6″-debromohamacanthin A, a bis (indole) alkaloid, inhibits angiogenesis by targeting the VEGFR2-mediated PI3K/AKT/mTOR signaling pathways

Marine Drugs

Volumn 11, Issue 4, 2013, Pages 1087-1103

  Kim, Gi Dae ^a   Cheong, Oug Jae ^b   Bae, Song Yi ^a   Shin, Jongheon ^a   Lee, Sang Kook ^a  

^a Seoul National University   (South Korea)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

6 debromohamacanthin A; Anti angiogenesis; HUVEC; Mouse embryonic stem cells; PI3K AKT mTOR

Indexed keywords

6'' DEBROMOHAMACANTHIN A; CD31 ANTIGEN; INDOLE ALKALOID; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 2; 6''-DEBROMOHAMACANTHIN A; ANGIOGENESIS INHIBITOR; TARGET OF RAPAMYCIN KINASE;

ANIMAL CELL; ANTIANGIOGENIC ACTIVITY; ARTICLE; CAPILLARY PROLIFERATION; CELL CULTURE; CELL DIFFERENTIATION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DRUG STRUCTURE; DRUG TARGETING; EMBRYONIC STEM CELL; ENDOTHELIUM CELL; EX VIVO STUDY; HUMAN; HUMAN CELL; INHIBITION KINETICS; MICROVASCULATURE; MOLECULAR MECHANICS; MOUSE; NONHUMAN; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UMBILICAL VEIN ENDOTHELIAL CELL; VASCULAR RING; ANIMAL; AORTA; CHEMISTRY; DRUG EFFECTS; ISOLATION AND PURIFICATION; METABOLISM; SPONGE (PORIFERA); DRUG EFFECT;

SPONGOSORITES;

ANGIOGENESIS INHIBITORS; ANIMALS; ANTIGENS, CD31; AORTA; EMBRYONIC STEM CELLS; ENDOTHELIAL CELLS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INDOLE ALKALOIDS; MICE; PHOSPHATIDYLINOSITOL 3-KINASES; PORIFERA; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 84876969387     PISSN: None     EISSN: 16603397     Source Type: Journal    
DOI: 10.3390/md11041087     Document Type: Article

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