Downregulation of Fas activity rescues early onset of diabetes in c-KitWv/+ mice

American Journal of Physiology - Endocrinology and Metabolism

Volumn 304, Issue 6, 2013, Pages

  Feng, Zhi Chao ^a,b   Riopel, Matthew ^a,b   Li, Jinming ^a,b   Donnelly, Lisa ^a   Wang, Rennian ^a,b  

^a CHILDREN S HEALTH RESEARCH INSTITUTE   (Canada)

^b WESTERN UNIVERSITY   (Canada)

Author keywords

cell apoptosis; c Kit; Diabetes; fas; Insulin secretion

Indexed keywords

FAS LIGAND; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN P53; STEM CELL FACTOR; APOPTOSIS REGULATORY PROTEIN; FAS ANTIGEN; FAS PROTEIN, MOUSE; INSULIN; RECOMBINANT PROTEIN; STEM CELL FACTOR RECEPTOR;

ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; B LYMPHOCYTE; CELL FUNCTION; CELL PROLIFERATION; CELL SURVIVAL; DOWN REGULATION; IN VIVO STUDY; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CELL LINE; CROSS BREEDING; DRUG ANTAGONISM; GENE EXPRESSION REGULATION; GENETICS; HETEROZYGOTE; METABOLISM; MOUSE MUTANT; PANCREAS ISLET BETA CELL; PATHOLOGY; PATHOPHYSIOLOGY; RNA INTERFERENCE; SECRETION (PROCESS); TISSUE CULTURE TECHNIQUE;

ANIMALS; ANTIGENS, CD95; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CELL LINE; CROSSES, GENETIC; DIABETES MELLITUS, TYPE 1; GENE EXPRESSION REGULATION; HETEROZYGOTE; INSULIN; INSULIN-SECRETING CELLS; MALE; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; PROTO-ONCOGENE PROTEINS C-KIT; RECOMBINANT PROTEINS; RNA INTERFERENCE; SIGNAL TRANSDUCTION; STEM CELL FACTOR; TISSUE CULTURE TECHNIQUES; TUMOR SUPPRESSOR PROTEIN P53;

MLCS; MLOWN;

EID: 84877309386     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00453.2012     Document Type: Article

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