Glutathione depletion by buthionine sulfoximine induces oxidative damage to DNA in organs of rabbits in vivo

Biochemistry

Volumn 48, Issue 22, 2009, Pages 4980-4987

  Gokce, Goksel ^a   Ozsarlak Sozer, Gonen ^a   Oktay, Gulgun ^b   Kirkali, Güldal ^b   Jaruga, Pawel ^c,d   Dizdaroglu, Miral ^c   Kerry, Zeliha ^a  

^a EGE UNIVERSITY   (Turkey)

^b DOKUZ EYLUL UNIVERSITY   (Turkey)

^c NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY   (United States)

^d NICOLAUS COPERNICUS UNIVERSITY   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

8-HYDROXYGUANINE; ANTI-CANCER THERAPEUTICS; ANTIOXIDANT RESPONSE; BIOLOGICAL MOLECULE; DEOXYADENOSINE; DNA DAMAGES; DNA PRODUCTS; DNA SAMPLES; FORMAMIDOPYRIMIDINE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GLUTATHIONE; HIGH CONCENTRATION; IN-VIVO; INDUCED DAMAGE; ISOTOPE DILUTION METHODS; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY; MAMMALIAN TISSUES; OXIDATIVE DAMAGE; SULFOXIMINE;

AMINES; AMINO ACIDS; CHROMATOGRAPHIC ANALYSIS; DNA; GAS CHROMATOGRAPHY; GENES; HISTOLOGY; LIQUID CHROMATOGRAPHY; LIVER; MAMMALS; MASS SPECTROMETERS; MASS SPECTROMETRY; ORGANIC ACIDS; SPECTRUM ANALYSIS;

NUCLEIC ACIDS;

2,6 DIAMINO 4 HYDROXY 5 FORMAMIDOPYRIMIDINE; 8 HYDROXYADENINE; 8 HYDROXYGUANINE 2,6 DIAMINO 4 HYDROXY 5 FORMAMIDOPYRIMIDINE; 8,5' CYCLO 2' DEOXYADENOSINE; BUTHIONINE SULFOXIMINE; DNA; ESSENTIAL AMINO ACID; GLUTATHIONE; TAURINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN; CONTROLLED STUDY; CORRELATION ANALYSIS; DNA DAMAGE; FEMALE; HEART; IN VIVO STUDY; ISOTOPE DILUTION ASSAY; KIDNEY; LIQUID CHROMATOGRAPHY; LIVER; MALE; MASS FRAGMENTOGRAPHY; MASS SPECTROMETRY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEPLETION; RABBIT;

ANIMALS; ANTIMETABOLITES; BRAIN; BUTHIONINE SULFOXIMINE; DNA DAMAGE; FEMALE; GLUTATHIONE; HEART; INJECTIONS, SUBCUTANEOUS; KIDNEY; LIVER; MALE; MYOCARDIUM; OXIDATIVE STRESS; RABBITS; TAURINE;

ANIMALIA; MAMMALIA; ORYCTOLAGUS CUNICULUS;

EID: 66649095844     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi900030z     Document Type: Article

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