IGF signaling contributes to malignant transformation of hematopoietic progenitors by the MLL-AF9 oncoprotein

Experimental Hematology

Volumn 40, Issue 9, 2012, Pages

  Jenkins, Catherine E ^a   Shevchuk, Olena O ^a   Giambra, Vincenzo ^a   Lam, Sonya H ^a   Carboni, Joan M ^b   Gottardis, Marco M ^b   Holzenberger, Martin ^c   Pollak, Michael ^d   Humphries, R Keith ^a   Weng, Andrew P ^a  

^a BRITISH COLUMBIA CANCER AGENCY   (Canada)

^b BRISTOL MYERS SQUIBB   (United States)

^c INSERM   (France)

^d MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AF9 MIXED LINEAGE LEUKEMIA PROTEIN FUSION PROTEIN; ANTINEOPLASTIC AGENT; BMS 536924; BMS 754807; CRE RECOMBINASE; HYBRID PROTEIN; SOMATOMEDIN; SOMATOMEDIN C RECEPTOR; UNCLASSIFIED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW TRANSPLANTATION; CANCER GROWTH; CARCINOGENESIS; CELL ACTIVITY; CELL SURVIVAL; CELL TRANSFORMATION; CELL VIABILITY; CLONOGENESIS; CONTROLLED STUDY; DRUG CYTOTOXICITY; ENZYME ACTIVITY; GENE DELETION; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; INSULIN LIKE GROWTH FACTOR 1 RECEPTOR GENE; INTRACELLULAR SIGNALING; LEUKEMIA CELL; MOUSE; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; PROTEIN FUNCTION;

EID: 84865011155     PISSN: 0301472X     EISSN: 18732399     Source Type: Journal    
DOI: 10.1016/j.exphem.2012.05.003     Document Type: Article

References (29)

1. Muntean A.G., Hess J.L. The pathogenesis of mixed-lineage leukemia. Annu Rev Pathol 2012, 7:283-301.
2. Krivtsov A.V., Twomey D., Feng Z., et al. Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9. Nature 2006, 442:818-822.
3. Somervaille T.C.P., Cleary M.L. Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia. Cancer Cell 2006, 10:257-268.
4. Martin M.E., Milne T.A., Bloyer S., et al. Dimerization of MLL fusion proteins immortalizes hematopoietic cells. Cancer Cell 2003, 4:197-207.
5. Wang Y., Krivtsov A.V., Sinha A.U., et al. The Wnt/{beta}-catenin pathway is required for the development of leukemia stem cells in AML. Science 2010, 327:1650-1653.
6. Pollak M.N., Schernhammer E.S., Hankinson S.E. Insulin-like growth factors and neoplasia. Nat Rev Cancer 2004, 4:505-518.
7. Baker J., Liu J.P., Robertson E.J., Efstratiadis A. Role of insulin-like growth factors in embryonic and postnatal growth. Cell 1993, 75:73-82.
8. Bendall S.C., Stewart M.H., Menendez P., et al. IGF and FGF cooperatively establish the regulatory stem cell niche of pluripotent human cells in vitro. Nature 2007, 448:1015-1021.
9. Ivanova N.B., Dimos J.T., Schaniel C., Hackney J.A., Moore K.A., Lemischka I.R. A stem cell molecular signature. Science 2002, 298:601-604.
10. Chapuis N., Tamburini J., Cornillet-Lefebvre P., et al. Autocrine IGF-1/IGF-1R signalling is responsible for constitutive PI3K/Akt activation in acute myeloid leukemia: therapeutic value of neutralizing anti-IGF-1R antibody. Haematologica 2010, 95:415-423.
11. Doepfner K.T., Spertini O., Arcaro A. Autocrine insulin-like growth factor-I signaling promotes growth and survival of human acute myeloid leukemia cells via the phosphoinositide 3-kinase/Akt pathway. Leukemia 2007, 21:1921-1930.
12. Tazzari P.L., Tabellini G., Bortul R., et al. The insulin-like growth factor-I receptor kinase inhibitor NVP-AEW541 induces apoptosis in acute myeloid leukemia cells exhibiting autocrine insulin-like growth factor-I secretion. Leukemia 2007, 21:886-896.
13. Wahner Hendrickson A.E., Haluska P., Schneider P.A., et al. Expression of insulin receptor isoform A and insulin-like growth factor-1 receptor in human acute myelogenous leukemia: effect of the dual-receptor inhibitor BMS-536924 in vitro. Cancer Res 2009, 69:7635-7643.
14. Gu T.L., Nardone J., Wang Y., et al. Survey of activated FLT3 signaling in leukemia. PLoS One 2011, 6:e19169.
15. Chapuis N., Lacombe C., Tamburini J., Bouscary D., Mayeux P. Insulin receptor A and IGF-1R in AML-Letter. Cancer Res 2010, 70:7010.
16. Wahner Hendrickson A.E., Haluska P., Erlichman C., et al. Insulin receptor A and IGF-IR in AML-Response. Cancer Res 2010, 70:7010.
17. Medyouf H., Gusscott S., Wang H., et al. High-level IGF1R expression is required for leukemia-initiating cell activity in T-ALL and is supported by Notch signaling. J Exp Med 2011, 208:1809-1822.
18. Holzenberger M., Leneuve P., Hamard G., et al. A targeted partial invalidation of the insulin-like growth factor I receptor gene in mice causes a postnatal growth deficit. Endocrinology 2000, 141:2557-2566.
19. Morita S., Kojima T., Kitamura T. Plat-E: an efficient and stable system for transient packaging of retroviruses. Gene Ther 2000, 7:1063-1066.
20. Weng A.P., Nam Y., Wolfe M.S., et al. Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling. Mol Cell Biol 2003, 23:655-664.
21. Akashi K., Traver D., Miyamoto T., Weissman I.L. A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature 2000, 404:193-197.
22. Wittman M., Carboni J., Attar R., et al. Discovery of a (1H-benzoimidazol-2-yl)-1H-pyridin-2-one (BMS-536924) inhibitor of insulin-like growth factor I receptor kinase with in vivo antitumor activity. J Med Chem 2005, 48:5639-5643.
23. Carboni J.M., Wittman M., Yang Z., et al. BMS-754807, a small molecule inhibitor of insulin-like growth factor-1R/IR. Mol Cancer Ther 2009, 8:3341-3349.
24. Lehne G., Grasmo-Wendler U.H., Berner J.M., et al. Upregulation of stem cell genes in multidrug resistant K562 leukemia cells. Leuk Res 2009, 33:1379-1385.
25. Abe S., Funato T., Takahashi S., et al. Increased expression of insulin-like growth factor i is associated with Ara-C resistance in leukemia. Tohoku J Exp Med 2006, 209:217-228.
26. Gal H., Amariglio N., Trakhtenbrot L., et al. Gene expression profiles of AML derived stem cells; similarity to hematopoietic stem cells. Leukemia 2006, 20:2147-2154.
27. Chen W., Kumar A.R., Hudson W.A., et al. Malignant transformation initiated by Mll-AF9: gene dosage and critical target cells. Cancer Cell 2008, 13:432-440.
28. Whelan J.T., Ludwig D.L., Bertrand F.E. HoxA9 induces insulin-like growth factor-1 receptor expression in B-lineage acute lymphoblastic leukemia. Leukemia 2008, 22:1161-1169.
29. Guenther M.G., Lawton L.N., Rozovskaia T., et al. Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia. Genes Dev 2008, 22:3403-3408.