Reactions of glyceraldehyde 3-phosphate dehydrogenase sulfhydryl groups with bis-electrophiles produce DNA-protein cross-links but not mutations

Chemical Research in Toxicology

Volumn 21, Issue 2, 2008, Pages 453-458

  Loecken, Elisabeth M ^a   Guengerich, F Peter ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2 DIBROMOETHANE; 1,3 BUTADIENE; 6 O ALKYLGUANINE DNA ALKYLTRANSFERASE; BUTADIENE DIEPOXIDE; CYSTEINE; GLUTATHIONE TRANSFERASE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; NUCLEAR PROTEIN; THIOL GROUP; CROSS LINKING REAGENT; DNA; EPOXIDE; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; MUTAGENIC AGENT; RECOMBINANT PROTEIN; THIOL DERIVATIVE;

ARTICLE; CARCINOGENICITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CROSS LINKING; ENZYME INHIBITION; ENZYME MECHANISM; ESCHERICHIA COLI; GENOTOXICITY; IN VIVO STUDY; MASS SPECTROMETRY; MUTAGENESIS; MUTAGENICITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN DNA INTERACTION; PROTEIN EXPRESSION; CELL SURVIVAL; CHEMISTRY; DRUG EFFECT; ENZYMOLOGY; GENETICS; HUMAN; METABOLISM; MUTATION; POLLUTANT;

ESCHERICHIA COLI;

CELL SURVIVAL; CROSS-LINKING REAGENTS; DNA; ENVIRONMENTAL POLLUTANTS; EPOXY COMPOUNDS; ESCHERICHIA COLI; ETHYLENE DIBROMIDE; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASES; HUMANS; MUTAGENS; MUTATION; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; RECOMBINANT PROTEINS; SULFHYDRYL COMPOUNDS;

EID: 41649093578     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx7003618     Document Type: Article

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