Melanoidins isolated from heated potato fiber (Potex) affect human colon cancer cells growth via modulation of cell cycle and proliferation regulatory proteins

Food and Chemical Toxicology

Volumn 57, Issue , 2013, Pages 246-255

  Langner, Ewa ^a,c   Nunes, Fernando M ^b   Pozarowski, Piotr ^c   Kandefer Szerszeń, Martyna ^d   Pierzynowski, Stefan G ^a,e   Rzeski, Wojciech ^a,d  

^a INSTITUTE OF AGRICULTURAL MEDICINE   (Poland)

^b UNIVERSITY OF TRÁS OS MONTES AND ALTO DOURO   (Portugal)

^c MEDICAL UNIVERSITY OF LUBLIN   (Poland)

^d MARIA CURIE SK ODOWSKA UNIVERSITY   (Poland)

^e LUND UNIVERSITY   (Sweden)

Author keywords

Antiproliferative activity; Cell cycle inhibition; Colon cancer; Melanoidins; Potato fiber

Indexed keywords

CYCLIN D1; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; MELANOIDINE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PLANT EXTRACT; POTATO FIBER EXTRACT; PROTEIN P21; PROTEIN P27; PROTEIN P53; RETINOBLASTOMA PROTEIN; UNCLASSIFIED DRUG; VEGETABLE PROTEIN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL CYCLE G0 PHASE; CELL CYCLE REGULATION; CELL PROLIFERATION; COLON CANCER; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; FIBER CROP; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULAR WEIGHT; POTATO; SIGNAL TRANSDUCTION;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CARBOHYDRATES; CELL CYCLE; CELL LINE, TUMOR; CELL NUCLEUS; CELL PROLIFERATION; COLONIC NEOPLASMS; CYCLIN D1; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYTOPLASM; DOSE-RESPONSE RELATIONSHIP, DRUG; G0 PHASE; GENE SILENCING; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MOLECULAR WEIGHT; PLANT EXTRACTS; POLYMERS; PROTEIN TRANSPORT; SOLANUM TUBEROSUM; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84877314113     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2013.03.042     Document Type: Article

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