The bis-electrophile diepoxybutane cross-links DNA to human histones but does not result in enhanced mutagenesis in recombinant systems

Chemical Research in Toxicology

Volumn 22, Issue 6, 2009, Pages 1069-1076

  Loecken, Elisabeth M ^a   Dasari, Surendra ^a   Hill, Salisha ^a   Tabb, David L ^a   Guengerich, F Peter ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2 DIBROMOETHANE; BUTADIENE DIEPOXIDE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; HISTONE H2B; HISTONE H3; NUCLEAR PROTEIN;

ARTICLE; BINDING AFFINITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA BINDING; ESCHERICHIA COLI; HUMAN; LIVER; MASS SPECTROMETRY; MUTAGENESIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN CROSS LINKING; PROTEIN EXPRESSION; PROTEIN STRUCTURE;

ALKYL AND ARYL TRANSFERASES; CROSS-LINKING REAGENTS; DNA; EPOXY COMPOUNDS; HISTONES; HUMANS; MUTAGENESIS; MUTAGENS; PEPTIDE FRAGMENTS; RECOMBINANT PROTEINS;

ESCHERICHIA COLI;

EID: 67449113183     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx900037u     Document Type: Article

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