Simultaneous analysis of multiple monoclonal antibody biotherapeutics by LC-MS/MS method in rat plasma following cassette-dosing

AAPS Journal

Volumn 15, Issue 2, 2013, Pages 337-346

  Li, Hongyan ^a   Ortiz, Robert ^a   Tran, Linh T B ^a   Salimi Moosavi, Hossein ^a   Malella, Jennifer ^a   James, Christopher A ^a   Lee, Jean W ^a  

^a AMGEN INC   (United States)

Author keywords

cassette dosing of biologics; immunoaffinity mass spectrometry; ligand binding assay; monoclonal antibody biotherapeutics; multi analyte LC MS MS

Indexed keywords

MONOCLONAL ANTIBODY;

ALKYLATION; ANTIBODY AFFINITY; ANTIBODY DETECTION; ARTICLE; BIOLOGICAL THERAPY; BIOTINYLATION; CHEMOLUMINESCENCE; ENVIRONMENTAL TEMPERATURE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE CASSETTE; IMMUNOGENICITY; ISOTOPE LABELING; LIQUID CHROMATOGRAPHY; NONHUMAN; PROTEIN BINDING; PROTEIN DENATURATION; PROTEIN DETERMINATION; SENSITIVITY AND SPECIFICITY; SEQUENCE ALIGNMENT; TANDEM MASS SPECTROMETRY; WORKFLOW;

ANIMALS; ANTIBODIES, MONOCLONAL; BIOLOGICAL AGENTS; BIOTRANSFORMATION; CALIBRATION; CHROMATOGRAPHY, LIQUID; DRUG COMBINATIONS; ENZYME-LINKED IMMUNOSORBENT ASSAY; INJECTIONS, SUBCUTANEOUS; PEPTIDE FRAGMENTS; QUALITY CONTROL; RATS; RATS, SPRAGUE-DAWLEY; REFERENCE STANDARDS; TANDEM MASS SPECTROMETRY;

EID: 84877079010     PISSN: 15507416     EISSN: None     Source Type: Journal    
DOI: 10.1208/s12248-012-9435-5     Document Type: Article

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