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Volumn 233, Issue 1, 2010, Pages 146-161

Suppressive functions of activated B cells in autoimmune diseases reveal the dual roles of Toll-like receptors in immunity

Author keywords

Autoimmunity; B cells; Feedforward loop; Immunoregulation; Interleukin 10; Toll like receptor

Indexed keywords

BREAKPOINT CLUSTER REGION PROTEIN; CD40 ANTIGEN; INTERLEUKIN 10; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MYELOID DIFFERENTIATION FACTOR 88; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 9;

EID: 73249114021     PISSN: 01052896     EISSN: 1600065X     Source Type: Journal    
DOI: 10.1111/j.0105-2896.2009.00855.x     Document Type: Review
Times cited : (96)

References (119)
  • 1
    • 2942537697 scopus 로고    scopus 로고
    • Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis
    • Edwards JC, et al. Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis. N Engl J Med 2004 350 : 2572 2581.
    • (2004) N Engl J Med , vol.350 , pp. 2572-2581
    • Edwards, J.C.1
  • 2
    • 33646198040 scopus 로고    scopus 로고
    • B cell immunobiology in disease: Evolving concepts from the clinic
    • Martin F, Chan AC. B cell immunobiology in disease: evolving concepts from the clinic. Annu Rev Immunol 2006 24 : 467 496.
    • (2006) Annu Rev Immunol , vol.24 , pp. 467-496
    • Martin, F.1    Chan, A.C.2
  • 3
    • 0036197923 scopus 로고    scopus 로고
    • Chronic intestinal inflammatory condition generates IL-10-producing regulatory B cell subset characterized by CD1d upregulation
    • Mizoguchi A, Mizoguchi E, Takedatsu H, Blumberg RS, Bhan AK. Chronic intestinal inflammatory condition generates IL-10-producing regulatory B cell subset characterized by CD1d upregulation. Immunity 2002 16 : 219 230.
    • (2002) Immunity , vol.16 , pp. 219-230
    • Mizoguchi, A.1    Mizoguchi, E.2    Takedatsu, H.3    Blumberg, R.S.4    Bhan, A.K.5
  • 5
    • 30744458329 scopus 로고    scopus 로고
    • A case for regulatory B cells
    • Mizoguchi A, Bhan AK. A case for regulatory B cells. J Immunol 2006 176 : 705 710.
    • (2006) J Immunol , vol.176 , pp. 705-710
    • Mizoguchi, A.1    Bhan, A.K.2
  • 6
    • 42649124913 scopus 로고    scopus 로고
    • Not always the bad guys: B cells as regulators of autoimmune pathology
    • Fillatreau S, Gray D, Anderton SM. Not always the bad guys: B cells as regulators of autoimmune pathology. Nat Rev Immunol 2008 8 : 391 397.
    • (2008) Nat Rev Immunol , vol.8 , pp. 391-397
    • Fillatreau, S.1    Gray, D.2    Anderton, S.M.3
  • 7
    • 57149087682 scopus 로고    scopus 로고
    • Activated B cells in autoimmune diseases: The case for a regulatory role
    • Anderton SM, Fillatreau S. Activated B cells in autoimmune diseases: the case for a regulatory role. Nat Clin Pract Rheumatol 2008 4 : 657 666.
    • (2008) Nat Clin Pract Rheumatol , vol.4 , pp. 657-666
    • Anderton, S.M.1    Fillatreau, S.2
  • 8
    • 42649111367 scopus 로고    scopus 로고
    • TLR-activated B cells suppress T cell-mediated autoimmunity
    • Lampropoulou V, et al. TLR-activated B cells suppress T cell-mediated autoimmunity. J Immunol 2008 180 : 4763 4773.
    • (2008) J Immunol , vol.180 , pp. 4763-4773
    • Lampropoulou, V.1
  • 10
    • 50349101549 scopus 로고    scopus 로고
    • Immune regulation by B cells and antibodies a view towards the clinic
    • Hoehlig K, et al. Immune regulation by B cells and antibodies a view towards the clinic. Adv Immunol 2008 98 : 1 38.
    • (2008) Adv Immunol , vol.98 , pp. 1-38
    • Hoehlig, K.1
  • 11
    • 0030666959 scopus 로고    scopus 로고
    • Suppressive role of B cells in chronic colitis of T cell receptor alpha mutant mice
    • Mizoguchi A, Mizoguchi E, Smith RN, Preffer FI, Bhan AK. Suppressive role of B cells in chronic colitis of T cell receptor alpha mutant mice. J Exp Med 1997 186 : 1749 1756.
    • (1997) J Exp Med , vol.186 , pp. 1749-1756
    • Mizoguchi, A.1    Mizoguchi, E.2    Smith, R.N.3    Preffer, F.I.4    Bhan, A.K.5
  • 12
    • 0030456897 scopus 로고    scopus 로고
    • Experimental autoimmune encephalomyelitis induction in genetically B cell-deficient mice
    • Wolf SD, Dittel BN, Hardardottir F, Janeway CA Jr. Experimental autoimmune encephalomyelitis induction in genetically B cell-deficient mice. J Exp Med 1996 184 : 2271 2278.
    • (1996) J Exp Med , vol.184 , pp. 2271-2278
    • Wolf, S.D.1    Dittel, B.N.2    Hardardottir, F.3    Janeway, Jr.C.A.4
  • 13
    • 0034013685 scopus 로고    scopus 로고
    • Regulatory role of mature B cells in a murine model of inflammatory bowel disease
    • Mizoguchi E, Mizoguchi A, Preffer FI, Bhan AK. Regulatory role of mature B cells in a murine model of inflammatory bowel disease. Int Immunol 2000 12 : 597 605.
    • (2000) Int Immunol , vol.12 , pp. 597-605
    • Mizoguchi, E.1    Mizoguchi, A.2    Preffer, F.I.3    Bhan, A.K.4
  • 14
    • 0037450740 scopus 로고    scopus 로고
    • Prevention of arthritis by interleukin 10-producing B cells
    • Mauri C, Gray D, Mushtaq N, Londei M. Prevention of arthritis by interleukin 10-producing B cells. J Exp Med 2003 197 : 489 501.
    • (2003) J Exp Med , vol.197 , pp. 489-501
    • Mauri, C.1    Gray, D.2    Mushtaq, N.3    Londei, M.4
  • 15
    • 34247602173 scopus 로고    scopus 로고
    • B lymphocytopenia in rheumatoid arthritis is associated with the DRB1 shared epitope and increased acute phase response
    • Wagner U, Kaltenhauser S, Pierer M, Wilke B, Arnold S, Hantzschel H. B lymphocytopenia in rheumatoid arthritis is associated with the DRB1 shared epitope and increased acute phase response. Arthritis Res 2002 4 : R1.
    • (2002) Arthritis Res , vol.4 , pp. 1
    • Wagner, U.1    Kaltenhauser, S.2    Pierer, M.3    Wilke, B.4    Arnold, S.5    Hantzschel, H.6
  • 16
    • 24144442841 scopus 로고    scopus 로고
    • Worsening after rituximab treatment in anti-mag neuropathy
    • Broglio L, Lauria G. Worsening after rituximab treatment in anti-mag neuropathy. Muscle Nerve 2005 32 : 378 379.
    • (2005) Muscle Nerve , vol.32 , pp. 378-379
    • Broglio, L.1    Lauria, G.2
  • 17
    • 0242349131 scopus 로고    scopus 로고
    • Rituximab in the treatment of polyneuropathy associated with anti-MAG antibodies
    • Renaud S, et al. Rituximab in the treatment of polyneuropathy associated with anti-MAG antibodies. Muscle Nerve 2003 27 : 611 615.
    • (2003) Muscle Nerve , vol.27 , pp. 611-615
    • Renaud, S.1
  • 18
    • 42549142171 scopus 로고    scopus 로고
    • Ulcerative colitis following B lymphocyte depletion with rituximab in a patient with Graves' disease
    • El Fassi D, Nielsen CH, Kjeldsen J, Clemmensen O, Hegedus L. Ulcerative colitis following B lymphocyte depletion with rituximab in a patient with Graves' disease. Gut 2008 57 : 714 715.
    • (2008) Gut , vol.57 , pp. 714-715
    • El Fassi, D.1    Nielsen, C.H.2    Kjeldsen, J.3    Clemmensen, O.4    Hegedus, L.5
  • 19
    • 34547786479 scopus 로고    scopus 로고
    • Development of psoriasis after B cell depletion with rituximab
    • Dass S, Vital EM, Emery P. Development of psoriasis after B cell depletion with rituximab. Arthritis Rheum 2007 56 : 2715 2718.
    • (2007) Arthritis Rheum , vol.56 , pp. 2715-2718
    • Dass, S.1    Vital, E.M.2    Emery, P.3
  • 20
    • 1542514778 scopus 로고    scopus 로고
    • Distinct profiles of human B cell effector cytokines: A role in immune regulation?
    • Duddy ME, Alter A, Bar-Or A. Distinct profiles of human B cell effector cytokines: a role in immune regulation? J Immunol 2004 172 : 3422 3427.
    • (2004) J Immunol , vol.172 , pp. 3422-3427
    • Duddy, M.E.1    Alter, A.2    Bar-Or, A.3
  • 21
    • 34248230257 scopus 로고    scopus 로고
    • Distinct effector cytokine profiles of memory and naive human B cell subsets and implication in multiple sclerosis
    • Duddy M, et al. Distinct effector cytokine profiles of memory and naive human B cell subsets and implication in multiple sclerosis. J Immunol 2007 178 : 6092 6099.
    • (2007) J Immunol , vol.178 , pp. 6092-6099
    • Duddy, M.1
  • 22
    • 0027427223 scopus 로고
    • Cytokines and adhesion molecules contribute to the ability of myelin proteolipid protein-specific T cell clones to mediate experimental allergic encephalomyelitis
    • Kuchroo VK, Martin CA, Greer JM, Ju ST, Sobel RA, Dorf ME. Cytokines and adhesion molecules contribute to the ability of myelin proteolipid protein-specific T cell clones to mediate experimental allergic encephalomyelitis. J Immunol 1993 151 : 4371 4382.
    • (1993) J Immunol , vol.151 , pp. 4371-4382
    • Kuchroo, V.K.1    Martin, C.A.2    Greer, J.M.3    Ju, S.T.4    Sobel, R.A.5    Dorf, M.E.6
  • 23
    • 27544465354 scopus 로고    scopus 로고
    • A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
    • Park H, et al. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol 2005 6 : 1133 1141.
    • (2005) Nat Immunol , vol.6 , pp. 1133-1141
    • Park, H.1
  • 24
    • 0035879105 scopus 로고    scopus 로고
    • Lipopolysaccharide-activated B cells down-regulate Th1 immunity and prevent autoimmune diabetes in nonobese diabetic mice
    • Tian J, Zekzer D, Hanssen L, Lu Y, Olcott A, Kaufman DL. Lipopolysaccharide-activated B cells down-regulate Th1 immunity and prevent autoimmune diabetes in nonobese diabetic mice. J Immunol 2001 167 : 1081 1089.
    • (2001) J Immunol , vol.167 , pp. 1081-1089
    • Tian, J.1    Zekzer, D.2    Hanssen, L.3    Lu, Y.4    Olcott, A.5    Kaufman, D.L.6
  • 25
    • 0026451165 scopus 로고
    • B cells turn off virgin but not memory T cells
    • Fuchs EJ, Matzinger P. B cells turn off virgin but not memory T cells. Science 1992 258 : 1156 1159.
    • (1992) Science , vol.258 , pp. 1156-1159
    • Fuchs, E.J.1    Matzinger, P.2
  • 26
    • 0037441998 scopus 로고    scopus 로고
    • B cell developmental requirement for the G alpha i2 gene
    • Dalwadi H, et al. B cell developmental requirement for the G alpha i2 gene. J Immunol 2003 170 : 1707 1715.
    • (2003) J Immunol , vol.170 , pp. 1707-1715
    • Dalwadi, H.1
  • 27
    • 13844320401 scopus 로고    scopus 로고
    • Mesenteric B cells centrally inhibit CD4+ T cell colitis through interaction with regulatory T cell subsets
    • Wei B, et al. Mesenteric B cells centrally inhibit CD4+ T cell colitis through interaction with regulatory T cell subsets. Proc Natl Acad Sci USA 2005 102 : 2010 2015.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 2010-2015
    • Wei, B.1
  • 28
    • 45249115068 scopus 로고    scopus 로고
    • Integration of B cells and CD8+ T in the protective regulation of systemic epithelial inflammation
    • Wei B, et al. Integration of B cells and CD8+ T in the protective regulation of systemic epithelial inflammation. Clin Immunol 2008 127 : 303 312.
    • (2008) Clin Immunol , vol.127 , pp. 303-312
    • Wei, B.1
  • 29
    • 64049112820 scopus 로고    scopus 로고
    • Regulatory function of CpG-activated B cells in late-phase experimental allergic conjunctivitis
    • Miyazaki D, Kuo CH, Tominaga T, Inoue Y, Ono SJ. Regulatory function of CpG-activated B cells in late-phase experimental allergic conjunctivitis. Invest Ophthalmol Vis Sci 2009 50 : 1626 1635.
    • (2009) Invest Ophthalmol Vis Sci , vol.50 , pp. 1626-1635
    • Miyazaki, D.1    Kuo, C.H.2    Tominaga, T.3    Inoue, Y.4    Ono, S.J.5
  • 30
    • 17444374245 scopus 로고    scopus 로고
    • Upon TLR9 signaling, CD5+ B cells control the IL-12-dependent Th1-priming capacity of neonatal DCs
    • Sun CM, Deriaud E, Leclerc C, Lo-Man R. Upon TLR9 signaling, CD5+ B cells control the IL-12-dependent Th1-priming capacity of neonatal DCs. Immunity 2005 22 : 467 477.
    • (2005) Immunity , vol.22 , pp. 467-477
    • Sun, C.M.1    Deriaud, E.2    Leclerc, C.3    Lo-Man, R.4
  • 31
    • 0034698829 scopus 로고    scopus 로고
    • B lymphocytes regulate dendritic cell (DC) function in vivo: Increased interleukin 12 production by DCs from B cell-deficient mice results in T helper cell type 1 deviation
    • Moulin V, Andris F, Thielemans K, Maliszewski C, Urbain J, Moser M. B lymphocytes regulate dendritic cell (DC) function in vivo: increased interleukin 12 production by DCs from B cell-deficient mice results in T helper cell type 1 deviation. J Exp Med 2000 192 : 475 482.
    • (2000) J Exp Med , vol.192 , pp. 475-482
    • Moulin, V.1    Andris, F.2    Thielemans, K.3    Maliszewski, C.4    Urbain, J.5    Moser, M.6
  • 32
    • 0034097970 scopus 로고    scopus 로고
    • Therapeutic activity of agonistic monoclonal antibodies against CD40 in a chronic autoimmune inflammatory process
    • Mauri C, Mars LT, Londei M. Therapeutic activity of agonistic monoclonal antibodies against CD40 in a chronic autoimmune inflammatory process. Nat Med 2000 6 : 673 679.
    • (2000) Nat Med , vol.6 , pp. 673-679
    • Mauri, C.1    Mars, L.T.2    Londei, M.3
  • 34
    • 34248512211 scopus 로고    scopus 로고
    • Protection against autoimmune nephritis in MyD88-deficient MRL/lpr mice
    • Sadanaga A, et al. Protection against autoimmune nephritis in MyD88-deficient MRL/lpr mice. Arthritis Rheum 2007 56 : 1618 1628.
    • (2007) Arthritis Rheum , vol.56 , pp. 1618-1628
    • Sadanaga, A.1
  • 35
    • 0027816953 scopus 로고
    • Prevention of collagen-induced arthritis with an antibody to gp39, the ligand for CD40
    • Durie FH, Fava RA, Foy TM, Aruffo A, Ledbetter JA, Noelle RJ. Prevention of collagen-induced arthritis with an antibody to gp39, the ligand for CD40. Science 1993 261 : 1328 1330.
    • (1993) Science , vol.261 , pp. 1328-1330
    • Durie, F.H.1    Fava, R.A.2    Foy, T.M.3    Aruffo, A.4    Ledbetter, J.A.5    Noelle, R.J.6
  • 36
    • 0028783963 scopus 로고
    • Generalized autoimmune disease in interleukin-2-deficient mice is triggered by an uncontrolled activation and proliferation of CD4+ T cells
    • Sadlack B, et al. Generalized autoimmune disease in interleukin-2- deficient mice is triggered by an uncontrolled activation and proliferation of CD4+ T cells. Eur J Immunol 1995 25 : 3053 3059.
    • (1995) Eur J Immunol , vol.25 , pp. 3053-3059
    • Sadlack, B.1
  • 37
    • 0037436119 scopus 로고    scopus 로고
    • Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells
    • Pasare C, Medzhitov R. Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells. Science 2003 299 : 1033 1036.
    • (2003) Science , vol.299 , pp. 1033-1036
    • Pasare, C.1    Medzhitov, R.2
  • 38
    • 35348957966 scopus 로고    scopus 로고
    • Tolerance induction by gene transfer to lymphocytes
    • Skupsky J, Su Y, Lei TC, Scott DW. Tolerance induction by gene transfer to lymphocytes. Curr Gene Ther 2007 7 : 369 380.
    • (2007) Curr Gene Ther , vol.7 , pp. 369-380
    • Skupsky, J.1    Su, Y.2    Lei, T.C.3    Scott, D.W.4
  • 39
    • 0033587771 scopus 로고    scopus 로고
    • Induction of hyporesponsiveness to intact foreign protein via retroviral-mediated gene expression: The IgG scaffold is important for induction and maintenance of immune hyporesponsiveness
    • Kang Y, Melo M, Deng E, Tisch R, El-Amine M, Scott DW. Induction of hyporesponsiveness to intact foreign protein via retroviral-mediated gene expression: the IgG scaffold is important for induction and maintenance of immune hyporesponsiveness. Proc Natl Acad Sci USA 1999 96 : 8609 8614.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 8609-8614
    • Kang, Y.1    Melo, M.2    Deng, E.3    Tisch, R.4    El-Amine, M.5    Scott, D.W.6
  • 40
    • 23244454645 scopus 로고    scopus 로고
    • Mechanisms of gene therapy for tolerance: B7 signaling is required for peptide-IgG gene-transferred tolerance induction
    • Litzinger MT, Su Y, Lei TC, Soukhareva N, Scott DW. Mechanisms of gene therapy for tolerance: B7 signaling is required for peptide-IgG gene-transferred tolerance induction. J Immunol 2005 175 : 780 787.
    • (2005) J Immunol , vol.175 , pp. 780-787
    • Litzinger, M.T.1    Su, Y.2    Lei, T.C.3    Soukhareva, N.4    Scott, D.W.5
  • 41
    • 0028337459 scopus 로고
    • Comparative analysis of B7-1 and B7-2 costimulatory ligands: Expression and function
    • Hathcock KS, Laszlo G, Pucillo C, Linsley P, Hodes RJ. Comparative analysis of B7-1 and B7-2 costimulatory ligands: expression and function. J Exp Med 1994 180 : 631 640.
    • (1994) J Exp Med , vol.180 , pp. 631-640
    • Hathcock, K.S.1    Laszlo, G.2    Pucillo, C.3    Linsley, P.4    Hodes, R.J.5
  • 42
    • 0024327899 scopus 로고
    • Clonal expansion versus functional clonal inactivation: A costimulatory signalling pathway determines the outcome of T cell antigen receptor occupancy
    • Mueller DL, Jenkins MK, Schwartz RH. Clonal expansion versus functional clonal inactivation: a costimulatory signalling pathway determines the outcome of T cell antigen receptor occupancy. Annu Rev Immunol 1989 7 : 445 480.
    • (1989) Annu Rev Immunol , vol.7 , pp. 445-480
    • Mueller, D.L.1    Jenkins, M.K.2    Schwartz, R.H.3
  • 43
    • 0034669953 scopus 로고    scopus 로고
    • Mechanisms of tolerance induction by a gene-transferred peptide-IgG fusion protein expressed in B lineage cells
    • El-Amine M, Melo M, Kang Y, Nguyen H, Qian J, Scott DW. Mechanisms of tolerance induction by a gene-transferred peptide-IgG fusion protein expressed in B lineage cells. J Immunol 2000 165 : 5631 5636.
    • (2000) J Immunol , vol.165 , pp. 5631-5636
    • El-Amine, M.1    Melo, M.2    Kang, Y.3    Nguyen, H.4    Qian, J.5    Scott, D.W.6
  • 44
    • 0031093505 scopus 로고    scopus 로고
    • Both resting and activated B lymphocytes expressing engineered peptide-Ig molecules serve as highly efficient tolerogenic vehicles in immunocompetent adult recipients
    • Zambidis ET, Barth RK, Scott DW. Both resting and activated B lymphocytes expressing engineered peptide-Ig molecules serve as highly efficient tolerogenic vehicles in immunocompetent adult recipients. J Immunol 1997 158 : 2174 2182.
    • (1997) J Immunol , vol.158 , pp. 2174-2182
    • Zambidis, E.T.1    Barth, R.K.2    Scott, D.W.3
  • 45
    • 0033927572 scopus 로고    scopus 로고
    • Retroviral gene therapy with an immunoglobulin-antigen fusion construct protects from experimental autoimmune uveitis
    • Agarwal RK, Kang Y, Zambidis E, Scott DW, Chan CC, Caspi RR. Retroviral gene therapy with an immunoglobulin-antigen fusion construct protects from experimental autoimmune uveitis. J Clin Invest 2000 106 : 245 252.
    • (2000) J Clin Invest , vol.106 , pp. 245-252
    • Agarwal, R.K.1    Kang, Y.2    Zambidis, E.3    Scott, D.W.4    Chan, C.C.5    Caspi, R.R.6
  • 46
    • 0036569428 scopus 로고    scopus 로고
    • Gene transfer of Ig-fusion proteins into B cells prevents and treats autoimmune diseases
    • Melo ME, et al. Gene transfer of Ig-fusion proteins into B cells prevents and treats autoimmune diseases. J Immunol 2002 168 : 4788 4795.
    • (2002) J Immunol , vol.168 , pp. 4788-4795
    • Melo, M.E.1
  • 47
    • 1842685036 scopus 로고    scopus 로고
    • A novel retroviral gene therapy approach to inhibit specific antibody production and suppress experimental autoimmune encephalomyelitis induced by MOG and MBP
    • Xu B, Scott DW. A novel retroviral gene therapy approach to inhibit specific antibody production and suppress experimental autoimmune encephalomyelitis induced by MOG and MBP. Clin Immunol 2004 111 : 47 52.
    • (2004) Clin Immunol , vol.111 , pp. 47-52
    • Xu, B.1    Scott, D.W.2
  • 48
    • 33747842285 scopus 로고    scopus 로고
    • Treatment of diabetes in NOD mice by gene transfer of Ig-fusion proteins into B cells: Role of T regulatory cells
    • Soukhareva N, Jiang Y, Scott DW. Treatment of diabetes in NOD mice by gene transfer of Ig-fusion proteins into B cells: role of T regulatory cells. Cell Immunol 2006 240 : 41 46.
    • (2006) Cell Immunol , vol.240 , pp. 41-46
    • Soukhareva, N.1    Jiang, Y.2    Scott, D.W.3
  • 49
    • 29444447786 scopus 로고    scopus 로고
    • B-cell delivered gene transfer of human S-Ag-Ig fusion protein protects from experimental autoimmune uveitis
    • Liang W, et al. B-cell delivered gene transfer of human S-Ag-Ig fusion protein protects from experimental autoimmune uveitis. Clin Immunol 2006 118 : 35 41.
    • (2006) Clin Immunol , vol.118 , pp. 35-41
    • Liang, W.1
  • 50
    • 34248548655 scopus 로고    scopus 로고
    • Mycobacterial Hsp65-IgG-expressing tolerogenic B cells confer protection against adjuvant-induced arthritis in Lewis rats
    • Satpute SR, Soukhareva N, Scott DW, Moudgil KD. Mycobacterial Hsp65-IgG-expressing tolerogenic B cells confer protection against adjuvant-induced arthritis in Lewis rats. Arthritis Rheum 2007 56 : 1490 1496.
    • (2007) Arthritis Rheum , vol.56 , pp. 1490-1496
    • Satpute, S.R.1    Soukhareva, N.2    Scott, D.W.3    Moudgil, K.D.4
  • 51
    • 0035865707 scopus 로고    scopus 로고
    • A gene therapy approach for treating T-cell-mediated autoimmune diseases
    • Chen C, Rivera A, Ron N, Dougherty JP, Ron Y. A gene therapy approach for treating T-cell-mediated autoimmune diseases. Blood 2001 97 : 886 894.
    • (2001) Blood , vol.97 , pp. 886-894
    • Chen, C.1    Rivera, A.2    Ron, N.3    Dougherty, J.P.4    Ron, Y.5
  • 52
    • 2942625421 scopus 로고    scopus 로고
    • Complete protection from relapsing experimental autoimmune encephalomyelitis induced by syngeneic B cells expressing the autoantigen
    • Chen CC, Rivera A, Dougherty JP, Ron Y. Complete protection from relapsing experimental autoimmune encephalomyelitis induced by syngeneic B cells expressing the autoantigen. Blood 2004 103 : 4616 4618.
    • (2004) Blood , vol.103 , pp. 4616-4618
    • Chen, C.C.1    Rivera, A.2    Dougherty, J.P.3    Ron, Y.4
  • 53
    • 0027368141 scopus 로고
    • Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes
    • Kaufman DL, et al. Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes. Nature 1993 366 : 69 72.
    • (1993) Nature , vol.366 , pp. 69-72
    • Kaufman, D.L.1
  • 54
    • 65449188259 scopus 로고    scopus 로고
    • Selective targeting of B cells with agonistic anti-CD40 is an efficacious strategy for the generation of induced regulatory T2-like B cells and for the suppression of lupus in MRL/lpr mice
    • Blair PA, et al. Selective targeting of B cells with agonistic anti-CD40 is an efficacious strategy for the generation of induced regulatory T2-like B cells and for the suppression of lupus in MRL/lpr mice. J Immunol 2009 182 : 3492 3502.
    • (2009) J Immunol , vol.182 , pp. 3492-3502
    • Blair, P.A.1
  • 55
    • 0041743207 scopus 로고    scopus 로고
    • The toll-like receptor repertoire of human B lymphocytes: Inducible and selective expression of TLR9 and TLR10 in normal and transformed cells
    • Bourke E, Bosisio D, Golay J, Polentarutti N, Mantovani A. The toll-like receptor repertoire of human B lymphocytes: inducible and selective expression of TLR9 and TLR10 in normal and transformed cells. Blood 2003 102 : 956 963.
    • (2003) Blood , vol.102 , pp. 956-963
    • Bourke, E.1    Bosisio, D.2    Golay, J.3    Polentarutti, N.4    Mantovani, A.5
  • 56
    • 0038142387 scopus 로고    scopus 로고
    • A role for Toll-like receptors in acquired immunity: Up-regulation of TLR9 by BCR triggering in naive B cells and constitutive expression in memory B cells
    • Bernasconi NL, Onai N, Lanzavecchia A. A role for Toll-like receptors in acquired immunity: up-regulation of TLR9 by BCR triggering in naive B cells and constitutive expression in memory B cells. Blood 2003 101 : 4500 4504.
    • (2003) Blood , vol.101 , pp. 4500-4504
    • Bernasconi, N.L.1    Onai, N.2    Lanzavecchia, A.3
  • 57
    • 26944475538 scopus 로고    scopus 로고
    • Tolerance induction via a B-cell delivered gene therapy-based protocol: Optimization and role of the Ig scaffold
    • Lei TC, Su Y, Scott DW. Tolerance induction via a B-cell delivered gene therapy-based protocol: optimization and role of the Ig scaffold. Cell Immunol 2005 235 : 12 20.
    • (2005) Cell Immunol , vol.235 , pp. 12-20
    • Lei, T.C.1    Su, Y.2    Scott, D.W.3
  • 58
    • 0037606009 scopus 로고    scopus 로고
    • B cells activated by lipopolysaccharide, but not by anti-Ig and anti-CD40 antibody, induce anergy in CD8+ T cells: Role of TGF-beta 1
    • Parekh VV, Prasad DV, Banerjee PP, Joshi BN, Kumar A, Mishra GC. B cells activated by lipopolysaccharide, but not by anti-Ig and anti-CD40 antibody, induce anergy in CD8+ T cells: role of TGF-beta 1. J Immunol 2003 170 : 5897 5911.
    • (2003) J Immunol , vol.170 , pp. 5897-5911
    • Parekh, V.V.1    Prasad, D.V.2    Banerjee, P.P.3    Joshi, B.N.4    Kumar, A.5    Mishra, G.C.6
  • 59
  • 60
    • 0031738699 scopus 로고    scopus 로고
    • Characterization of immature B cells by a novel monoclonal antibody, by turnover and by mitogen reactivity
    • Rolink AG, Andersson J, Melchers F. Characterization of immature B cells by a novel monoclonal antibody, by turnover and by mitogen reactivity. Eur J Immunol 1998 28 : 3738 3748.
    • (1998) Eur J Immunol , vol.28 , pp. 3738-3748
    • Rolink, A.G.1    Andersson, J.2    Melchers, F.3
  • 61
    • 0942290444 scopus 로고    scopus 로고
    • Molecular mechanisms guiding late stages of B-cell development
    • Rolink AG, Andersson J, Melchers F. Molecular mechanisms guiding late stages of B-cell development. Immunol Rev 2004 197 : 41 50.
    • (2004) Immunol Rev , vol.197 , pp. 41-50
    • Rolink, A.G.1    Andersson, J.2    Melchers, F.3
  • 62
    • 0033526816 scopus 로고    scopus 로고
    • B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals
    • Loder F, et al. B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals. J Exp Med 1999 190 : 75 89.
    • (1999) J Exp Med , vol.190 , pp. 75-89
    • Loder, F.1
  • 63
    • 0035892228 scopus 로고    scopus 로고
    • Resolution of three nonproliferative immature splenic B cell subsets reveals multiple selection points during peripheral B cell maturation
    • Allman D, Lindsley RC, DeMuth W, Rudd K, Shinton SA, Hardy RR. Resolution of three nonproliferative immature splenic B cell subsets reveals multiple selection points during peripheral B cell maturation. J Immunol 2001 167 : 6834 6840.
    • (2001) J Immunol , vol.167 , pp. 6834-6840
    • Allman, D.1    Lindsley, R.C.2    Demuth, W.3    Rudd, K.4    Shinton, S.A.5    Hardy, R.R.6
  • 65
    • 0036498795 scopus 로고    scopus 로고
    • Transitional B lymphocyte subsets operate as distinct checkpoints in murine splenic B cell development
    • Su TT, Rawlings DJ. Transitional B lymphocyte subsets operate as distinct checkpoints in murine splenic B cell development. J Immunol 2002 168 : 2101 2110.
    • (2002) J Immunol , vol.168 , pp. 2101-2110
    • Su, T.T.1    Rawlings, D.J.2
  • 66
    • 0036201875 scopus 로고    scopus 로고
    • CD1d on antigen-transporting APC and splenic marginal zone B cells promotes NKT cell-dependent tolerance
    • Sonoda KH, Stein-Streilein J. CD1d on antigen-transporting APC and splenic marginal zone B cells promotes NKT cell-dependent tolerance. Eur J Immunol 2002 32 : 848 857.
    • (2002) Eur J Immunol , vol.32 , pp. 848-857
    • Sonoda, K.H.1    Stein-Streilein, J.2
  • 67
    • 53849128828 scopus 로고    scopus 로고
    • Immune regulation and the eye
    • Stein-Streilein J. Immune regulation and the eye. Trends Immunol 2008 29 : 548 554.
    • (2008) Trends Immunol , vol.29 , pp. 548-554
    • Stein-Streilein, J.1
  • 68
    • 16344380083 scopus 로고    scopus 로고
    • Inherent specificities in natural antibodies: A key to immune defense against pathogen invasion
    • Baumgarth N, Tung JW, Herzenberg LA. Inherent specificities in natural antibodies: a key to immune defense against pathogen invasion. Springer Semin Immunopathol 2005 26 : 347 362.
    • (2005) Springer Semin Immunopathol , vol.26 , pp. 347-362
    • Baumgarth, N.1    Tung, J.W.2    Herzenberg, L.A.3
  • 69
    • 0025758378 scopus 로고
    • Treatment of murine CD5- B cells with anti-Ig, but not LPS, induces surface CD5: Two B-cell activation pathways
    • Cong YZ, Rabin E, Wortis HH. Treatment of murine CD5- B cells with anti-Ig, but not LPS, induces surface CD5: two B-cell activation pathways. Int Immunol 1991 3 : 467 476.
    • (1991) Int Immunol , vol.3 , pp. 467-476
    • Cong, Y.Z.1    Rabin, E.2    Wortis, H.H.3
  • 70
    • 0037332017 scopus 로고    scopus 로고
    • Recirculating and germinal center B cells differentiate into cells responsive to polysaccharide antigens
    • Vinuesa CG, et al. Recirculating and germinal center B cells differentiate into cells responsive to polysaccharide antigens. Eur J Immunol 2003 33 : 297 305.
    • (2003) Eur J Immunol , vol.33 , pp. 297-305
    • Vinuesa, C.G.1
  • 71
    • 0033579933 scopus 로고    scopus 로고
    • Transfer of small resting B cells into immunodeficient hosts results in the selection of a self-renewing activated B cell population
    • Agenes F, Freitas AA. Transfer of small resting B cells into immunodeficient hosts results in the selection of a self-renewing activated B cell population. J Exp Med 1999 189 : 319 330.
    • (1999) J Exp Med , vol.189 , pp. 319-330
    • Agenes, F.1    Freitas, A.A.2
  • 72
    • 0033598846 scopus 로고    scopus 로고
    • Ligation of intestinal epithelial CD1d induces bioactive IL-10: Critical role of the cytoplasmic tail in autocrine signaling
    • Colgan SP, Hershberg RM, Furuta GT, Blumberg RS. Ligation of intestinal epithelial CD1d induces bioactive IL-10: critical role of the cytoplasmic tail in autocrine signaling. Proc Natl Acad Sci USA 1999 96 : 13938 13943.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 13938-13943
    • Colgan, S.P.1    Hershberg, R.M.2    Furuta, G.T.3    Blumberg, R.S.4
  • 73
    • 0035188018 scopus 로고    scopus 로고
    • Role of the high affinity immunoglobulin e receptor in bacterial translocation and intestinal inflammation
    • Dombrowicz D, et al. Role of the high affinity immunoglobulin E receptor in bacterial translocation and intestinal inflammation. J Exp Med 2001 193 : 25 34.
    • (2001) J Exp Med , vol.193 , pp. 25-34
    • Dombrowicz, D.1
  • 74
    • 54949141219 scopus 로고    scopus 로고
    • Regulatory B cells inhibit EAE initiation in mice while other B cells promote disease progression
    • Matsushita T, Yanaba K, Bouaziz JD, Fujimoto M, Tedder TF. Regulatory B cells inhibit EAE initiation in mice while other B cells promote disease progression. J Clin Invest 2008 118 : 3420 3430.
    • (2008) J Clin Invest , vol.118 , pp. 3420-3430
    • Matsushita, T.1    Yanaba, K.2    Bouaziz, J.D.3    Fujimoto, M.4    Tedder, T.F.5
  • 76
    • 43049156086 scopus 로고    scopus 로고
    • A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responses
    • Yanaba K, Bouaziz JD, Haas KM, Poe JC, Fujimoto M, Tedder TF. A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responses. Immunity 2008 28 : 639 650.
    • (2008) Immunity , vol.28 , pp. 639-650
    • Yanaba, K.1    Bouaziz, J.D.2    Haas, K.M.3    Poe, J.C.4    Fujimoto, M.5    Tedder, T.F.6
  • 77
    • 67649235672 scopus 로고    scopus 로고
    • The development and function of regulatory B cells expressing IL-10 (B10 cells) requires antigen receptor diversity and TLR signals
    • Yanaba K, Bouaziz JD, Matsushita T, Tsubata T, Tedder TF. The development and function of regulatory B cells expressing IL-10 (B10 cells) requires antigen receptor diversity and TLR signals. J Immunol 2009 182 : 7459 7472.
    • (2009) J Immunol , vol.182 , pp. 7459-7472
    • Yanaba, K.1    Bouaziz, J.D.2    Matsushita, T.3    Tsubata, T.4    Tedder, T.F.5
  • 78
    • 34250179766 scopus 로고    scopus 로고
    • Novel suppressive function of transitional 2 B cells in experimental arthritis
    • Evans JG, et al. Novel suppressive function of transitional 2 B cells in experimental arthritis. J Immunol 2007 178 : 7868 7878.
    • (2007) J Immunol , vol.178 , pp. 7868-7878
    • Evans, J.G.1
  • 79
    • 0037103150 scopus 로고    scopus 로고
    • IL-10 regulates murine lupus
    • Yin Z, et al. IL-10 regulates murine lupus. J Immunol 2002 169 : 2148 2155.
    • (2002) J Immunol , vol.169 , pp. 2148-2155
    • Yin, Z.1
  • 80
    • 44849114332 scopus 로고    scopus 로고
    • Regulatory role of B-1 B cells in chronic colitis
    • Shimomura Y, et al. Regulatory role of B-1 B cells in chronic colitis. Int Immunol 2008 20 : 729 737.
    • (2008) Int Immunol , vol.20 , pp. 729-737
    • Shimomura, Y.1
  • 81
    • 60449119927 scopus 로고    scopus 로고
    • B cells suppress the inflammatory response in a mouse model of primary biliary cirrhosis
    • Moritoki Y, et al. B cells suppress the inflammatory response in a mouse model of primary biliary cirrhosis. Gastroenterology 2009 136 : 1037 1047.
    • (2009) Gastroenterology , vol.136 , pp. 1037-1047
    • Moritoki, Y.1
  • 82
    • 0035314006 scopus 로고    scopus 로고
    • B1 cells: Similarities and differences with other B cell subsets
    • Martin F, Kearney JF. B1 cells: similarities and differences with other B cell subsets. Curr Opin Immunol 2001 13 : 195 201.
    • (2001) Curr Opin Immunol , vol.13 , pp. 195-201
    • Martin, F.1    Kearney, J.F.2
  • 83
    • 70149098555 scopus 로고    scopus 로고
    • Nonredundant roles for B cell-derived IL-10 in immune counter-regulation
    • Madan R, et al. Nonredundant roles for B cell-derived IL-10 in immune counter-regulation. J Immunol 2009 183 : 2312 2320.
    • (2009) J Immunol , vol.183 , pp. 2312-2320
    • Madan, R.1
  • 84
    • 51549097819 scopus 로고    scopus 로고
    • Reprogrammed FoxP3+ T regulatory cells become IL-17+ antigen-specific autoimmune effectors in vitro and in vivo
    • Radhakrishnan S, et al. Reprogrammed FoxP3+ T regulatory cells become IL-17+ antigen-specific autoimmune effectors in vitro and in vivo. J Immunol 2008 181 : 3137 3147.
    • (2008) J Immunol , vol.181 , pp. 3137-3147
    • Radhakrishnan, S.1
  • 85
    • 0024955886 scopus 로고
    • Approaching the asymptote? Evolution and revolution in immunology
    • Janeway CA Jr. Approaching the asymptote? Evolution and revolution in immunology. Cold Spring Harb Symp Quant Biol 1989 54 : 1 13.
    • (1989) Cold Spring Harb Symp Quant Biol , vol.54 , pp. 1-13
    • Janeway, Jr.C.A.1
  • 86
    • 0014941813 scopus 로고
    • A theory of self-nonself discrimination
    • Bretscher P, Cohn M. A theory of self-nonself discrimination. Science 1970 169 : 1042 1049.
    • (1970) Science , vol.169 , pp. 1042-1049
    • Bretscher, P.1    Cohn, M.2
  • 87
    • 34249079154 scopus 로고    scopus 로고
    • Network motifs: Theory and experimental approaches
    • Alon U. Network motifs: theory and experimental approaches. Nat Rev Genet 2007 8 : 450 461.
    • (2007) Nat Rev Genet , vol.8 , pp. 450-461
    • Alon, U.1
  • 88
    • 0141484562 scopus 로고    scopus 로고
    • Biological networks: The tinkerer as an engineer
    • Alon U. Biological networks: the tinkerer as an engineer. Science 2003 301 : 1866 1867.
    • (2003) Science , vol.301 , pp. 1866-1867
    • Alon, U.1
  • 89
    • 35348913768 scopus 로고    scopus 로고
    • Apoptotic cells protect mice from autoimmune inflammation by the induction of regulatory B cells
    • Gray M, Miles K, Salter D, Gray D, Savill J. Apoptotic cells protect mice from autoimmune inflammation by the induction of regulatory B cells. Proc Natl Acad Sci USA 2007 104 : 14080 14085.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 14080-14085
    • Gray, M.1    Miles, K.2    Salter, D.3    Gray, D.4    Savill, J.5
  • 90
    • 58049193003 scopus 로고    scopus 로고
    • Microbe sensing, positive feedback loops, and the pathogenesis of inflammatory diseases
    • Beutler B. Microbe sensing, positive feedback loops, and the pathogenesis of inflammatory diseases. Immunol Rev 2009 227 : 248 263.
    • (2009) Immunol Rev , vol.227 , pp. 248-263
    • Beutler, B.1
  • 91
    • 44849085921 scopus 로고    scopus 로고
    • TLR agonists promote marginal zone B cell activation and facilitate T-dependent IgM responses
    • Rubtsov AV, Swanson CL, Troy S, Strauch P, Pelanda R, Torres RM. TLR agonists promote marginal zone B cell activation and facilitate T-dependent IgM responses. J Immunol 2008 180 : 3882 3888.
    • (2008) J Immunol , vol.180 , pp. 3882-3888
    • Rubtsov, A.V.1    Swanson, C.L.2    Troy, S.3    Strauch, P.4    Pelanda, R.5    Torres, R.M.6
  • 92
    • 0034700160 scopus 로고    scopus 로고
    • Dynamic expression of multiple scavenger receptor cysteine-rich genes in coelomocytes of the purple sea urchin
    • Pancer Z. Dynamic expression of multiple scavenger receptor cysteine-rich genes in coelomocytes of the purple sea urchin. Proc Natl Acad Sci USA 2000 97 : 13156 13161.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 13156-13161
    • Pancer, Z.1
  • 93
    • 33751549306 scopus 로고    scopus 로고
    • The immune gene repertoire encoded in the purple sea urchin genome
    • Hibino T, et al. The immune gene repertoire encoded in the purple sea urchin genome. Dev Biol 2006 300 : 349 365.
    • (2006) Dev Biol , vol.300 , pp. 349-365
    • Hibino, T.1
  • 94
    • 63049093367 scopus 로고    scopus 로고
    • A large new subset of TRIM genes highly diversified by duplication and positive selection in teleost fish
    • van der Aa LM, et al. A large new subset of TRIM genes highly diversified by duplication and positive selection in teleost fish. BMC Biol 2009 7 : 7.
    • (2009) BMC Biol , vol.7 , pp. 7
    • Van Der Aa, L.M.1
  • 95
    • 40949159815 scopus 로고    scopus 로고
    • A genomic view of the NOD-like receptor family in teleost fish: Identification of a novel NLR subfamily in zebrafish
    • Laing KJ, Purcell MK, Winton JR, Hansen JD. A genomic view of the NOD-like receptor family in teleost fish: identification of a novel NLR subfamily in zebrafish. BMC Evol Biol 2008 8 : 42.
    • (2008) BMC Evol Biol , vol.8 , pp. 42
    • Laing, K.J.1    Purcell, M.K.2    Winton, J.R.3    Hansen, J.D.4
  • 96
    • 39549123040 scopus 로고    scopus 로고
    • Toll-like receptor polymorphisms and susceptibility to human disease
    • Misch EA, Hawn TR. Toll-like receptor polymorphisms and susceptibility to human disease. Clin Sci 2008 114 : 347 360.
    • (2008) Clin Sci , vol.114 , pp. 347-360
    • Misch, E.A.1    Hawn, T.R.2
  • 97
    • 0015956495 scopus 로고
    • Towards a network theory of the immune system
    • Jerne NK. Towards a network theory of the immune system. Ann Immunol (Paris) 1974 125C : 373 389.
    • (1974) Ann Immunol (Paris) , vol.125 , pp. 373-389
    • Jerne, N.K.1
  • 98
    • 7644238181 scopus 로고    scopus 로고
    • Biological robustness
    • Kitano H. Biological robustness. Nat Rev Genet 2004 5 : 826 837.
    • (2004) Nat Rev Genet , vol.5 , pp. 826-837
    • Kitano, H.1
  • 99
    • 18844371714 scopus 로고    scopus 로고
    • Regulation of CD4+CD25+ regulatory T cell activity: It takes (IL-)two to tango
    • Scheffold A, Huhn J, Hofer T. Regulation of CD4+CD25+ regulatory T cell activity: it takes (IL-)two to tango. Eur J Immunol 2005 35 : 1336 1341.
    • (2005) Eur J Immunol , vol.35 , pp. 1336-1341
    • Scheffold, A.1    Huhn, J.2    Hofer, T.3
  • 100
    • 33646577466 scopus 로고    scopus 로고
    • Reciprocal developmental pathways for the generation of pathogenic effector Th17 and regulatory T cells
    • Bettelli E, et al. Reciprocal developmental pathways for the generation of pathogenic effector Th17 and regulatory T cells. Nature 2006 441 : 235 238.
    • (2006) Nature , vol.441 , pp. 235-238
    • Bettelli, E.1
  • 101
    • 51549118693 scopus 로고    scopus 로고
    • Helminth infections associated with multiple sclerosis induce regulatory B cells
    • Correale J, Farez M, Razzitte G. Helminth infections associated with multiple sclerosis induce regulatory B cells. Ann Neurol 2008 64 : 187 199.
    • (2008) Ann Neurol , vol.64 , pp. 187-199
    • Correale, J.1    Farez, M.2    Razzitte, G.3
  • 102
    • 0028098117 scopus 로고
    • Oligosaccharide-specific induction of interleukin 10 production by B220+ cells from schistosome-infected mice: A mechanism for regulation of CD4+ T-cell subsets
    • Velupillai P, Harn DA. Oligosaccharide-specific induction of interleukin 10 production by B220+ cells from schistosome-infected mice: a mechanism for regulation of CD4+ T-cell subsets. Proc Natl Acad Sci USA 1994 91 : 18 22.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 18-22
    • Velupillai, P.1    Harn, D.A.2
  • 104
    • 0037136537 scopus 로고    scopus 로고
    • The effect of infections on susceptibility to autoimmune and allergic diseases
    • Bach JF. The effect of infections on susceptibility to autoimmune and allergic diseases. N Engl J Med 2002 347 : 911 920.
    • (2002) N Engl J Med , vol.347 , pp. 911-920
    • Bach, J.F.1
  • 105
    • 23644449245 scopus 로고    scopus 로고
    • The expression of toll-like receptors 3 and 7 in rheumatoid arthritis synovium is increased and costimulation of toll-like receptors 3, 4, and 7/8 results in synergistic cytokine production by dendritic cells
    • Roelofs MF, et al. The expression of toll-like receptors 3 and 7 in rheumatoid arthritis synovium is increased and costimulation of toll-like receptors 3, 4, and 7/8 results in synergistic cytokine production by dendritic cells. Arthritis Rheum 2005 52 : 2313 2322.
    • (2005) Arthritis Rheum , vol.52 , pp. 2313-2322
    • Roelofs, M.F.1
  • 106
    • 33947545388 scopus 로고    scopus 로고
    • The Toll-like receptor adaptor proteins MyD88 and Mal/TIRAP contribute to the inflammatory and destructive processes in a human model of rheumatoid arthritis
    • Sacre SM, et al. The Toll-like receptor adaptor proteins MyD88 and Mal/TIRAP contribute to the inflammatory and destructive processes in a human model of rheumatoid arthritis. Am J Pathol 2007 170 : 518 525.
    • (2007) Am J Pathol , vol.170 , pp. 518-525
    • Sacre, S.M.1
  • 107
    • 0034040746 scopus 로고    scopus 로고
    • Presence of bacterial DNA and bacterial peptidoglycans in joints of patients with rheumatoid arthritis and other arthritides
    • van der Heijden IM, et al. Presence of bacterial DNA and bacterial peptidoglycans in joints of patients with rheumatoid arthritis and other arthritides. Arthritis Rheum 2000 43 : 593 598.
    • (2000) Arthritis Rheum , vol.43 , pp. 593-598
    • Van Der Heijden, I.M.1
  • 108
    • 33646882893 scopus 로고    scopus 로고
    • Identification of small heat shock protein B8 (HSP22) as a novel TLR4 ligand and potential involvement in the pathogenesis of rheumatoid arthritis
    • Roelofs MF, et al. Identification of small heat shock protein B8 (HSP22) as a novel TLR4 ligand and potential involvement in the pathogenesis of rheumatoid arthritis. J Immunol 2006 176 : 7021 7027.
    • (2006) J Immunol , vol.176 , pp. 7021-7027
    • Roelofs, M.F.1
  • 109
    • 67650502739 scopus 로고    scopus 로고
    • Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease
    • Midwood K, et al. Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease. Nat Med 2009 15 : 774 780.
    • (2009) Nat Med , vol.15 , pp. 774-780
    • Midwood, K.1
  • 112
    • 0024472593 scopus 로고
    • Anti-idiotypes against autoantibodies in normal immunoglobulins: Evidence for network regulation of human autoimmune responses
    • Rossi F, Dietrich G, Kazatchkine MD. Anti-idiotypes against autoantibodies in normal immunoglobulins: evidence for network regulation of human autoimmune responses. Immunol Rev 1989 110 : 135 149.
    • (1989) Immunol Rev , vol.110 , pp. 135-149
    • Rossi, F.1    Dietrich, G.2    Kazatchkine, M.D.3
  • 113
    • 32044462728 scopus 로고    scopus 로고
    • The incoherent feed-forward loop accelerates the response-time of the gal system of Escherichia coli
    • Mangan S, Itzkovitz S, Zaslaver A, Alon U. The incoherent feed-forward loop accelerates the response-time of the gal system of Escherichia coli. J Mol Biol 2006 356 : 1073 1081.
    • (2006) J Mol Biol , vol.356 , pp. 1073-1081
    • Mangan, S.1    Itzkovitz, S.2    Zaslaver, A.3    Alon, U.4
  • 114
    • 36849033963 scopus 로고    scopus 로고
    • TAM receptors are pleiotropic inhibitors of the innate immune response
    • Rothlin CV, Ghosh S, Zuniga EI, Oldstone MB, Lemke G. TAM receptors are pleiotropic inhibitors of the innate immune response. Cell 2007 131 : 1124 1136.
    • (2007) Cell , vol.131 , pp. 1124-1136
    • Rothlin, C.V.1    Ghosh, S.2    Zuniga, E.I.3    Oldstone, M.B.4    Lemke, G.5
  • 115
    • 0035854442 scopus 로고    scopus 로고
    • Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 family
    • Lu Q, Lemke G. Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 family. Science 2001 293 : 306 311.
    • (2001) Science , vol.293 , pp. 306-311
    • Lu, Q.1    Lemke, G.2
  • 116
    • 10744223505 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling-1 is essential for suppressing dendritic cell activation and systemic autoimmunity
    • Hanada T, et al. Suppressor of cytokine signaling-1 is essential for suppressing dendritic cell activation and systemic autoimmunity. Immunity 2003 19 : 437 450.
    • (2003) Immunity , vol.19 , pp. 437-450
    • Hanada, T.1
  • 117
    • 5444223519 scopus 로고    scopus 로고
    • The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses
    • Boone DL, et al. The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses. Nat Immunol 2004 5 : 1052 1060.
    • (2004) Nat Immunol , vol.5 , pp. 1052-1060
    • Boone, D.L.1
  • 118
    • 0034730713 scopus 로고    scopus 로고
    • Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice
    • Lee EG, et al. Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice. Science 2000 289 : 2350 2354.
    • (2000) Science , vol.289 , pp. 2350-2354
    • Lee, E.G.1
  • 119
    • 39549107115 scopus 로고    scopus 로고
    • Homeostatic MyD88-dependent signals cause lethal inflammation in the absence of A20
    • Turer EE, et al. Homeostatic MyD88-dependent signals cause lethal inflammation in the absence of A20. J Exp Med 2008 205 : 451 464.
    • (2008) J Exp Med , vol.205 , pp. 451-464
    • Turer, E.E.1


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