLEIC ACID BASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL DEATH; CELL NUCLEUS; CELL SURVIVAL; CONTROLLED STUDY; CYTOTOXICITY; DNA CROSS LINKING; DNA DAMAGE; ELECTROPORATION; ELECTROSPRAY MASS SPECTROMETRY; GENE MUTATION; HUMAN; HUMAN CELL; HYDROLYSIS; MAMMAL CELL; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL;

ALKYLATION; AMINO ACID SEQUENCE; CELL DEATH; CELL LINE, TUMOR; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DNA; DNA-BINDING PROTEINS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; EPOXY COMPOUNDS; HUMANS; MOLECULAR SEQUENCE DATA; MUTAGENESIS; RECOMBINANT PROTEINS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 84877315908     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi400273m     Document Type: Article

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