Active-site alkylation destabilizes human O6-alkylguanine DNA alkyltransferase

Protein Science

Volumn 13, Issue 1, 2004, Pages 301-305

  Rasimas, Joseph J ^a   Dalessio, Paula A ^a   Ropson, Ira J ^a   Pegg, Anthony E ^a   Fried, Michael G ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

Denaturation; DNA binding; O 6 methylguanine methyltransferase; O6 alkylguanine DNA alkyltransferase; Protein alkylation

Indexed keywords

4 O METHYLTHYMINE; 6 O ALKYLGUANINE DNA ALKYLTRANSFERASE; THYMINE DERIVATIVE; UBIQUITIN;

ALKYLATION; ARTICLE; DNA DAMAGE; ENZYME ACTIVE SITE; ENZYME DEGRADATION; ENZYME STABILITY; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN FOLDING; UBIQUITINATION;

ALKYLATION; BINDING SITES; CIRCULAR DICHROISM; DNA; HUMANS; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DENATURATION; PROTEIN FOLDING; RECOMBINANT PROTEINS; UBIQUITIN; UREA;

EID: 0346733325     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1110/ps.03319404     Document Type: Article

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