99mTc-labeled dibenzylideneacetone derivatives as potential SPECT probes for in vivo imaging of β-amyloid plaque

European Journal of Medicinal Chemistry

Volumn 64, Issue , 2013, Pages 90-98

  Yang, Yanping ^a   Cui, Mengchao ^a   Jin, Bing ^a   Wang, Xuedan ^a   Li, Zijing ^a   Yu, Pingrong ^a   Jia, Jianhua ^a   Fu, Hualong ^a   Jia, Hongmei ^a   Liu, Boli ^a  

^a BEIJING NORMAL UNIVERSITY   (China)

Author keywords

Amyloid plaque; Alzheimer's disease; Dibenzylideneacetone; SPECT imaging; Technetium 99m

Indexed keywords

1 [4 (DIMETHYLAMINO)PHENYL] 5 [4 [3 [(2 MERCAPTOETHYL)[2 (2 MERCAPTOETHYLAMINO)ETHYL]AMINO]PROPOXY]PHENYL] PENTA 1,4 DIEN 3 ONE RHENIUM OXIDE TC 99M; 1 [4 (DIMETHYLAMINO)PHENYL] 5 [4 [5 [(2 MERCAPTOETHYL)[2 (2 MERCAPTOETHYLAMINO)ETHYL]AMINO]PROPOXY]PHENYL] PENTA 1,4 DIEN 3 ONE RHENIUM OXIDE TC 99M; 2 [[3 [4 [5 [4 (DIMETHYLAMINO)PHENYL] 3 OXOPENTA 1,4 DIENYL]PHENOXY]PROPYL](2 MERCAPTOETHYL) N (2 MERCAPTOETHYL]ACETAMIDE RHENIUM OXIDE TC 99M; 2 [[5 [4 [5 [4 (DIMETHYLAMINO)PHENYL] 3 OXOPENTA 1,4 DIENYL]PHENOXY]PENTYL](2 MERCAPTOETHYL) AMINO N (2 MERCAPTOETHYL]ACETAMIDE RHENIUM OXIDE TC 99M; AMYLOID BETA PROTEIN[1-42]; DIBENZYLIDENEACETONE TC 99M DERIVATIVE; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG PROTEIN BINDING; HEART; IN VITRO STUDY; IN VIVO STUDY; INTESTINE; KIDNEY; LIVER; LUNG; MOUSE; NONHUMAN; PANCREAS; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SPLEEN; STOMACH; TRANSGENIC MOUSE;

AMYLOID BETA-PEPTIDES; ANIMALS; BUTANONES; DISEASE MODELS, ANIMAL; FLUORESCENT DYES; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED ICR; MICE, TRANSGENIC; MOLECULAR IMAGING; MOLECULAR STRUCTURE; ORGANOMETALLIC COMPOUNDS; PEPTIDE FRAGMENTS; PLAQUE, AMYLOID; RHENIUM; STAINING AND LABELING; TECHNETIUM; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 84877074601     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.03.057     Document Type: Article

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