-
1
-
-
50649117912
-
Cellular defenses against superoxide and hydrogen peroxide
-
Imlay, J. A. Cellular defenses against superoxide and hydrogen peroxide Annu. Rev. Biochem. 2008, 77, 755-776
-
(2008)
Annu. Rev. Biochem.
, vol.77
, pp. 755-776
-
-
Imlay, J.A.1
-
2
-
-
84864396552
-
Role of Nrf2 in protection against triptolide-induced toxicity in rat kidney cells
-
Li, J.; Jin, J.; Li, M.; Guan, C.; Wang, W.; Zhu, S.; Qiu, Y.; Huang, M.; Huang, Z. Role of Nrf2 in protection against triptolide-induced toxicity in rat kidney cells Toxicol. Lett. 2012, 213, 194-202
-
(2012)
Toxicol. Lett.
, vol.213
, pp. 194-202
-
-
Li, J.1
Jin, J.2
Li, M.3
Guan, C.4
Wang, W.5
Zhu, S.6
Qiu, Y.7
Huang, M.8
Huang, Z.9
-
3
-
-
70349843323
-
Nrf2:INrf2 (Keap1) signaling in oxidative stress
-
Kaspar, J. W.; Niture, S. K.; Jaiswal, A. K. Nrf2:INrf2 (Keap1) signaling in oxidative stress Free Radical Biol. Med. 2009, 47, 1304-1309
-
(2009)
Free Radical Biol. Med.
, vol.47
, pp. 1304-1309
-
-
Kaspar, J.W.1
Niture, S.K.2
Jaiswal, A.K.3
-
4
-
-
84866333520
-
The Nrf2-antioxidant response element pathway: A target for regulating energy metabolism
-
Vomhof-Dekrey, E. E.; Picklo, M. J., Sr. The Nrf2-antioxidant response element pathway: a target for regulating energy metabolism J. Nutr. Biochem. 2012, 23, 1201-1206
-
(2012)
J. Nutr. Biochem.
, vol.23
, pp. 1201-1206
-
-
Vomhof-Dekrey, E.E.1
Picklo Sr., M.J.2
-
5
-
-
67649402187
-
The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress
-
Nguyen, T.; Nioi, P.; Pickett, C. B. The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress J. Biol. Chem. 2009, 284, 13291-13295
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 13291-13295
-
-
Nguyen, T.1
Nioi, P.2
Pickett, C.B.3
-
6
-
-
79955506237
-
Nrf2-mediated induction of phase 2 detoxifying enzymes by glyceollins derived from soybean exposed to Aspergillus sojae
-
Kim, H. J.; di Luccio, E.; Kong, A. N.; Kim, J. S. Nrf2-mediated induction of phase 2 detoxifying enzymes by glyceollins derived from soybean exposed to Aspergillus sojae Biotechnol. J. 2011, 6, 525-536
-
(2011)
Biotechnol. J.
, vol.6
, pp. 525-536
-
-
Kim, H.J.1
Di Luccio, E.2
Kong, A.N.3
Kim, J.S.4
-
7
-
-
33644649131
-
Nrf2 defends the lung from oxidative stress
-
Cho, H. Y.; Reddy, S. P.; Kleeberger, S. R. Nrf2 defends the lung from oxidative stress Antioxid. Redox Signal. 2006, 8, 76-87
-
(2006)
Antioxid. Redox Signal.
, vol.8
, pp. 76-87
-
-
Cho, H.Y.1
Reddy, S.P.2
Kleeberger, S.R.3
-
8
-
-
54949139208
-
Adaptive response to GSH depletion and resistance to l -buthionine-(S, R)-sulfoximine: Involvement of Nrf2 activation
-
Lee, H. R.; Cho, J. M.; Shin, D. H.; Yong, C. S.; Choi, H. G.; Wakabayashi, N.; Kwak, M. K. Adaptive response to GSH depletion and resistance to l -buthionine-(S, R)-sulfoximine: involvement of Nrf2 activation Mol. Cell. Biochem. 2008, 318, 23-31
-
(2008)
Mol. Cell. Biochem.
, vol.318
, pp. 23-31
-
-
Lee, H.R.1
Cho, J.M.2
Shin, D.H.3
Yong, C.S.4
Choi, H.G.5
Wakabayashi, N.6
Kwak, M.K.7
-
9
-
-
0042330074
-
Identification of a novel Nrf2-regulated antioxidant response element (ARE) in the mouse NAD(P)H:quinone oxidoreductase 1 gene: Reassessment of the ARE consensus sequence
-
Nioi, P.; McMahon, M.; Itoh, K.; Yamamoto, M.; Hayes, J. D. Identification of a novel Nrf2-regulated antioxidant response element (ARE) in the mouse NAD(P)H:quinone oxidoreductase 1 gene: reassessment of the ARE consensus sequence Biochem. J. 2003, 374, 337-348
-
(2003)
Biochem. J.
, vol.374
, pp. 337-348
-
-
Nioi, P.1
McMahon, M.2
Itoh, K.3
Yamamoto, M.4
Hayes, J.D.5
-
10
-
-
0032953192
-
Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
-
Itoh, K.; Wakabayashi, N.; Katoh, Y.; Ishii, T.; Igarashi, K.; Engel, J. D.; Yamamoto, M. Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain Genes Dev. 1999, 13, 76-86
-
(1999)
Genes Dev.
, vol.13
, pp. 76-86
-
-
Itoh, K.1
Wakabayashi, N.2
Katoh, Y.3
Ishii, T.4
Igarashi, K.5
Engel, J.D.6
Yamamoto, M.7
-
11
-
-
0242580049
-
Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress
-
Zhang, D. D.; Hannink, M. Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress Mol. Cell. Biol. 2003, 23, 8137-8151
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 8137-8151
-
-
Zhang, D.D.1
Hannink, M.2
-
12
-
-
4544294365
-
The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: Oxidative stress sensing by a Cul3-Keap1 ligase
-
Cullinan, S. B.; Gordan, J. D.; Jin, J.; Harper, J. W.; Diehl, J. A. The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase Mol. Cell. Biol. 2004, 24, 8477-8486
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 8477-8486
-
-
Cullinan, S.B.1
Gordan, J.D.2
Jin, J.3
Harper, J.W.4
Diehl, J.A.5
-
13
-
-
3543008924
-
Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2
-
Kobayashi, A.; Kang, M. I.; Okawa, H.; Ohtsuji, M.; Zenke, Y.; Chiba, T.; Igarashi, K.; Yamamoto, M. Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2 Mol. Cell. Biol. 2004, 24, 7130-7139
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 7130-7139
-
-
Kobayashi, A.1
Kang, M.I.2
Okawa, H.3
Ohtsuji, M.4
Zenke, Y.5
Chiba, T.6
Igarashi, K.7
Yamamoto, M.8
-
14
-
-
2342511435
-
Small Maf proteins serve as transcriptional cofactors for keratinocyte differentiation in the Keap1-Nrf2 regulatory pathway
-
Motohashi, H.; Katsuoka, F.; Engel, J. D.; Yamamoto, M. Small Maf proteins serve as transcriptional cofactors for keratinocyte differentiation in the Keap1-Nrf2 regulatory pathway Proc. Natl. Acad. Sci. U.S.A. 2004, 101, 6379-6384
-
(2004)
Proc. Natl. Acad. Sci. U.S.A.
, vol.101
, pp. 6379-6384
-
-
Motohashi, H.1
Katsuoka, F.2
Engel, J.D.3
Yamamoto, M.4
-
15
-
-
0025948113
-
The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity
-
Rushmore, T. H.; Morton, M. R.; Pickett, C. B. The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity J. Biol. Chem. 1991, 266, 11632-11639
-
(1991)
J. Biol. Chem.
, vol.266
, pp. 11632-11639
-
-
Rushmore, T.H.1
Morton, M.R.2
Pickett, C.B.3
-
16
-
-
84875161582
-
A transgenic mouse model for monitoring oxidative stress
-
Oikawa, D.; Akai, R.; Tokuda, M.; Iwawaki, T. A transgenic mouse model for monitoring oxidative stress Sci. Rep. 2012, 2, 229
-
(2012)
Sci. Rep.
, vol.2
, pp. 229
-
-
Oikawa, D.1
Akai, R.2
Tokuda, M.3
Iwawaki, T.4
-
17
-
-
58249117780
-
The antioxidant defense system Keap1-Nrf2 comprises a multiple sensing mechanism for responding to a wide range of chemical compounds
-
Kobayashi, M.; Li, L.; Iwamoto, N.; Nakajima-Takagi, Y.; Kaneko, H.; Nakayama, Y.; Eguchi, M.; Wada, Y.; Kumagai, Y.; Yamamoto, M. The antioxidant defense system Keap1-Nrf2 comprises a multiple sensing mechanism for responding to a wide range of chemical compounds Mol. Cell. Biol. 2009, 29, 493-502
-
(2009)
Mol. Cell. Biol.
, vol.29
, pp. 493-502
-
-
Kobayashi, M.1
Li, L.2
Iwamoto, N.3
Nakajima-Takagi, Y.4
Kaneko, H.5
Nakayama, Y.6
Eguchi, M.7
Wada, Y.8
Kumagai, Y.9
Yamamoto, M.10
-
18
-
-
66649095844
-
Glutathione depletion by buthionine sulfoximine induces oxidative damage to DNA in organs of rabbits in vivo
-
Gokce, G.; Ozsarlak-Sozer, G.; Oktay, G.; Kirkali, G.; Jaruga, P.; Dizdaroglu, M.; Kerry, Z. Glutathione depletion by buthionine sulfoximine induces oxidative damage to DNA in organs of rabbits in vivo Biochemistry 2009, 48, 4980-4987
-
(2009)
Biochemistry
, vol.48
, pp. 4980-4987
-
-
Gokce, G.1
Ozsarlak-Sozer, G.2
Oktay, G.3
Kirkali, G.4
Jaruga, P.5
Dizdaroglu, M.6
Kerry, Z.7
-
19
-
-
77956242160
-
Antifungal activity of glyceollins isolated from soybean elicited with Aspergillus sojae
-
Kim, H. J.; Suh, H. J.; Lee, C. H.; Kim, J. H.; Kang, S. C.; Park, S.; Kim, J. S. Antifungal activity of glyceollins isolated from soybean elicited with Aspergillus sojae J. Agric. Food Chem. 2010, 58, 9483-9487
-
(2010)
J. Agric. Food Chem.
, vol.58
, pp. 9483-9487
-
-
Kim, H.J.1
Suh, H.J.2
Lee, C.H.3
Kim, J.H.4
Kang, S.C.5
Park, S.6
Kim, J.S.7
-
21
-
-
0038537298
-
PI3K is a key molecule in the Nrf2-mediated regulation of antioxidative proteins by hemin in human neuroblastoma cells
-
Nakaso, K.; Yano, H.; Fukuhara, Y.; Takeshima, T.; Wada-Isoe, K.; Nakashima, K. PI3K is a key molecule in the Nrf2-mediated regulation of antioxidative proteins by hemin in human neuroblastoma cells FEBS Lett. 2003, 546, 181-184
-
(2003)
FEBS Lett.
, vol.546
, pp. 181-184
-
-
Nakaso, K.1
Yano, H.2
Fukuhara, Y.3
Takeshima, T.4
Wada-Isoe, K.5
Nakashima, K.6
-
22
-
-
0027050783
-
Biochemistry of protein prenylation
-
Casey, P. J. Biochemistry of protein prenylation J. Lipid Res. 1992, 33, 1731-1740
-
(1992)
J. Lipid Res.
, vol.33
, pp. 1731-1740
-
-
Casey, P.J.1
-
23
-
-
9944255781
-
Evolutionary conserved N-terminal domain of Nrf2 is essential for the Keap1-mediated degradation of the protein by proteasome
-
Katoh, Y.; Iida, K.; Kang, M. I.; Kobayashi, A.; Mizukami, M.; Tong, K. I.; McMahon, M.; Hayes, J. D.; Itoh, K.; Yamamoto, M. Evolutionary conserved N-terminal domain of Nrf2 is essential for the Keap1-mediated degradation of the protein by proteasome Arch. Biochem. Biophys. 2005, 433, 342-350
-
(2005)
Arch. Biochem. Biophys.
, vol.433
, pp. 342-350
-
-
Katoh, Y.1
Iida, K.2
Kang, M.I.3
Kobayashi, A.4
Mizukami, M.5
Tong, K.I.6
McMahon, M.7
Hayes, J.D.8
Itoh, K.9
Yamamoto, M.10
-
24
-
-
33845442925
-
Mechanistic studies of the Nrf2-Keap1 signaling pathway
-
Zhang, D. D. Mechanistic studies of the Nrf2-Keap1 signaling pathway Drug Metab. Rev. 2006, 38, 769-789
-
(2006)
Drug Metab. Rev.
, vol.38
, pp. 769-789
-
-
Zhang, D.D.1
-
25
-
-
1242319541
-
Induction of quinone reductase as a primary screen for natural product anticarcinogens
-
Kang, Y. H.; Pezzuto, J. M. Induction of quinone reductase as a primary screen for natural product anticarcinogens Methods Enzymol 2004, 382, 380-414
-
(2004)
Methods Enzymol
, vol.382
, pp. 380-414
-
-
Kang, Y.H.1
Pezzuto, J.M.2
-
26
-
-
47849083585
-
Nrf2 signaling: An adaptive response pathway for protection against environmental toxic insults
-
Osburn, W. O.; Kensler, T. W. Nrf2 signaling: an adaptive response pathway for protection against environmental toxic insults Mutat. Res. 2008, 659, 31-39
-
(2008)
Mutat. Res.
, vol.659
, pp. 31-39
-
-
Osburn, W.O.1
Kensler, T.W.2
-
27
-
-
43649093915
-
Oxygen sensing by metazoans: The central role of the HIF hydroxylase pathway
-
Kaelin, W. G., Jr.; Ratcliffe, P. J. Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway Mol. Cell 2008, 30, 393-402
-
(2008)
Mol. Cell
, vol.30
, pp. 393-402
-
-
Kaelin Jr., W.G.1
Ratcliffe, P.J.2
-
28
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
Semenza, G. L. Targeting HIF-1 for cancer therapy Nat. Rev. Cancer 2003, 3, 721-732
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 721-732
-
-
Semenza, G.L.1
-
29
-
-
77952671413
-
HIF-1 alpha signaling is augmented during intermittent hypoxia by induction of the Nrf2 pathway in NOX1-expressing adenocarcinoma A549 cells
-
Malec, V.; Gottschald, O. R.; Li, S.; Rose, F.; Seeger, W.; Hanze, J. HIF-1 alpha signaling is augmented during intermittent hypoxia by induction of the Nrf2 pathway in NOX1-expressing adenocarcinoma A549 cells Free Radical Biol. Med. 2010, 48, 1626-1635
-
(2010)
Free Radical Biol. Med.
, vol.48
, pp. 1626-1635
-
-
Malec, V.1
Gottschald, O.R.2
Li, S.3
Rose, F.4
Seeger, W.5
Hanze, J.6
-
30
-
-
79952749190
-
NRF2 blockade suppresses colon tumor angiogenesis by inhibiting hypoxia-induced activation of HIF-1α
-
Kim, T. H.; Hur, E. G.; Kang, S. J.; Kim, J. A.; Thapa, D.; Lee, Y. M.; Ku, S. K.; Jung, Y.; Kwak, M. K. NRF2 blockade suppresses colon tumor angiogenesis by inhibiting hypoxia-induced activation of HIF-1α Cancer Res. 2011, 71, 2260-2275
-
(2011)
Cancer Res.
, vol.71
, pp. 2260-2275
-
-
Kim, T.H.1
Hur, E.G.2
Kang, S.J.3
Kim, J.A.4
Thapa, D.5
Lee, Y.M.6
Ku, S.K.7
Jung, Y.8
Kwak, M.K.9
-
31
-
-
63849267401
-
Buthionine sulfoximine sensitizes antihormone-resistant human breast cancer cells to estrogen-induced apoptosis
-
Lewis-Wambi, J. S.; Kim, H. R.; Wambi, C.; Patel, R.; Pyle, J. R.; Klein-Szanto, A. J.; Jordan, V. C. Buthionine sulfoximine sensitizes antihormone-resistant human breast cancer cells to estrogen-induced apoptosis Breast Cancer Res. 2008, 10, R104
-
(2008)
Breast Cancer Res.
, vol.10
, pp. 104
-
-
Lewis-Wambi, J.S.1
Kim, H.R.2
Wambi, C.3
Patel, R.4
Pyle, J.R.5
Klein-Szanto, A.J.6
Jordan, V.C.7
|