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Volumn 15, Issue 3, 2013, Pages

The expression and significance of insulin-like growth factor-1 receptor and its pathway on breast cancer stem/progenitors

Author keywords

[No Author keywords available]

Indexed keywords

2 (4 HYDROXYPHENYL) 4 MORPHOLINOPYRIDO[3',2':4,5]FURO[3,2 D]PYRIMIDINE; ALDEHYDE DEHYDROGENASE; CB 124005; MAMMALIAN TARGET OF RAPAMYCIN; PICROPODOPHYLLIN; PROTEIN KINASE B; PROTEIN KINASE B INHIBITOR; RAPAMYCIN; RECEPTOR BLOCKING AGENT; SOMATOMEDIN C RECEPTOR; UNCLASSIFIED DRUG; PHOSPHATIDYLINOSITOL 3 KINASE; PODOPHYLLOTOXIN; SOMATOMEDIN C;

EID: 84877280627     PISSN: 14655411     EISSN: 1465542X     Source Type: Journal    
DOI: 10.1186/bcr3423     Document Type: Article
Times cited : (89)

References (53)
  • 1
    • 0017167185 scopus 로고
    • The clonal evolution of tumor cell populations
    • 10.1126/science.959840, 959840
    • Nowell PC. The clonal evolution of tumor cell populations. Science 1976, 194:23-28. 10.1126/science.959840, 959840.
    • (1976) Science , vol.194 , pp. 23-28
    • Nowell, P.C.1
  • 2
    • 0035499267 scopus 로고    scopus 로고
    • Stem cells, cancer, and cancer stem cells
    • 10.1038/35102167, 11689955
    • Reya T, Morrison SJ, Clarke MF, Weissman IL. Stem cells, cancer, and cancer stem cells. Nature 2001, 414:105-111. 10.1038/35102167, 11689955.
    • (2001) Nature , vol.414 , pp. 105-111
    • Reya, T.1    Morrison, S.J.2    Clarke, M.F.3    Weissman, I.L.4
  • 5
    • 0037388204 scopus 로고    scopus 로고
    • Prospective identification of tumorigenic breast cancer cells
    • 10.1073/pnas.0530291100, 153034, 12629218
    • Al-Hajj M, Wicha MS, Benito-Hernandez A, Morrison SJ, Clarke MF. Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci USA 2003, 100:3983-3988. 10.1073/pnas.0530291100, 153034, 12629218.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 3983-3988
    • Al-Hajj, M.1    Wicha, M.S.2    Benito-Hernandez, A.3    Morrison, S.J.4    Clarke, M.F.5
  • 6
    • 33846100356 scopus 로고    scopus 로고
    • A human colon cancer cell capable of initiating tumour growth in immunodeficient mice
    • 10.1038/nature05372, 17122772
    • O'Brien CA, Pollett A, Gallinger S, Dick JE. A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature 2007, 445:106-110. 10.1038/nature05372, 17122772.
    • (2007) Nature , vol.445 , pp. 106-110
    • O'Brien, C.A.1    Pollett, A.2    Gallinger, S.3    Dick, J.E.4
  • 8
    • 33845904383 scopus 로고    scopus 로고
    • The response of CD24-/low/CD44+ breast cancer-initiating cells to radiation
    • 10.1093/jnci/djj495, 17179479
    • Phillips TM, McBride WH, Pajonk F. The response of CD24-/low/CD44+ breast cancer-initiating cells to radiation. J Natl Cancer Inst 2006, 98:1777-1785. 10.1093/jnci/djj495, 17179479.
    • (2006) J Natl Cancer Inst , vol.98 , pp. 1777-1785
    • Phillips, T.M.1    McBride, W.H.2    Pajonk, F.3
  • 9
    • 33750306612 scopus 로고    scopus 로고
    • Most early disseminated cancer cells detected in bone marrow of breast cancer patients have a putative breast cancer stem cell phenotype
    • 10.1158/1078-0432.CCR-06-0169, 17020963
    • Balic M, Lin H, Young L, Hawes D, Giuliano A, McNamara G, Datar RH, Cote RJ. Most early disseminated cancer cells detected in bone marrow of breast cancer patients have a putative breast cancer stem cell phenotype. Clin Cancer Res 2006, 12:5615-5621. 10.1158/1078-0432.CCR-06-0169, 17020963.
    • (2006) Clin Cancer Res , vol.12 , pp. 5615-5621
    • Balic, M.1    Lin, H.2    Young, L.3    Hawes, D.4    Giuliano, A.5    McNamara, G.6    Datar, R.H.7    Cote, R.J.8
  • 11
    • 44949169522 scopus 로고    scopus 로고
    • Cancer stem cells in breast: current opinion and future challenges
    • 10.1159/000123845, 2789397, 18544962
    • Charafe-Jauffret E, Monville F, Ginestier C, Dontu G, Birnbaum D, Wicha MS. Cancer stem cells in breast: current opinion and future challenges. Pathobiology 2008, 75:75-84. 10.1159/000123845, 2789397, 18544962.
    • (2008) Pathobiology , vol.75 , pp. 75-84
    • Charafe-Jauffret, E.1    Monville, F.2    Ginestier, C.3    Dontu, G.4    Birnbaum, D.5    Wicha, M.S.6
  • 12
    • 0035902180 scopus 로고    scopus 로고
    • Oncogenic kinase signalling
    • 10.1038/35077225, 11357143
    • Blume-Jensen P, Hunter T. Oncogenic kinase signalling. Nature 2001, 411:355-365. 10.1038/35077225, 11357143.
    • (2001) Nature , vol.411 , pp. 355-365
    • Blume-Jensen, P.1    Hunter, T.2
  • 13
    • 30944442856 scopus 로고    scopus 로고
    • The Akt pathway in human breast cancer: a tissue-array-based analysis
    • Bose S, Chandran S, Mirocha JM, Bose N. The Akt pathway in human breast cancer: a tissue-array-based analysis. Modern Pathol 2006, 19:238-245.
    • (2006) Modern Pathol , vol.19 , pp. 238-245
    • Bose, S.1    Chandran, S.2    Mirocha, J.M.3    Bose, N.4
  • 14
    • 18244391514 scopus 로고    scopus 로고
    • Activation of AKT/PKB in breast cancer predicts a worse outcome among endocrine treated patients
    • 10.1038/sj.bjc.6600126, 2375266, 11870534
    • Perez-Tenorio G, Stal O. Activation of AKT/PKB in breast cancer predicts a worse outcome among endocrine treated patients. Br J Cancer 2002, 86:540-545. 10.1038/sj.bjc.6600126, 2375266, 11870534.
    • (2002) Br J Cancer , vol.86 , pp. 540-545
    • Perez-Tenorio, G.1    Stal, O.2
  • 15
    • 38149015503 scopus 로고    scopus 로고
    • PI3K/PTEN signaling in tumorigenesis and angiogenesis
    • 10.1016/j.bbapap.2007.09.008, 17964232
    • Jiang BH, Liu LZ. PI3K/PTEN signaling in tumorigenesis and angiogenesis. Biochim Biophys Acta 2008, 1784:150-158. 10.1016/j.bbapap.2007.09.008, 17964232.
    • (2008) Biochim Biophys Acta , vol.1784 , pp. 150-158
    • Jiang, B.H.1    Liu, L.Z.2
  • 16
    • 56749184290 scopus 로고    scopus 로고
    • Insulin and insulin-like growth factor signalling in neoplasia
    • 10.1038/nrc2536, 19029956
    • Pollak M. Insulin and insulin-like growth factor signalling in neoplasia. Nat Rev Cancer 2008, 8:915-928. 10.1038/nrc2536, 19029956.
    • (2008) Nat Rev Cancer , vol.8 , pp. 915-928
    • Pollak, M.1
  • 17
    • 0026746298 scopus 로고
    • Expression of IGF-I and IGF-II mRNA in breast tissue
    • 10.1007/BF01833331, 1421422
    • Paik S. Expression of IGF-I and IGF-II mRNA in breast tissue. Breast Cancer Res Treat 1992, 22:31-38. 10.1007/BF01833331, 1421422.
    • (1992) Breast Cancer Res Treat , vol.22 , pp. 31-38
    • Paik, S.1
  • 18
    • 0036111682 scopus 로고    scopus 로고
    • Insulin-like growth factors and cancer
    • 10.1016/S1470-2045(02)00731-3, 12067807
    • Furstenberger G, Senn HJ. Insulin-like growth factors and cancer. Lancet Oncol 2002, 3:298-302. 10.1016/S1470-2045(02)00731-3, 12067807.
    • (2002) Lancet Oncol , vol.3 , pp. 298-302
    • Furstenberger, G.1    Senn, H.J.2
  • 19
    • 0033838566 scopus 로고    scopus 로고
    • Function of the IGF-I receptor in breast cancer
    • 10.1023/A:1009523501499, 10791772
    • Surmacz E. Function of the IGF-I receptor in breast cancer. J Mammary Gland Biol Neoplasia 2000, 5:95-105. 10.1023/A:1009523501499, 10791772.
    • (2000) J Mammary Gland Biol Neoplasia , vol.5 , pp. 95-105
    • Surmacz, E.1
  • 20
    • 50149118358 scopus 로고    scopus 로고
    • Expression of Globo H and SSEA3 in breast cancer stem cells and the involvement of fucosyl transferases 1 and 2 in Globo H synthesis
    • 10.1073/pnas.0804979105, 2575305, 18685093
    • Chang WW, Lee CH, Lee P, Lin J, Hsu CW, Hung JT, Lin JJ, Yu JC, Shao LE, Yu J, Wong CH, Yu AL. Expression of Globo H and SSEA3 in breast cancer stem cells and the involvement of fucosyl transferases 1 and 2 in Globo H synthesis. Proc Natl Acad Sci USA 2008, 105:11667-11672. 10.1073/pnas.0804979105, 2575305, 18685093.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 11667-11672
    • Chang, W.W.1    Lee, C.H.2    Lee, P.3    Lin, J.4    Hsu, C.W.5    Hung, J.T.6    Lin, J.J.7    Yu, J.C.8    Shao, L.E.9    Yu, J.10    Wong, C.H.11    Yu, A.L.12
  • 21
    • 67650444760 scopus 로고    scopus 로고
    • ELDA: extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays
    • 10.1016/j.jim.2009.06.008, 19567251
    • Hu Y, Smyth GK. ELDA: extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays. J Immunol Methods 2009, 347:70-78. 10.1016/j.jim.2009.06.008, 19567251.
    • (2009) J Immunol Methods , vol.347 , pp. 70-78
    • Hu, Y.1    Smyth, G.K.2
  • 22
    • 34548479484 scopus 로고    scopus 로고
    • Disruption of the insulin-like growth factor type 1 receptor in osteoblasts enhances insulin signaling and action
    • 10.1074/jbc.M700651200, 17553792
    • Fulzele K, DiGirolamo DJ, Liu Z, Xu J, Messina JL, Clemens TL. Disruption of the insulin-like growth factor type 1 receptor in osteoblasts enhances insulin signaling and action. J Biol Chem 2007, 282:25649-25658. 10.1074/jbc.M700651200, 17553792.
    • (2007) J Biol Chem , vol.282 , pp. 25649-25658
    • Fulzele, K.1    DiGirolamo, D.J.2    Liu, Z.3    Xu, J.4    Messina, J.L.5    Clemens, T.L.6
  • 23
    • 1642494838 scopus 로고    scopus 로고
    • Cyclolignans as inhibitors of the insulin-like growth factor-1 receptor and malignant cell growth
    • 10.1158/0008-5472.CAN-03-2522, 14729630
    • Girnita A, Girnita L, del Prete F, Bartolazzi A, Larsson O, Axelson M. Cyclolignans as inhibitors of the insulin-like growth factor-1 receptor and malignant cell growth. Cancer Res 2004, 64:236-242. 10.1158/0008-5472.CAN-03-2522, 14729630.
    • (2004) Cancer Res , vol.64 , pp. 236-242
    • Girnita, A.1    Girnita, L.2    del Prete, F.3    Bartolazzi, A.4    Larsson, O.5    Axelson, M.6
  • 24
    • 57149100169 scopus 로고    scopus 로고
    • Bidirectional crosstalk between leptin and insulin-like growth factor-I signaling promotes invasion and migration of breast cancer cells via transactivation of epidermal growth factor receptor
    • 10.1158/0008-5472.CAN-08-1952, 3180854, 19047149
    • Saxena NK, Taliaferro-Smith L, Knight BB, Merlin D, Anania FA, O'Regan RM, Sharma D. Bidirectional crosstalk between leptin and insulin-like growth factor-I signaling promotes invasion and migration of breast cancer cells via transactivation of epidermal growth factor receptor. Cancer Res 2008, 68:9712-9722. 10.1158/0008-5472.CAN-08-1952, 3180854, 19047149.
    • (2008) Cancer Res , vol.68 , pp. 9712-9722
    • Saxena, N.K.1    Taliaferro-Smith, L.2    Knight, B.B.3    Merlin, D.4    Anania, F.A.5    O'Regan, R.M.6    Sharma, D.7
  • 25
    • 57149139395 scopus 로고    scopus 로고
    • Regulation of breast cancer metastasis by IGF signaling
    • 10.1007/s10911-008-9105-5, 19030970
    • Sachdev D. Regulation of breast cancer metastasis by IGF signaling. J Mammary Gland Biol Neoplasia 2008, 13:431-441. 10.1007/s10911-008-9105-5, 19030970.
    • (2008) J Mammary Gland Biol Neoplasia , vol.13 , pp. 431-441
    • Sachdev, D.1
  • 26
    • 79956105716 scopus 로고    scopus 로고
    • CCN6 (WISP3) decreases ZEB1-mediated EMT and invasion by attenuation of IGF-1 receptor signaling in breast cancer
    • 10.1242/jcs.084194, 3085438, 21525039
    • Lorenzatti G, Huang W, Pal A, Cabanillas AM, Kleer CG. CCN6 (WISP3) decreases ZEB1-mediated EMT and invasion by attenuation of IGF-1 receptor signaling in breast cancer. J Cell Sci 2011, 124:1752-1758. 10.1242/jcs.084194, 3085438, 21525039.
    • (2011) J Cell Sci , vol.124 , pp. 1752-1758
    • Lorenzatti, G.1    Huang, W.2    Pal, A.3    Cabanillas, A.M.4    Kleer, C.G.5
  • 30
    • 68249144780 scopus 로고    scopus 로고
    • Breast cancer subtypes based on ER/PR and Her2 expression: comparison of clinicopathologic features and survival
    • 10.3121/cmr.2008.825, 2705275, 19574486
    • Onitilo AA, Engel JM, Greenlee RT, Mukesh BN. Breast cancer subtypes based on ER/PR and Her2 expression: comparison of clinicopathologic features and survival. Clin Med Res 2009, 7:4-13. 10.3121/cmr.2008.825, 2705275, 19574486.
    • (2009) Clin Med Res , vol.7 , pp. 4-13
    • Onitilo, A.A.1    Engel, J.M.2    Greenlee, R.T.3    Mukesh, B.N.4
  • 31
    • 77952611330 scopus 로고    scopus 로고
    • Resveratrol suppresses IGF-1 induced human colon cancer cell proliferation and elevates apoptosis via suppression of IGF-1R/Wnt and activation of p53 signaling pathways
    • 10.1186/1471-2407-10-238, 2891636, 20504360
    • Vanamala J, Reddivari L, Radhakrishnan S, Tarver C. Resveratrol suppresses IGF-1 induced human colon cancer cell proliferation and elevates apoptosis via suppression of IGF-1R/Wnt and activation of p53 signaling pathways. BMC Cancer 2010, 10:238. 10.1186/1471-2407-10-238, 2891636, 20504360.
    • (2010) BMC Cancer , vol.10 , pp. 238
    • Vanamala, J.1    Reddivari, L.2    Radhakrishnan, S.3    Tarver, C.4
  • 32
    • 77954419279 scopus 로고    scopus 로고
    • Beta-catenin mediates insulin-like growth factor-I actions to promote cyclin D1 mRNA expression, cell proliferation and survival in oligodendroglial cultures
    • 10.1002/glia.20984, 2917840, 20235220
    • Ye P, Hu Q, Liu H, Yan Y, D'Ercole AJ. beta-catenin mediates insulin-like growth factor-I actions to promote cyclin D1 mRNA expression, cell proliferation and survival in oligodendroglial cultures. Glia 2010, 58:1031-1041. 10.1002/glia.20984, 2917840, 20235220.
    • (2010) Glia , vol.58 , pp. 1031-1041
    • Ye, P.1    Hu, Q.2    Liu, H.3    Yan, Y.4    D'Ercole, A.J.5
  • 33
    • 77953525666 scopus 로고    scopus 로고
    • Thyroid hormone-mediated growth and differentiation of growth plate chondrocytes involves IGF-1 modulation of beta-catenin signaling
    • Wang L, Shao YY, Ballock RT. Thyroid hormone-mediated growth and differentiation of growth plate chondrocytes involves IGF-1 modulation of beta-catenin signaling. J Bone Mineral Res 2010, 25:1138-1146.
    • (2010) J Bone Mineral Res , vol.25 , pp. 1138-1146
    • Wang, L.1    Shao, Y.Y.2    Ballock, R.T.3
  • 37
    • 36248953716 scopus 로고    scopus 로고
    • Mammary stem cells and breast cancer - role of Notch signalling
    • 10.1007/s12015-007-0023-5, 17873349
    • Farnie G, Clarke RB. Mammary stem cells and breast cancer - role of Notch signalling. Stem Cell Rev 2007, 3:169-175. 10.1007/s12015-007-0023-5, 17873349.
    • (2007) Stem Cell Rev , vol.3 , pp. 169-175
    • Farnie, G.1    Clarke, R.B.2
  • 38
    • 62449205665 scopus 로고    scopus 로고
    • Chemoresistant colorectal cancer cells, the cancer stem cell phenotype, and increased sensitivity to insulin-like growth factor-I receptor inhibition
    • 10.1158/0008-5472.CAN-08-2023, 3198868, 19244128
    • Dallas NA, Xia L, Fan F, Gray MJ, Gaur P, van Buren G, Samuel S, Kim MP, Lim SJ, Ellis LM. Chemoresistant colorectal cancer cells, the cancer stem cell phenotype, and increased sensitivity to insulin-like growth factor-I receptor inhibition. Cancer Res 2009, 69:1951-1957. 10.1158/0008-5472.CAN-08-2023, 3198868, 19244128.
    • (2009) Cancer Res , vol.69 , pp. 1951-1957
    • Dallas, N.A.1    Xia, L.2    Fan, F.3    Gray, M.J.4    Gaur, P.5    van Buren, G.6    Samuel, S.7    Kim, M.P.8    Lim, S.J.9    Ellis, L.M.10
  • 40
    • 0032540288 scopus 로고    scopus 로고
    • Insulin receptor substrate-1 is the predominant signaling molecule activated by insulin-like growth factor-I, insulin, and interleukin-4 in estrogen receptor-positive human breast cancer cells
    • 10.1074/jbc.273.16.9994, 9545345
    • Jackson JG, White MF, Yee D. Insulin receptor substrate-1 is the predominant signaling molecule activated by insulin-like growth factor-I, insulin, and interleukin-4 in estrogen receptor-positive human breast cancer cells. J Biol Chem 1998, 273:9994-10003. 10.1074/jbc.273.16.9994, 9545345.
    • (1998) J Biol Chem , vol.273 , pp. 9994-10003
    • Jackson, J.G.1    White, M.F.2    Yee, D.3
  • 41
    • 0035504405 scopus 로고    scopus 로고
    • Regulation of breast cancer cell motility by insulin receptor substrate-2 (IRS-2) in metastatic variants of human breast cancer cell lines
    • 10.1038/sj.onc.1204920, 11704861
    • Jackson JG, Zhang X, Yoneda T, Yee D. Regulation of breast cancer cell motility by insulin receptor substrate-2 (IRS-2) in metastatic variants of human breast cancer cell lines. Oncogene 2001, 20:7318-7325. 10.1038/sj.onc.1204920, 11704861.
    • (2001) Oncogene , vol.20 , pp. 7318-7325
    • Jackson, J.G.1    Zhang, X.2    Yoneda, T.3    Yee, D.4
  • 43
    • 77957010441 scopus 로고    scopus 로고
    • Targeting tumour-initiating cells to improve the cure rates for triple-negative breast cancer
    • Stratford AL, Reipas K, Maxwell C, Dunn SE. Targeting tumour-initiating cells to improve the cure rates for triple-negative breast cancer. Expert Rev Mol Med 2010, 12:e22.
    • (2010) Expert Rev Mol Med , vol.12
    • Stratford, A.L.1    Reipas, K.2    Maxwell, C.3    Dunn, S.E.4
  • 44
    • 67349222877 scopus 로고    scopus 로고
    • Reversibility and recurrence of IGF-IR-induced mammary tumors
    • 10.1038/onc.2009.79, 19377512
    • Jones RA, Campbell CI, Wood GA, Petrik JJ, Moorehead RA. Reversibility and recurrence of IGF-IR-induced mammary tumors. Oncogene 2009, 28:2152-2162. 10.1038/onc.2009.79, 19377512.
    • (2009) Oncogene , vol.28 , pp. 2152-2162
    • Jones, R.A.1    Campbell, C.I.2    Wood, G.A.3    Petrik, J.J.4    Moorehead, R.A.5
  • 45
    • 84860390217 scopus 로고    scopus 로고
    • Elevated insulin-like growth factor 1 receptor signaling induces antiestrogen resistance through the MAPK/ERK and PI3K/Akt signaling routes
    • 10.1186/bcr2883, 3218939, 21595894
    • Zhang Y, Moerkens M, Ramaiahgari S, de Bont H, Price L, Meerman J, van de Water B. Elevated insulin-like growth factor 1 receptor signaling induces antiestrogen resistance through the MAPK/ERK and PI3K/Akt signaling routes. Breast Cancer Res 2011, 13:R52. 10.1186/bcr2883, 3218939, 21595894.
    • (2011) Breast Cancer Res , vol.13
    • Zhang, Y.1    Moerkens, M.2    Ramaiahgari, S.3    de Bont, H.4    Price, L.5    Meerman, J.6    van de Water, B.7
  • 47
    • 36048963331 scopus 로고    scopus 로고
    • Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance
    • 10.1073/pnas.0702596104, 2042178, 17911267
    • Zhou J, Wulfkuhle J, Zhang H, Gu P, Yang Y, Deng J, Margolick JB, Liotta LA, Petricoin E, Zhang Y. Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance. Proc Natl Acad Sci USA 2007, 104:16158-16163. 10.1073/pnas.0702596104, 2042178, 17911267.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 16158-16163
    • Zhou, J.1    Wulfkuhle, J.2    Zhang, H.3    Gu, P.4    Yang, Y.5    Deng, J.6    Margolick, J.B.7    Liotta, L.A.8    Petricoin, E.9    Zhang, Y.10
  • 48
    • 84863900275 scopus 로고    scopus 로고
    • Insulin-like growth factor receptor inhibitors: baby or the bathwater?
    • 10.1093/jnci/djs258, 22761272
    • Yee D. Insulin-like growth factor receptor inhibitors: baby or the bathwater?. J Natl Cancer Inst 2012, 104:975-981. 10.1093/jnci/djs258, 22761272.
    • (2012) J Natl Cancer Inst , vol.104 , pp. 975-981
    • Yee, D.1
  • 49
    • 33846458639 scopus 로고    scopus 로고
    • Down-regulation of type I insulin-like growth factor receptor increases sensitivity of breast cancer cells to insulin
    • 10.1158/0008-5472.CAN-06-1712, 17210722
    • Zhang H, Pelzer AM, Kiang DT, Yee D. Down-regulation of type I insulin-like growth factor receptor increases sensitivity of breast cancer cells to insulin. Cancer Res 2007, 67:391-397. 10.1158/0008-5472.CAN-06-1712, 17210722.
    • (2007) Cancer Res , vol.67 , pp. 391-397
    • Zhang, H.1    Pelzer, A.M.2    Kiang, D.T.3    Yee, D.4
  • 50
    • 54749095517 scopus 로고    scopus 로고
    • Enhancing mammalian target of rapamycin (mTOR)-targeted cancer therapy by preventing mTOR/raptor inhibition-initiated, mTOR/rictor-independent Akt activation
    • 10.1158/0008-5472.CAN-08-1522, 2562339, 18794129
    • Wang X, Yue P, Kim YA, Fu H, Khuri FR, Sun SY. Enhancing mammalian target of rapamycin (mTOR)-targeted cancer therapy by preventing mTOR/raptor inhibition-initiated, mTOR/rictor-independent Akt activation. Cancer Res 2008, 68:7409-7418. 10.1158/0008-5472.CAN-08-1522, 2562339, 18794129.
    • (2008) Cancer Res , vol.68 , pp. 7409-7418
    • Wang, X.1    Yue, P.2    Kim, Y.A.3    Fu, H.4    Khuri, F.R.5    Sun, S.Y.6
  • 52
    • 84860506226 scopus 로고    scopus 로고
    • Insulin growth factor-receptor (IGF-1R) antibody cixutumumab combined with the mTOR inhibitor temsirolimus in patients with refractory Ewing's sarcoma family tumors
    • 10.1158/1078-0432.CCR-12-0061, 22465830
    • Naing A, LoRusso P, Fu S, Hong DS, Anderson P, Benjamin RS, Ludwig J, Chen HX, Doyle LA, Kurzrock R. Insulin growth factor-receptor (IGF-1R) antibody cixutumumab combined with the mTOR inhibitor temsirolimus in patients with refractory Ewing's sarcoma family tumors. Clin Cancer Res 2012, 18:2625-2631. 10.1158/1078-0432.CCR-12-0061, 22465830.
    • (2012) Clin Cancer Res , vol.18 , pp. 2625-2631
    • Naing, A.1    LoRusso, P.2    Fu, S.3    Hong, D.S.4    Anderson, P.5    Benjamin, R.S.6    Ludwig, J.7    Chen, H.X.8    Doyle, L.A.9    Kurzrock, R.10
  • 53
    • 0035300564 scopus 로고    scopus 로고
    • Inhibition of heat shock protein 90 function by ansamycins causes the morphological and functional differentiation of breast cancer cells
    • Munster PN, Srethapakdi M, Moasser MM, Rosen N. Inhibition of heat shock protein 90 function by ansamycins causes the morphological and functional differentiation of breast cancer cells. Cancer Res 2001, 61:2945-2952.
    • (2001) Cancer Res , vol.61 , pp. 2945-2952
    • Munster, P.N.1    Srethapakdi, M.2    Moasser, M.M.3    Rosen, N.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.