Early Onset Pre-Eclampsia Is Associated with Altered DNA Methylation of Cortisol-Signalling and Steroidogenic Genes in the Placenta

PLoS ONE

Volumn 8, Issue 5, 2013, Pages

  Hogg, Kirsten ^a,b   Blair, John D ^a,b   McFadden, Deborah E ^a,b   von Dadelszen, Peter ^a,b   Robinson, Wendy P ^a,b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 2; BISULFITE; GLUCOCORTICOID; HYDROCORTISONE; MESSENGER RNA;

11BETA HYDROXYSTEROID DEHYDROGENASE TYPE 2 GENE; 3 BETA HYDROXY DELTA 5 STEROID DEHYDROGENASE TYPE 1 GENE; 5' UNTRANSLATED REGION; ADULT; ARTICLE; CONTROLLED STUDY; CORTICOTROPIN RELEASING HORMONE BINDING PROTEIN GENE; CPG ISLAND; CYP11A1 GENE; CYP19 GENE; DISEASE ASSOCIATION; DNA METHYLATION; EXON; FEMALE; GENE; GENE EXPRESSION; GENE LOCATION; GENETIC CODE; GENETIC TRANSCRIPTION; GESTATIONAL AGE; HUMAN; INTRAUTERINE GROWTH RETARDATION; INTRON; MAJOR CLINICAL STUDY; MATERNAL HYPERTENSION; NR3C1 GENE; NUCLEOTIDE SEQUENCE; PLACENTA; PREECLAMPSIA; PROMOTER REGION; PYROSEQUENCING; SIGNAL TRANSDUCTION; STEROIDOGENESIS; TEA DOMAIN FAMILY MEMBER 3 GENE;

ADULT; DNA METHYLATION; EXONS; FEMALE; GESTATIONAL AGE; GLUCOCORTICOIDS; HUMANS; HYDROCORTISONE; LABOR ONSET; MALE; PLACENTA; PRE-ECLAMPSIA; PREGNANCY; RECEPTORS, GLUCOCORTICOID; RNA, MESSENGER; SIGNAL TRANSDUCTION; STRESS, PHYSIOLOGICAL; TIME FACTORS;

EID: 84877114667     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0062969     Document Type: Article

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